{"id":"https://openalex.org/W4412489354","doi":"https://doi.org/10.1371/journal.pcbi.1013318","title":"Cardiogenic and chronobiological mechanisms in seizure-induced sinus arrhythmias","display_name":"Cardiogenic and chronobiological mechanisms in seizure-induced sinus arrhythmias","publication_year":2025,"publication_date":"2025-07-16","ids":{"openalex":"https://openalex.org/W4412489354","doi":"https://doi.org/10.1371/journal.pcbi.1013318","pmid":"https://pubmed.ncbi.nlm.nih.gov/40668822"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013318","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013318","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013318&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013318&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100455195","display_name":"Pan Li","orcid":"https://orcid.org/0000-0002-3630-2807"},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Pan Li","raw_affiliation_strings":["Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036430413","display_name":"Sangbo Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sangbo Lee","raw_affiliation_strings":["Division of Pediatric Neurology, Department of Pediatrics, Severance Children's Hospital, Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Neurology, Department of Pediatrics, Severance Children's Hospital, Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000237975","display_name":"Kwang\u2010Yeon Choi","orcid":"https://orcid.org/0000-0001-7134-8723"},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang-Yeon Choi","raw_affiliation_strings":["Department of Psychiatry, College of Medicine, Chungnam National University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, College of Medicine, Chungnam National University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064289022","display_name":"Jonathan E. Rubin","orcid":"https://orcid.org/0000-0002-1513-1551"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan E. Rubin","raw_affiliation_strings":["Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067034493","display_name":"Jae Kyoung Kim","orcid":"https://orcid.org/0000-0001-7842-2172"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]},{"id":"https://openalex.org/I4210158432","display_name":"National Institute for Mathematical Sciences","ror":"https://ror.org/04n7py080","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210158432"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jae Kyoung Kim","raw_affiliation_strings":["Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea","Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea","Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7842-2172","affiliations":[{"raw_affiliation_string":"Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424","https://openalex.org/I4210158432"]},{"raw_affiliation_string":"Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I197347611"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5064289022","https://openalex.org/A5067034493"],"corresponding_institution_ids":["https://openalex.org/I157485424","https://openalex.org/I170201317","https://openalex.org/I197347611","https://openalex.org/I4210104335","https://openalex.org/I4210158432"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25809378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"7","first_page":"e1013318","last_page":"e1013318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.6014000177383423,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.6014000177383423,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.5242000222206116,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.5974792242050171},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.52898108959198},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4640941023826599},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"Electrocardiography","score":0.41563618183135986}],"concepts":[{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5974792242050171},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.52898108959198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4640941023826599},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.41563618183135986}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001146","descriptor_name":"Arrhythmia, Sinus","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001146","descriptor_name":"Arrhythmia, Sinus","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001146","descriptor_name":"Arrhythmia, Sinus","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D001146","descriptor_name":"Arrhythmia, Sinus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001146","descriptor_name":"Arrhythmia, Sinus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001146","descriptor_name":"Arrhythmia, Sinus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1013318","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013318","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013318&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40668822","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40668822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:4a3e6e888bcb460bb683f272af7e08c3","is_oa":true,"landing_page_url":"https://doaj.org/article/4a3e6e888bcb460bb683f272af7e08c3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 7, p e1013318 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12286331","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12286331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013318","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013318","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013318&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2039478025","display_name":"Emergence and Coordination of Rhythmic Activity in Respiratory Neurons and Networks","funder_award_id":"1951095","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G482713564","display_name":null,"funder_award_id":"IBS-R029-C3","funder_id":"https://openalex.org/F4320326441","funder_display_name":"Institute for Basic Science"},{"id":"https://openalex.org/G8850967928","display_name":null,"funder_award_id":"R029-C3","funder_id":"https://openalex.org/F4320326441","funder_display_name":"Institute for Basic Science"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320326441","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412489354.pdf","grobid_xml":"https://content.openalex.org/works/W4412489354.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W1494964562","https://openalex.org/W1589779343","https://openalex.org/W1590401753","https://openalex.org/W1883887341","https://openalex.org/W1964927671","https://openalex.org/W1973406213","https://openalex.org/W1978086516","https://openalex.org/W1982665126","https://openalex.org/W1995342618","https://openalex.org/W1998340140","https://openalex.org/W2008966677","https://openalex.org/W2010552891","https://openalex.org/W2012276882","https://openalex.org/W2020044675","https://openalex.org/W2034699502","https://openalex.org/W2049022194","https://openalex.org/W2057298430","https://openalex.org/W2058279449","https://openalex.org/W2069456627","https://openalex.org/W2069763668","https://openalex.org/W2078621608","https://openalex.org/W2080018957","https://openalex.org/W2085570310","https://openalex.org/W2108209278","https://openalex.org/W2114464146","https://openalex.org/W2120366984","https://openalex.org/W2122821074","https://openalex.org/W2128189756","https://openalex.org/W2135733572","https://openalex.org/W2137936462","https://openalex.org/W2142946819","https://openalex.org/W2150471812","https://openalex.org/W2160054565","https://openalex.org/W2166275389","https://openalex.org/W2169887104","https://openalex.org/W2193128485","https://openalex.org/W2258329494","https://openalex.org/W2329325149","https://openalex.org/W2331477266","https://openalex.org/W2336384540","https://openalex.org/W2462002236","https://openalex.org/W2512981267","https://openalex.org/W2546338548","https://openalex.org/W2564375465","https://openalex.org/W2583745971","https://openalex.org/W2738523377","https://openalex.org/W2743197439","https://openalex.org/W2753761054","https://openalex.org/W2766387209","https://openalex.org/W2792795909","https://openalex.org/W2889184839","https://openalex.org/W2894060947","https://openalex.org/W2896611699","https://openalex.org/W2905195301","https://openalex.org/W2944022602","https://openalex.org/W2953870087","https://openalex.org/W2964968773","https://openalex.org/W2967786139","https://openalex.org/W2975951367","https://openalex.org/W2995469271","https://openalex.org/W2999092309","https://openalex.org/W3005543067","https://openalex.org/W3037688992","https://openalex.org/W3038987671","https://openalex.org/W3045366558","https://openalex.org/W3093034649","https://openalex.org/W3097101425","https://openalex.org/W3109123888","https://openalex.org/W3112085950","https://openalex.org/W3131160888","https://openalex.org/W3164057060","https://openalex.org/W3164709737","https://openalex.org/W3205703818","https://openalex.org/W3212410380","https://openalex.org/W3217276944","https://openalex.org/W4226337292","https://openalex.org/W4233084959","https://openalex.org/W4249265228","https://openalex.org/W4283661439","https://openalex.org/W4306698769","https://openalex.org/W4306756865","https://openalex.org/W4311253225","https://openalex.org/W4323832128","https://openalex.org/W4324344363","https://openalex.org/W4387362626","https://openalex.org/W4392153895","https://openalex.org/W4392502802","https://openalex.org/W4399694821","https://openalex.org/W6660146005","https://openalex.org/W6781219150","https://openalex.org/W7074057642","https://openalex.org/W7075617579"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W2748952813","https://openalex.org/W1531601525"],"abstract_inverted_index":{"Seizure-induced":[0],"cardiac":[1,155],"arrhythmias,":[2,12,218],"such":[3],"as":[4,38],"ictal":[5,34,145,222],"(during":[6],"seizure)":[7],"or":[8,35,146],"postictal":[9,36,147,216],"(post-seizure)":[10],"sinus":[11,103,217,223,254],"are":[13,235],"potential":[14],"triggers":[15],"for":[16,160,266],"sudden":[17,271],"unexpected":[18,272],"death":[19,273],"in":[20,30,101,126,163,178,274],"epilepsy.":[21,275],"Traditionally,":[22],"these":[23,48,120,226],"arrhythmias":[24,49,73,104],"have":[25],"been":[26],"attributed":[27],"to":[28,71,75,97,106,119,215],"changes":[29,162],"autonomic":[31,94,131,165],"balance":[32],"during":[33,144],"phases,":[37],"per":[39],"the":[40,108,127,158,170,186,189,241,260,268],"neurogenic":[41,63,174,190],"mechanism.":[42,191],"However,":[43,225],"it":[44],"remains":[45,74],"unclear":[46],"if":[47],"may":[50,258],"involve":[51],"intrinsic":[52,154],"cardiogenic":[53,65,176],"mechanisms.":[54],"Furthermore,":[55],"while":[56,208],"circadian":[57,111,199,227,238],"and":[58,64,92,105,112,175,200],"sleep-wake":[59,113,233,244],"patterns":[60,143,203,228,245],"influence":[61],"both":[62],"mechanisms,":[66],"a":[67,83,249],"direct":[68],"mechanistic":[69],"link":[70],"seizure-induced":[72,102,138,205,253],"be":[76,150,230,248],"established.":[77],"In":[78],"this":[79],"study,":[80],"we":[81],"utilized":[82],"mathematical":[84],"model":[85],"of":[86,129,173,188,204,252,262,270],"mouse":[87],"sinoatrial":[88,139,180,212],"nodal":[89,140,181,213],"cell":[90,141,182],"pacemaking":[91],"an":[93],"clamping":[95],"protocol,":[96],"dissect":[98],"neurocardiogenic":[99,193],"mechanisms":[100,177],"test":[107],"hypothesis":[109,242],"that":[110,243],"rhythms":[114],"directly":[115,152,247],"modulate":[116],"cellular":[117],"susceptibility":[118],"arrhythmias.":[121,206,224,255],"Our":[122,256],"simulations":[123],"revealed":[124],"that,":[125],"context":[128],"altered":[130],"levels":[132],"associated":[133],"with":[134],"seizure":[135],"progression,":[136],"diverse":[137],"firing":[142,183],"phases":[148],"can":[149,229,246],"triggered":[151],"by":[153],"dynamics,":[156],"without":[157],"need":[159],"dynamical":[161],"within-phase":[164],"activities.":[166],"This":[167,192],"finding":[168],"highlights":[169],"distinct":[171,198],"roles":[172],"shaping":[179],"patterns,":[184],"challenging":[185],"predominance":[187],"framework":[194],"also":[195],"successfully":[196],"captures":[197],"vigilance":[201],"state":[202],"Specifically,":[207],"daytime":[209],"sleep":[210],"predisposed":[211],"cells":[214],"nighttime":[219],"wakefulness":[220],"promotes":[221],"disrupted":[231],"when":[232],"cycles":[234],"decoupled":[236],"from":[237],"rhythms,":[239],"supporting":[240],"key":[250],"determinant":[251],"findings":[257],"facilitate":[259],"development":[261],"novel":[263],"therapeutic":[264],"strategies":[265],"managing":[267],"risk":[269]},"counts_by_year":[],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}
