{"id":"https://openalex.org/W4412488884","doi":"https://doi.org/10.1371/journal.pcbi.1013254","title":"Impact of ligand binding on VEGFR1, VEGFR2, and NRP1 localization in human endothelial cells","display_name":"Impact of ligand binding on VEGFR1, VEGFR2, and NRP1 localization in human endothelial cells","publication_year":2025,"publication_date":"2025-07-16","ids":{"openalex":"https://openalex.org/W4412488884","doi":"https://doi.org/10.1371/journal.pcbi.1013254","pmid":"https://pubmed.ncbi.nlm.nih.gov/40668864"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013254","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013254","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013254","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025520854","display_name":"Sarvenaz Sarabipour","orcid":"https://orcid.org/0000-0001-5097-5509"},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarvenaz Sarabipour","raw_affiliation_strings":["Center for Cell Analysis & Modeling, Center for Vascular Biology, Department of Cell Biology, Department of Biomedical Engineering, University of Connecticut School of Medicine, Farmington, Connecticut, United States of America","Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5097-5509","affiliations":[{"raw_affiliation_string":"Center for Cell Analysis & Modeling, Center for Vascular Biology, Department of Cell Biology, Department of Biomedical Engineering, University of Connecticut School of Medicine, Farmington, Connecticut, United States of America","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041806591","display_name":"Karina Kinghorn","orcid":"https://orcid.org/0000-0002-2736-220X"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karina Kinghorn","raw_affiliation_strings":["Curriculum in Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States of America","Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2736-220X","affiliations":[{"raw_affiliation_string":"Curriculum in Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007365562","display_name":"Kaitlyn Quigley","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlyn M. Quigley","raw_affiliation_strings":["Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080823317","display_name":"Anita Kov\u00e1cs\u2010K\u00e1sa","orcid":"https://orcid.org/0000-0001-7244-5517"},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita Kovacs-Kasa","raw_affiliation_strings":["Vascular Biology Center and Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Center and Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, United States of America","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022456171","display_name":"Brian H. Annex","orcid":"https://orcid.org/0000-0001-6538-8243"},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian H. Annex","raw_affiliation_strings":["Vascular Biology Center and Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-6538-8243","affiliations":[{"raw_affiliation_string":"Vascular Biology Center and Department of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, United States of America","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068807010","display_name":"Victoria L. Bautch","orcid":"https://orcid.org/0000-0003-2135-5153"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria L. Bautch","raw_affiliation_strings":["Curriculum in Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States of America","Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America","McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2135-5153","affiliations":[{"raw_affiliation_string":"Curriculum in Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045576072","display_name":"Feilim Mac Gabhann","orcid":"https://orcid.org/0000-0003-3481-7740"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feilim Mac Gabhann","raw_affiliation_strings":["Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3481-7740","affiliations":[{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0923,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.77639043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"21","issue":"7","first_page":"e1013254","last_page":"e1013254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9693999886512756,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.7313108444213867},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.6890255212783813},{"id":"https://openalex.org/keywords/internalization","display_name":"Internalization","score":0.6442303657531738},{"id":"https://openalex.org/keywords/neuropilin-1","display_name":"Neuropilin 1","score":0.614814817905426},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase","display_name":"Receptor tyrosine kinase","score":0.5648946762084961},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.5311554670333862},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.5179773569107056},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5107166767120361},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.48672130703926086},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4826931953430176},{"id":"https://openalex.org/keywords/kinase-insert-domain-receptor","display_name":"Kinase insert domain receptor","score":0.46648386120796204},{"id":"https://openalex.org/keywords/cell-surface-receptor","display_name":"Cell surface receptor","score":0.4154677987098694},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3828888535499573},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor-a","display_name":"Vascular endothelial growth factor A","score":0.3395226001739502},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"Vascular endothelial growth factor","score":0.31946277618408203},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2902427911758423},{"id":"https://openalex.org/keywords/vegf-receptors","display_name":"VEGF receptors","score":0.19503650069236755},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.13618993759155273}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7313108444213867},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6890255212783813},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.6442303657531738},{"id":"https://openalex.org/C34425596","wikidata":"https://www.wikidata.org/wiki/Q18033463","display_name":"Neuropilin 1","level":4,"score":0.614814817905426},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5648946762084961},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5311554670333862},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5179773569107056},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5107166767120361},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.48672130703926086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4826931953430176},{"id":"https://openalex.org/C14858245","wikidata":"https://www.wikidata.org/wiki/Q18028241","display_name":"Kinase insert domain receptor","level":5,"score":0.46648386120796204},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.4154677987098694},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3828888535499573},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.3395226001739502},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.31946277618408203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2902427911758423},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.19503650069236755},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.13618993759155273}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039942","descriptor_name":"Neuropilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039942","descriptor_name":"Neuropilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039942","descriptor_name":"Neuropilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039942","descriptor_name":"Neuropilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040281","descriptor_name":"Vascular Endothelial Growth Factor Receptor-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040281","descriptor_name":"Vascular Endothelial Growth Factor Receptor-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040281","descriptor_name":"Vascular Endothelial Growth Factor Receptor-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040281","descriptor_name":"Vascular Endothelial Growth Factor Receptor-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1013254","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013254","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40668864","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40668864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:7a0df3d47c304dd29ebfaffcafede1df","is_oa":true,"landing_page_url":"https://doaj.org/article/7a0df3d47c304dd29ebfaffcafede1df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 7, p e1013254 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12310042","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12310042","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013254","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013254","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3541691592","display_name":null,"funder_award_id":"R35-HL139950","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4639804785","display_name":null,"funder_award_id":"R01 GM129074","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5274348335","display_name":null,"funder_award_id":"R01 HL101200","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6507348221","display_name":null,"funder_award_id":"R01-GM129074","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7441592715","display_name":null,"funder_award_id":"R35 HL139950","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8217763361","display_name":null,"funder_award_id":"R01-HL101200","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W187023503","https://openalex.org/W632061114","https://openalex.org/W1495287184","https://openalex.org/W1875554126","https://openalex.org/W1950623720","https://openalex.org/W1964621218","https://openalex.org/W1970338125","https://openalex.org/W1978927205","https://openalex.org/W1981812533","https://openalex.org/W1982383741","https://openalex.org/W1986559037","https://openalex.org/W1988864250","https://openalex.org/W1991994014","https://openalex.org/W1992049575","https://openalex.org/W1994719482","https://openalex.org/W1998767340","https://openalex.org/W1999956350","https://openalex.org/W2010641085","https://openalex.org/W2011416603","https://openalex.org/W2013166677","https://openalex.org/W2014148719","https://openalex.org/W2018291504","https://openalex.org/W2030615367","https://openalex.org/W2031228967","https://openalex.org/W2034073329","https://openalex.org/W2040892290","https://openalex.org/W2043765960","https://openalex.org/W2049408374","https://openalex.org/W2053026927","https://openalex.org/W2053547715","https://openalex.org/W2059229484","https://openalex.org/W2059772655","https://openalex.org/W2068465610","https://openalex.org/W2070655502","https://openalex.org/W2070691519","https://openalex.org/W2073131598","https://openalex.org/W2082240332","https://openalex.org/W2082664513","https://openalex.org/W2084947524","https://openalex.org/W2096136598","https://openalex.org/W2098728140","https://openalex.org/W2111009402","https://openalex.org/W2114257111","https://openalex.org/W2115892984","https://openalex.org/W2117743783","https://openalex.org/W2119729707","https://openalex.org/W2119748249","https://openalex.org/W2120469095","https://openalex.org/W2125801586","https://openalex.org/W2125907821","https://openalex.org/W2127738535","https://openalex.org/W2127878160","https://openalex.org/W2138318533","https://openalex.org/W2138321569","https://openalex.org/W2140642422","https://openalex.org/W2146293179","https://openalex.org/W2166085065","https://openalex.org/W2171114052","https://openalex.org/W2171350162","https://openalex.org/W2171715330","https://openalex.org/W2276765336","https://openalex.org/W2303100661","https://openalex.org/W2311113928","https://openalex.org/W2327393368","https://openalex.org/W2486397717","https://openalex.org/W2563544597","https://openalex.org/W2571726968","https://openalex.org/W2592120049","https://openalex.org/W2597572948","https://openalex.org/W2623584391","https://openalex.org/W2770220364","https://openalex.org/W2786175404","https://openalex.org/W2903371348","https://openalex.org/W3089416259","https://openalex.org/W3166518985","https://openalex.org/W4213048200","https://openalex.org/W4235948748","https://openalex.org/W4282927552","https://openalex.org/W4391594237","https://openalex.org/W4407718801","https://openalex.org/W6678359005"],"related_works":["https://openalex.org/W4405316370","https://openalex.org/W4391160446","https://openalex.org/W2049292409","https://openalex.org/W4229879599","https://openalex.org/W2418180845","https://openalex.org/W2621284822","https://openalex.org/W1551174843","https://openalex.org/W2067817921","https://openalex.org/W1967810599","https://openalex.org/W2908012703"],"abstract_inverted_index":{"The":[0],"vascular":[1],"endothelial":[2],"growth":[3,19],"factor":[4],"receptors":[5,32,48,106,253],"(VEGFRs)":[6],"bind":[7,38],"to":[8,11,37,91,142,160,175,208,339,343],"cognate":[9],"ligands":[10,99,159],"facilitate":[12],"signaling":[13,60,349],"pathways":[14],"critical":[15,332],"for":[16,155,239,254,333],"angiogenesis,":[17],"the":[18,29,34,44,50,73,94,101,109,118,146,189,203,220,231,236,249,252,257,268,278,280,294,298,301,307,311,318,334],"of":[20,31,46,76,96,103,111,122,129,134,139,145,157,181,202,223,228,235,300,326,336],"new":[21,152],"capillaries":[22],"from":[23],"existing":[24],"vasculature.":[25],"Intracellular":[26],"trafficking":[27,75,102,170,180,191,328],"regulates":[28],"availability":[30,342],"on":[33,117,230,267],"cell":[35,232,269,279],"surface":[36,51,270],"ligands,":[39],"which":[40,140],"regulate":[41,340],"activation,":[42],"and":[43,52,65,71,82,107,114,120,136,149,162,242,261,285,330,345],"movement":[45],"activated":[47],"between":[49,251],"intracellular":[53],"pools,":[54],"where":[55],"they":[56],"can":[57,192,282],"initiate":[58],"different":[59,97,131,143],"pathways.":[61],"Using":[62],"experimental":[63,153],"data":[64,154],"computational":[66],"modeling,":[67],"we":[68,87,150,185],"recently":[69],"demonstrated":[70],"quantified":[72],"differential":[74],"three":[77],"VEGF":[78,98,105,147,347],"receptors,":[79,148],"VEGFR1,":[80],"VEGFR2,":[81],"coreceptor":[83],"Neuropilin-1":[84],"(NRP1).":[85],"Here,":[86],"expand":[88,323],"that":[89,168,179,188,217,263],"approach":[90],"quantify":[92],"how":[93],"binding":[95,116],"alters":[100],"these":[104,158],"demonstrate":[108],"consequences":[110],"receptor":[112,205,224,348],"localization":[113,119],"ligand":[115,176,255,303,341],"dynamics":[121,329],"signal":[123],"initiation":[124],"complexes.":[125],"We":[126,166,214,246,289],"include":[127],"simulations":[128],"four":[130],"splice":[132],"isoforms":[133],"VEGF-A":[135],"PLGF,":[137],"each":[138],"binds":[141],"combinations":[144],"use":[151],"two":[156],"parameterize":[161],"validate":[163],"our":[164,324],"model.":[165],"show":[167,187,216,262],"VEGFR2":[169,204,243],"is":[171,183,227],"altered":[172,190],"in":[173,265,317,350],"response":[174],"binding,":[177,256],"but":[178],"VEGFR1":[182,241,344],"not;":[184],"also":[186,247],"be":[193,275,283],"explained":[194],"by":[195],"a":[196],"single":[197],"mechanistic":[198],"process,":[199],"increased":[200],"internalization":[201],"when":[206],"bound":[207],"ligand;":[209],"other":[210],"processes":[211],"are":[212,244,331],"unaffected.":[213],"further":[215],"even":[218],"though":[219],"canonical":[221],"view":[222],"tyrosine":[225],"kinases":[226],"activation":[229],"surface,":[233],"most":[234],"ligand-receptor":[237],"complexes":[238],"both":[240],"intracellular.":[245],"explore":[248],"competition":[250],"so-called":[258],"'decoy":[259],"effect',":[260],"while":[264],"vitro":[266],"minimal":[271],"such":[272],"effect":[273,281],"would":[274],"observed,":[276],"inside":[277,310],"substantial":[284],"may":[286],"influence":[287],"signaling.":[288],"term":[290],"this":[291],"location":[292],"dependence":[293],"'reservoir":[295],"effect'":[296],"as":[297],"size":[299],"local":[302],"reservoir":[304],"(large":[305],"outside":[306],"cell,":[308],"small":[309],"cell)":[312],"plays":[313],"an":[314],"integral":[315],"role":[316],"receptor-receptor":[319],"competition.":[320],"These":[321],"results":[322],"understanding":[325],"receptor-ligand":[327],"design":[335],"therapeutic":[337],"agents":[338],"hence":[346],"angiogenesis.":[351]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
