{"id":"https://openalex.org/W4412072985","doi":"https://doi.org/10.1371/journal.pcbi.1013241","title":"Single-cell mutational burden distributions in birth\u2013death processes","display_name":"Single-cell mutational burden distributions in birth\u2013death processes","publication_year":2025,"publication_date":"2025-07-07","ids":{"openalex":"https://openalex.org/W4412072985","doi":"https://doi.org/10.1371/journal.pcbi.1013241","pmid":"https://pubmed.ncbi.nlm.nih.gov/40623094"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013241","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013241","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013241","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092883969","display_name":"Christo Morison","orcid":"https://orcid.org/0000-0002-9350-7833"},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christo Morison","raw_affiliation_strings":["School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9350-7833","affiliations":[{"raw_affiliation_string":"School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052564891","display_name":"Dudley Stark","orcid":"https://orcid.org/0000-0001-8527-3996"},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dudley Stark","raw_affiliation_strings":["School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-8527-3996","affiliations":[{"raw_affiliation_string":"School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082497527","display_name":"Weini Huang","orcid":"https://orcid.org/0000-0002-9016-2665"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Weini Huang","raw_affiliation_strings":["Group of Theoretical Biology, Research Section of Genomics, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9016-2665","affiliations":[{"raw_affiliation_string":"Group of Theoretical Biology, Research Section of Genomics, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5092883969"],"corresponding_institution_ids":["https://openalex.org/I166337079"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.211366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"7","first_page":"e1013241","last_page":"e1013241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5452284812927246},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.5204382538795471},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5064996480941772},{"id":"https://openalex.org/keywords/birth\u2013death-process","display_name":"Birth\u2013death process","score":0.43758997321128845},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4100536108016968},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3593597710132599},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.34963661432266235},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30305278301239014},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22778421640396118},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2001517415046692},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.16572505235671997}],"concepts":[{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5452284812927246},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.5204382538795471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5064996480941772},{"id":"https://openalex.org/C65990518","wikidata":"https://www.wikidata.org/wiki/Q1456275","display_name":"Birth\u2013death process","level":3,"score":0.43758997321128845},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4100536108016968},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3593597710132599},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.34963661432266235},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30305278301239014},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22778421640396118},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2001517415046692},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.16572505235671997},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1013241","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013241","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40623094","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40623094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:2da35beca13f45efba910a5719f0b092","is_oa":true,"landing_page_url":"https://doaj.org/article/2da35beca13f45efba910a5719f0b092","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 7, p e1013241 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12266427","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12266427","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013241","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013241","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"awards":[{"id":"https://openalex.org/G4803470049","display_name":null,"funder_award_id":"955708","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W1667778445","https://openalex.org/W1922239489","https://openalex.org/W1963559748","https://openalex.org/W1963935421","https://openalex.org/W1964154017","https://openalex.org/W1964525108","https://openalex.org/W1982669163","https://openalex.org/W2010873488","https://openalex.org/W2013612669","https://openalex.org/W2013753628","https://openalex.org/W2026180657","https://openalex.org/W2029588642","https://openalex.org/W2034231842","https://openalex.org/W2041993682","https://openalex.org/W2042321087","https://openalex.org/W2054851696","https://openalex.org/W2061445495","https://openalex.org/W2085807917","https://openalex.org/W2094494177","https://openalex.org/W2107680358","https://openalex.org/W2117276798","https://openalex.org/W2122333508","https://openalex.org/W2133811295","https://openalex.org/W2137635563","https://openalex.org/W2145913466","https://openalex.org/W2145929705","https://openalex.org/W2147476214","https://openalex.org/W2177689130","https://openalex.org/W2231820207","https://openalex.org/W2255988550","https://openalex.org/W2260951263","https://openalex.org/W2606495925","https://openalex.org/W2762185802","https://openalex.org/W2767150039","https://openalex.org/W2771602668","https://openalex.org/W2798041799","https://openalex.org/W2800375152","https://openalex.org/W2889734305","https://openalex.org/W2919779091","https://openalex.org/W2951391875","https://openalex.org/W2963667930","https://openalex.org/W2965689846","https://openalex.org/W2966362872","https://openalex.org/W2992640343","https://openalex.org/W3005127469","https://openalex.org/W3008012817","https://openalex.org/W3009639605","https://openalex.org/W3013784317","https://openalex.org/W3015416694","https://openalex.org/W3033423050","https://openalex.org/W3033558827","https://openalex.org/W3045551527","https://openalex.org/W3099373549","https://openalex.org/W3103401970","https://openalex.org/W3131065743","https://openalex.org/W3153023831","https://openalex.org/W3158308213","https://openalex.org/W3200057065","https://openalex.org/W3200681829","https://openalex.org/W3209926184","https://openalex.org/W4231518691","https://openalex.org/W4232392628","https://openalex.org/W4281913860","https://openalex.org/W4282836866","https://openalex.org/W4284974281","https://openalex.org/W4289260419","https://openalex.org/W4367365624","https://openalex.org/W4378903458","https://openalex.org/W4386691782","https://openalex.org/W4386828501","https://openalex.org/W4394749968","https://openalex.org/W4403364242","https://openalex.org/W4408007061","https://openalex.org/W4410840674","https://openalex.org/W6637022290"],"related_works":["https://openalex.org/W2146397496","https://openalex.org/W2076383445","https://openalex.org/W2592888218","https://openalex.org/W2804435636","https://openalex.org/W2136281516","https://openalex.org/W2025340064","https://openalex.org/W4384665577","https://openalex.org/W4231831369","https://openalex.org/W4281740518","https://openalex.org/W2097774084"],"abstract_inverted_index":{"Genetic":[0],"mutations":[1,226],"are":[2,17],"footprints":[3],"of":[4,12,65,70,98,116,139,225],"cancer":[5],"evolution":[6],"and":[7,46,53,103,113,125,130,132,156,171,188,192],"reveal":[8],"critical":[9],"dynamic":[10],"parameters":[11],"tumour":[13,27],"growth,":[14],"which":[15],"otherwise":[16],"hard":[18],"to":[19,108,123],"measure":[20],"in":[21,26,59,150,214,222],"vivo.":[22],"The":[23],"mutation":[24],"accumulation":[25],"cell":[28,229],"populations":[29],"has":[30,74],"been":[31,56],"described":[32],"by":[33,210],"various":[34],"statistics,":[35],"such":[36],"as":[37],"site":[38],"frequency":[39],"spectra":[40],"(SFS),":[41],"single-cell":[42,81,190,205],"division":[43],"distributions":[44,49,100,175],"(DD)":[45],"mutational":[47],"burden":[48],"(MBD).":[50],"While":[51,143],"DD":[52,129,158],"SFS":[54,155,187],"have":[55],"intensively":[57],"studied":[58],"phylogenetics":[60],"especially":[61],"after":[62],"the":[63,80,90,111,127,137,154,157,169,186,189,195,201,204,211,215,219,223],"development":[64],"whole":[66],"genome":[67],"sequencing":[68,82],"technology":[69],"bulk":[71],"samples,":[72],"MBD":[73,131,170,196,206],"drawn":[75],"attention":[76],"more":[77],"recently":[78],"with":[79],"data.":[83],"Although":[84],"those":[85],"statistics":[86],"all":[87,173],"arise":[88],"from":[89],"same":[91],"somatic":[92],"evolutionary":[93,114],"process,":[94],"an":[95],"integrated":[96],"understanding":[97],"these":[99,140],"is":[101,178,207],"missing":[102],"requires":[104],"novel":[105],"mathematical":[106],"tools":[107],"better":[109],"inform":[110],"ecological":[112],"dynamics":[115],"tumours.":[117],"Here":[118],"we":[119,144,163],"introduce":[120],"dynamical":[121],"matrices":[122],"analyse":[124],"unite":[126],"SFS,":[128],"derive":[133,164],"recurrence":[134],"relations":[135],"for":[136,153,168],"expectations":[138],"three":[141,174],"distributions.":[142],"successfully":[145],"recover":[146],"classic":[147],"exact":[148],"results":[149],"pure-birth":[151],"cases":[152],"through":[159,200],"our":[160],"new":[161,166],"framework,":[162],"a":[165,182],"expression":[167],"approximate":[172],"when":[176],"death":[177],"introduced.":[179],"We":[180],"demonstrate":[181],"natural":[183],"link":[184],"between":[185],"MBD,":[191],"show":[193],"that":[194],"can":[197],"be":[198],"regenerated":[199],"DD.":[202],"Counter-intuitively,":[203],"mainly":[208],"driven":[209],"stochasticity":[212,221],"arising":[213],"DD,":[216],"rather":[217],"than":[218],"extra":[220],"number":[224],"at":[227],"each":[228],"division.":[230]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}