{"id":"https://openalex.org/W4405719362","doi":"https://doi.org/10.1371/journal.pcbi.1012648","title":"Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53","display_name":"Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53","publication_year":2024,"publication_date":"2024-12-23","ids":{"openalex":"https://openalex.org/W4405719362","doi":"https://doi.org/10.1371/journal.pcbi.1012648","pmid":"https://pubmed.ncbi.nlm.nih.gov/39715281"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012648","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012648","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1012648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031096293","display_name":"Kenneth Y. Wertheim","orcid":"https://orcid.org/0000-0002-4152-2898"},"institutions":[{"id":"https://openalex.org/I191240316","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30","country_code":"GB","type":"education","lineage":["https://openalex.org/I191240316"]},{"id":"https://openalex.org/I4210147861","display_name":"Insigneo","ror":"https://ror.org/04ve58z79","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210147861"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Kenneth Y. Wertheim","raw_affiliation_strings":["Centre of Excellence for Data Science, Artificial Intelligence, and Modelling, University of Hull, Kingston upon Hull, United Kingdom","Insigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United Kingdom","School of Computer Science, University of Hull, Kingston upon Hull, United Kingdom","School of Computer Science, University of Sheffield, Sheffield, United Kingdom","Department of Computer Science, University of Sheffield, Sheffield, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4152-2898","affiliations":[{"raw_affiliation_string":"Centre of Excellence for Data Science, Artificial Intelligence, and Modelling, University of Hull, Kingston upon Hull, United Kingdom","institution_ids":["https://openalex.org/I191240316"]},{"raw_affiliation_string":"Insigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I4210147861","https://openalex.org/I91136226"]},{"raw_affiliation_string":"School of Computer Science, University of Hull, Kingston upon Hull, United Kingdom","institution_ids":["https://openalex.org/I191240316"]},{"raw_affiliation_string":"School of Computer Science, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Computer Science, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054859730","display_name":"Robert Chisholm","orcid":"https://orcid.org/0000-0003-3379-9042"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Robert Chisholm","raw_affiliation_strings":["School of Computer Science, University of Sheffield, Sheffield, United Kingdom","Department of Computer Science, University of Sheffield, Sheffield, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-3379-9042","affiliations":[{"raw_affiliation_string":"School of Computer Science, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Computer Science, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011413276","display_name":"Paul Richmond","orcid":"https://orcid.org/0000-0002-4657-5518"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paul Richmond","raw_affiliation_strings":["School of Computer Science, University of Sheffield, Sheffield, United Kingdom","Department of Computer Science, University of Sheffield, Sheffield, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4657-5518","affiliations":[{"raw_affiliation_string":"School of Computer Science, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Computer Science, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045485251","display_name":"Dawn Walker","orcid":"https://orcid.org/0000-0001-8801-8093"},"institutions":[{"id":"https://openalex.org/I4210147861","display_name":"Insigneo","ror":"https://ror.org/04ve58z79","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210147861"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dawn Walker","raw_affiliation_strings":["Insigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United Kingdom","School of Computer Science, University of Sheffield, Sheffield, United Kingdom","Department of Computer Science, University of Sheffield, Sheffield, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-8801-8093","affiliations":[{"raw_affiliation_string":"Insigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I4210147861","https://openalex.org/I91136226"]},{"raw_affiliation_string":"School of Computer Science, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Computer Science, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011413276","https://openalex.org/A5031096293","https://openalex.org/A5045485251","https://openalex.org/A5054859730"],"corresponding_institution_ids":["https://openalex.org/I191240316","https://openalex.org/I4210147861","https://openalex.org/I91136226"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6868,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.74225294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"20","issue":"12","first_page":"e1012648","last_page":"e1012648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"Neuroblastoma","score":0.915077805519104},{"id":"https://openalex.org/keywords/clone","display_name":"clone (Java method)","score":0.7184865474700928},{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.6599510908126831},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5018372535705566},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47492557764053345},{"id":"https://openalex.org/keywords/cellular-automaton","display_name":"Cellular automaton","score":0.45716890692710876},{"id":"https://openalex.org/keywords/stochastic-cellular-automaton","display_name":"Stochastic cellular automaton","score":0.45616796612739563},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41255488991737366},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4002875089645386},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3881094753742218},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.38699308037757874},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3662492334842682},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.24076902866363525},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22645536065101624},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.21471473574638367}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.915077805519104},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.7184865474700928},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.6599510908126831},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5018372535705566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47492557764053345},{"id":"https://openalex.org/C35527583","wikidata":"https://www.wikidata.org/wiki/Q189156","display_name":"Cellular automaton","level":2,"score":0.45716890692710876},{"id":"https://openalex.org/C192499940","wikidata":"https://www.wikidata.org/wiki/Q17022326","display_name":"Stochastic cellular automaton","level":3,"score":0.45616796612739563},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41255488991737366},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4002875089645386},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3881094753742218},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38699308037757874},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3662492334842682},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.24076902866363525},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22645536065101624},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.21471473574638367}],"mesh":[{"descriptor_ui":"D000071447","descriptor_name":"N-Myc Proto-Oncogene Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071447","descriptor_name":"N-Myc Proto-Oncogene Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071447","descriptor_name":"N-Myc Proto-Oncogene Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071447","descriptor_name":"N-Myc Proto-Oncogene Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071447","descriptor_name":"N-Myc Proto-Oncogene Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071447","descriptor_name":"N-Myc Proto-Oncogene Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1012648","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012648","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:39715281","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39715281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:eprints.whiterose.ac.uk:221470","is_oa":true,"landing_page_url":"https://orcid.org/0000-0002-4152-2898>,","pdf_url":"https://eprints.whiterose.ac.uk/221470/1/journal.pcbi.1012648.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:hull-repository.worktribe.com:5001193","is_oa":true,"landing_page_url":"https://hull-repository.worktribe.com/output/5001193","pdf_url":"https://hull-repository.worktribe.com/file/5001193/1/Published%20article","source":{"id":"https://openalex.org/S4306400827","display_name":"Repository@Hull (Worktribe) (University of Hull)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I191240316","host_organization_name":"University of Hull","host_organization_lineage":["https://openalex.org/I191240316"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:11723635","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11723635","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11723635/pdf/pcbi.1012648.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c3c1547120594237bd6c09187a48df8e","is_oa":false,"landing_page_url":"https://doaj.org/article/c3c1547120594237bd6c09187a48df8e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 12, p e1012648 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012648","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012648","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G4175812583","display_name":null,"funder_award_id":"826494","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5251372987","display_name":null,"funder_award_id":"826494","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":123,"referenced_works":["https://openalex.org/W9732639","https://openalex.org/W1554925061","https://openalex.org/W1555714030","https://openalex.org/W1665436044","https://openalex.org/W1915238740","https://openalex.org/W1974317126","https://openalex.org/W1982390426","https://openalex.org/W1984996499","https://openalex.org/W1990212229","https://openalex.org/W1993428519","https://openalex.org/W1999920932","https://openalex.org/W2003670869","https://openalex.org/W2004314923","https://openalex.org/W2008757142","https://openalex.org/W2012687605","https://openalex.org/W2016701600","https://openalex.org/W2018722597","https://openalex.org/W2020910848","https://openalex.org/W2023808520","https://openalex.org/W2028769064","https://openalex.org/W2033392600","https://openalex.org/W2034280388","https://openalex.org/W2036370250","https://openalex.org/W2046288207","https://openalex.org/W2048836357","https://openalex.org/W2051183457","https://openalex.org/W2052801268","https://openalex.org/W2055545693","https://openalex.org/W2063556542","https://openalex.org/W2082281812","https://openalex.org/W2092362354","https://openalex.org/W2096719369","https://openalex.org/W2097572806","https://openalex.org/W2098282574","https://openalex.org/W2101042741","https://openalex.org/W2109414887","https://openalex.org/W2109920630","https://openalex.org/W2116195296","https://openalex.org/W2123345036","https://openalex.org/W2129364443","https://openalex.org/W2135535670","https://openalex.org/W2137077335","https://openalex.org/W2137390239","https://openalex.org/W2137844574","https://openalex.org/W2142884934","https://openalex.org/W2143108036","https://openalex.org/W2147575945","https://openalex.org/W2149004512","https://openalex.org/W2150642049","https://openalex.org/W2156829777","https://openalex.org/W2158255775","https://openalex.org/W2160425601","https://openalex.org/W2162131389","https://openalex.org/W2180650559","https://openalex.org/W2180975946","https://openalex.org/W2197234859","https://openalex.org/W2228109521","https://openalex.org/W2271801128","https://openalex.org/W2278029862","https://openalex.org/W2280759825","https://openalex.org/W2321944794","https://openalex.org/W2323701738","https://openalex.org/W2342518537","https://openalex.org/W2550232998","https://openalex.org/W2586610307","https://openalex.org/W2773314453","https://openalex.org/W2783322160","https://openalex.org/W2802287235","https://openalex.org/W2808537874","https://openalex.org/W2885727541","https://openalex.org/W2888407647","https://openalex.org/W2889489530","https://openalex.org/W2898056719","https://openalex.org/W2902229746","https://openalex.org/W2903619166","https://openalex.org/W2970240468","https://openalex.org/W3000574471","https://openalex.org/W3007502369","https://openalex.org/W3014304753","https://openalex.org/W3032372859","https://openalex.org/W3042190218","https://openalex.org/W3045230440","https://openalex.org/W3089806275","https://openalex.org/W3112248352","https://openalex.org/W3120756887","https://openalex.org/W3131102773","https://openalex.org/W3133837583","https://openalex.org/W3134164720","https://openalex.org/W3135194706","https://openalex.org/W3143387950","https://openalex.org/W3146576696","https://openalex.org/W3160372485","https://openalex.org/W3161739057","https://openalex.org/W3173686793","https://openalex.org/W3174068094","https://openalex.org/W3188503398","https://openalex.org/W3206094592","https://openalex.org/W3209572508","https://openalex.org/W3213824183","https://openalex.org/W4210725470","https://openalex.org/W4211147182","https://openalex.org/W4213088740","https://openalex.org/W4225888008","https://openalex.org/W4229968312","https://openalex.org/W4280498362","https://openalex.org/W4281486974","https://openalex.org/W4281564822","https://openalex.org/W4281652948","https://openalex.org/W4285276701","https://openalex.org/W4288060654","https://openalex.org/W4292243175","https://openalex.org/W4307922001","https://openalex.org/W4309787428","https://openalex.org/W4311290048","https://openalex.org/W4318776819","https://openalex.org/W4319084049","https://openalex.org/W4319161361","https://openalex.org/W4321509052","https://openalex.org/W4361008644","https://openalex.org/W4385407819","https://openalex.org/W6633137868","https://openalex.org/W6637166452","https://openalex.org/W6931524023"],"related_works":["https://openalex.org/W4211227983","https://openalex.org/W4255696416","https://openalex.org/W2147358629","https://openalex.org/W2007974154","https://openalex.org/W1969391024","https://openalex.org/W3208503416","https://openalex.org/W2023344115","https://openalex.org/W2064715443","https://openalex.org/W3178597981","https://openalex.org/W2028377826"],"abstract_inverted_index":{"Neuroblastoma":[0],"is":[1,38,89,104,278,305],"the":[2,21,30,40,68,79,96,140,168,190,197,220,228,240,248,255,273,275,285,316],"most":[3],"common":[4],"extra-cranial":[5],"solid":[6],"tumour":[7,80],"in":[8,35,194,214,219,233,272,280,284],"children.":[9],"Over":[10],"half":[11],"of":[12,32,51,142,170,179,269,318,333],"all":[13],"high-risk":[14],"cases":[15],"are":[16,213,251,265],"expected":[17],"to":[18,20,207,294,301],"succumb":[19],"disease":[22,37],"even":[23],"after":[24],"chemotherapy,":[25],"surgery,":[26],"and":[27,60,118,126,188,203,222,247,282,298,322],"immunotherapy.":[28],"Although":[29],"importance":[31],"MYCN":[33],"amplification":[34],"this":[36],"indisputable,":[39],"mechanistic":[41],"details":[42],"remain":[43],"enigmatic.":[44],"Here,":[45],"we":[46,71,166,182,257],"present":[47],"a":[48,54,61,83,159,177,234,259,306,326],"multicellular":[49,313],"model":[50,138,314],"neuroblastoma":[52,174,270,334],"comprising":[53],"continuous":[55,76,92],"automaton,":[56],"discrete":[57,101],"cell":[58,102,111,124,127],"agents,":[59],"centre-based":[62,136],"mechanical":[63,137],"model,":[64],"as":[65,67,82,95,123,145,154],"well":[66],"simulation":[69,161],"results":[70,212],"obtained":[72],"with":[73,91,120,216],"it.":[74],"The":[75,135,312],"automaton":[77],"represents":[78,139],"microenvironment":[81,250],"grid-like":[84],"structure,":[85],"where":[86],"each":[87,152],"voxel":[88],"associated":[90],"variables":[93],"such":[94,122],"oxygen":[97],"level":[98],"therein.":[99],"Each":[100],"agent":[103],"defined":[105],"by":[106],"several":[107],"attributes,":[108],"including":[109],"its":[110,201,205,236],"cycle":[112],"position,":[113],"mutations,":[114],"gene":[115,237],"expression":[116,238],"pattern,":[117],"more":[119],"behaviours":[121],"cycling":[125],"death":[128],"being":[129],"stochastically":[130],"dependent":[131],"on":[132,163,254],"these":[133,143],"attributes.":[134],"properties":[141],"agents":[144],"physical":[146],"objects,":[147],"describing":[148],"how":[149,227],"they":[150],"repel":[151],"other":[153,242],"soft":[155],"spheres.":[156],"By":[157],"implementing":[158],"stochastic":[160],"algorithm":[162],"modern":[164],"GPUs,":[165],"simulated":[167],"dynamics":[169,193],"over":[171,176],"one":[172,281],"million":[173],"cells":[175,271],"period":[178],"months.":[180],"Specifically,":[181],"set":[183],"up":[184],"1200":[185],"heterogeneous":[186],"tumours":[187],"tracked":[189],"MYCN-amplified":[191,229],"clone's":[192,230],"each,":[195],"revealed":[196],"conditions":[198],"that":[199,263,289],"favour":[200],"growth,":[202],"tested":[204],"responses":[206],"5000":[208],"drug":[209],"combinations.":[210],"Our":[211],"agreement":[215],"those":[217],"reported":[218],"literature":[221],"add":[223],"new":[224],"insights":[225],"into":[226],"reproductive":[231],"advantage":[232],"tumour,":[235],"profile,":[239],"tumour's":[241,249],"clones":[243],"(with":[244],"different":[245],"mutations),":[246],"inter-related.":[252],"Based":[253],"results,":[256],"formulated":[258],"hypothesis,":[260],"which":[261],"argues":[262],"there":[264],"two":[266],"distinct":[267],"populations":[268],"tumour;":[274],"p53":[276,296,303],"protein":[277],"pro-survival":[279],"pro-apoptosis":[283],"other.":[286],"It":[287],"follows":[288],"alternating":[290],"between":[291],"inhibiting":[292,299],"MDM2":[293],"restore":[295],"activity":[297,304],"ARF":[300],"attenuate":[302],"promising,":[307],"if":[308],"unorthodox,":[309],"therapeutic":[310],"strategy.":[311],"has":[315],"advantages":[317],"modularity,":[319],"high":[320],"resolution,":[321],"scalability,":[323],"making":[324],"it":[325],"potential":[327],"foundation":[328],"for":[329],"creating":[330],"digital":[331],"twins":[332],"patients.":[335]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-08T15:41:06.802602","created_date":"2025-10-10T00:00:00"}
