{"id":"https://openalex.org/W4409227941","doi":"https://doi.org/10.1371/journal.pcbi.1012961","title":"Neural energy coding patterns of dopaminergic neural microcircuit and its impairment in major depressive disorder: A computational study","display_name":"Neural energy coding patterns of dopaminergic neural microcircuit and its impairment in major depressive disorder: A computational study","publication_year":2025,"publication_date":"2025-04-07","ids":{"openalex":"https://openalex.org/W4409227941","doi":"https://doi.org/10.1371/journal.pcbi.1012961","pmid":"https://pubmed.ncbi.nlm.nih.gov/40193386"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012961","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012961","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1012961","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101974070","display_name":"Yuanxi Li","orcid":"https://orcid.org/0000-0002-9170-7022"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuanxi Li","raw_affiliation_strings":["Institute for Cognitive Neurodynamics, School of Mathematics, East China University of Science and Technology, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Institute for Cognitive Neurodynamics, School of Mathematics, East China University of Science and Technology, Shanghai, China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389686","display_name":"Bing Zhang","orcid":"https://orcid.org/0000-0002-3953-0290"},"institutions":[{"id":"https://openalex.org/I4210146205","display_name":"Obstetrics and Gynecology Hospital of Fudan University","ror":"https://ror.org/04rhdtb47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146205"]},{"id":"https://openalex.org/I4210153623","display_name":"Shanghai First Maternity and Infant Hospital","ror":"https://ror.org/05myyzn85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153623"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Zhang","raw_affiliation_strings":["Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Fudan University, Shanghai, China","Department of Anesthesiology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I4210146205"]},{"raw_affiliation_string":"Department of Anesthesiology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210153623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101697111","display_name":"Jinqi Liu","orcid":"https://orcid.org/0000-0002-0094-9801"},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinqi Liu","raw_affiliation_strings":["University of Rochester, Rochester, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"University of Rochester, Rochester, New York, United States of America","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026577634","display_name":"Rubin Wang","orcid":"https://orcid.org/0000-0003-4110-2022"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rubin Wang","raw_affiliation_strings":["Institute for Cognitive Neurodynamics, School of Mathematics, East China University of Science and Technology, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Institute for Cognitive Neurodynamics, School of Mathematics, East China University of Science and Technology, Shanghai, China","institution_ids":["https://openalex.org/I143593769"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101974070"],"corresponding_institution_ids":["https://openalex.org/I143593769"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.774,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.88729715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"21","issue":"4","first_page":"e1012961","last_page":"e1012961"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopaminergic","display_name":"Dopaminergic","score":0.7468592524528503},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6890218257904053},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5935846567153931},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"Major depressive disorder","score":0.554542064666748},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.47613194584846497},{"id":"https://openalex.org/keywords/neural-coding","display_name":"Neural coding","score":0.4276779890060425},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.4150190055370331},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.38549214601516724},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.343189537525177},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3233254551887512},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.250857412815094},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.08340376615524292}],"concepts":[{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7468592524528503},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6890218257904053},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5935846567153931},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.554542064666748},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.47613194584846497},{"id":"https://openalex.org/C77637269","wikidata":"https://www.wikidata.org/wiki/Q7002051","display_name":"Neural coding","level":2,"score":0.4276779890060425},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4150190055370331},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38549214601516724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.343189537525177},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3233254551887512},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.250857412815094},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.08340376615524292}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1012961","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012961","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40193386","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40193386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:7ba215f1e2f84d04850d629d74f225ba","is_oa":true,"landing_page_url":"https://doaj.org/article/7ba215f1e2f84d04850d629d74f225ba","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 4, p e1012961 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12002636","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12002636","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012961","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012961","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.8999999761581421,"display_name":"Affordable and clean energy"}],"awards":[{"id":"https://openalex.org/G1414875191","display_name":null,"funder_award_id":"82271582","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1440824464","display_name":null,"funder_award_id":"23S11900600","funder_id":"https://openalex.org/F4320336652","funder_display_name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336652","display_name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W88389025","https://openalex.org/W316919195","https://openalex.org/W1471744102","https://openalex.org/W1557303332","https://openalex.org/W1892194563","https://openalex.org/W1970174017","https://openalex.org/W1985940938","https://openalex.org/W1990316687","https://openalex.org/W2010943643","https://openalex.org/W2026489687","https://openalex.org/W2028980996","https://openalex.org/W2039554946","https://openalex.org/W2039701538","https://openalex.org/W2042422091","https://openalex.org/W2045143577","https://openalex.org/W2049058862","https://openalex.org/W2067197999","https://openalex.org/W2071815275","https://openalex.org/W2076148352","https://openalex.org/W2092408101","https://openalex.org/W2094998611","https://openalex.org/W2126000479","https://openalex.org/W2144816990","https://openalex.org/W2343802789","https://openalex.org/W2730900010","https://openalex.org/W2787343838","https://openalex.org/W2807334958","https://openalex.org/W2984595278","https://openalex.org/W3000625380","https://openalex.org/W3037718909","https://openalex.org/W3132000637","https://openalex.org/W4205829227","https://openalex.org/W4286717293","https://openalex.org/W4295898206","https://openalex.org/W4362607789","https://openalex.org/W4381856118","https://openalex.org/W4386812979","https://openalex.org/W4389246192","https://openalex.org/W4391987373","https://openalex.org/W4394978490","https://openalex.org/W6603654520"],"related_works":["https://openalex.org/W3092411928","https://openalex.org/W2021873022","https://openalex.org/W2388200580","https://openalex.org/W4205296828","https://openalex.org/W3027081464","https://openalex.org/W4229779921","https://openalex.org/W2059208649","https://openalex.org/W2093078804","https://openalex.org/W2053807370","https://openalex.org/W2076034638"],"abstract_inverted_index":{"Numerous":[0],"experiments":[1],"have":[2],"found":[3,155,175],"that":[4,89,156,176,297,338],"the":[5,27,30,65,70,90,95,110,116,123,134,148,177,188,194,201,211,219,232,238,245,257,269,284,298,320,324,332,339,343,356,381,387,398,404],"behavioral":[6,31],"characteristics":[7],"of":[8,69,94,125,139,150,182,323,342,358,373,400],"major":[9],"depressive":[10],"disorder":[11],"(MDD)":[12],"animals":[13],"are":[14],"usually":[15],"associated":[16],"with":[17,50],"abnormal":[18],"neural":[19,33,56,77,81,91,112,135,179,207,221,260,264,292,302,344,348,382,389,405,409],"activity":[20,34],"patterns":[21,35,59,138,262,267,385],"and":[22,36,80,154,263,291,301,315,328,347,362,408],"brain":[23,37],"energy":[24,38,57,82,92,113,127,136,180,208,222,240,265,349,383,410],"metabolism.":[25],"However,":[26],"relationship":[28,258],"among":[29],"characteristics,":[32],"metabolism":[39],"remains":[40],"unknown.":[41],"In":[42],"this":[43,48,363],"paper,":[44],"we":[45,174,272],"computationally":[46],"investigated":[47,133],"relationship,":[49],"a":[51,394],"particular":[52],"focus":[53],"on":[54,74,403],"how":[55],"coding":[58,261,266,345,350,384,406,411],"change":[60],"in":[61,64,99,115,129,143,162,187,193,200,210,215,231,244,268,273,331,371],"MDD":[62,100,170,195,233,246,401],"brains,":[63],"VTA-NAc-mPFC":[66,97,145,270,388],"dopaminergic":[67],"pathway":[68],"reward":[71],"system":[72],"based":[73,402],"our":[75,86,144,376],"biological":[76],"network":[78],"model":[79],"calculation":[83],"model.":[84],"Interestingly,":[85],"results":[87,295],"suggested":[88,337],"consumption":[93,114,128,137,181,209],"whole":[96],"microcircuit":[98,146],"group":[101,247],"was":[102,106,191,229],"significantly":[103],"reduced,":[104],"which":[105,164],"mainly":[107],"attributed":[108],"to":[109,224,249,313,355],"decreasing":[111],"mPFC":[117,202,333],"region.":[118,334],"This":[119],"observation":[120],"theoretically":[121],"supported":[122],"view":[124],"low-level":[126],"MDD.":[130,374],"We":[131],"also":[132,392],"various":[140],"neuronal":[141,280],"types":[142],"under":[147],"influence":[149],"different":[151],"dopamine":[152,316],"concentrations,":[153],"there":[157],"were":[158,304],"some":[159,166],"specific":[160],"impairments":[161],"MDD,":[163],"provided":[165],"potential":[167,228,290,300],"biomarkers":[168],"for":[169,278,386,397],"diagnosis.":[171],"More":[172],"specifically,":[173],"actual":[178,206,220],"medium":[183],"spiny":[184],"neurons":[185,199,243,327],"(MSNs)":[186],"NAc":[189],"region":[190,203],"increased":[192],"group,":[196,234],"whereas":[197],"pyramidal":[198,326],"exhibited":[204],"higher":[205,230],"NC":[212],"group.":[213],"Additionally,":[214],"both":[216],"neuron":[217],"types,":[218],"required":[223],"generate":[225,250],"an":[226],"action":[227,252],"suggesting":[235],"that,":[236],"given":[237],"same":[239],"budget,":[241],"these":[242],"tended":[248],"fewer":[251],"potentials.":[253],"To":[254],"further":[255],"explore":[256],"between":[259,288],"microcircuit,":[271,390],"addition":[274],"calculated":[275],"P-V":[276,321],"correlation":[277,286],"each":[279],"type,":[281],"defined":[282],"as":[283],"Pearson's":[285],"coefficient":[287],"membrane":[289,299],"power.":[293],"The":[294],"showed":[296],"power":[303],"not":[305,378],"perfectly":[306],"correlated":[307],"(P-V":[308],"correlations":[309,322],"ranged":[310],"from":[311],"0.6":[312],"0.9),":[314],"concentration":[317],"inputs":[318],"affected":[319],"MSN,":[325],"CB":[329],"interneurons":[330],"These":[335],"findings":[336],"joint":[340,364],"application":[341,357,365],"theory":[346,351,407],"will":[352],"be":[353],"superior":[354],"any":[359],"single":[360],"theory,":[361],"could":[366],"help":[367],"discover":[368],"new":[369],"mechanisms":[370],"neurocircuits":[372],"Overall,":[375],"study":[377,399],"only":[379],"uncovered":[380],"but":[391],"presented":[393],"novel":[395],"pipeline":[396],"theory.":[412]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-06T07:47:59.780226","created_date":"2025-10-10T00:00:00"}