{"id":"https://openalex.org/W4414501073","doi":"https://doi.org/10.1371/journal.pcbi.1013333","title":"Exploration of potential novel drug targets for rheumatoid arthritis by plasma proteome screening","display_name":"Exploration of potential novel drug targets for rheumatoid arthritis by plasma proteome screening","publication_year":2025,"publication_date":"2025-09-25","ids":{"openalex":"https://openalex.org/W4414501073","doi":"https://doi.org/10.1371/journal.pcbi.1013333","pmid":"https://pubmed.ncbi.nlm.nih.gov/40996951"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013333","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013333","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013333","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101765974","display_name":"Zhiqiang Ma","orcid":"https://orcid.org/0000-0001-7568-3588"},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210093739","display_name":"First Affiliated Hospital of Jiangxi Medical College","ror":"https://ror.org/00g3pqv36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093739"]},{"id":"https://openalex.org/I4210114086","display_name":"Third Affiliated Hospital of Nanchang University","ror":"https://ror.org/02g9jg318","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114086"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiqiang Ma","raw_affiliation_strings":["Department of Cardiovascular Medicine, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210114086"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ran Chen","orcid":"https://orcid.org/0009-0009-2973-3914"},"institutions":[{"id":"https://openalex.org/I4210131149","display_name":"Yanbian University Hospital","ror":"https://ror.org/037ve0v69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131149"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ran Chen","raw_affiliation_strings":["Department of Cardiology and Hypertension, Yanbian University Hospital, Yanji, Jilin, China","The Laboratory of Metabolic Disorders and Vascular Aging, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":"https://orcid.org/0009-0009-2973-3914","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Hypertension, Yanbian University Hospital, Yanji, Jilin, China","institution_ids":["https://openalex.org/I4210131149"]},{"raw_affiliation_string":"The Laboratory of Metabolic Disorders and Vascular Aging, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019016681","display_name":"Zibo Feng","orcid":"https://orcid.org/0009-0006-2940-8095"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zibo Feng","raw_affiliation_strings":["Department of Wound Repair Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Wound Repair Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019016681","https://openalex.org/A5101765974"],"corresponding_institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210093739","https://openalex.org/I4210114086","https://openalex.org/I4210131149","https://openalex.org/I47720641"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2482,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.83047124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"21","issue":"9","first_page":"e1013333","last_page":"e1013333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9629999995231628,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9629999995231628,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"Rheumatoid arthritis","score":0.7825999855995178},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6747999787330627},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.6739000082015991},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4700999855995178},{"id":"https://openalex.org/keywords/blood-proteins","display_name":"Blood proteins","score":0.385699987411499},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.36570000648498535},{"id":"https://openalex.org/keywords/arthritis","display_name":"Arthritis","score":0.35989999771118164},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.3176000118255615}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7825999855995178},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6747999787330627},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6739000082015991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5945000052452087},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4700999855995178},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4675999879837036},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.46720001101493835},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4413999915122986},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.385699987411499},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.36570000648498535},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.35989999771118164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3402000069618225},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.3176000118255615},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.3019999861717224},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.29899999499320984},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.29510000348091125},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2912999987602234},{"id":"https://openalex.org/C2908701176","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biological drugs","level":3,"score":0.29030001163482666},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.26750001311302185},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.26179999113082886}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1013333","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013333","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40996951","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40996951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:0e3ebf589f7a46fbafd0d2f72e09ecd6","is_oa":true,"landing_page_url":"https://doaj.org/article/0e3ebf589f7a46fbafd0d2f72e09ecd6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 9 (2025)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d1887bab8e164f58a64e8c5c05bc8fdd","is_oa":true,"landing_page_url":"https://doaj.org/article/d1887bab8e164f58a64e8c5c05bc8fdd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 9, p e1013333 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11271669","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12463240","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12463240","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12463240/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013333","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013333","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W1964349500","https://openalex.org/W1966078827","https://openalex.org/W1968114652","https://openalex.org/W1989590412","https://openalex.org/W2002133510","https://openalex.org/W2006617902","https://openalex.org/W2015786574","https://openalex.org/W2025041169","https://openalex.org/W2027893043","https://openalex.org/W2028483223","https://openalex.org/W2030160120","https://openalex.org/W2033577358","https://openalex.org/W2035036601","https://openalex.org/W2035266068","https://openalex.org/W2035688075","https://openalex.org/W2048075876","https://openalex.org/W2053921780","https://openalex.org/W2068295615","https://openalex.org/W2068802249","https://openalex.org/W2091221676","https://openalex.org/W2091432870","https://openalex.org/W2092304883","https://openalex.org/W2092530870","https://openalex.org/W2098231920","https://openalex.org/W2103783427","https://openalex.org/W2104806243","https://openalex.org/W2106523535","https://openalex.org/W2113699335","https://openalex.org/W2132991384","https://openalex.org/W2138632270","https://openalex.org/W2142879323","https://openalex.org/W2155402987","https://openalex.org/W2160310346","https://openalex.org/W2163957506","https://openalex.org/W2164610354","https://openalex.org/W2168368423","https://openalex.org/W2219275658","https://openalex.org/W2219952730","https://openalex.org/W2324862792","https://openalex.org/W2344089776","https://openalex.org/W2345356016","https://openalex.org/W2405373297","https://openalex.org/W2555870966","https://openalex.org/W2591044853","https://openalex.org/W2609949613","https://openalex.org/W2610324781","https://openalex.org/W2620908531","https://openalex.org/W2622000437","https://openalex.org/W2771000689","https://openalex.org/W2771596200","https://openalex.org/W2860509233","https://openalex.org/W2888655270","https://openalex.org/W2891474673","https://openalex.org/W2901023217","https://openalex.org/W2947745075","https://openalex.org/W3014067294","https://openalex.org/W3140403198","https://openalex.org/W3174811345","https://openalex.org/W3184098173","https://openalex.org/W3194582202","https://openalex.org/W3210570897","https://openalex.org/W3211795435","https://openalex.org/W3215894083","https://openalex.org/W4213435145","https://openalex.org/W4220740336","https://openalex.org/W4282913408","https://openalex.org/W4283213514","https://openalex.org/W4301183285","https://openalex.org/W4308834664","https://openalex.org/W4308834893","https://openalex.org/W4309908854","https://openalex.org/W4317211957","https://openalex.org/W4317390883","https://openalex.org/W4319322402","https://openalex.org/W4319456837","https://openalex.org/W4381597657","https://openalex.org/W4383498490","https://openalex.org/W4386070276","https://openalex.org/W4386303479","https://openalex.org/W4386601635","https://openalex.org/W4387344289","https://openalex.org/W4387580004","https://openalex.org/W4388464011","https://openalex.org/W4388522045","https://openalex.org/W4398174727","https://openalex.org/W4402285476","https://openalex.org/W4404523657"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Circulating":[1],"proteins":[2,50,65,115,132,151,163,238,253],"play":[3],"a":[4,31,202],"critical":[5],"role":[6],"in":[7,221,230],"rheumatoid":[8],"arthritis":[9],"(RA),":[10],"yet":[11],"few":[12],"have":[13,171,201,240],"been":[14,172],"targeted":[15],"therapeutically.":[16],"This":[17],"study":[18,141,246],"aimed":[19],"to":[20,43,107],"identify":[21,108],"novel":[22],"protein":[23],"targets":[24,183],"for":[25,184,207],"RA":[26,97,135],"therapy.":[27],"METHODS:":[28],"We":[29],"conducted":[30],"comprehensive":[32],"proteome-wide":[33],"Mendelian":[34],"Randomization":[35],"(MR),":[36],"colocalization":[37,157],"analysis,":[38,160],"and":[39,51,78,113,122,158,169,176,199,219,254,263],"summary-data-based":[40],"MR":[41],"(SMR)":[42],"explore":[44],"potential":[45,109,180,204,241],"causal":[46,249],"relationships":[47,250],"between":[48,251],"plasma":[49,64,131,150,162,252],"RA,":[52,222,255],"with":[53,119,134,154],"an":[54],"overall":[55],"sample":[56],"size":[57],"of":[58,84,130,148,215,228,259,267],"1,148,608.":[59],"The":[60],"GWAS":[61,80],"data":[62,95],"on":[63],"were":[66,136,152],"obtained":[67],"from":[68,96],"the":[69,72,100,213,226,248,260,265],"FinnGen":[70],"study,":[71],"UK":[73],"Biobank":[74],"Pharma":[75],"Proteomics":[76],"Project":[77],"Iceland":[79],"data.":[81],"Then,":[82],"validation":[83],"key":[85],"molecules'":[86],"differential":[87],"expression":[88],"pattern":[89],"was":[90,105,117],"done":[91],"using":[92],"external":[93],"transcriptomic":[94],"patients,":[98],"while":[99],"Drug":[101],"Signatures":[102],"Database":[103],"(DsigDB)":[104],"used":[106],"therapeutic":[110,182,269],"drugs.":[111,270],"Drugs":[112],"target":[114],"interactions":[116],"evaluated":[118],"molecular":[120,123,261],"docking":[121],"dynamics":[124],"simulations":[125],"approaches.":[126],"Potential":[127],"side":[128,242],"effects":[129],"associated":[133,153],"elucidated":[137],"by":[138],"phenome-wide":[139],"association":[140],"(Phe-WAS)":[142],"approach.":[143],"RESULTS:":[144],"Genetically":[145],"predicted":[146],"levels":[147],"68":[149],"RA.":[155,185,208,231],"After":[156],"SMR":[159],"6":[161],"(FCRL3,":[164],"SUGP1,":[165],"TNFAIP3,":[166],"EHBP1,":[167],"HAPLN4,":[168,216],"CILP2)":[170],"passed":[173],"all":[174],"tests":[175],"identified":[177],"as":[178,181,205,223,225],"having":[179],"Further":[186,232],"Receiver":[187],"operating":[188],"characteristic":[189],"curve":[190],"(ROC)":[191],"analysis":[192,211],"indicated":[193],"that":[194,235],"three":[195],"protiens":[196],"(CILP2,":[197],"TNFAIP3":[198,220],"EHBP)":[200],"good":[203],"biomarkers":[206],"Differential":[209],"gene":[210],"showed":[212],"downregulation":[214],"FCRL3,":[217],"EHBP1":[218],"well":[224],"upregulation":[227],"CILP2":[229],"Phe-WAS":[233],"suggested":[234],"targeting":[236],"these":[237],"may":[239],"effects.":[243],"CONCLUSION:":[244],"Our":[245],"investigated":[247],"deepening":[256],"our":[257],"understanding":[258],"mechanisms":[262],"facilitating":[264],"development":[266],"new":[268]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
