{"id":"https://openalex.org/W7117487654","doi":"https://doi.org/10.1371/journal.pcbi.1013833","title":"A novel generative framework for designing pathogen-targeted antimicrobial peptides with programmable physicochemical properties","display_name":"A novel generative framework for designing pathogen-targeted antimicrobial peptides with programmable physicochemical properties","publication_year":2025,"publication_date":"2025-12-29","ids":{"openalex":"https://openalex.org/W7117487654","doi":"https://doi.org/10.1371/journal.pcbi.1013833","pmid":"https://pubmed.ncbi.nlm.nih.gov/41460918"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013833","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013833","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013833","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121420414","display_name":"Weizhong Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weizhong Zhao","raw_affiliation_strings":["Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning, Central China Normal University, Wuhan, Hubei, China","National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, Hubei, China","School of Computer, Central China Normal University, Wuhan, Hubei, China"],"raw_orcid":"https://orcid.org/0000-0001-8552-6084","affiliations":[{"raw_affiliation_string":"Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning, Central China Normal University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113195073","display_name":"Keyuan Hou","orcid":null},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaijieyi Hou","raw_affiliation_strings":["Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning, Central China Normal University, Wuhan, Hubei, China","National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, Hubei, China","School of Computer, Central China Normal University, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning, Central China Normal University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033240507","display_name":"Chang Tang","orcid":"https://orcid.org/0000-0002-6515-7696"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Tang","raw_affiliation_strings":["Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning, Central China Normal University, Wuhan, Hubei, China","National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, Hubei, China","School of Computer, Central China Normal University, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning, Central China Normal University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121481513","display_name":"Yiting Shen","orcid":null},"institutions":[{"id":"https://openalex.org/I74525822","display_name":"Hubei University of Technology","ror":"https://ror.org/02d3fj342","country_code":"CN","type":"education","lineage":["https://openalex.org/I74525822"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiting Shen","raw_affiliation_strings":["Detroit Green Technology Institute, Hubei University of Technology, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Detroit Green Technology Institute, Hubei University of Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I74525822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121487091","display_name":"Jinlin Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinlin Liu","raw_affiliation_strings":["School of Life Sciences, Central China Normal University, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Central China Normal University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121449872","display_name":"Xiaohua Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohua Hu","raw_affiliation_strings":["College of Computing and Informatics, Drexel University, Philadelphia, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computing and Informatics, Drexel University, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.9418,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.88280791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"21","issue":"12","first_page":"e1013833","last_page":"e1013833"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9664000272750854,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9664000272750854,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"Antimicrobial peptides","score":0.760200023651123},{"id":"https://openalex.org/keywords/antimicrobial","display_name":"Antimicrobial","score":0.5611000061035156},{"id":"https://openalex.org/keywords/autoencoder","display_name":"Autoencoder","score":0.4690999984741211},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.45570001006126404},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.37619999051094055},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.760200023651123},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5611000061035156},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5432000160217285},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5425000190734863},{"id":"https://openalex.org/C101738243","wikidata":"https://www.wikidata.org/wiki/Q786435","display_name":"Autoencoder","level":3,"score":0.4690999984741211},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.45570001006126404},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44179999828338623},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.40220001339912415},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.34200000762939453},{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.32280001044273376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3181000053882599},{"id":"https://openalex.org/C2779362680","wikidata":"https://www.wikidata.org/wiki/Q905000","display_name":"hERG","level":3,"score":0.3009999990463257},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.28119999170303345},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.2694000005722046},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.26910001039505005}],"mesh":[{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1371/journal.pcbi.1013833","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013833","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:41460918","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41460918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12747415","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12747415/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12747415/pdf/pcbi.1013833.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013833","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013833","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","score":0.5786440968513489,"id":"https://metadata.un.org/sdg/9"}],"awards":[{"id":"https://openalex.org/G2235372276","display_name":null,"funder_award_id":"62472192","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G235156935","display_name":null,"funder_award_id":"62372205","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7106341088","display_name":null,"funder_award_id":"KJ02502022-0450","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G8880026606","display_name":null,"funder_award_id":"62472192; 62372205","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320323173","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1973742248","https://openalex.org/W2021520922","https://openalex.org/W2791848964","https://openalex.org/W2958929976","https://openalex.org/W2963223306","https://openalex.org/W2991576191","https://openalex.org/W3015438624","https://openalex.org/W3026218946","https://openalex.org/W3048827317","https://openalex.org/W3049225057","https://openalex.org/W3094089973","https://openalex.org/W3133978231","https://openalex.org/W3135130381","https://openalex.org/W3145130117","https://openalex.org/W3146944767","https://openalex.org/W3154086429","https://openalex.org/W3177828909","https://openalex.org/W4224997444","https://openalex.org/W4281567959","https://openalex.org/W4315784590","https://openalex.org/W4324344300","https://openalex.org/W4387401786","https://openalex.org/W4392571650","https://openalex.org/W4399302728","https://openalex.org/W4400026633","https://openalex.org/W4400864148","https://openalex.org/W4402053335","https://openalex.org/W4402989199","https://openalex.org/W4403253158","https://openalex.org/W4403676148","https://openalex.org/W4403767533","https://openalex.org/W4404148841","https://openalex.org/W4404458588","https://openalex.org/W4406261446","https://openalex.org/W4406334052","https://openalex.org/W4406454031","https://openalex.org/W4406536366","https://openalex.org/W4406781767","https://openalex.org/W4407127289","https://openalex.org/W4407160027","https://openalex.org/W4407360649","https://openalex.org/W4407412534","https://openalex.org/W4408221130","https://openalex.org/W4408410901","https://openalex.org/W4408459591"],"related_works":[],"abstract_inverted_index":{"Antimicrobial":[0],"peptides":[1,52],"(AMPs)":[2],"are":[3,15],"crucial":[4],"in":[5,19,28,114,155],"addressing":[6],"the":[7,107,138,167],"global":[8],"crisis":[9],"of":[10,84,89,116,137,150],"bacterial":[11,37,98,121,141],"resistance.":[12],"However,":[13],"there":[14],"still":[16],"significant":[17],"limitations":[18],"existing":[20,112],"methods":[21],"on":[22],"de":[23],"novo":[24],"AMPs":[25,30,68,85,134],"design,":[26],"especially":[27],"designing":[29,49],"with":[31,53,69],"desirable":[32],"physicochemical":[33,55,71],"properties":[34],"for":[35,48,66,86,96,135,171,176],"specific":[36,97,120],"pathogens.":[38],"In":[39],"this":[40,164],"study,":[41],"we":[42,104,129],"propose":[43],"a":[44,59,76],"novel":[45],"generative":[46],"framework":[47,109],"pathogen-targeted":[50],"antimicrobial":[51,117,177],"programmable":[54],"properties.":[56,72],"More":[57],"specifically,":[58],"conditional":[60,77],"Variational":[61],"Autoencoder":[62],"is":[63],"first":[64],"pretrained":[65],"generating":[67],"editable":[70],"We":[73],"then":[74],"develop":[75],"diffusion":[78],"model":[79],"to":[80],"learn":[81],"hidden":[82],"representations":[83],"targeting":[87],"pathogens":[88],"interest,":[90],"and":[91,127],"construct":[92],"corresponding":[93],"MIC":[94],"predictors":[95],"strains.":[99],"Through":[100],"comprehensive":[101],"simulation":[102],"experiments,":[103],"demonstrate":[105],"that":[106],"proposed":[108],"outperforms":[110],"most":[111],"models":[113],"terms":[115],"efficacy":[118],"against":[119],"targets.":[122],"Moreover,":[123],"through":[124],"systematic":[125],"screening":[126],"analysis,":[128],"have":[130],"identified":[131],"two":[132,139],"star":[133],"each":[136],"target":[140],"species":[142],"(i.e.,":[143],"E.":[144],"coli":[145],"or":[146],"S.":[147],"aureus),":[148],"both":[149],"which":[151],"exhibit":[152],"excellent":[153],"performance":[154],"antibacterial":[156],"activity,":[157],"hemolytic":[158],"properties,":[159],"toxicity":[160],"profiles,":[161],"etc.":[162],"Overall,":[163],"study":[165],"provides":[166],"key":[168],"technological":[169],"support":[170],"developing":[172],"next-generation":[173],"intelligent":[174],"platforms":[175],"agents":[178],"design.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-07-18T07:39:51.176621","created_date":"2025-12-29T00:00:00"}
