{"id":"https://openalex.org/W4409640489","doi":"https://doi.org/10.1371/journal.pcbi.1013026","title":"Modelling transmission thresholds and hypoendemic stability for onchocerciasis elimination","display_name":"Modelling transmission thresholds and hypoendemic stability for onchocerciasis elimination","publication_year":2025,"publication_date":"2025-04-21","ids":{"openalex":"https://openalex.org/W4409640489","doi":"https://doi.org/10.1371/journal.pcbi.1013026","pmid":"https://pubmed.ncbi.nlm.nih.gov/40258021"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013026","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013026","pdf_url":"https://www.cor-ntd.org/sites/default/files/content/document/Loa%20Loa%20Expert%20Committee%20Meeting%20Report_AUG2024_FINAL.pdf","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cor-ntd.org/sites/default/files/content/document/Loa%20Loa%20Expert%20Committee%20Meeting%20Report_AUG2024_FINAL.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105081471","display_name":"Jacob N. Stapley","orcid":"https://orcid.org/0000-0003-0732-1600"},"institutions":[{"id":"https://openalex.org/I4210163563","display_name":"London Centre for Neglected Tropical Disease Research","ror":"https://ror.org/05jx29z89","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210163563"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jacob N. Stapley","raw_affiliation_strings":["MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-0732-1600","affiliations":[{"raw_affiliation_string":"MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210163563","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040737387","display_name":"Jonathan I. D. Hamley","orcid":"https://orcid.org/0000-0001-5755-2867"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]},{"id":"https://openalex.org/I4210163563","display_name":"London Centre for Neglected Tropical Disease Research","ror":"https://ror.org/05jx29z89","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210163563"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["CH","GB"],"is_corresponding":false,"raw_author_name":"Jonathan I.D. Hamley","raw_affiliation_strings":["Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom","Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210163563","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063396041","display_name":"Mar\u0131\u0301a-Gloria Bas\u00e1\u00f1ez","orcid":"https://orcid.org/0000-0001-5031-3361"},"institutions":[{"id":"https://openalex.org/I4210163563","display_name":"London Centre for Neglected Tropical Disease Research","ror":"https://ror.org/05jx29z89","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210163563"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria-Gloria Bas\u00e1\u00f1ez","raw_affiliation_strings":["MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-5031-3361","affiliations":[{"raw_affiliation_string":"MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210163563","https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031563853","display_name":"Martin Walker","orcid":"https://orcid.org/0000-0001-8714-5365"},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]},{"id":"https://openalex.org/I4210163563","display_name":"London Centre for Neglected Tropical Disease Research","ror":"https://ror.org/05jx29z89","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210163563"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Walker","raw_affiliation_strings":["Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, United Kingdom","MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-8714-5365","affiliations":[{"raw_affiliation_string":"Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, United Kingdom","institution_ids":["https://openalex.org/I133836048"]},{"raw_affiliation_string":"MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210163563","https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5105081471"],"corresponding_institution_ids":["https://openalex.org/I4210163563","https://openalex.org/I47508984"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.7756,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.95248337,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"21","issue":"4","first_page":"e1013026","last_page":"e1013026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.9699000120162964,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14324","display_name":"Insects and Parasite Interactions","score":0.967199981212616,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5897138118743896},{"id":"https://openalex.org/keywords/transmission","display_name":"Transmission (telecommunications)","score":0.5869205594062805},{"id":"https://openalex.org/keywords/ivermectin","display_name":"Ivermectin","score":0.5660154819488525},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.42801788449287415},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.38811194896698},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.29884058237075806},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.10579189658164978},{"id":"https://openalex.org/keywords/veterinary-medicine","display_name":"Veterinary medicine","score":0.10309001803398132}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5897138118743896},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.5869205594062805},{"id":"https://openalex.org/C2777499811","wikidata":"https://www.wikidata.org/wiki/Q415178","display_name":"Ivermectin","level":2,"score":0.5660154819488525},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42801788449287415},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.38811194896698},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29884058237075806},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.10579189658164978},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.10309001803398132}],"mesh":[{"descriptor_ui":"D000074381","descriptor_name":"Mass Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074381","descriptor_name":"Mass Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074381","descriptor_name":"Mass Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000349","descriptor_name":"Africa","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000349","descriptor_name":"Africa","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000349","descriptor_name":"Africa","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007303","descriptor_name":"Insect Vectors","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007303","descriptor_name":"Insect Vectors","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007303","descriptor_name":"Insect Vectors","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007559","descriptor_name":"Ivermectin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007559","descriptor_name":"Ivermectin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007559","descriptor_name":"Ivermectin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009855","descriptor_name":"Onchocerciasis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009855","descriptor_name":"Onchocerciasis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009855","descriptor_name":"Onchocerciasis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009855","descriptor_name":"Onchocerciasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009855","descriptor_name":"Onchocerciasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009855","descriptor_name":"Onchocerciasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009855","descriptor_name":"Onchocerciasis","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D009855","descriptor_name":"Onchocerciasis","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D009855","descriptor_name":"Onchocerciasis","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019353","descriptor_name":"Endemic Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D019353","descriptor_name":"Endemic Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D019353","descriptor_name":"Endemic Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D060740","descriptor_name":"Disease Eradication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060740","descriptor_name":"Disease Eradication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060740","descriptor_name":"Disease Eradication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1371/journal.pcbi.1013026","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013026","pdf_url":"https://www.cor-ntd.org/sites/default/files/content/document/Loa%20Loa%20Expert%20Committee%20Meeting%20Report_AUG2024_FINAL.pdf","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40258021","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40258021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:europepmc.org:10864534","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12052207","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013026","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013026","pdf_url":"https://www.cor-ntd.org/sites/default/files/content/document/Loa%20Loa%20Expert%20Committee%20Meeting%20Report_AUG2024_FINAL.pdf","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46000000834465027}],"awards":[{"id":"https://openalex.org/G4744390789","display_name":"University of Oxford - to support the NTD Modelling Consortium to conduct modeling to inform global policy and national NTD program decision-making","funder_award_id":"INV-030046","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G6492113386","display_name":"MRC Centre for Global Infectious Disease Analysis (MRC GIDA)","funder_award_id":"MR/X020258/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7033804744","display_name":"MRC Centre for Global Infectious Disease Analysis - Studentships","funder_award_id":"MR/S502388/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409640489.pdf","grobid_xml":"https://content.openalex.org/works/W4409640489.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W127142759","https://openalex.org/W1550107760","https://openalex.org/W1585762477","https://openalex.org/W1910724526","https://openalex.org/W1977023430","https://openalex.org/W1984920491","https://openalex.org/W1997678378","https://openalex.org/W2010541669","https://openalex.org/W2015771998","https://openalex.org/W2077519968","https://openalex.org/W2105272113","https://openalex.org/W2109616016","https://openalex.org/W2112720640","https://openalex.org/W2139377323","https://openalex.org/W2144364566","https://openalex.org/W2166034413","https://openalex.org/W2210922403","https://openalex.org/W2238130454","https://openalex.org/W2479374960","https://openalex.org/W2551101600","https://openalex.org/W2594112973","https://openalex.org/W2734076361","https://openalex.org/W2761181483","https://openalex.org/W2767594581","https://openalex.org/W2790131152","https://openalex.org/W2804429525","https://openalex.org/W2808945123","https://openalex.org/W2884992881","https://openalex.org/W2893298662","https://openalex.org/W2992609767","https://openalex.org/W3011264512","https://openalex.org/W3016094212","https://openalex.org/W3122614294","https://openalex.org/W3162464095","https://openalex.org/W3176313179","https://openalex.org/W4205296087","https://openalex.org/W4248413598","https://openalex.org/W4385422916","https://openalex.org/W4386011952","https://openalex.org/W4394894573","https://openalex.org/W4400981227","https://openalex.org/W4402300513","https://openalex.org/W6677275098"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W2109097527","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166"],"abstract_inverted_index":{"The":[0,70],"World":[1],"Health":[2],"Organization":[3],"(WHO)":[4],"has":[5,72],"proposed":[6],"elimination":[7],"of":[8,15,24,76,86,106,116,245],"onchocerciasis":[9],"transmission":[10,56,87,100,107,128,158],"(EOT)":[11],"in":[12,36,109,203],"a":[13,114],"third":[14],"endemic":[16],"countries":[17],"by":[18],"2030.":[19],"This":[20],"requires":[21],"country-wide":[22],"verification":[23],"EOT.":[25],"Prior":[26],"to":[27,33,43,79,102,211,218],"the":[28,74,84,97,104,121,192,227],"shift":[29],"from":[30,172],"morbidity":[31,47],"control":[32],"EOT,":[34,213],"interventions":[35],"Africa":[37],"were":[38],"mostly":[39],"targeted":[40],"at":[41,88],"moderate-":[42],"high-transmission":[44],"settings,":[45],"where":[46,221,247],"was":[48],"most":[49],"severe.":[50],"Consequently,":[51],"there":[52,152],"remain":[53],"numerous":[54],"low":[55,90],"(hypoendemic)":[57],"settings":[58,78,111],"which":[59,127],"have":[60],"hitherto":[61],"not":[62,250],"received":[63],"mass":[64],"drug":[65],"administration":[66],"(MDA)":[67],"with":[68,149],"ivermectin.":[69],"WHO":[71],"prioritised":[73],"delineation":[75],"hypoendemic":[77,110,184,195],"ascertain":[80],"treatment":[81,202,214,244],"needs.":[82],"However,":[83],"stability":[85,105],"such":[89],"levels":[91],"remains":[92],"poorly":[93],"understood.":[94],"We":[95,132],"use":[96],"stochastic":[98],"EPIONCHO-IBM":[99],"model":[101,173],"characterise":[103],"dynamics":[108],"and":[112,144,163,238],"identify":[113],"range":[115],"threshold":[117],"biting":[118,124,180],"rates":[119,125,181],"(TBRs,":[120],"annual":[122],"vector":[123,179],"below":[126],"cannot":[129],"be":[130,216,251],"sustained).":[131],"show":[133],"how":[134],"TBRs":[135],"are":[136],"dependent":[137],"on":[138,169],"population":[139],"size,":[140],"inter-individual":[141],"exposure":[142],"heterogeneity":[143],"simulation":[145],"time.":[146],"In":[147],"contrast":[148],"deterministic":[150],"expectations,":[151],"is":[153,224],"no":[154],"fixed":[155],"TBR;":[156],"instead,":[157],"can":[159,182],"persist":[160],"between":[161],"70":[162],"300":[164],"bites/person/year.":[165],"Using":[166],"survivorship":[167],"models":[168],"data":[170],"generated":[171],"simulations,":[174],"we":[175],"find":[176],"that":[177,194,241],"multiple":[178],"sustain":[183],"prevalence":[185],"for":[186,229,234,239],"several":[187],"decades.":[188],"These":[189],"findings":[190],"challenge":[191],"assumption":[193],"foci":[196],"would":[197,249],"naturally":[198],"fade":[199],"out":[200],"following":[201],"nearby":[204],"higher-endemicity":[205],"regions.":[206],"Our":[207],"modelling":[208],"suggests":[209],"that,":[210],"achieve":[212],"should":[215],"extended":[217],"all":[219],"areas":[220],"endogenous":[222],"infection":[223,237],"identified,":[225],"emphasising":[226],"need":[228],"improved":[230],"diagnostic":[231],"tools":[232],"suitable":[233],"detecting":[235],"low-prevalence":[236],"strategies":[240],"allow":[242],"safe":[243],"communities":[246],"MDA":[248],"suitable.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2025-10-10T00:00:00"}