{"id":"https://openalex.org/W4410294348","doi":"https://doi.org/10.1371/journal.pcbi.1013052","title":"How are estimated cellular turnover rates influenced by the dynamics of a source population?","display_name":"How are estimated cellular turnover rates influenced by the dynamics of a source population?","publication_year":2025,"publication_date":"2025-05-12","ids":{"openalex":"https://openalex.org/W4410294348","doi":"https://doi.org/10.1371/journal.pcbi.1013052","pmid":"https://pubmed.ncbi.nlm.nih.gov/40354492"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013052","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013052","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013052","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014975375","display_name":"Arpit Chandan Swain","orcid":"https://orcid.org/0000-0002-7816-1053"},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL","US"],"is_corresponding":true,"raw_author_name":"Arpit C. Swain","raw_affiliation_strings":["Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands","Theoretical Biology, Utrecht University, Utrecht, The Netherlands","Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7816-1053","affiliations":[{"raw_affiliation_string":"Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Theoretical Biology, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, United States of America","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027314935","display_name":"Jos\u00e9 A. M. Borghans","orcid":"https://orcid.org/0000-0002-2931-0390"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A. M. Borghans","raw_affiliation_strings":["Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053694044","display_name":"Rob J. de Boer","orcid":"https://orcid.org/0000-0002-2130-691X"},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rob J. de Boer","raw_affiliation_strings":["Theoretical Biology, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2130-691X","affiliations":[{"raw_affiliation_string":"Theoretical Biology, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014975375"],"corresponding_institution_ids":["https://openalex.org/I193662353","https://openalex.org/I2799503643","https://openalex.org/I3018483916"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.3603,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.79999843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"21","issue":"5","first_page":"e1013052","last_page":"e1013052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9815999865531921,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9747999906539917,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/labelling","display_name":"Labelling","score":0.8059439659118652},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6379993557929993},{"id":"https://openalex.org/keywords/turnover","display_name":"Turnover","score":0.5791351795196533},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.569373607635498},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.493224561214447},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.4462672770023346},{"id":"https://openalex.org/keywords/deuterium","display_name":"Deuterium","score":0.4120478928089142},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3889031410217285},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3653682470321655},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3357142210006714},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.32169264554977417},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21437612175941467},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20851662755012512},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.16079244017601013},{"id":"https://openalex.org/keywords/economics","display_name":"Economics","score":0.1445412039756775},{"id":"https://openalex.org/keywords/demography","display_name":"Demography","score":0.08616939187049866}],"concepts":[{"id":"https://openalex.org/C2780523633","wikidata":"https://www.wikidata.org/wiki/Q380709","display_name":"Labelling","level":2,"score":0.8059439659118652},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6379993557929993},{"id":"https://openalex.org/C26077564","wikidata":"https://www.wikidata.org/wiki/Q1910318","display_name":"Turnover","level":2,"score":0.5791351795196533},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.569373607635498},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.493224561214447},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.4462672770023346},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.4120478928089142},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3889031410217285},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3653682470321655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3357142210006714},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.32169264554977417},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21437612175941467},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20851662755012512},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16079244017601013},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.1445412039756775},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.08616939187049866},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1013052","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013052","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40354492","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40354492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:5e6da2ce97ef46f1934af5a564807977","is_oa":true,"landing_page_url":"https://doaj.org/article/5e6da2ce97ef46f1934af5a564807977","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 5, p e1013052 (2025)","raw_type":"article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/466066","is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/466066","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/480109","is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/480109","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12129353","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12129353","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013052","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013052","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.550000011920929,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"awards":[{"id":"https://openalex.org/G3877961870","display_name":null,"funder_award_id":"ALWOP.265","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5781785318","display_name":null,"funder_award_id":"Vici 09150181910016","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1515865309","https://openalex.org/W1966047059","https://openalex.org/W1971931476","https://openalex.org/W1976831998","https://openalex.org/W2008512164","https://openalex.org/W2031468048","https://openalex.org/W2092459975","https://openalex.org/W2110394694","https://openalex.org/W2113847305","https://openalex.org/W2116712689","https://openalex.org/W2118342395","https://openalex.org/W2124860027","https://openalex.org/W2155507496","https://openalex.org/W2347022381","https://openalex.org/W2404959529","https://openalex.org/W2594102594","https://openalex.org/W2887452509","https://openalex.org/W3112154475"],"related_works":["https://openalex.org/W1525479493","https://openalex.org/W1976633635","https://openalex.org/W2396436470","https://openalex.org/W1970064489","https://openalex.org/W4241622628","https://openalex.org/W1991894391","https://openalex.org/W2070829827","https://openalex.org/W2078502149","https://openalex.org/W2022106528","https://openalex.org/W2380886523"],"abstract_inverted_index":{"Estimating":[0],"production":[1],"and":[2,58,95,160],"loss":[3,96],"rates":[4,19,71,85,97],"of":[5,23,37,40,86,98,106,118,132,167,181,191],"cell":[6],"populations":[7],"is":[8,43,54,60,135,144],"essential":[9],"but":[10],"difficult.":[11],"The":[12],"current":[13],"state-of-the-art":[14],"method":[15],"to":[16,45],"estimate":[17],"these":[18],"involves":[20],"mathematical":[21],"modelling":[22,103],"deuterium":[24,47],"labelling":[25,33,74,116],"experiments.":[26,75],"Current":[27],"models":[28],"typically":[29],"assume":[30],"that":[31,62,81,114,175],"the":[32,35,38,46,70,79,87,92,104,107,115,119,129,133,139,142,165,168,178,189],"in":[34,49],"precursors":[36,88,134,143],"population":[39],"interest":[41],"(POI)":[42],"proportional":[44],"enrichment":[48],"body":[50],"water/glucose.":[51],"This":[52],"assumption":[53],"not":[55],"always":[56],"true":[57],"it":[59],"known":[61],"this":[63,163],"can":[64,89],"have":[65,90],"a":[66,99,154,182],"significant":[67],"effect":[68,80],"on":[69,91,188],"estimated":[72,93],"from":[73,141],"Here":[76],"we":[77,148],"quantify":[78],"different":[82,169],"turnover":[83,125,130,179,190],"(replacement)":[84],"proliferation":[94],"POI":[100,120,183],"by":[101],"explicitly":[102],"dynamics":[105],"precursors.":[108,194],"We":[109],"first":[110],"confirm":[111],"earlier":[112],"results":[113],"curve":[117],"only":[121],"reflects":[122],"its":[123,192],"own":[124],"rate":[126,131,180],"if":[127],"either":[128],"sufficiently":[136,145],"fast,":[137],"or":[138],"contribution":[140],"small.":[146],"Next,":[147],"describe":[149],"three":[150],"realistic":[151],"scenarios":[152],"with":[153],"slowly":[155],"turning":[156],"over":[157],"precursor":[158],"population,":[159],"show":[161],"how":[162],"changes":[164],"interpretation":[166],"parameter":[170],"estimates.":[171],"Our":[172],"analyses":[173],"underpin":[174],"uniquely":[176],"identifying":[177],"requires":[184],"measurements":[185],"(or":[186],"knowledge)":[187],"immediate":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
