{"id":"https://openalex.org/W4414053860","doi":"https://doi.org/10.1371/journal.pcbi.1013269","title":"Understanding thromboembolus transport patterns in the brain for stroke in the presence of carotid artery stenosis","display_name":"Understanding thromboembolus transport patterns in the brain for stroke in the presence of carotid artery stenosis","publication_year":2025,"publication_date":"2025-09-08","ids":{"openalex":"https://openalex.org/W4414053860","doi":"https://doi.org/10.1371/journal.pcbi.1013269","pmid":"https://pubmed.ncbi.nlm.nih.gov/40920876"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013269","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013269","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013269&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013269&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079912824","display_name":"Ricardo Roopnarinesingh","orcid":"https://orcid.org/0009-0001-2076-234X"},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo Roopnarinesingh","raw_affiliation_strings":["Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004161131","display_name":"Niraj Jani","orcid":"https://orcid.org/0000-0001-6535-0982"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neel D. Jani","raw_affiliation_strings":["Department of Neurology, University of Wisconsin, Madison, Madison, Wisconsin, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-6535-0982","affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Wisconsin, Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028179600","display_name":"Michelle Leppert","orcid":"https://orcid.org/0000-0002-0679-7634"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Leppert","raw_affiliation_strings":["Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076257236","display_name":"Debanjan Mukherjee","orcid":"https://orcid.org/0000-0002-7080-1757"},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Debanjan Mukherjee","raw_affiliation_strings":["Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, Colorado, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7080-1757","affiliations":[{"raw_affiliation_string":"Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076257236"],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":1.3603,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.82576017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"21","issue":"9","first_page":"e1013269","last_page":"e1013269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9758999943733215,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stenosis","display_name":"Stenosis","score":0.863099992275238},{"id":"https://openalex.org/keywords/stroke","display_name":"Stroke (engine)","score":0.6176999807357788},{"id":"https://openalex.org/keywords/embolism","display_name":"Embolism","score":0.5259000062942505},{"id":"https://openalex.org/keywords/carotid-arteries","display_name":"Carotid arteries","score":0.44179999828338623},{"id":"https://openalex.org/keywords/occlusion","display_name":"Occlusion","score":0.3686000108718872},{"id":"https://openalex.org/keywords/carotid-artery-disease","display_name":"Carotid artery disease","score":0.36800000071525574},{"id":"https://openalex.org/keywords/icad","display_name":"ICAD","score":0.3172999918460846}],"concepts":[{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.863099992275238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7745000123977661},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7268000245094299},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6176999807357788},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5884000062942505},{"id":"https://openalex.org/C2777185221","wikidata":"https://www.wikidata.org/wiki/Q275466","display_name":"Embolism","level":2,"score":0.5259000062942505},{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.44179999828338623},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.40299999713897705},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.3686000108718872},{"id":"https://openalex.org/C2776184368","wikidata":"https://www.wikidata.org/wiki/Q1576205","display_name":"Carotid artery disease","level":4,"score":0.36800000071525574},{"id":"https://openalex.org/C2779820911","wikidata":"https://www.wikidata.org/wiki/Q5969307","display_name":"ICAD","level":3,"score":0.3172999918460846},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.31200000643730164},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.289900004863739},{"id":"https://openalex.org/C2778333808","wikidata":"https://www.wikidata.org/wiki/Q515848","display_name":"Internal carotid artery","level":2,"score":0.2858000099658966},{"id":"https://openalex.org/C2779450755","wikidata":"https://www.wikidata.org/wiki/Q1209150","display_name":"Cerebral infarction","level":3,"score":0.2858000099658966},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C2910003425","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Embolic stroke","level":4,"score":0.25029999017715454}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1013269","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013269","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013269&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40920876","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40920876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11341827","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12533973","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1e19dcf398d54e5ea542259810b858dc","is_oa":true,"landing_page_url":"https://doaj.org/article/1e19dcf398d54e5ea542259810b858dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 9, p e1013269 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013269","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013269","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013269&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1354291523","display_name":null,"funder_award_id":"ACI-1532235","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2586609609","display_name":null,"funder_award_id":"ACI-1532236","funder_id":"https://openalex.org/F4320332538","funder_display_name":"University of Colorado Boulder"},{"id":"https://openalex.org/G2796167598","display_name":null,"funder_award_id":"ACI-1532236","funder_id":"https://openalex.org/F4320309627","funder_display_name":"Colorado State University"},{"id":"https://openalex.org/G299533568","display_name":null,"funder_award_id":"R21 EB029736","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4233695085","display_name":"MRI Collaborative Consortium:  Acquisition of a Shared Supercomputer by the Rocky Mountain Advanced Computing Consortium","funder_award_id":"1532235","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4958434179","display_name":null,"funder_award_id":"ACI-1532235","funder_id":"https://openalex.org/F4320309627","funder_display_name":"Colorado State University"},{"id":"https://openalex.org/G5128710979","display_name":"MRI Collaborative Consortium: Acquisition of a Shared Supercomputer by the Rocky Mountain Advanced Computing Consortium","funder_award_id":"1532236","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6942722009","display_name":null,"funder_award_id":"ACI-1532236","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7910085276","display_name":"In Silico Mapping of the Heart-Brain Embolus Transport Pathway for Stroke","funder_award_id":"1r21eb029736-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8929392486","display_name":null,"funder_award_id":"ACI-1532235","funder_id":"https://openalex.org/F4320332538","funder_display_name":"University of Colorado Boulder"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309627","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332538","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414053860.pdf","grobid_xml":"https://content.openalex.org/works/W4414053860.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W798370296","https://openalex.org/W1278334305","https://openalex.org/W1933835782","https://openalex.org/W1976623067","https://openalex.org/W1978862459","https://openalex.org/W2007412473","https://openalex.org/W2042621618","https://openalex.org/W2044665398","https://openalex.org/W2049304501","https://openalex.org/W2066565386","https://openalex.org/W2081779159","https://openalex.org/W2083497737","https://openalex.org/W2089525740","https://openalex.org/W2097663931","https://openalex.org/W2100750655","https://openalex.org/W2101912507","https://openalex.org/W2102672091","https://openalex.org/W2111177859","https://openalex.org/W2131813159","https://openalex.org/W2138743911","https://openalex.org/W2175485826","https://openalex.org/W2467951386","https://openalex.org/W2559292439","https://openalex.org/W2560585316","https://openalex.org/W2564708072","https://openalex.org/W2742796440","https://openalex.org/W2806931860","https://openalex.org/W2912913457","https://openalex.org/W2951237743","https://openalex.org/W2965067097","https://openalex.org/W3001886997","https://openalex.org/W3131987456","https://openalex.org/W3173746046","https://openalex.org/W3212091088","https://openalex.org/W4226391152","https://openalex.org/W4242649591","https://openalex.org/W4250456883","https://openalex.org/W4385723731","https://openalex.org/W4389088625","https://openalex.org/W4393993656","https://openalex.org/W4396498300"],"related_works":["https://openalex.org/W2357116652","https://openalex.org/W4393376145","https://openalex.org/W176377466","https://openalex.org/W2257485906","https://openalex.org/W2399265450","https://openalex.org/W2145572842","https://openalex.org/W2327257564","https://openalex.org/W2097138474","https://openalex.org/W2957784","https://openalex.org/W2417931305"],"abstract_inverted_index":{"Deciphering":[0],"the":[1,37,41,48,164,179,188,199],"source":[2,19],"of":[3,20,58,99,114,190,201],"an":[4,87,149],"embolism":[5],"is":[6,16,45,71,214],"a":[7,17,29,55,75],"common":[8],"challenge":[9],"encountered":[10],"in":[11,36,82,88],"stroke":[12],"treatment.":[13],"Carotid":[14,23],"stenosis":[15,35,104,159,173,192],"key":[18],"embolic":[21],"strokes.":[22],"interventions":[24],"can":[25,193,205],"be":[26],"indicated":[27],"when":[28,210],"patient":[30],"has":[31],"greater":[32],"than":[33],"50%":[34],"carotid":[38,61,70,119,134,172,213],"ipsilateral":[39,177],"to":[40,66,85,110,178,208],"cerebral":[42],"infarction,":[43],"which":[44,69,204,212],"designated":[46],"as":[47],"symptomatic":[49],"carotid.":[50],"However,":[51],"there":[52],"are":[53],"often":[54],"significant":[56],"number":[57],"cases":[59,127],"where":[60],"emboli":[62,195],"travel":[63,197],"contralaterally,":[64],"leading":[65],"ambiguity":[67,209],"regarding":[68],"symptomatic.":[72,216],"We":[73,106,140],"use":[74],"patient-specific":[76],"computational":[77],"embolus-hemodynamics":[78],"interaction":[79],"model":[80],"developed":[81],"prior":[83],"works":[84],"conduct":[86],"silico":[89],"experiment":[90],"spanning":[91],"30":[92],"heart-to-brain":[93],"arterial":[94],"models":[95,109],"with":[96,171],"differing":[97],"combinations":[98],"bilateral":[100],"severe":[101],"and":[102,122,132],"mild":[103],"degrees.":[105],"used":[107],"these":[108],"study":[111],"source-to-destination":[112],"transport":[113,155],"thromboemboli":[115,129,145],"released":[116],"from":[117,130],"left/right":[118],"disease":[120],"sites,":[121],"cardiogenic":[123,144],"sources.":[124],"Across":[125],"all":[126],"considered,":[128],"left":[131],"right":[133],"sources":[135],"showed":[136],"non-zero":[137],"contralateral":[138,191],"transport.":[139],"also":[141],"found":[142],"that":[143,187,196],"do":[146],"not":[147],"have":[148,185],"altered":[150],"hemisphere":[151],"distribution":[152],"or":[153,174],"distinct":[154],"preference":[156],"dependent":[157],"on":[158],"degree,":[160],"thus":[161],"potentially":[162,206],"making":[163],"underlying":[165],"etiology":[166],"more":[167],"cryptic.":[168],"In":[169],"patients":[170],"chronic":[175],"occlusion":[176],"area":[180],"affected":[181],"by":[182],"stroke,":[183],"we":[184],"demonstrated":[186],"presence":[189],"cause":[194],"across":[198],"Circle":[200],"Willis":[202],"(CoW)":[203],"lead":[207],"deciding":[211],"truly":[215]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2025-10-10T00:00:00"}
