{"id":"https://openalex.org/W4409129510","doi":"https://doi.org/10.1371/journal.pcbi.1012861","title":"Spatial structure facilitates evolutionary rescue by drug resistance","display_name":"Spatial structure facilitates evolutionary rescue by drug resistance","publication_year":2025,"publication_date":"2025-04-03","ids":{"openalex":"https://openalex.org/W4409129510","doi":"https://doi.org/10.1371/journal.pcbi.1012861","pmid":"https://pubmed.ncbi.nlm.nih.gov/40179127"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012861","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012861","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1012861","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093420178","display_name":"Cecilia Fruet","orcid":"https://orcid.org/0009-0000-1260-0351"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Cecilia Fruet","raw_affiliation_strings":["Institute of Bioengineering, School of Life Sciences, \u00c9colePolytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","SIB SwissInstitute of Bioinformatics, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0009-0000-1260-0351","affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, \u00c9colePolytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"SIB SwissInstitute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106955930","display_name":"Ella Linxia M\u00fcller","orcid":null},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ella Linxia M\u00fcller","raw_affiliation_strings":["Institute of Bioengineering, School of Life Sciences, \u00c9colePolytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","SIB SwissInstitute of Bioinformatics, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, \u00c9colePolytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"SIB SwissInstitute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090746251","display_name":"Claude Loverdo","orcid":"https://orcid.org/0000-0002-0888-1717"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210094907","display_name":"Laboratoire Jean Perrin","ror":"https://ror.org/01ghvgs84","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210094907","https://openalex.org/I4210098836"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude Loverdo","raw_affiliation_strings":["Sorbonne Universit\u00e9, CNRS,Institut de Biologie Paris-Seine (IBPS), Laboratoire Jean Perrin (LJP), Paris,France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorbonne Universit\u00e9, CNRS,Institut de Biologie Paris-Seine (IBPS), Laboratoire Jean Perrin (LJP), Paris,France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210094907","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030010662","display_name":"Anne\u2010Florence Bitbol","orcid":"https://orcid.org/0000-0003-1020-494X"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Anne-Florence Bitbol","raw_affiliation_strings":["Institute of Bioengineering, School of Life Sciences, \u00c9colePolytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","SIB SwissInstitute of Bioinformatics, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-1020-494X","affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, School of Life Sciences, \u00c9colePolytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"SIB SwissInstitute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":6.8147,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.96774505,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"21","issue":"4","first_page":"e1012861","last_page":"e1012861"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10487","display_name":"Plant and animal studies","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.703424334526062},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6787887215614319},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.6342175006866455},{"id":"https://openalex.org/keywords/fixation","display_name":"Fixation (population genetics)","score":0.5906493663787842},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"Antibiotic resistance","score":0.5777556896209717},{"id":"https://openalex.org/keywords/resistance-mutation","display_name":"Resistance mutation","score":0.5568632483482361},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5456732511520386},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5264171957969666},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.523951530456543},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.4696195423603058},{"id":"https://openalex.org/keywords/population-structure","display_name":"Population structure","score":0.4495288133621216},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.41950953006744385},{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.39309990406036377},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15227580070495605},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.06935828924179077}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.703424334526062},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6787887215614319},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6342175006866455},{"id":"https://openalex.org/C146249460","wikidata":"https://www.wikidata.org/wiki/Q2914991","display_name":"Fixation (population genetics)","level":3,"score":0.5906493663787842},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5777556896209717},{"id":"https://openalex.org/C182707283","wikidata":"https://www.wikidata.org/wiki/Q7315622","display_name":"Resistance mutation","level":5,"score":0.5568632483482361},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5456732511520386},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5264171957969666},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.523951530456543},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.4696195423603058},{"id":"https://openalex.org/C2983611323","wikidata":"https://www.wikidata.org/wiki/Q7229822","display_name":"Population structure","level":3,"score":0.4495288133621216},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.41950953006744385},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.39309990406036377},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15227580070495605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06935828924179077},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1012861","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012861","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40179127","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40179127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-04785253v1","is_oa":false,"landing_page_url":"https://hal.science/hal-04785253","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2025, 21 (4), pp.e1012861. ⟨10.1371/journal.pcbi.1012861⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:66a39b147f284640862dd2edf525f62f","is_oa":true,"landing_page_url":"https://doaj.org/article/66a39b147f284640862dd2edf525f62f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 4, p e1012861 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11967957","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11967957","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012861","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012861","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"awards":[{"id":"https://openalex.org/G4088942591","display_name":null,"funder_award_id":"851173","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G5168826729","display_name":null,"funder_award_id":"315230_208196","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W592154304","https://openalex.org/W1902150932","https://openalex.org/W1922732464","https://openalex.org/W1961980423","https://openalex.org/W1969218422","https://openalex.org/W1990453514","https://openalex.org/W2000492287","https://openalex.org/W2005545097","https://openalex.org/W2015077069","https://openalex.org/W2015274943","https://openalex.org/W2019078491","https://openalex.org/W2019385975","https://openalex.org/W2020281792","https://openalex.org/W2021155015","https://openalex.org/W2023264366","https://openalex.org/W2033787149","https://openalex.org/W2042321087","https://openalex.org/W2046799846","https://openalex.org/W2048203037","https://openalex.org/W2049708607","https://openalex.org/W2054949696","https://openalex.org/W2059905849","https://openalex.org/W2063563543","https://openalex.org/W2064733777","https://openalex.org/W2071219762","https://openalex.org/W2073556554","https://openalex.org/W2079460424","https://openalex.org/W2082929763","https://openalex.org/W2095782520","https://openalex.org/W2099745607","https://openalex.org/W2100988322","https://openalex.org/W2102868720","https://openalex.org/W2105950028","https://openalex.org/W2119698477","https://openalex.org/W2128177025","https://openalex.org/W2129903473","https://openalex.org/W2131090481","https://openalex.org/W2143946385","https://openalex.org/W2152177323","https://openalex.org/W2153587490","https://openalex.org/W2155418451","https://openalex.org/W2171463101","https://openalex.org/W2326607751","https://openalex.org/W2397945787","https://openalex.org/W2401891657","https://openalex.org/W2511099695","https://openalex.org/W2676659422","https://openalex.org/W2789673251","https://openalex.org/W2789816271","https://openalex.org/W2793686504","https://openalex.org/W2913805776","https://openalex.org/W2918089352","https://openalex.org/W2943148793","https://openalex.org/W2948945081","https://openalex.org/W3016048262","https://openalex.org/W3034261265","https://openalex.org/W3039025765","https://openalex.org/W3043863276","https://openalex.org/W3049137842","https://openalex.org/W3082475311","https://openalex.org/W3106031838","https://openalex.org/W3108628125","https://openalex.org/W3134653900","https://openalex.org/W3160965520","https://openalex.org/W3177187149","https://openalex.org/W3198865802","https://openalex.org/W3214355212","https://openalex.org/W4205627330","https://openalex.org/W4211117603","https://openalex.org/W4213354399","https://openalex.org/W4220718067","https://openalex.org/W4226086076","https://openalex.org/W4229800699","https://openalex.org/W4254142273","https://openalex.org/W4282962135","https://openalex.org/W4297183131","https://openalex.org/W4311495912","https://openalex.org/W4319655586","https://openalex.org/W4385801843","https://openalex.org/W4386968159","https://openalex.org/W4387574295","https://openalex.org/W4388074590","https://openalex.org/W4388666939","https://openalex.org/W4389109952","https://openalex.org/W4390702068","https://openalex.org/W4392168060","https://openalex.org/W4396849575","https://openalex.org/W4402301231","https://openalex.org/W4402853268","https://openalex.org/W4403785081","https://openalex.org/W4408129312"],"related_works":["https://openalex.org/W2612650019","https://openalex.org/W3029687925","https://openalex.org/W2103021217","https://openalex.org/W2378384631","https://openalex.org/W2136603740","https://openalex.org/W2798117401","https://openalex.org/W2209214508","https://openalex.org/W2008775144","https://openalex.org/W2187081677","https://openalex.org/W2417587390"],"abstract_inverted_index":{"Bacterial":[0],"populations":[1,36],"often":[2],"have":[3],"complex":[4,182],"spatial":[5,16,56,94,171,183],"structures,":[6,184],"which":[7,139],"can":[8,58,78,96],"impact":[9,97],"their":[10],"evolution.":[11],"Here,":[12],"we":[13],"study":[14],"how":[15],"structure":[17,57,95,172],"affects":[18],"the":[19,60,75,98,104,111,136,147,152,187,195],"evolution":[20],"of":[21,33,62,100,113,115,132],"antibiotic":[22,67,82,177],"resistance":[23,122,145,178],"in":[24,125,135,146,164,194],"a":[25,30,63,71],"bacterial":[26,64,76],"population.":[27],"We":[28,53],"consider":[29],"minimal":[31],"model":[32],"spatially":[34],"structured":[35,137],"where":[37,189],"all":[38,165],"demes":[39],"(i.e.,":[40],"subpopulations)":[41],"are":[42,87,108,191],"identical":[43,50],"and":[44,86,93,103,185],"connected":[45],"to":[46,66,162,180,186],"each":[47],"other":[48],"by":[49,143,156,176],"migration":[51],"rates.":[52],"show":[54],"that":[55,106,170],"facilitate":[59],"survival":[61],"population":[65,77,153],"treatment,":[68],"starting":[69],"from":[70],"sensitive":[72],"inoculum.":[73,196],"Specifically,":[74],"be":[79],"rescued":[80,155],"if":[81],"resistant":[83,133,160,192],"mutants":[84,102,134,161,193],"appear":[85],"present":[88],"when":[89],"drug":[90,121,144],"is":[91,123,154],"added,":[92],"fate":[99],"these":[101],"probability":[105,112],"they":[107],"present.":[109],"Indeed,":[110],"fixation":[114,131],"neutral":[116],"or":[117],"deleterious":[118],"mutations":[119],"providing":[120],"increased":[124],"smaller":[126],"populations.":[127],"This":[128],"promotes":[129],"local":[130],"population,":[138],"facilitates":[140,173],"evolutionary":[141,174],"rescue":[142,175],"rare":[148],"mutation":[149],"regime.":[150],"Once":[151],"resistance,":[157],"migrations":[158],"allow":[159],"spread":[163],"demes.":[166],"Our":[167],"main":[168],"result":[169],"extends":[179],"more":[181],"case":[188],"there":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}