{"id":"https://openalex.org/W4416872397","doi":"https://doi.org/10.1371/journal.pcbi.1013765","title":"A unified model library maps how neuromodulation reshapes the excitability landscape of neurons across the brain","display_name":"A unified model library maps how neuromodulation reshapes the excitability landscape of neurons across the brain","publication_year":2025,"publication_date":"2025-12-01","ids":{"openalex":"https://openalex.org/W4416872397","doi":"https://doi.org/10.1371/journal.pcbi.1013765","pmid":"https://pubmed.ncbi.nlm.nih.gov/41325433"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013765","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013765","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013765","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056050892","display_name":"Domenico Guarino","orcid":"https://orcid.org/0000-0003-4793-9560"},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210086740","display_name":"Institut des Neurosciences Paris-Saclay","ror":"https://ror.org/002v40q27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210086740"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Domenico Guarino","raw_affiliation_strings":["Department for Integrative and Computational Neuroscience (ICN), Paris-Saclay Institute of Neuroscience (NeuroPSI), Gif-sur-Yvette, France","HABS, Institut des Neurosciences de Paris Saclay, Centre CEA Paris Saclay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Integrative and Computational Neuroscience (ICN), Paris-Saclay Institute of Neuroscience (NeuroPSI), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I4210086740"]},{"raw_affiliation_string":"HABS, Institut des Neurosciences de Paris Saclay, Centre CEA Paris Saclay, France","institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210086740","https://openalex.org/I4210128565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059113679","display_name":"Ilaria Carannante","orcid":"https://orcid.org/0000-0001-8210-8709"},"institutions":[{"id":"https://openalex.org/I4210086740","display_name":"Institut des Neurosciences Paris-Saclay","ror":"https://ror.org/002v40q27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210086740"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Ilaria Carannante","raw_affiliation_strings":["Department for Integrative and Computational Neuroscience (ICN), Paris-Saclay Institute of Neuroscience (NeuroPSI), Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0001-8210-8709","affiliations":[{"raw_affiliation_string":"Department for Integrative and Computational Neuroscience (ICN), Paris-Saclay Institute of Neuroscience (NeuroPSI), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I4210086740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022027790","display_name":"Alain Destexhe","orcid":"https://orcid.org/0000-0001-7405-0455"},"institutions":[{"id":"https://openalex.org/I4210086740","display_name":"Institut des Neurosciences Paris-Saclay","ror":"https://ror.org/002v40q27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210086740"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Alain Destexhe","raw_affiliation_strings":["Department for Integrative and Computational Neuroscience (ICN), Paris-Saclay Institute of Neuroscience (NeuroPSI), Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Integrative and Computational Neuroscience (ICN), Paris-Saclay Institute of Neuroscience (NeuroPSI), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I4210086740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022027790","https://openalex.org/A5056050892","https://openalex.org/A5059113679"],"corresponding_institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I4210086740","https://openalex.org/I4210128565"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34067912,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"12","first_page":"e1013765","last_page":"e1013765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.6656000018119812,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.6656000018119812,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.16599999368190765,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.041600000113248825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.9016000032424927},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.5174000263214111},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.47290000319480896},{"id":"https://openalex.org/keywords/bursting","display_name":"Bursting","score":0.41530001163482666},{"id":"https://openalex.org/keywords/computational-neuroscience","display_name":"Computational neuroscience","score":0.396699994802475},{"id":"https://openalex.org/keywords/premovement-neuronal-activity","display_name":"Premovement neuronal activity","score":0.39570000767707825},{"id":"https://openalex.org/keywords/neurophysiology","display_name":"Neurophysiology","score":0.3882000148296356},{"id":"https://openalex.org/keywords/nerve-net","display_name":"Nerve net","score":0.3813000023365021},{"id":"https://openalex.org/keywords/perspective","display_name":"Perspective (graphical)","score":0.37540000677108765}],"concepts":[{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.9016000032424927},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7929999828338623},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5670999884605408},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5174000263214111},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.47290000319480896},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.41530001163482666},{"id":"https://openalex.org/C15286952","wikidata":"https://www.wikidata.org/wiki/Q8037925","display_name":"Computational neuroscience","level":2,"score":0.396699994802475},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.39570000767707825},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.3882000148296356},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.3813000023365021},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.37540000677108765},{"id":"https://openalex.org/C31288803","wikidata":"https://www.wikidata.org/wiki/Q2617516","display_name":"Systems neuroscience","level":5,"score":0.34630000591278076},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33899998664855957},{"id":"https://openalex.org/C186565885","wikidata":"https://www.wikidata.org/wiki/Q1651163","display_name":"Biological neuron model","level":3,"score":0.3264000117778778},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3240000009536743},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.29660001397132874},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.29600000381469727},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C197525751","wikidata":"https://www.wikidata.org/wiki/Q1431093","display_name":"Neuroprosthetics","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.28279998898506165},{"id":"https://openalex.org/C169453685","wikidata":"https://www.wikidata.org/wiki/Q1054066","display_name":"Central pattern generator","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.27639999985694885},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C73586568","wikidata":"https://www.wikidata.org/wiki/Q2600211","display_name":"Parameter space","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2678000032901764},{"id":"https://openalex.org/C117838684","wikidata":"https://www.wikidata.org/wiki/Q533483","display_name":"Local field potential","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.25040000677108765}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1013765","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013765","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:41325433","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41325433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-05524915v1","is_oa":true,"landing_page_url":"https://hal.science/hal-05524915","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2025, 21 (12), pp.e1013765. ⟨10.1371/journal.pcbi.1013765⟩","raw_type":"Journal articles"},{"id":"pmh:oai:pubmedcentral.nih.gov:12680334","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12680334/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013765","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013765","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W81520806","https://openalex.org/W1633465816","https://openalex.org/W1736719008","https://openalex.org/W1810900778","https://openalex.org/W1861512592","https://openalex.org/W1978145060","https://openalex.org/W1983312292","https://openalex.org/W1990454576","https://openalex.org/W1992669875","https://openalex.org/W1994667935","https://openalex.org/W2001947879","https://openalex.org/W2011301426","https://openalex.org/W2011601662","https://openalex.org/W2016914301","https://openalex.org/W2022764592","https://openalex.org/W2026409252","https://openalex.org/W2032202532","https://openalex.org/W2032924239","https://openalex.org/W2033233305","https://openalex.org/W2034450065","https://openalex.org/W2038869309","https://openalex.org/W2044937225","https://openalex.org/W2045143577","https://openalex.org/W2048349186","https://openalex.org/W2053441706","https://openalex.org/W2054914622","https://openalex.org/W2064063251","https://openalex.org/W2068401524","https://openalex.org/W2083253722","https://openalex.org/W2087861759","https://openalex.org/W2101578047","https://openalex.org/W2103111028","https://openalex.org/W2118830830","https://openalex.org/W2125706064","https://openalex.org/W2128589492","https://openalex.org/W2128949090","https://openalex.org/W2132862169","https://openalex.org/W2135447632","https://openalex.org/W2142329149","https://openalex.org/W2147289447","https://openalex.org/W2148574157","https://openalex.org/W2154959070","https://openalex.org/W2155837964","https://openalex.org/W2164701017","https://openalex.org/W2168529864","https://openalex.org/W2171476909","https://openalex.org/W2290883297","https://openalex.org/W2338375276","https://openalex.org/W2411013142","https://openalex.org/W2472803348","https://openalex.org/W2790354390","https://openalex.org/W2891188947","https://openalex.org/W2969331319","https://openalex.org/W3003257820","https://openalex.org/W3035965352","https://openalex.org/W3080436007","https://openalex.org/W3188628968","https://openalex.org/W3209238463","https://openalex.org/W4220945110","https://openalex.org/W4229487902","https://openalex.org/W4285891880","https://openalex.org/W4380853678"],"related_works":[],"abstract_inverted_index":{"The":[0,249],"activity":[1],"of":[2,41,53,82,87,98,130,141,160,185,219,243],"neurons":[3,83,161],"in":[4,167,181,221],"the":[5,39,88,96,107,127,131,139,157,182,199,217],"central":[6,92],"nervous":[7,93],"system":[8],"changes":[9,27,166],"drastically":[10],"across":[11],"different":[12,154],"states":[13],"like":[14],"asleep":[15],"or":[16,19,22,207],"awake,":[17],"attentive":[18],"drowsy,":[20],"behaving":[21],"resting.":[23],"Neuromodulation":[24],"supports":[25],"these":[26],"by":[28,171,176],"altering":[29],"neuronal":[30,57,247],"excitability.":[31],"Much":[32],"work":[33],"has":[34],"been":[35],"devoted":[36],"to":[37,65,125,258],"understanding":[38],"effects":[40],"neuromodulators":[42,155,172],"on":[43,234,246],"various":[44],"neurons.":[45],"However,":[46],"we":[47,60,69,102,119,137,215],"still":[48],"lack":[49],"a":[50,121,240],"cohesive":[51],"picture":[52],"how":[54],"neuromodulation":[55,220],"affects":[56],"dynamics.":[58],"Here,":[59],"provide":[61],"an":[62,209,231],"analytical":[63],"framework":[64],"characterise":[66],"neuromodulation.":[67],"First,":[68],"analyse":[70],"electrophysiological":[71,168],"data":[72,105,225],"from":[73,84,226],"published":[74],"papers":[75],"and":[76,90,133,146,187,203,238,255],"extract":[77],"features":[78],"for":[79],"seven":[80],"types":[81],"five":[85,99],"areas":[86],"human":[89],"rodent":[91],"system,":[94],"under":[95],"effect":[97,218],"neuromodulators.":[100],"Second,":[101],"describe":[103],"this":[104,213],"using":[106,224],"widespread,":[108],"simple,":[109],"yet":[110],"biologically":[111],"accurate,":[112],"Adaptive":[113],"Exponential":[114],"Integrate-and-Fire":[115],"model":[116],"(AdEx).":[117],"Third,":[118],"use":[120],"dimensionality":[122],"reduction":[123],"technique":[124],"study":[126,229],"parameter":[128],"space":[129,159],"control":[132],"neuromodulated":[134],"conditions.":[135],"Fourth,":[136],"examine":[138],"dynamics":[140],"each":[142],"neuromodulator":[143],"through":[144],"bifurcation":[145],"phase-plane":[147],"analyses.":[148],"Our":[149],"analyses":[150],"revealed":[151],"that:":[152],"(i)":[153],"remap":[156],"parameters":[158],"into":[162],"non-overlapping":[163],"clusters,":[164],"(ii)":[165],"properties":[169],"induced":[170],"can":[173],"be":[174],"explained":[175],"transitions":[177],"between":[178],"dynamical":[179],"regimes":[180],"excitability":[183],"landscape":[184],"neurons,":[186],"(iii)":[188],"there":[189],"are":[190],"only":[191],"two":[192],"distinct":[193],"neuromodulatory":[194],"effects:":[195],"\"switching\"":[196],"-":[197,202,205],"changing":[198],"spiking":[200],"behaviour":[201],"\"scaling\"":[204],"strengthening":[206],"weakening":[208],"existing":[210],"behaviour.":[211],"Leveraging":[212],"framework,":[214],"estimated":[216],"one":[222],"species":[223],"another":[227],"species.This":[228],"provides":[230],"integrative":[232],"perspective":[233],"neuromodulation,":[235],"offering":[236],"experimenters":[237],"theoreticians":[239],"compact":[241],"description":[242],"its":[244],"impact":[245],"activity.":[248],"open-source":[250],"Python-based":[251],"workflow":[252],"is":[253],"modular":[254],"readily":[256],"applicable":[257],"other":[259],"datasets.":[260]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-12-01T00:00:00"}