{"id":"https://openalex.org/W4408224551","doi":"https://doi.org/10.1371/journal.pcbi.1012859","title":"Penalised regression improves imputation of cell-type specific expression using RNA-seq data from mixed cell populations compared to domain-specific methods","display_name":"Penalised regression improves imputation of cell-type specific expression using RNA-seq data from mixed cell populations compared to domain-specific methods","publication_year":2025,"publication_date":"2025-03-07","ids":{"openalex":"https://openalex.org/W4408224551","doi":"https://doi.org/10.1371/journal.pcbi.1012859","pmid":"https://pubmed.ncbi.nlm.nih.gov/40053530"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012859","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012859","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1012859","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101550260","display_name":"Wei\u2010Yu Lin","orcid":"https://orcid.org/0000-0002-9267-7988"},"institutions":[{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wei-Yu Lin","raw_affiliation_strings":["MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9267-7988","affiliations":[{"raw_affiliation_string":"MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210134973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020715360","display_name":"Melissa Kartawinata","orcid":"https://orcid.org/0000-0002-9432-393X"},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Melissa Kartawinata","raw_affiliation_strings":["Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I4210117448","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022225922","display_name":"Bethany R. Jebson","orcid":"https://orcid.org/0000-0002-2794-8606"},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bethany R. Jebson","raw_affiliation_strings":["Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I4210117448","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077444040","display_name":"Restuadi Restuadi","orcid":"https://orcid.org/0000-0001-8434-4465"},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Restuadi Restuadi","raw_affiliation_strings":["Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I4210117448","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054382730","display_name":"Hannah Peckham","orcid":"https://orcid.org/0000-0002-9668-4683"},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]},{"id":"https://openalex.org/I4210133952","display_name":"Regenerative Medicine Institute","ror":"https://ror.org/02q13mm97","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210133952"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","MX"],"is_corresponding":false,"raw_author_name":"Hannah Peckham","raw_affiliation_strings":["Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","Division of Medicine, Department of Ageing, Rheumatology & Regenerative Medicine, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I4210117448","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Division of Medicine, Department of Ageing, Rheumatology & Regenerative Medicine, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I4210133952","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060933624","display_name":"Anna Radziszewska","orcid":null},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]},{"id":"https://openalex.org/I4210133952","display_name":"Regenerative Medicine Institute","ror":"https://ror.org/02q13mm97","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210133952"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","MX"],"is_corresponding":false,"raw_author_name":"Anna Radziszewska","raw_affiliation_strings":["Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","Division of Medicine, Department of Ageing, Rheumatology & Regenerative Medicine, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I4210117448","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Division of Medicine, Department of Ageing, Rheumatology & Regenerative Medicine, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I4210133952","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001029994","display_name":"Claire T. Deakin","orcid":"https://orcid.org/0000-0002-7044-5801"},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire T. Deakin","raw_affiliation_strings":["Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom","National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I4210117448","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, London, United Kingdom","institution_ids":["https://openalex.org/I34931013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083838326","display_name":"Coziana Ciurtin","orcid":"https://orcid.org/0000-0002-8911-4113"},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]},{"id":"https://openalex.org/I4210133952","display_name":"Regenerative Medicine Institute","ror":"https://ror.org/02q13mm97","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210133952"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","MX"],"is_corresponding":false,"raw_author_name":"Coziana Ciurtin","raw_affiliation_strings":["Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","Division of Medicine, Department of Ageing, Rheumatology & Regenerative Medicine, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I4210117448","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Division of Medicine, Department of Ageing, Rheumatology & Regenerative Medicine, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I4210133952","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037338479","display_name":"Lucy R. Wedderburn","orcid":"https://orcid.org/0000-0002-7495-1429"},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lucy R. Wedderburn","raw_affiliation_strings":["Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom","National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-7495-1429","affiliations":[{"raw_affiliation_string":"Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I4210117448","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, London, United Kingdom","institution_ids":["https://openalex.org/I34931013"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006577577","display_name":"Chris Wallace","orcid":"https://orcid.org/0000-0001-9755-1703"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Chris Wallace","raw_affiliation_strings":["Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom","MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-9755-1703","affiliations":[{"raw_affiliation_string":"Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210134973"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5006577577"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210134973"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.3814,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54344294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"21","issue":"3","first_page":"e1012859","last_page":"e1012859"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deconvolution","display_name":"Deconvolution","score":0.5698848962783813},{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.531084418296814},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5058236122131348},{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.5052316784858704},{"id":"https://openalex.org/keywords/elastic-net-regularization","display_name":"Elastic net regularization","score":0.4805867671966553},{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.4646069407463074},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4439193904399872},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4221772849559784},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35970258712768555},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3248136639595032},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3078032433986664},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.29434531927108765},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.288119375705719},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22539880871772766},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.19954857230186462},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17698794603347778},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.1145661473274231}],"concepts":[{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.5698848962783813},{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.531084418296814},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5058236122131348},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.5052316784858704},{"id":"https://openalex.org/C203868755","wikidata":"https://www.wikidata.org/wiki/Q5353562","display_name":"Elastic net regularization","level":3,"score":0.4805867671966553},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.4646069407463074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4439193904399872},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4221772849559784},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35970258712768555},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3248136639595032},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3078032433986664},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.29434531927108765},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.288119375705719},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22539880871772766},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.19954857230186462},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17698794603347778},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.1145661473274231},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1012859","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012859","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40053530","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40053530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:europepmc.org:10770981","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11957391","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:513197c246284facb690f140e0fcd6d4","is_oa":true,"landing_page_url":"https://doaj.org/article/513197c246284facb690f140e0fcd6d4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 3, p e1012859 (2025)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10209729","is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10209729/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology , 21 (3) , Article e1012859. (2025)","raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/382210","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/382210","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012859","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012859","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G139696651","display_name":null,"funder_award_id":"(BRC-1215-20014)","funder_id":"https://openalex.org/F4320336709","funder_display_name":"NIHR Cambridge Biomedical Research Centre"},{"id":"https://openalex.org/G1723865417","display_name":"MICA: Childhood arthritis and its associated uveitis: stratification through endotypes and mechanism to deliver benefit; the CLUSTER Consortium.","funder_award_id":"MR/R013926/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1846267218","display_name":"Centre for Adolescent Rheumatology Arthritis UK","funder_award_id":"21593","funder_id":"https://openalex.org/F4320327444","funder_display_name":"Versus Arthritis"},{"id":"https://openalex.org/G2436070468","display_name":null,"funder_award_id":"MR/R013926/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2488951246","display_name":null,"funder_award_id":"20164","funder_id":"https://openalex.org/F4320327444","funder_display_name":"Versus Arthritis"},{"id":"https://openalex.org/G3202681502","display_name":null,"funder_award_id":"MC_UU_00002/4","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3415658128","display_name":null,"funder_award_id":"22203","funder_id":"https://openalex.org/F4320327444","funder_display_name":"Versus Arthritis"},{"id":"https://openalex.org/G3935550431","display_name":null,"funder_award_id":"WT220788","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4604040521","display_name":null,"funder_award_id":"VS0518","funder_id":"https://openalex.org/F4320320637","funder_display_name":"Great Ormond Street Hospital Charity"},{"id":"https://openalex.org/G4655031120","display_name":"Statistical \u2018omics approaches to understanding autoimmune diseases","funder_award_id":"MC_UU_00002/4","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5340677143","display_name":null,"funder_award_id":"22084","funder_id":"https://openalex.org/F4320327444","funder_display_name":"Versus Arthritis"},{"id":"https://openalex.org/G8798172021","display_name":null,"funder_award_id":"GOSH102019","funder_id":"https://openalex.org/F4320317994","funder_display_name":"Cure JM Foundation"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320317994","display_name":"Cure JM Foundation","ror":null},{"id":"https://openalex.org/F4320320637","display_name":"Great Ormond Street Hospital Charity","ror":"https://ror.org/03vjq7x94"},{"id":"https://openalex.org/F4320327444","display_name":"Versus Arthritis","ror":"https://ror.org/02jkpm469"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320336709","display_name":"NIHR Cambridge Biomedical Research Centre","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1985987855","https://openalex.org/W2006617902","https://openalex.org/W2015008025","https://openalex.org/W2092644774","https://openalex.org/W2097360283","https://openalex.org/W2103056503","https://openalex.org/W2114104545","https://openalex.org/W2138207763","https://openalex.org/W2146512944","https://openalex.org/W2155388222","https://openalex.org/W2168197335","https://openalex.org/W2169456326","https://openalex.org/W2221264044","https://openalex.org/W2507880739","https://openalex.org/W2529694725","https://openalex.org/W2600132724","https://openalex.org/W2605897695","https://openalex.org/W2788357641","https://openalex.org/W2789878273","https://openalex.org/W2942610007","https://openalex.org/W2947554843","https://openalex.org/W2953365463","https://openalex.org/W2953757801","https://openalex.org/W2967063345","https://openalex.org/W2993244493","https://openalex.org/W3013579737","https://openalex.org/W3088521497","https://openalex.org/W3096486123","https://openalex.org/W3124408455","https://openalex.org/W3145087249","https://openalex.org/W3155679615","https://openalex.org/W3164414718","https://openalex.org/W3175529520","https://openalex.org/W4205894915","https://openalex.org/W4282024710","https://openalex.org/W4294541781","https://openalex.org/W4399496083"],"related_works":["https://openalex.org/W2468272465","https://openalex.org/W2429564919","https://openalex.org/W757986597","https://openalex.org/W4212910148","https://openalex.org/W4213314600","https://openalex.org/W4210804200","https://openalex.org/W4399551893","https://openalex.org/W2954774635","https://openalex.org/W4392841950","https://openalex.org/W3123944750"],"abstract_inverted_index":{"Gene":[0],"expression":[1,29,49,55,69,79,97,177],"studies":[2,26],"often":[3],"use":[4],"bulk":[5,48],"RNA":[6,115],"sequencing":[7,18,116],"of":[8,59,93],"mixed":[9,24,103],"cell":[10,14,17,25,36,45,132],"populations":[11],"because":[12],"single":[13,131],"or":[15,63],"sorted":[16,110],"may":[19,27],"be":[20,41],"prohibitively":[21],"expensive.":[22],"However,":[23],"miss":[28],"patterns":[30],"that":[31,155],"are":[32,223],"restricted":[33],"to":[34,43,80,170,173,196,215],"specific":[35],"populations.":[37],"Computational":[38],"deconvolution":[39,197,207],"can":[40],"used":[42,159],"estimate":[44],"fractions":[46],"from":[47,120,129],"data":[50,117,194,222],"and":[51,83,109,125,142,144,153],"infer":[52],"average":[53],"cell-type":[54,68,96],"in":[56,192],"a":[57,99],"set":[58],"samples":[60],"(e.g.,":[61],"cases":[62],"controls),":[64],"but":[65,184],"imputing":[66,94],"sample-level":[67,95],"is":[70,84],"required":[71],"for":[72,160,187],"more":[73],"detailed":[74],"analyses,":[75],"such":[76],"as":[77],"relating":[78],"quantitative":[81],"traits,":[82],"less":[85],"commonly":[86],"addressed.":[87],"Here,":[88],"we":[89],"assessed":[90,166],"the":[91,121,167,213],"accuracy":[92],"using":[98],"real":[100],"dataset":[101],"where":[102],"peripheral":[104],"blood":[105],"mononuclear":[106],"cells":[107],"(PBMC)":[108],"(CD4,":[111],"CD8,":[112],"CD14,":[113],"CD19)":[114],"were":[118],"generated":[119],"same":[122],"subjects":[123],"(N=158),":[124],"pseudobulk":[126],"datasets":[127],"synthesised":[128],"eQTLgen":[130],"RNA-seq":[133],"data.":[134],"We":[135,164],"compared":[136,195],"three":[137],"domain-specific":[138,217],"methods,":[139,149,198],"CIBERSORTx,":[140],"bMIND":[141],"debCAM/swCAM,":[143],"two":[145],"cross-domain":[146],"machine":[147],"learning":[148,210],"multiple":[150],"response":[151],"LASSO":[152],"ridge,":[154],"had":[156,201],"not":[157],"been":[158],"this":[161],"task":[162],"before.":[163],"also":[165],"methods":[168,211,218],"according":[169],"their":[171],"ability":[172],"recover":[174],"differential":[175],"gene":[176],"(DGE)":[178],"results.":[179],"LASSO/ridge":[180,200],"showed":[181],"higher":[182,202],"sensitivity":[183],"lower":[185],"specificity":[186],"recovering":[188],"DGE":[189],"signals":[190],"seen":[191],"observed":[193],"although":[199],"area":[203],"under":[204],"curves":[205],"than":[206],"methods.":[208],"Machine":[209],"have":[212],"potential":[214],"outperform":[216],"when":[219],"suitable":[220],"training":[221],"available.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-08-19T15:00:24.278416","created_date":"2025-10-10T00:00:00"}