{"id":"https://openalex.org/W4415159600","doi":"https://doi.org/10.1371/journal.pcbi.1013556","title":"Deep learning detection of dynamic exocytosis events in fluorescence TIRF microscopy","display_name":"Deep learning detection of dynamic exocytosis events in fluorescence TIRF microscopy","publication_year":2025,"publication_date":"2025-10-14","ids":{"openalex":"https://openalex.org/W4415159600","doi":"https://doi.org/10.1371/journal.pcbi.1013556","pmid":"https://pubmed.ncbi.nlm.nih.gov/41086183"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013556","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013556","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013556","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017385054","display_name":"Hugo Lachuer","orcid":"https://orcid.org/0000-0001-9090-7893"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210113761","display_name":"Institut Jacques Monod","ror":"https://ror.org/02c5gc203","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210113761"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Hugo Lachuer","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, CNRS, Institut Jacques Monod, Paris, France"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, CNRS, Institut Jacques Monod, Paris, France","institution_ids":["https://openalex.org/I4210113761","https://openalex.org/I204730241","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068813161","display_name":"Emmanuel Moebel","orcid":"https://orcid.org/0000-0001-6264-3245"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Emmanuel Moebel","raw_affiliation_strings":["Inria Center at University of Rennes, SAIRPICO Team, U1339 INSERM, Institut Curie, Chemical Biology of Cancer Unit, Paris, France"],"affiliations":[{"raw_affiliation_string":"Inria Center at University of Rennes, SAIRPICO Team, U1339 INSERM, Institut Curie, Chemical Biology of Cancer Unit, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005617827","display_name":"Anne\u2010Sophie Mac\u00e9","orcid":"https://orcid.org/0000-0003-3072-3819"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210161403","display_name":"Biologie cellulaire et Cancer","ror":"https://ror.org/04w11tv37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210161403","https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Anne-Sophie Mac\u00e9","raw_affiliation_strings":["Institut Curie, PSL Research University, CNRS, UMR 144, Cell and Tissue Imaging Facility (PICT-IBiSA), Paris, France"],"affiliations":[{"raw_affiliation_string":"Institut Curie, PSL Research University, CNRS, UMR 144, Cell and Tissue Imaging Facility (PICT-IBiSA), Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I1294671590","https://openalex.org/I4210161403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108398825","display_name":"A. Masson","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Arthur Masson","raw_affiliation_strings":["Inria Center at University of Rennes, SAIRPICO Team, U1339 INSERM, Institut Curie, Chemical Biology of Cancer Unit, Paris, France"],"affiliations":[{"raw_affiliation_string":"Inria Center at University of Rennes, SAIRPICO Team, U1339 INSERM, Institut Curie, Chemical Biology of Cancer Unit, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057239052","display_name":"Kristine Schauer","orcid":"https://orcid.org/0000-0002-6102-8790"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Kristine Schauer","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm U1279, Centre National de la Recherche Scientifique, Villejuif, France"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Gustave Roussy, Inserm U1279, Centre National de la Recherche Scientifique, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033807512","display_name":"Charles Kervrann","orcid":"https://orcid.org/0000-0001-6263-0452"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Charles Kervrann","raw_affiliation_strings":["Inria Center at University of Rennes, SAIRPICO Team, U1339 INSERM, Institut Curie, Chemical Biology of Cancer Unit, Paris, France"],"affiliations":[{"raw_affiliation_string":"Inria Center at University of Rennes, SAIRPICO Team, U1339 INSERM, Institut Curie, Chemical Biology of Cancer Unit, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I80043"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5005617827","https://openalex.org/A5017385054","https://openalex.org/A5033807512","https://openalex.org/A5057239052","https://openalex.org/A5068813161","https://openalex.org/A5108398825"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I2746051580","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4210113761","https://openalex.org/I4210161403","https://openalex.org/I80043"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20296235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"10","first_page":"e1013556","last_page":"e1013556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11897","display_name":"Digital Holography and Microscopy","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.7278000116348267},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6421999931335449},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5983999967575073},{"id":"https://openalex.org/keywords/total-internal-reflection-fluorescence-microscope","display_name":"Total internal reflection fluorescence microscope","score":0.5548999905586243},{"id":"https://openalex.org/keywords/exocytosis","display_name":"Exocytosis","score":0.5167999863624573},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.47600001096725464},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4255000054836273},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.40560001134872437}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7437999844551086},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.7278000116348267},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6421999931335449},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6220999956130981},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5983999967575073},{"id":"https://openalex.org/C121381206","wikidata":"https://www.wikidata.org/wiki/Q902514","display_name":"Total internal reflection fluorescence microscope","level":3,"score":0.5548999905586243},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.5167999863624573},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.47600001096725464},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4255000054836273},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4165000021457672},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.40560001134872437},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.3917999863624573},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3880999982357025},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.3407999873161316},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.3343000113964081},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.31349998712539673},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.311599999666214},{"id":"https://openalex.org/C77967617","wikidata":"https://www.wikidata.org/wiki/Q4677561","display_name":"Active learning (machine learning)","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C8038995","wikidata":"https://www.wikidata.org/wiki/Q1152135","display_name":"Unsupervised learning","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.2955999970436096},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.27880001068115234},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.2506999969482422}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1013556","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013556","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:41086183","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41086183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-04874728v1","is_oa":true,"landing_page_url":"https://inria.hal.science/hal-04874728","pdf_url":"https://inria.hal.science/hal-04874728/document","source":{"id":"https://openalex.org/S4406922466","display_name":"SPIRE - Sciences Po Institutional REpository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2025, 21 (10), pp.e1013556. ⟨10.1371/journal.pcbi.1013556⟩","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:0c47d12dcb624098b633208814aa8c31","is_oa":true,"landing_page_url":"https://doaj.org/article/0c47d12dcb624098b633208814aa8c31","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 10, p e1013556 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11327978","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12520386","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013556","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013556","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1128484202","display_name":null,"funder_award_id":"ANR-10-IDEX-0001-02","funder_id":"https://openalex.org/F4320325835","funder_display_name":"Universit\u00e9 de Recherche Paris Sciences et Lettres"},{"id":"https://openalex.org/G1472707349","display_name":null,"funder_award_id":"ANR-10-IDEX-0001-02","funder_id":"https://openalex.org/F4320309749","funder_display_name":"Association pour la Recherche sur le Cancer"},{"id":"https://openalex.org/G172085353","display_name":null,"funder_award_id":"ANR-20-ASTR-0005","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1732524921","display_name":null,"funder_award_id":"PhD fellowship","funder_id":"https://openalex.org/F4320322892","funder_display_name":"Centre National de la Recherche Scientifique"},{"id":"https://openalex.org/G1916321118","display_name":null,"funder_award_id":"ANR-10-INBS-0","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1928233322","display_name":null,"funder_award_id":"ANR-10-INBS-04-07","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1960712518","display_name":null,"funder_award_id":"ANR-10-INBS-04","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2077798120","display_name":null,"funder_award_id":"ANR-10-IDEX-","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2169153225","display_name":null,"funder_award_id":"ANR-10-IDEX-0001-02 PSL","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2614703714","display_name":null,"funder_award_id":"ANR-10-IDEX-0001-02","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2658974192","display_name":null,"funder_award_id":"ANR-10-IDEX-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2871517121","display_name":null,"funder_award_id":"10-IDEX-0001-02 PSL","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3860367528","display_name":null,"funder_award_id":"10-IDEX-0001-02","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3882170237","display_name":null,"funder_award_id":"11-LBX-0038","funder_id":"https://openalex.org/F4320322892","funder_display_name":"Centre National de la Recherche Scientifique"},{"id":"https://openalex.org/G4536025636","display_name":null,"funder_award_id":"ANR-10-IDEX-0001-02 PS","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G471331628","display_name":null,"funder_award_id":"ANR-10-IDEX","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5018964308","display_name":null,"funder_award_id":"France","funder_id":"https://openalex.org/F4320309749","funder_display_name":"Association pour la Recherche sur le Cancer"},{"id":"https://openalex.org/G5610283560","display_name":null,"funder_award_id":"ANR-10-IDEX-0001-02 PSL","funder_id":"https://openalex.org/F4320322892","funder_display_name":"Centre National de la Recherche Scientifique"},{"id":"https://openalex.org/G591834160","display_name":null,"funder_award_id":"11-LBX-0038","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7156242077","display_name":null,"funder_award_id":"ANR-10-INBS-04-0","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7758152977","display_name":null,"funder_award_id":"support","funder_id":"https://openalex.org/F4320322892","funder_display_name":"Centre National de la Recherche Scientifique"},{"id":"https://openalex.org/G782245399","display_name":null,"funder_award_id":"IDEX-0001-02","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8385319089","display_name":null,"funder_award_id":"10-IDEX-0001-0","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8594515782","display_name":null,"funder_award_id":"ANR-21-CE13- 0010-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8644237715","display_name":"Actin cortex regulation by class I myosin Myo1C","funder_award_id":"ANR-21-CE13-0010","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G914543418","display_name":null,"funder_award_id":"ANR-10-IDEX-0001-02 PSL","funder_id":"https://openalex.org/F4320325835","funder_display_name":"Universit\u00e9 de Recherche Paris Sciences et Lettres"}],"funders":[{"id":"https://openalex.org/F4320309749","display_name":"Association pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320325835","display_name":"Universit\u00e9 de Recherche Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W91925406","https://openalex.org/W1497467118","https://openalex.org/W1512578733","https://openalex.org/W1598263505","https://openalex.org/W1901129140","https://openalex.org/W1987739173","https://openalex.org/W2001031594","https://openalex.org/W2012518093","https://openalex.org/W2014004683","https://openalex.org/W2034528152","https://openalex.org/W2090840279","https://openalex.org/W2121749936","https://openalex.org/W2128970032","https://openalex.org/W2142142736","https://openalex.org/W2170076642","https://openalex.org/W2180552766","https://openalex.org/W2606502005","https://openalex.org/W2621053731","https://openalex.org/W2737380341","https://openalex.org/W2767430428","https://openalex.org/W2783004471","https://openalex.org/W2785136186","https://openalex.org/W2887935569","https://openalex.org/W2888107234","https://openalex.org/W2947430915","https://openalex.org/W2952651429","https://openalex.org/W2964098128","https://openalex.org/W3048053687","https://openalex.org/W3091097738","https://openalex.org/W3132455321","https://openalex.org/W3142849873","https://openalex.org/W3166157844","https://openalex.org/W3200897044","https://openalex.org/W3207554858","https://openalex.org/W4286979524","https://openalex.org/W4287639323","https://openalex.org/W4292092915","https://openalex.org/W4321169423","https://openalex.org/W4379599678","https://openalex.org/W4387210928","https://openalex.org/W4389084798","https://openalex.org/W4396568673","https://openalex.org/W4399757462","https://openalex.org/W4402138169"],"related_works":[],"abstract_inverted_index":{"Segmentation":[0],"and":[1,26,148,186,198,210],"detection":[2,77],"of":[3,10,31,40,43,49,78,89,109,170,212,227],"biological":[4],"objects":[5,42],"in":[6,13,86,112,151,230],"fluorescence":[7],"microscopy":[8],"is":[9],"paramount":[11],"importance":[12],"cell":[14,152],"imaging.":[15,232],"Deep":[16],"learning":[17,119,173,224],"approaches":[18],"have":[19],"recently":[20],"shown":[21],"promise":[22],"to":[23,37,139,159,203,214],"advance,":[24],"automatize":[25],"accelerate":[27],"analysis.":[28],"However,":[29],"most":[30],"the":[32,38,47,76,126,130,140,179],"interest":[33],"has":[34,56],"been":[35,57],"given":[36],"segmentation":[39,48],"static":[41],"2D/3D":[44],"images":[45],"whereas":[46],"dynamic":[50,80,216,228],"processes":[51,229],"obtained":[52],"from":[53,125],"time-lapse":[54],"acquisitions":[55],"less":[58],"explored.":[59],"Here":[60],"we":[61],"adapted":[62],"DeepFinder,":[63],"a":[64,104,136,195],"U-Net":[65],"originally":[66],"designed":[67],"for":[68,75,221],"3D":[69],"noisy":[70],"cryo-electron":[71],"tomography":[72],"(cryo-ET)":[73],"data,":[74],"rare":[79],"exocytosis":[81],"events":[82,111,217],"(termed":[83],"ExoDeepFinder)":[84],"observed":[85],"temporal":[87],"series":[88],"2D":[90],"Total":[91],"Internal":[92],"Reflection":[93],"Fluorescence":[94],"Microscopy":[95],"(TIRFM)":[96],"images.":[97],"ExoDeepFinder":[98,128,213],"achieved":[99],"good":[100],"absolute":[101],"performances":[102,120,211],"with":[103,121],"relatively":[105],"small":[106],"training":[107,181],"dataset":[108],"12000":[110],"60":[113],"cells.":[114],"We":[115],"rigorously":[116],"compared":[117],"deep":[118,172,223],"unsupervised":[122],"conventional":[123],"methods":[124],"literature.":[127],"outcompeted":[129],"tested":[131,144],"methods,":[132],"but":[133],"also":[134],"exhibited":[135],"greater":[137],"plasticity":[138,209],"experimental":[141,161],"conditions":[142,162],"when":[143],"under":[145],"drug":[146],"treatments":[147],"after":[149],"changes":[150],"line":[153],"or":[154],"imaged":[155],"reporter.":[156],"This":[157],"robustness":[158],"unseen":[160],"did":[163],"not":[164],"require":[165],"re-training":[166],"demonstrating":[167],"generalization":[168],"capability":[169],"our":[171],"model.":[174],"ExoDeepFinder,":[175],"as":[176,178,192,194],"well":[177,193],"annotated":[180],"datasets,":[182],"were":[183],"made":[184],"transparent":[185],"available":[187],"through":[188],"an":[189],"open-source":[190],"software":[191],"Napari":[196],"plugin":[197],"can":[199],"directly":[200],"be":[201],"applied":[202],"custom":[204],"user":[205],"data.":[206],"The":[207],"apparent":[208],"detect":[215],"open":[218],"new":[219],"opportunities":[220],"future":[222],"guided":[225],"analysis":[226],"live-cell":[231]},"counts_by_year":[],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-14T00:00:00"}