{"id":"https://openalex.org/W4413395419","doi":"https://doi.org/10.1371/journal.pcbi.1013407","title":"In silico modeling of directed differentiation of induced pluripotent stem cells to definitive endoderm","display_name":"In silico modeling of directed differentiation of induced pluripotent stem cells to definitive endoderm","publication_year":2025,"publication_date":"2025-08-21","ids":{"openalex":"https://openalex.org/W4413395419","doi":"https://doi.org/10.1371/journal.pcbi.1013407","pmid":"https://pubmed.ncbi.nlm.nih.gov/40839670"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013407","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013407","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013407","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013448735","display_name":"Amirmahdi Mostofinejad","orcid":"https://orcid.org/0000-0003-0783-8757"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Amirmahdi Mostofinejad","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0003-0783-8757","affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055981131","display_name":"David A. Romero","orcid":"https://orcid.org/0000-0002-3603-7361"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"David A. Romero","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113208918","display_name":"Dana Brinson","orcid":"https://orcid.org/0000-0002-5006-1149"},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Dana Brinson","raw_affiliation_strings":["Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada","Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030295431","display_name":"Thomas K. Waddell","orcid":"https://orcid.org/0000-0002-3235-9208"},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Thomas K. Waddell","raw_affiliation_strings":["Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada","Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada","Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003169841","display_name":"Golnaz Karoubi","orcid":"https://orcid.org/0000-0003-3764-3379"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Golnaz Karoubi","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada","Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada","Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089189620","display_name":"Cristina H. Amon","orcid":"https://orcid.org/0000-0003-4314-8120"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Cristina H. Amon","raw_affiliation_strings":["Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada","Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003169841","https://openalex.org/A5013448735","https://openalex.org/A5030295431","https://openalex.org/A5055981131","https://openalex.org/A5089189620","https://openalex.org/A5113208918"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2801845744"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0173,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.76973508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"21","issue":"8","first_page":"e1013407","last_page":"e1013407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9782000184059143,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9599000215530396,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell","display_name":"Induced pluripotent stem cell","score":0.7498680949211121},{"id":"https://openalex.org/keywords/endoderm","display_name":"Endoderm","score":0.7212359309196472},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6651926636695862},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5793037414550781},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5634766817092896},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.5384141802787781},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.48716971278190613},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.40195050835609436},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4018595218658447},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3571200966835022},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18853121995925903},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08153364062309265}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7498680949211121},{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.7212359309196472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6651926636695862},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5793037414550781},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5634766817092896},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5384141802787781},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.48716971278190613},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.40195050835609436},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4018595218658447},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3571200966835022},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18853121995925903},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08153364062309265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004707","descriptor_name":"Endoderm","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004707","descriptor_name":"Endoderm","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1013407","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013407","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40839670","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40839670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:a8c1fe42e60341f39c1668a2d4977cdd","is_oa":true,"landing_page_url":"https://doaj.org/article/a8c1fe42e60341f39c1668a2d4977cdd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 8, p e1013407 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11214723","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12404646","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12404646","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12404646/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013407","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013407","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1262813933","display_name":null,"funder_award_id":"NFRFT-2020-00787","funder_id":"https://openalex.org/F4320315777","funder_display_name":"Canada Research Coordinating Committee"},{"id":"https://openalex.org/G1588677328","display_name":null,"funder_award_id":"158270","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G5392296748","display_name":null,"funder_award_id":"NFRFT-2022-00447","funder_id":"https://openalex.org/F4320315777","funder_display_name":"Canada Research Coordinating Committee"},{"id":"https://openalex.org/G8126218889","display_name":null,"funder_award_id":"158270","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320315777","display_name":"Canada Research Coordinating Committee","ror":null},{"id":"https://openalex.org/F4320326644","display_name":"Canada First Research Excellence Fund","ror":null},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W1595159159","https://openalex.org/W1597787921","https://openalex.org/W1879678483","https://openalex.org/W1969925326","https://openalex.org/W1973239973","https://openalex.org/W1977905227","https://openalex.org/W1979927933","https://openalex.org/W1990804327","https://openalex.org/W2003211588","https://openalex.org/W2008878870","https://openalex.org/W2015616421","https://openalex.org/W2038404321","https://openalex.org/W2043046233","https://openalex.org/W2052750950","https://openalex.org/W2055830107","https://openalex.org/W2059246518","https://openalex.org/W2098597036","https://openalex.org/W2103443944","https://openalex.org/W2106831544","https://openalex.org/W2118077148","https://openalex.org/W2120575449","https://openalex.org/W2125987139","https://openalex.org/W2127479534","https://openalex.org/W2136732727","https://openalex.org/W2137175341","https://openalex.org/W2138442302","https://openalex.org/W2140909735","https://openalex.org/W2148890861","https://openalex.org/W2152426454","https://openalex.org/W2156103849","https://openalex.org/W2160803964","https://openalex.org/W2171074980","https://openalex.org/W2471509833","https://openalex.org/W2511896561","https://openalex.org/W2570895165","https://openalex.org/W2611660641","https://openalex.org/W2619381903","https://openalex.org/W2754522606","https://openalex.org/W2756634427","https://openalex.org/W2766538386","https://openalex.org/W2773071317","https://openalex.org/W2774095582","https://openalex.org/W2802309935","https://openalex.org/W2883518737","https://openalex.org/W2904703945","https://openalex.org/W2945064381","https://openalex.org/W2952455424","https://openalex.org/W2953316346","https://openalex.org/W2958817003","https://openalex.org/W2962804139","https://openalex.org/W2982674042","https://openalex.org/W2986023022","https://openalex.org/W2996205391","https://openalex.org/W2999570606","https://openalex.org/W3010833563","https://openalex.org/W3035193052","https://openalex.org/W3042178423","https://openalex.org/W3106932903","https://openalex.org/W3126293391","https://openalex.org/W3133538896","https://openalex.org/W3139456908","https://openalex.org/W3139799783","https://openalex.org/W3169788139","https://openalex.org/W3184532314","https://openalex.org/W3203779568","https://openalex.org/W3203786787","https://openalex.org/W3204234525","https://openalex.org/W4206430709","https://openalex.org/W4221109706","https://openalex.org/W4226096213","https://openalex.org/W4238063882","https://openalex.org/W4247680473","https://openalex.org/W4247904703","https://openalex.org/W4250883246","https://openalex.org/W4286879859","https://openalex.org/W4291655034","https://openalex.org/W4292133640","https://openalex.org/W4299798163","https://openalex.org/W4312082635","https://openalex.org/W4360999352","https://openalex.org/W4386242987","https://openalex.org/W4387168298","https://openalex.org/W4388322985","https://openalex.org/W4389127898","https://openalex.org/W4392844042","https://openalex.org/W4396939020","https://openalex.org/W4403847690","https://openalex.org/W4410872914","https://openalex.org/W6893630014","https://openalex.org/W6950206143"],"related_works":["https://openalex.org/W1564861386","https://openalex.org/W2006730050","https://openalex.org/W2063353254","https://openalex.org/W4249379514","https://openalex.org/W2034421461","https://openalex.org/W4300930565","https://openalex.org/W2075519766","https://openalex.org/W2768952912","https://openalex.org/W3110176598","https://openalex.org/W2053561999"],"abstract_inverted_index":{"Differentiation":[0],"of":[1,50,98,152,163,210,224],"embryonic":[2],"stem":[3,8],"cells":[4,9,189],"and":[5,19,27,31,77,80,113,130,145,180,198],"induced":[6],"pluripotent":[7],"(iPSCs)":[10],"into":[11,52,244],"endoderm":[12,54],"derivatives,":[13],"including":[14],"thyroid,":[15],"thymus,":[16],"lungs,":[17],"liver,":[18],"pancreas,":[20],"has":[21],"broad":[22],"implications":[23],"for":[24,46,89,108,238],"disease":[25],"modeling":[26],"therapy.":[28],"We":[29,214],"utilize":[30],"expand":[32],"a":[33,44,65,96,132,235],"model":[34,45,109,111,155,219,232],"development":[35],"approach":[36],"previously":[37],"outlined":[38],"by":[39,135],"the":[40,47,61,126,153,166,173,194,203,207,211,218,222],"authors":[41],"to":[42,186],"construct":[43],"directed":[48],"differentiation":[49,62,124,175,201,240],"iPSCs":[51],"definitive":[53],"(DE).":[55],"Assuming":[56],"discrete":[57],"intermediate":[58],"stages":[59],"in":[60,68,95,104,160,193],"process":[63],"with":[64,74,156],"homogeneous":[66],"population":[67,212,229],"each":[69],"stage,":[70],"three":[71,81,87],"lineage":[72],"models":[73,83,88],"two,":[75],"three,":[76],"four":[78],"populations":[79,184],"growth":[82,140,225],"are":[84,92,106],"constructed.":[85],"Additionally,":[86,138],"error":[90],"distribution":[91],"defined,":[93],"resulting":[94],"total":[97],"27":[99],"models.":[100],"Experimental":[101],"data":[102,158],"obtained":[103],"vitro":[105],"used":[107],"calibration,":[110],"selection,":[112],"final":[114],"validation.":[115],"Model":[116],"selection":[117],"suggests":[118],"that":[119,172,199,217],"no":[120],"transitory":[121],"state":[122],"during":[123],"expresses":[125],"DE":[127,204],"biomarkers":[128],"CD117":[129],"CD184,":[131],"finding":[133],"corroborated":[134],"existing":[136],"literature.":[137],"space-limited":[139],"models,":[141],"such":[142],"as":[143,206,234],"logistic":[144],"Gompertz":[146],"growth,":[147],"outperform":[148],"exponential":[149],"growth.":[150],"Validation":[151],"inferred":[154,167],"leave-out":[157],"results":[159],"prediction":[161],"errors":[162],"26.4%.":[164],"Using":[165],"model,":[168],"it":[169],"is":[170,177],"predicted":[171],"optimal":[174],"period":[176],"between":[178],"1.9":[179],"2.4":[181],"days,":[182],"plating":[183],"closer":[185],"300":[187],"000":[188],"per":[190],"well":[191],"result":[192],"highest":[195],"yield":[196],"efficiency,":[197],"iPSC":[200],"outpaces":[202],"proliferation":[205],"main":[208],"driver":[209],"dynamics.":[213,230],"also":[215],"demonstrate":[216],"can":[220],"predict":[221],"effect":[223],"modulators":[226],"on":[227],"cell":[228],"Our":[231],"serves":[233],"valuable":[236],"tool":[237],"optimizing":[239],"protocols,":[241],"providing":[242],"insights":[243],"developmental":[245],"biology.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
