{"id":"https://openalex.org/W4412624848","doi":"https://doi.org/10.1371/journal.pcbi.1013242","title":"A variational deep-learning approach to modeling memory T cell dynamics","display_name":"A variational deep-learning approach to modeling memory T cell dynamics","publication_year":2025,"publication_date":"2025-07-24","ids":{"openalex":"https://openalex.org/W4412624848","doi":"https://doi.org/10.1371/journal.pcbi.1013242","pmid":"https://pubmed.ncbi.nlm.nih.gov/40705818"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013242","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013242","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013242","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023400595","display_name":"Christiaan H. van Dorp","orcid":"https://orcid.org/0000-0002-7504-9947"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christiaan H. van Dorp","raw_affiliation_strings":["Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7504-9947","affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, United States of America","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103239440","display_name":"Joshua I. Gray","orcid":"https://orcid.org/0000-0003-2796-5470"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua I. Gray","raw_affiliation_strings":["Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041434692","display_name":"Daniel H. Paik","orcid":"https://orcid.org/0000-0002-6644-4742"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel H. Paik","raw_affiliation_strings":["Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6644-4742","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065092305","display_name":"Donna L. F\u00e4rber","orcid":"https://orcid.org/0000-0001-8236-9183"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donna L. Farber","raw_affiliation_strings":["Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020536875","display_name":"Andrew J. Yates","orcid":"https://orcid.org/0000-0003-4606-4483"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew J. Yates","raw_affiliation_strings":["Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-4606-4483","affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, United States of America","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020536875","https://openalex.org/A5023400595","https://openalex.org/A5041434692","https://openalex.org/A5065092305","https://openalex.org/A5103239440"],"corresponding_institution_ids":["https://openalex.org/I2799503643"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.4103,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.89529289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"21","issue":"7","first_page":"e1013242","last_page":"e1013242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.545157790184021},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5388234853744507},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5207234025001526},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4526599645614624},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.41854792833328247}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.545157790184021},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5388234853744507},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5207234025001526},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4526599645614624},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.41854792833328247},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000091246","descriptor_name":"Memory T Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000091246","descriptor_name":"Memory T Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1013242","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013242","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40705818","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40705818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:4901575af94a4118b5be8a08bfa3b32d","is_oa":true,"landing_page_url":"https://doaj.org/article/4901575af94a4118b5be8a08bfa3b32d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 7, p e1013242 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12360662","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12360662","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013242","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013242","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4300000071525574,"id":"https://metadata.un.org/sdg/4","display_name":"Quality Education"}],"awards":[{"id":"https://openalex.org/G196352881","display_name":null,"funder_award_id":"U01 AI150680","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3353835341","display_name":null,"funder_award_id":"R01 AI093870","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1507160172","https://openalex.org/W1583837637","https://openalex.org/W1631320694","https://openalex.org/W1988511365","https://openalex.org/W2021137021","https://openalex.org/W2029903525","https://openalex.org/W2122553231","https://openalex.org/W2130446440","https://openalex.org/W2131681506","https://openalex.org/W2135046866","https://openalex.org/W2155051381","https://openalex.org/W2203714058","https://openalex.org/W2238214435","https://openalex.org/W2560258181","https://openalex.org/W2577537660","https://openalex.org/W2594102594","https://openalex.org/W2620974035","https://openalex.org/W2730106296","https://openalex.org/W2754079107","https://openalex.org/W2800392236","https://openalex.org/W2809123551","https://openalex.org/W2897249806","https://openalex.org/W2897613819","https://openalex.org/W2901677030","https://openalex.org/W2909267293","https://openalex.org/W2910719176","https://openalex.org/W2911279170","https://openalex.org/W2922826800","https://openalex.org/W2928871599","https://openalex.org/W2948978827","https://openalex.org/W2951381561","https://openalex.org/W2956132863","https://openalex.org/W2977101849","https://openalex.org/W2986778077","https://openalex.org/W3000094117","https://openalex.org/W3003753408","https://openalex.org/W3095680124","https://openalex.org/W3099768174","https://openalex.org/W3103853875","https://openalex.org/W3106188259","https://openalex.org/W3121105779","https://openalex.org/W3121168830","https://openalex.org/W3123421154","https://openalex.org/W3161562754","https://openalex.org/W3175719984","https://openalex.org/W3212164957","https://openalex.org/W4205496949","https://openalex.org/W4226051117","https://openalex.org/W4286879859","https://openalex.org/W4290617521","https://openalex.org/W4302763572","https://openalex.org/W4385216428","https://openalex.org/W4385945347","https://openalex.org/W4399291580","https://openalex.org/W4401537232","https://openalex.org/W4405638647","https://openalex.org/W4406715779","https://openalex.org/W4408367796"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4387369504","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W3107602296","https://openalex.org/W4364306694","https://openalex.org/W4312192474","https://openalex.org/W4283697347"],"abstract_inverted_index":{"Mechanistic":[0],"models":[1,21,55],"of":[2,16,26,34,39,69,126,136,170,195,208],"dynamic,":[3],"interacting":[4],"cell":[5,28],"populations":[6],"have":[7,22],"yielded":[8],"many":[9],"insights":[10,191],"into":[11,183,192],"the":[12,24,65,97,116,124,133,137,147,193],"growth":[13],"and":[14,52,67,74,96,108,112,142,157,175,199],"resolution":[15,134],"immune":[17,138,197],"responses.":[18],"Historically":[19],"these":[20],"described":[23],"behavior":[25],"pre-defined":[27],"types":[29],"based":[30],"on":[31,115,123],"small":[32],"numbers":[33],"phenotypic":[35],"markers.":[36],"The":[37],"ubiquity":[38],"deep":[40,106],"phenotyping":[41],"therefore":[42],"presents":[43],"a":[44,201],"new":[45,190],"challenge;":[46],"how":[47],"do":[48],"we":[49,63],"confront":[50],"tractable":[51],"interpretable":[53],"mathematical":[54],"with":[56,84,152],"high-dimensional":[57,209],"data?":[58],"To":[59],"tackle":[60],"this":[61],"problem,":[62],"studied":[64],"development":[66],"persistence":[68],"lung":[70,148],"tissue-resident":[71],"memory":[72,140],"CD4":[73,141,174],"CD8":[75,143,176],"T":[76,144],"cells":[77,145],"([Formula:":[78],"see":[79,161,178],"text])":[80],"in":[81,91],"mice":[82],"infected":[83],"influenza":[85],"virus.":[86],"We":[87,129],"developed":[88],"an":[89],"approach":[90,188],"which":[92,181],"dynamical":[93],"model":[94],"parameters":[95],"population":[98],"structure":[99],"are":[100,149],"inferred":[101],"simultaneously.":[102],"This":[103],"method":[104],"uses":[105],"learning":[107],"stochastic":[109],"variational":[110],"inference":[111],"is":[113,164,200],"trained":[114],"single-cell":[117],"flow-cytometry":[118],"data":[119],"directly,":[120],"rather":[121],"than":[122],"kinetics":[125],"pre-identified":[127],"clusters.":[128],"show":[130],"that":[131],"during":[132],"phase":[135],"response,":[139],"within":[146],"phenotypically":[150],"diverse,":[151],"subsets":[153,180],"exhibiting":[154],"highly":[155],"distinct":[156,184],"time-dependent":[158],"dynamics.":[159],"[Formula:":[160,177],"text]":[162,179],"heterogeneity":[163],"maintained":[165],"long-term":[166],"by":[167],"ongoing":[168],"differentiation":[169],"relatively":[171],"persistent":[172],"Bcl-2hi":[173],"resolve":[182],"functional":[185],"populations.":[186],"Our":[187],"yields":[189],"dynamics":[194],"tissue-localized":[196],"memory,":[198],"novel":[202],"basis":[203],"for":[204],"interpreting":[205],"time":[206],"series":[207],"data,":[210],"broadly":[211],"applicable":[212],"to":[213],"diverse":[214],"biological":[215],"systems.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
