{"id":"https://openalex.org/W4410949294","doi":"https://doi.org/10.1371/journal.pcbi.1013072","title":"Features influencing the health and economic impact of preventing COVID-19 in immunocompromised individuals","display_name":"Features influencing the health and economic impact of preventing COVID-19 in immunocompromised individuals","publication_year":2025,"publication_date":"2025-06-02","ids":{"openalex":"https://openalex.org/W4410949294","doi":"https://doi.org/10.1371/journal.pcbi.1013072","pmid":"https://pubmed.ncbi.nlm.nih.gov/40455922"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013072","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013072","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013072","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100325168","display_name":"Siyu Chen","orcid":"https://orcid.org/0000-0001-9418-2527"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Siyu Chen","raw_affiliation_strings":["Department of Public and Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9418-2527","affiliations":[{"raw_affiliation_string":"Department of Public and Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086864560","display_name":"Sudhir Venkatesan","orcid":"https://orcid.org/0000-0002-2093-5781"},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sudhir Venkatesan","raw_affiliation_strings":["Medical and Payer Evidence, BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-2093-5781","affiliations":[{"raw_affiliation_string":"Medical and Payer Evidence, BioPharmaceuticals Medical, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043442748","display_name":"Sofie Arnetorp","orcid":"https://orcid.org/0009-0004-7624-0091"},"institutions":[{"id":"https://openalex.org/I4210128198","display_name":"AstraZeneca (Switzerland)","ror":"https://ror.org/034rhks82","country_code":"CH","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210128198"]},{"id":"https://openalex.org/I4210137263","display_name":"AstraZeneca (Finland)","ror":"https://ror.org/035n56j11","country_code":"FI","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210137263"]},{"id":"https://openalex.org/I4210139728","display_name":"AstraZeneca (Italy)","ror":"https://ror.org/04e6qgn10","country_code":"IT","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210139728"]}],"countries":["CH","FI","IT"],"is_corresponding":true,"raw_author_name":"Sofie Arnetorp","raw_affiliation_strings":["Health Economics & Payer Evidence, BioPharmaceuticals R.&D., AstraZeneca, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Economics & Payer Evidence, BioPharmaceuticals R.&D., AstraZeneca, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210139728","https://openalex.org/I4210128198","https://openalex.org/I4210137263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007186254","display_name":"Klas Bergenheim","orcid":"https://orcid.org/0000-0002-2113-8477"},"institutions":[{"id":"https://openalex.org/I4210128198","display_name":"AstraZeneca (Switzerland)","ror":"https://ror.org/034rhks82","country_code":"CH","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210128198"]},{"id":"https://openalex.org/I4210137263","display_name":"AstraZeneca (Finland)","ror":"https://ror.org/035n56j11","country_code":"FI","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210137263"]},{"id":"https://openalex.org/I4210139728","display_name":"AstraZeneca (Italy)","ror":"https://ror.org/04e6qgn10","country_code":"IT","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210139728"]}],"countries":["CH","FI","IT"],"is_corresponding":true,"raw_author_name":"Klas Bergenheim","raw_affiliation_strings":["Health Economics & Payer Evidence, BioPharmaceuticals R.&D., AstraZeneca, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Economics & Payer Evidence, BioPharmaceuticals R.&D., AstraZeneca, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210139728","https://openalex.org/I4210128198","https://openalex.org/I4210137263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073606422","display_name":"Sabada Dube","orcid":"https://orcid.org/0000-0001-8631-8244"},"institutions":[{"id":"https://openalex.org/I4210110908","display_name":"AstraZeneca (France)","ror":"https://ror.org/016qv5070","country_code":"FR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210110908"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Sabada Dube","raw_affiliation_strings":["Medical Evidence, Vaccines and Immune Therapies Unit, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Evidence, Vaccines and Immune Therapies Unit, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210110908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018842279","display_name":"Wilhelmine Meeraus","orcid":null},"institutions":[{"id":"https://openalex.org/I4210110908","display_name":"AstraZeneca (France)","ror":"https://ror.org/016qv5070","country_code":"FR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210110908"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Wilhelmine Meeraus","raw_affiliation_strings":["Medical Evidence, Vaccines and Immune Therapies Unit, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Evidence, Vaccines and Immune Therapies Unit, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210110908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045236176","display_name":"C\u00e1tia Ferreira","orcid":"https://orcid.org/0000-0001-8312-5199"},"institutions":[{"id":"https://openalex.org/I4210110908","display_name":"AstraZeneca (France)","ror":"https://ror.org/016qv5070","country_code":"FR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210110908"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"C\u00e1tia Ferreira","raw_affiliation_strings":["Vaccines and Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Wilmington, Delaware, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccines and Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Wilmington, Delaware, United States of America","institution_ids":["https://openalex.org/I4210110908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104203521","display_name":"Sylvia Taylor","orcid":null},"institutions":[{"id":"https://openalex.org/I4210113648","display_name":"Federation of Small Businesses","ror":"https://ror.org/025a7c117","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210113648"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sylvia Taylor","raw_affiliation_strings":["Self-employed, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Self-employed, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210113648"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005021967","display_name":"Lisa J. White","orcid":"https://orcid.org/0000-0002-6523-185X"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Lisa J. White","raw_affiliation_strings":["Department of Biology, University of Oxford, Oxford, United Kingdom","Model Health Ltd, Oxford, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-6523-185X","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Model Health Ltd, Oxford, United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5005021967","https://openalex.org/A5007186254","https://openalex.org/A5018842279","https://openalex.org/A5043442748","https://openalex.org/A5045236176","https://openalex.org/A5073606422","https://openalex.org/A5086864560","https://openalex.org/A5100325168","https://openalex.org/A5104203521"],"corresponding_institution_ids":["https://openalex.org/I105036370","https://openalex.org/I205783295","https://openalex.org/I40120149","https://openalex.org/I4210110908","https://openalex.org/I4210113648","https://openalex.org/I4210128198","https://openalex.org/I4210137263","https://openalex.org/I4210139728"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16335488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":"e1013072","last_page":"e1013072"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10168","display_name":"COVID-19 and Mental Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10168","display_name":"COVID-19 and Mental Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11987","display_name":"COVID-19 Impact on Reproduction","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.7410072684288025},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5752650499343872},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.5209668874740601},{"id":"https://openalex.org/keywords/pre-exposure-prophylaxis","display_name":"Pre-exposure prophylaxis","score":0.42485421895980835},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"Cost effectiveness","score":0.41057926416397095},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.33691054582595825},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2824375331401825},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.24454563856124878},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.19949325919151306},{"id":"https://openalex.org/keywords/men-who-have-sex-with-men","display_name":"Men who have sex with men","score":0.14626222848892212},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11614638566970825},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.09857848286628723},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.08839139342308044}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.7410072684288025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5752650499343872},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5209668874740601},{"id":"https://openalex.org/C2779496540","wikidata":"https://www.wikidata.org/wiki/Q7239230","display_name":"Pre-exposure prophylaxis","level":5,"score":0.42485421895980835},{"id":"https://openalex.org/C3019080777","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost effectiveness","level":2,"score":0.41057926416397095},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.33691054582595825},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2824375331401825},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.24454563856124878},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.19949325919151306},{"id":"https://openalex.org/C2776939746","wikidata":"https://www.wikidata.org/wiki/Q853451","display_name":"Men who have sex with men","level":4,"score":0.14626222848892212},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11614638566970825},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09857848286628723},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08839139342308044},{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016867","descriptor_name":"Immunocompromised Host","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016867","descriptor_name":"Immunocompromised Host","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016867","descriptor_name":"Immunocompromised Host","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016867","descriptor_name":"Immunocompromised Host","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D065129","descriptor_name":"Pre-Exposure Prophylaxis","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D065129","descriptor_name":"Pre-Exposure Prophylaxis","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D065129","descriptor_name":"Pre-Exposure Prophylaxis","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D065129","descriptor_name":"Pre-Exposure Prophylaxis","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1013072","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013072","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40455922","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40455922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:a4c0b880406e4ba6b5245009fc4e5e3e","is_oa":true,"landing_page_url":"https://doaj.org/article/a4c0b880406e4ba6b5245009fc4e5e3e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 6 (2025)","raw_type":"article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:0314a932-233c-4898-a2b1-86975e2c2dbb","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jisc Publications Router","raw_type":"http://purl.org/coar/resource_type/c_dcae04bc"},{"id":"pmh:oai:pubmedcentral.nih.gov:12129335","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12129335","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013072","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013072","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7699999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2252441064","display_name":null,"funder_award_id":"NCT05047822","funder_id":"https://openalex.org/F4320320290","funder_display_name":"University of Oxford"},{"id":"https://openalex.org/G8457139176","display_name":null,"funder_award_id":"EUPAS43571","funder_id":"https://openalex.org/F4320320290","funder_display_name":"University of Oxford"}],"funders":[{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2041483726","https://openalex.org/W3045346667","https://openalex.org/W3120077800","https://openalex.org/W3125712166","https://openalex.org/W3164832774","https://openalex.org/W3183544040","https://openalex.org/W3186939453","https://openalex.org/W3204258569","https://openalex.org/W3211736376","https://openalex.org/W4200487669","https://openalex.org/W4210449375","https://openalex.org/W4212932178","https://openalex.org/W4220739924","https://openalex.org/W4224289402","https://openalex.org/W4226046713","https://openalex.org/W4226246286","https://openalex.org/W4226525051","https://openalex.org/W4288049404","https://openalex.org/W4307945505","https://openalex.org/W4317212025","https://openalex.org/W4318672214","https://openalex.org/W4320921354","https://openalex.org/W4323322137","https://openalex.org/W4361278468","https://openalex.org/W4366237423","https://openalex.org/W4379768499","https://openalex.org/W4383373316","https://openalex.org/W4385313091","https://openalex.org/W4387610864","https://openalex.org/W4391845075"],"related_works":["https://openalex.org/W3086345252","https://openalex.org/W3134272441","https://openalex.org/W4205698903","https://openalex.org/W4400613637","https://openalex.org/W4294968941","https://openalex.org/W4283819461","https://openalex.org/W4390279739","https://openalex.org/W2802142510","https://openalex.org/W4205413867","https://openalex.org/W2521174025"],"abstract_inverted_index":{"Many":[0],"immunocompromised":[1,56,114,134,157,192],"individuals":[2,57,115,135,158,193,212],"mount":[3],"inadequate":[4],"immune":[5],"responses":[6],"following":[7],"COVID-19":[8,54,111,132,154],"vaccination,":[9],"thus":[10],"relying":[11],"on":[12],"other":[13],"social":[14],"distancing":[15],"behaviours,":[16],"particularly":[17],"shielding,":[18,145,151],"for":[19,74,164,172,181],"protection,":[20],"impacting":[21],"their":[22],"quality":[23],"of":[24,35,71,105,108,129,142,144,150,153,175],"life.":[25],"However,":[26,66],"little":[27],"is":[28,80,179,220],"known":[29],"about":[30],"historical/current":[31],"levels":[32],"and":[33,61,69,86,102,159],"effectiveness":[34,104],"shielding":[36,147,214],"or":[37],"factors":[38],"influencing":[39],"individuals'":[40],"decision":[41],"to":[42,64,94,183,205],"continue":[43,63],"shielding.":[44],"Long-acting":[45],"antibody":[46],"pre-exposure":[47],"prophylaxis":[48],"(LAAB-PrEP)":[49],"provides":[50],"direct":[51],"protection":[52],"against":[53,110,131],"in":[55,113,116,133],"who":[58],"have":[59],"been":[60],"may":[62],"shield.":[65],"the":[67,117,124,160,165,188],"proportion":[68],"incidence":[70],"circulating":[72],"variants":[73],"which":[75],"LAAB-PrEP":[76,109,130,182,206,219],"would":[77,194,203],"be":[78,137,184],"effective":[79,186],"unpredictable.":[81],"Given":[82],"this":[83],"uncertain":[84],"behavioural":[85],"immuno-epidemiological":[87],"context,":[88],"we":[89],"developed":[90],"a":[91],"modelling":[92],"framework":[93],"explore":[95],"features":[96,141],"that":[97,123,171,190],"most":[98,191],"impact":[99],"health":[100],"outcomes":[101],"cost":[103,149,185,221],"long-term":[106],"administration":[107],"infection":[112],"English":[118],"context.":[119],"The":[120,168],"model":[121,169],"predicted":[122],"incremental":[125],"cost-effectiveness":[126,166],"ratio":[127],"(ICER)":[128],"will":[136],"largely":[138],"driven":[139],"by":[140],"utility":[143],"current/future":[146],"behaviour,":[148],"risk":[152],"hospitalisation":[155],"among":[156],"time":[161],"horizon":[162],"used":[163],"analysis.":[167],"estimated":[170],"realistic":[173],"ranges":[174],"influential":[176],"factors,":[177],"it":[178,198,208],"possible":[180],"under":[187],"conditions":[189],"shield":[195],"indefinitely":[196],"if":[197,207,211],"were":[199],"not":[200],"available":[201],"but":[202],"switch":[204],"were.":[209],"Thus,":[210],"stop":[213],"when":[215],"taking":[216],"LAAB-PrEP,":[217],"then":[218],"effective.":[222]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}