{"id":"https://openalex.org/W4414494413","doi":"https://doi.org/10.1371/journal.pcbi.1013508","title":"Mathematical modeling of dopamine rhythms and timing of dopamine reuptake inhibitors","display_name":"Mathematical modeling of dopamine rhythms and timing of dopamine reuptake inhibitors","publication_year":2025,"publication_date":"2025-09-25","ids":{"openalex":"https://openalex.org/W4414494413","doi":"https://doi.org/10.1371/journal.pcbi.1013508","pmid":"https://pubmed.ncbi.nlm.nih.gov/40997123"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013508","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013508","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013508","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045342397","display_name":"Tianyong Yao","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tianyong Yao","raw_affiliation_strings":["Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0009-0001-3175-1988","affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070632329","display_name":"Ruby Kim","orcid":"https://orcid.org/0000-0003-0209-4875"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ruby Kim","raw_affiliation_strings":["Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan, United States of America","Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0209-4875","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I4210114445","https://openalex.org/I4210111179"]},{"raw_affiliation_string":"Department of Mathematics, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045342397","https://openalex.org/A5070632329"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179","https://openalex.org/I4210114445"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25044092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"9","first_page":"e1013508","last_page":"e1013508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.9837999939918518,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9649999737739563,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultradian-rhythm","display_name":"Ultradian rhythm","score":0.9257000088691711},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.8206999897956848},{"id":"https://openalex.org/keywords/dopaminergic","display_name":"Dopaminergic","score":0.7746999859809875},{"id":"https://openalex.org/keywords/reuptake","display_name":"Reuptake","score":0.73580002784729},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"Circadian rhythm","score":0.6777999997138977},{"id":"https://openalex.org/keywords/chronobiology","display_name":"Chronobiology","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C136792703","wikidata":"https://www.wikidata.org/wiki/Q377893","display_name":"Ultradian rhythm","level":3,"score":0.9257000088691711},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.8206999897956848},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7746999859809875},{"id":"https://openalex.org/C99631742","wikidata":"https://www.wikidata.org/wiki/Q22290476","display_name":"Reuptake","level":4,"score":0.73580002784729},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.6777999997138977},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6442999839782715},{"id":"https://openalex.org/C187765855","wikidata":"https://www.wikidata.org/wiki/Q506874","display_name":"Chronobiology","level":3,"score":0.5189999938011169},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34310001134872437},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.3301999866962433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3228999972343445},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.32269999384880066},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.311599999666214},{"id":"https://openalex.org/C128188215","wikidata":"https://www.wikidata.org/wiki/Q3026765","display_name":"Neuropharmacology","level":2,"score":0.2994999885559082},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2784999907016754},{"id":"https://openalex.org/C2779910239","wikidata":"https://www.wikidata.org/wiki/Q7539765","display_name":"Chronotherapy (sleep phase)","level":3,"score":0.2782999873161316},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25609999895095825},{"id":"https://openalex.org/C199596767","wikidata":"https://www.wikidata.org/wiki/Q21110872","display_name":"Dopamine receptor D3","level":4,"score":0.2554999887943268}],"mesh":[{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018765","descriptor_name":"Dopamine Uptake Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018765","descriptor_name":"Dopamine Uptake Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018765","descriptor_name":"Dopamine Uptake Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018765","descriptor_name":"Dopamine Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018765","descriptor_name":"Dopamine Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018765","descriptor_name":"Dopamine Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1013508","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013508","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40997123","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40997123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:1997ee43dd0f47df9fea8005e72fa8f1","is_oa":true,"landing_page_url":"https://doaj.org/article/1997ee43dd0f47df9fea8005e72fa8f1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 9, p e1013508 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11303980","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12494296","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12494296","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12494296/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013508","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013508","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5679944289","display_name":null,"funder_award_id":"ARO W911NF-22-1-0223","funder_id":"https://openalex.org/F4320333591","funder_display_name":"Multidisciplinary University Research Initiative"}],"funders":[{"id":"https://openalex.org/F4320333591","display_name":"Multidisciplinary University Research Initiative","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1717491325","https://openalex.org/W1883830744","https://openalex.org/W1967458028","https://openalex.org/W1972995503","https://openalex.org/W1976789367","https://openalex.org/W1990106511","https://openalex.org/W2002962484","https://openalex.org/W2004358311","https://openalex.org/W2011737473","https://openalex.org/W2012002548","https://openalex.org/W2013743740","https://openalex.org/W2020286809","https://openalex.org/W2025381000","https://openalex.org/W2025797408","https://openalex.org/W2033799348","https://openalex.org/W2046570249","https://openalex.org/W2048727294","https://openalex.org/W2048941040","https://openalex.org/W2050826226","https://openalex.org/W2050841794","https://openalex.org/W2052500414","https://openalex.org/W2055584145","https://openalex.org/W2071749684","https://openalex.org/W2071899799","https://openalex.org/W2093116126","https://openalex.org/W2101113365","https://openalex.org/W2103493168","https://openalex.org/W2103500041","https://openalex.org/W2111696544","https://openalex.org/W2116143765","https://openalex.org/W2123427001","https://openalex.org/W2124856028","https://openalex.org/W2134271906","https://openalex.org/W2141283844","https://openalex.org/W2141410612","https://openalex.org/W2151189356","https://openalex.org/W2154761807","https://openalex.org/W2157391191","https://openalex.org/W2164797304","https://openalex.org/W2167027322","https://openalex.org/W2226351303","https://openalex.org/W2411013142","https://openalex.org/W2516258368","https://openalex.org/W2530533726","https://openalex.org/W2581326701","https://openalex.org/W2583749032","https://openalex.org/W2587889281","https://openalex.org/W2598018500","https://openalex.org/W2606908338","https://openalex.org/W2743429878","https://openalex.org/W2769205725","https://openalex.org/W2798666152","https://openalex.org/W2921621685","https://openalex.org/W2944474274","https://openalex.org/W2990921391","https://openalex.org/W3130859833","https://openalex.org/W3215563353","https://openalex.org/W4200625113","https://openalex.org/W4226106141","https://openalex.org/W4312220884","https://openalex.org/W4312425786","https://openalex.org/W4396606349","https://openalex.org/W4402314345"],"related_works":[],"abstract_inverted_index":{"Dopamine":[0],"(DA)":[1],"plays":[2],"a":[3,31,67,189],"vital":[4],"role":[5],"in":[6,58,136,155,177,182],"mood,":[7],"alertness,":[8],"and":[9,22,29,39,49,75,77,98],"behavior,":[10],"with":[11],"dysregulation":[12],"linked":[13],"to":[14,41,111,133,144],"disorders":[15],"such":[16],"as":[17],"Parkinson's":[18],"disease,":[19],"ADHD,":[20],"depression,":[21],"addiction.":[23],"In":[24],"this":[25],"study,":[26],"we":[27],"develop":[28],"analyze":[30],"reduced":[32,81],"mathematical":[33,69],"model":[34,70,93,143,157],"of":[35,52,61,71,129,159,163,186],"dopamine":[36,47,53,72,109],"synthesis,":[37,73],"release,":[38,74],"reuptake":[40,54,76],"investigate":[42],"how":[43],"daily":[44],"rhythms":[45],"influence":[46],"dynamics":[48],"the":[50,59,127,142,156,166,183],"efficacy":[51],"inhibitors":[55],"(DRIs)":[56],"used":[57],"treatment":[60],"various":[62],"neuropsychiatric":[63],"conditions.":[64],"We":[65,139],"simplify":[66],"detailed":[68],"demonstrate":[78],"that":[79,100,174],"our":[80],"system":[82],"maintains":[83],"key":[84],"dynamical":[85],"features":[86],"including":[87],"homeostatic":[88],"regulation":[89],"via":[90],"autoreceptors.":[91],"Our":[92,169],"captures":[94],"core":[95],"autoregulatory":[96],"mechanisms":[97],"reveals":[99],"DRIs":[101,164],"can":[102],"exert":[103],"substantial":[104],"time-of-day":[105],"effects,":[106],"allowing":[107],"for":[108,192],"levels":[110,116],"be":[112,180],"sustained":[113],"at":[114,119],"elevated":[115],"when":[117],"administered":[118],"circadian":[120,134,160],"troughs.":[121],"These":[122],"fluctuations":[123,176],"depend":[124],"sensitively":[125],"on":[126],"timing":[128],"DRI":[130],"administration":[131],"relative":[132],"variations":[135],"enzyme":[137],"activity.":[138],"further":[140],"extend":[141],"incorporate":[145],"feedback":[146],"from":[147],"local":[148],"dopaminergic":[149,197],"tone,":[150],"which":[151],"generates":[152],"ultradian":[153,167],"oscillations":[154],"independent":[158],"regulation.":[161],"Administration":[162],"lengthens":[165],"periodicity.":[168],"findings":[170],"provide":[171],"strong":[172],"evidence":[173],"intrinsic":[175],"DA":[178],"should":[179],"considered":[181],"clinical":[184],"use":[185],"DRIs,":[187],"offering":[188],"mechanistic":[190],"framework":[191],"improving":[193],"chronotherapeutic":[194],"strategies":[195],"targeting":[196],"dysfunction.":[198]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}