{"id":"https://openalex.org/W4413118002","doi":"https://doi.org/10.1371/journal.pcbi.1013363","title":"The role of feedforward and feedback inhibition in modulating theta-gamma cross-frequency interactions in neural circuits","display_name":"The role of feedforward and feedback inhibition in modulating theta-gamma cross-frequency interactions in neural circuits","publication_year":2025,"publication_date":"2025-08-13","ids":{"openalex":"https://openalex.org/W4413118002","doi":"https://doi.org/10.1371/journal.pcbi.1013363","pmid":"https://pubmed.ncbi.nlm.nih.gov/40802842"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013363","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013363","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013363","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029380795","display_name":"Dimitrios Chalkiadakis","orcid":"https://orcid.org/0000-0001-8327-4514"},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210087099","display_name":"Instituto de Neurociencias","ror":"https://ror.org/000nhpy59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I111262870","https://openalex.org/I134820265","https://openalex.org/I4210087099"]},{"id":"https://openalex.org/I4210095952","display_name":"Institute for Cross-Disciplinary Physics and Complex Systems","ror":"https://ror.org/00pfxsh56","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210095952","https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Dimitrios Chalkiadakis","raw_affiliation_strings":["Instituto de F\u00edsica Interdisciplinar y Sistemas Complejos (IFISC, UIB-CSIC), Campus UIB, Palma de Mallorca, Spain","Instituto de Neurociencias, Consejo Superior de Investigaciones Cient\u00edficas, Universidad Miguel Hern\u00e1ndez, Sant Joan d'Alacant, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de F\u00edsica Interdisciplinar y Sistemas Complejos (IFISC, UIB-CSIC), Campus UIB, Palma de Mallorca, Spain","institution_ids":["https://openalex.org/I4210095952"]},{"raw_affiliation_string":"Instituto de Neurociencias, Consejo Superior de Investigaciones Cient\u00edficas, Universidad Miguel Hern\u00e1ndez, Sant Joan d'Alacant, Spain","institution_ids":["https://openalex.org/I4210087099","https://openalex.org/I134820265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069787135","display_name":"Jaime S\u00e1nchez-Claros","orcid":null},"institutions":[{"id":"https://openalex.org/I4210095952","display_name":"Institute for Cross-Disciplinary Physics and Complex Systems","ror":"https://ror.org/00pfxsh56","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210095952","https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jaime S\u00e1nchez-Claros","raw_affiliation_strings":["Instituto de F\u00edsica Interdisciplinar y Sistemas Complejos (IFISC, UIB-CSIC), Campus UIB, Palma de Mallorca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de F\u00edsica Interdisciplinar y Sistemas Complejos (IFISC, UIB-CSIC), Campus UIB, Palma de Mallorca, Spain","institution_ids":["https://openalex.org/I4210095952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073216157","display_name":"V\u00edctor J. L\u00f3pez\u2010Madrona","orcid":"https://orcid.org/0000-0001-8234-7160"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210110495","display_name":"Institut de Neurosciences des Syst\u00e8mes","ror":"https://ror.org/019kqby73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210087487","https://openalex.org/I4210110495"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"V\u00edctor J. L\u00f3pez-Madrona","raw_affiliation_strings":["Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0001-8234-7160","affiliations":[{"raw_affiliation_string":"Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France","institution_ids":["https://openalex.org/I4210110495","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074753807","display_name":"Santiago Canals","orcid":"https://orcid.org/0000-0003-2175-8139"},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210087099","display_name":"Instituto de Neurociencias","ror":"https://ror.org/000nhpy59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I111262870","https://openalex.org/I134820265","https://openalex.org/I4210087099"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Santiago Canals","raw_affiliation_strings":["Instituto de Neurociencias, Consejo Superior de Investigaciones Cient\u00edficas, Universidad Miguel Hern\u00e1ndez, Sant Joan d'Alacant, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Neurociencias, Consejo Superior de Investigaciones Cient\u00edficas, Universidad Miguel Hern\u00e1ndez, Sant Joan d'Alacant, Spain","institution_ids":["https://openalex.org/I4210087099","https://openalex.org/I134820265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075774125","display_name":"Cl\u00e1udio R. Mirasso","orcid":"https://orcid.org/0000-0003-2980-7038"},"institutions":[{"id":"https://openalex.org/I4210095952","display_name":"Institute for Cross-Disciplinary Physics and Complex Systems","ror":"https://ror.org/00pfxsh56","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210095952","https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Claudio R. Mirasso","raw_affiliation_strings":["Instituto de F\u00edsica Interdisciplinar y Sistemas Complejos (IFISC, UIB-CSIC), Campus UIB, Palma de Mallorca, Spain"],"raw_orcid":"https://orcid.org/0000-0003-2980-7038","affiliations":[{"raw_affiliation_string":"Instituto de F\u00edsica Interdisciplinar y Sistemas Complejos (IFISC, UIB-CSIC), Campus UIB, Palma de Mallorca, Spain","institution_ids":["https://openalex.org/I4210095952"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5029380795","https://openalex.org/A5069787135","https://openalex.org/A5073216157","https://openalex.org/A5074753807","https://openalex.org/A5075774125"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I154526488","https://openalex.org/I4210087099","https://openalex.org/I4210095952","https://openalex.org/I4210110495"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9344,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.7619888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"21","issue":"8","first_page":"e1013363","last_page":"e1013363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feed-forward","display_name":"Feed forward","score":0.7231865525245667},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6603807210922241},{"id":"https://openalex.org/keywords/interneuron","display_name":"Interneuron","score":0.6025634407997131},{"id":"https://openalex.org/keywords/oscillation","display_name":"Oscillation (cell signaling)","score":0.51479172706604},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.49129408597946167},{"id":"https://openalex.org/keywords/directionality","display_name":"Directionality","score":0.46231895685195923},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.44888627529144287},{"id":"https://openalex.org/keywords/biological-neural-network","display_name":"Biological neural network","score":0.4368022084236145},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3457627594470978},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24677985906600952},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.17597106099128723}],"concepts":[{"id":"https://openalex.org/C38858127","wikidata":"https://www.wikidata.org/wiki/Q5441228","display_name":"Feed forward","level":2,"score":0.7231865525245667},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6603807210922241},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.6025634407997131},{"id":"https://openalex.org/C2778439541","wikidata":"https://www.wikidata.org/wiki/Q7106412","display_name":"Oscillation (cell signaling)","level":2,"score":0.51479172706604},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.49129408597946167},{"id":"https://openalex.org/C29648211","wikidata":"https://www.wikidata.org/wiki/Q1995607","display_name":"Directionality","level":2,"score":0.46231895685195923},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.44888627529144287},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.4368022084236145},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3457627594470978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24677985906600952},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.17597106099128723},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013826","descriptor_name":"Theta Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013826","descriptor_name":"Theta Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013826","descriptor_name":"Theta Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013826","descriptor_name":"Theta Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065818","descriptor_name":"Gamma Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D065818","descriptor_name":"Gamma Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D065818","descriptor_name":"Gamma Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D065818","descriptor_name":"Gamma Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1013363","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013363","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40802842","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40802842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:digital.csic.es:10261/401193","is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/401193","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:de30ff5022414d18b187a10e860f5320","is_oa":true,"landing_page_url":"https://doaj.org/article/de30ff5022414d18b187a10e860f5320","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 8, p e1013363 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12393765","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12393765","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013363","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013363","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1722358650","display_name":null,"funder_award_id":"CEX2021-001164-M","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G2262748287","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G2446644622","display_name":null,"funder_award_id":"PID2021-128158NB-C21","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G272237818","display_name":null,"funder_award_id":"CEX2021-001164-M","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G3480869486","display_name":null,"funder_award_id":"13039","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G4159157134","display_name":null,"funder_award_id":"PID2021-128158NB-C21","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G5362055841","display_name":null,"funder_award_id":"CEX2021-001165-S","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G5635532810","display_name":null,"funder_award_id":"13039","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G5783602811","display_name":null,"funder_award_id":"PID2021-128158NB-C22","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G6509204744","display_name":null,"funder_award_id":"CEX2021-001165-S","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G7084143925","display_name":null,"funder_award_id":"AEI/10","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G7266728691","display_name":null,"funder_award_id":"13039/501100011033","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G7920858549","display_name":null,"funder_award_id":"PID2021-128158NB-C22","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G8497050386","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G8516412140","display_name":null,"funder_award_id":"13039/501100011033","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G8667377315","display_name":null,"funder_award_id":"MICIU/AEI/10","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"}],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1501360999","https://openalex.org/W1528942588","https://openalex.org/W1622642999","https://openalex.org/W1881288755","https://openalex.org/W1902335101","https://openalex.org/W1968520062","https://openalex.org/W1975221291","https://openalex.org/W1976437022","https://openalex.org/W1976804176","https://openalex.org/W1996032190","https://openalex.org/W1998240840","https://openalex.org/W2003520218","https://openalex.org/W2011909109","https://openalex.org/W2027205525","https://openalex.org/W2039128802","https://openalex.org/W2046198005","https://openalex.org/W2052170508","https://openalex.org/W2057019330","https://openalex.org/W2067501282","https://openalex.org/W2081263388","https://openalex.org/W2085534172","https://openalex.org/W2088358935","https://openalex.org/W2098330912","https://openalex.org/W2099512174","https://openalex.org/W2110802967","https://openalex.org/W2112463907","https://openalex.org/W2117120818","https://openalex.org/W2124909604","https://openalex.org/W2129452432","https://openalex.org/W2134072465","https://openalex.org/W2141807462","https://openalex.org/W2142875089","https://openalex.org/W2152372327","https://openalex.org/W2154348072","https://openalex.org/W2159098673","https://openalex.org/W2162013747","https://openalex.org/W2165730296","https://openalex.org/W2170430044","https://openalex.org/W2170527455","https://openalex.org/W2422269554","https://openalex.org/W2509935589","https://openalex.org/W2530399318","https://openalex.org/W2561068888","https://openalex.org/W2565869006","https://openalex.org/W2586708934","https://openalex.org/W2593308454","https://openalex.org/W2605700843","https://openalex.org/W2794973687","https://openalex.org/W2952311516","https://openalex.org/W2967100650","https://openalex.org/W2994688838","https://openalex.org/W2997591727","https://openalex.org/W3042586354","https://openalex.org/W3116682288","https://openalex.org/W3148616091","https://openalex.org/W3183812096","https://openalex.org/W4200040888","https://openalex.org/W4307816035","https://openalex.org/W4313491496","https://openalex.org/W4362604137","https://openalex.org/W4384701022","https://openalex.org/W4392292155","https://openalex.org/W4403863339","https://openalex.org/W6675354045"],"related_works":["https://openalex.org/W2624817431","https://openalex.org/W2794987474","https://openalex.org/W33032069","https://openalex.org/W1599251874","https://openalex.org/W4232225082","https://openalex.org/W2029088481","https://openalex.org/W2334790377","https://openalex.org/W2473013794","https://openalex.org/W2916176852","https://openalex.org/W2104672920"],"abstract_inverted_index":{"Interactions":[0],"among":[1],"brain":[2],"rhythms":[3],"play":[4],"a":[5,73,83,97,168,173,228],"crucial":[6],"role":[7],"in":[8,39,109,141,167,172],"organizing":[9],"neuronal":[10],"firing":[11],"sequences":[12],"during":[13],"specific":[14],"cognitive":[15],"functions.":[16],"In":[17],"memory":[18],"formation,":[19],"the":[20,23,26,30,40,46,49,53,161,186,189,195,198,207,238],"coupling":[21],"between":[22,209],"phase":[24,47],"of":[25,32,48,134,149,163,188,217,240],"theta":[27],"rhythm":[28],"and":[29,114,152,183,211,220],"amplitude":[31],"gamma":[33,147,190],"oscillations":[34,148],"has":[35],"been":[36],"extensively":[37],"studied":[38],"hippocampus.":[41],"Prevailing":[42],"perspectives":[43],"suggest":[44],"that":[45,65,78,138,178,244],"slower":[50],"oscillation":[51],"modulates":[52],"fast":[54],"activity.":[55],"However,":[56],"recent":[57],"metrics,":[58],"such":[59],"as":[60,117,192],"Cross-Frequency":[61],"Directionality":[62],"(CFD),":[63],"indicate":[64],"these":[66],"electrophysiological":[67,158],"interactions":[68],"can":[69],"be":[70],"bidirectional.":[71],"Using":[72,155],"computational":[74,223,247],"model,":[75],"we":[76,176],"demonstrate":[77],"feedforward":[79,113,142,210],"inhibition":[80,95],"modeled":[81],"by":[82,125,194,206],"theta-modulated":[84,98],"ING":[85],"(Interneuron":[86],"Network":[87,102],"Gamma)":[88,103],"mechanism":[89],"induces":[90],"fast-to-slow":[91,139],"interactions,":[92],"while":[93],"feedback":[94,115,212],"through":[96],"PING":[99],"(Pyramidal":[100],"Interneuron":[101],"model":[104,199],"drives":[105],"slow-to-fast":[106],"interactions.":[107],"Importantly,":[108],"circuits":[110],"combining":[111],"both":[112],"motifs,":[116],"commonly":[118],"found":[119],"experimentally,":[120],"directionality":[121,234],"is":[122,137,144,180],"flexibly":[123],"modulated":[124],"synaptic":[126],"strength":[127],"within":[128],"biologically":[129],"realistic":[130],"ranges.":[131],"A":[132],"signature":[133],"this":[135],"interaction":[136,203],"dominance":[140],"motifs":[143,243],"associated":[145,236],"with":[146,237],"higher":[150],"frequency,":[151],"vice":[153],"versa.":[154],"previously":[156],"acquired":[157],"data":[159],"from":[160],"hippocampus":[162],"rats":[164],"freely":[165],"navigating":[166],"familiar":[169],"environment":[170],"or":[171],"novel":[174],"one,":[175],"show":[177],"CFD":[179],"dynamically":[181],"regulated":[182],"linked":[184],"to":[185,214],"frequency":[187],"band,":[191],"predicted":[193],"model.":[196],"Finally,":[197],"attributes":[200],"each":[201],"theta-gamma":[202],"scheme,":[204],"determined":[205],"balance":[208],"inhibition,":[213],"distinct":[215,246],"modes":[216],"information":[218],"transmission":[219],"integration,":[221],"adding":[222],"flexibility.":[224],"Our":[225],"results":[226],"offer":[227],"plausible":[229],"neurobiological":[230],"interpretation":[231],"for":[232],"cross-frequency":[233],"measurements":[235],"activation":[239],"different":[241],"underlying":[242],"serve":[245],"needs.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}