{"id":"https://openalex.org/W4405464463","doi":"https://doi.org/10.1371/journal.pcbi.1012645","title":"In\u2013silico simultaneous respiratory and circulatory measurement during voluntary breathing, exercise, and mental stress: A computational approach","display_name":"In\u2013silico simultaneous respiratory and circulatory measurement during voluntary breathing, exercise, and mental stress: A computational approach","publication_year":2024,"publication_date":"2024-12-17","ids":{"openalex":"https://openalex.org/W4405464463","doi":"https://doi.org/10.1371/journal.pcbi.1012645","pmid":"https://pubmed.ncbi.nlm.nih.gov/39689064"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012645","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012645","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012645&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012645&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103087763","display_name":"Masami Iwamoto","orcid":"https://orcid.org/0000-0002-0738-521X"},"institutions":[{"id":"https://openalex.org/I4210165351","display_name":"Toyota Central Research and Development Laboratories (Japan)","ror":"https://ror.org/05mjgqe69","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210125472","https://openalex.org/I4210165351"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masami Iwamoto","raw_affiliation_strings":["Human Science Research-Domain, Toyota Central R&D Labs., Inc., Nagakute, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0738-521X","affiliations":[{"raw_affiliation_string":"Human Science Research-Domain, Toyota Central R&D Labs., Inc., Nagakute, Japan","institution_ids":["https://openalex.org/I4210165351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067291421","display_name":"Satoko HIRABAYASHI","orcid":"https://orcid.org/0000-0002-6657-7166"},"institutions":[{"id":"https://openalex.org/I4210165351","display_name":"Toyota Central Research and Development Laboratories (Japan)","ror":"https://ror.org/05mjgqe69","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210125472","https://openalex.org/I4210165351"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoko Hirabayashi","raw_affiliation_strings":["Human Science Research-Domain, Toyota Central R&D Labs., Inc., Nagakute, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6657-7166","affiliations":[{"raw_affiliation_string":"Human Science Research-Domain, Toyota Central R&D Labs., Inc., Nagakute, Japan","institution_ids":["https://openalex.org/I4210165351"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041906648","display_name":"Noritoshi Atsumi","orcid":"https://orcid.org/0000-0001-5938-9557"},"institutions":[{"id":"https://openalex.org/I4210165351","display_name":"Toyota Central Research and Development Laboratories (Japan)","ror":"https://ror.org/05mjgqe69","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210125472","https://openalex.org/I4210165351"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Noritoshi Atsumi","raw_affiliation_strings":["Human Science Research-Domain, Toyota Central R&D Labs., Inc., Nagakute, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5938-9557","affiliations":[{"raw_affiliation_string":"Human Science Research-Domain, Toyota Central R&D Labs., Inc., Nagakute, Japan","institution_ids":["https://openalex.org/I4210165351"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041906648","https://openalex.org/A5067291421","https://openalex.org/A5103087763"],"corresponding_institution_ids":["https://openalex.org/I4210165351"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7506,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.77571363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"20","issue":"12","first_page":"e1012645","last_page":"e1012645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11196","display_name":"Non-Invasive Vital Sign Monitoring","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.6175479888916016},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"Heart rate variability","score":0.5867753624916077},{"id":"https://openalex.org/keywords/respiratory-rate","display_name":"Respiratory rate","score":0.5638653635978699},{"id":"https://openalex.org/keywords/breathing","display_name":"Breathing","score":0.526171088218689},{"id":"https://openalex.org/keywords/respiratory-minute-volume","display_name":"Respiratory minute volume","score":0.47539839148521423},{"id":"https://openalex.org/keywords/hyperventilation","display_name":"Hyperventilation","score":0.46166330575942993},{"id":"https://openalex.org/keywords/tidal-volume","display_name":"Tidal volume","score":0.4581519663333893},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.39054369926452637},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.3405490219593048},{"id":"https://openalex.org/keywords/respiratory-system","display_name":"Respiratory system","score":0.3366957902908325},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3244122266769409},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.27150607109069824},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26727497577667236}],"concepts":[{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6175479888916016},{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.5867753624916077},{"id":"https://openalex.org/C8213797","wikidata":"https://www.wikidata.org/wiki/Q754250","display_name":"Respiratory rate","level":4,"score":0.5638653635978699},{"id":"https://openalex.org/C39300077","wikidata":"https://www.wikidata.org/wiki/Q9530","display_name":"Breathing","level":2,"score":0.526171088218689},{"id":"https://openalex.org/C79959777","wikidata":"https://www.wikidata.org/wiki/Q754333","display_name":"Respiratory minute volume","level":3,"score":0.47539839148521423},{"id":"https://openalex.org/C2777449187","wikidata":"https://www.wikidata.org/wiki/Q575168","display_name":"Hyperventilation","level":2,"score":0.46166330575942993},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.4581519663333893},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.39054369926452637},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3405490219593048},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3366957902908325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3244122266769409},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.27150607109069824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26727497577667236}],"mesh":[{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056152","descriptor_name":"Respiratory Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D056152","descriptor_name":"Respiratory Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D056152","descriptor_name":"Respiratory Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D056152","descriptor_name":"Respiratory Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1012645","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012645","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012645&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:39689064","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39689064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11651585","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11651585","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11651585/pdf/pcbi.1012645.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3b262ce775f948c29f5ba2fc31799d09","is_oa":true,"landing_page_url":"https://doaj.org/article/3b262ce775f948c29f5ba2fc31799d09","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 12, p e1012645 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012645","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012645","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012645&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6499999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320317988","display_name":"Artificial Intelligence Research Center","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405464463.pdf","grobid_xml":"https://content.openalex.org/works/W4405464463.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W159680228","https://openalex.org/W182856779","https://openalex.org/W1549591614","https://openalex.org/W1848462296","https://openalex.org/W1903440721","https://openalex.org/W1966232511","https://openalex.org/W1973269950","https://openalex.org/W1979106866","https://openalex.org/W1985954324","https://openalex.org/W1996117824","https://openalex.org/W1996285069","https://openalex.org/W2004642868","https://openalex.org/W2005631536","https://openalex.org/W2006062168","https://openalex.org/W2008750525","https://openalex.org/W2012462205","https://openalex.org/W2013761125","https://openalex.org/W2016132529","https://openalex.org/W2033262131","https://openalex.org/W2034734862","https://openalex.org/W2041332565","https://openalex.org/W2044443742","https://openalex.org/W2057130871","https://openalex.org/W2065110791","https://openalex.org/W2075652159","https://openalex.org/W2076251943","https://openalex.org/W2086517899","https://openalex.org/W2091108618","https://openalex.org/W2108591604","https://openalex.org/W2112812932","https://openalex.org/W2113501460","https://openalex.org/W2120369706","https://openalex.org/W2125579882","https://openalex.org/W2125885409","https://openalex.org/W2137524850","https://openalex.org/W2138123121","https://openalex.org/W2144120285","https://openalex.org/W2153948178","https://openalex.org/W2162134198","https://openalex.org/W2166680592","https://openalex.org/W2168715575","https://openalex.org/W2395031608","https://openalex.org/W2587593459","https://openalex.org/W2621012322","https://openalex.org/W2750510341","https://openalex.org/W2759190050","https://openalex.org/W2767851849","https://openalex.org/W2792140820","https://openalex.org/W2794059873","https://openalex.org/W2799378468","https://openalex.org/W2801395383","https://openalex.org/W2900319448","https://openalex.org/W2901027086","https://openalex.org/W2923031892","https://openalex.org/W2936721389","https://openalex.org/W2952140702","https://openalex.org/W2982122294","https://openalex.org/W2991521698","https://openalex.org/W3034151881","https://openalex.org/W3080136705","https://openalex.org/W3083563689","https://openalex.org/W3094602391","https://openalex.org/W3186266645","https://openalex.org/W4211102059","https://openalex.org/W4220957241","https://openalex.org/W4225137380","https://openalex.org/W4246739026","https://openalex.org/W4285147536","https://openalex.org/W4292829028","https://openalex.org/W4309080116","https://openalex.org/W4309705193","https://openalex.org/W4323531640","https://openalex.org/W4367597931","https://openalex.org/W4386569693","https://openalex.org/W4387866329"],"related_works":["https://openalex.org/W3032736716","https://openalex.org/W1996447318","https://openalex.org/W2239550753","https://openalex.org/W1732138557","https://openalex.org/W2032936085","https://openalex.org/W2144328154","https://openalex.org/W2072898286","https://openalex.org/W2083596363","https://openalex.org/W2549160642","https://openalex.org/W2059403142"],"abstract_inverted_index":{"Voluntary":[0],"breathing":[1,12,152,232],"(VB),":[2],"short-term":[3],"exercise":[4],"(STE),":[5],"and":[6,18,26,42,45,56,62,84,122,160,187,198,222,244,258,263,273],"mental":[7,27,129,262],"stress":[8,130,144],"(MS)":[9],"can":[10],"modulate":[11],"rate":[13,16,153,213],"(BR),":[14,154],"heart":[15,212],"(HR),":[17],"blood":[19],"pressure":[20],"(BP),":[21],"thereby":[22],"affecting":[23],"human":[24],"physical":[25,264],"state.":[28],"While":[29],"existing":[30],"experimental":[31,196],"studies":[32,141],"have":[33],"explored":[34],"the":[35,75,82,136,204,223],"relationship":[36],"between":[37],"VB,":[38,89],"STE,":[39,90,186],"or":[40,91,120,182],"MS":[41,188,248],"BR,":[43,60],"HR,":[44,61,159],"BP":[46,63,161,250],"changes,":[47],"their":[48],"findings":[49],"remain":[50],"fragmented":[51],"due":[52],"to":[53,88,108,116,135,146,178,202],"individual":[54,207,282],"differences":[55],"challenges":[57],"in":[58],"simultaneous,":[59],"measurements.":[64],"We":[65,112,127],"propose":[66],"a":[67,97,101,234],"computational":[68,269],"approach":[69,270],"for":[70,118,151,261,281],"in-silico":[71],"simultaneous":[72,272],"measurements":[73],"of":[74,81,206,217,226,236,276],"physiological":[76,278],"values":[77],"by":[78,125],"comprehensive":[79],"prediction":[80],"respiratory":[83,98,110],"circulatory":[85,102],"system":[86,99],"responses":[87],"MS.":[92],"Our":[93,149,209],"integrated":[94],"model":[95,191,210],"combines":[96],"with":[100,195],"model,":[103],"leveraging":[104],"actor-critic":[105],"reinforcement":[106],"learning":[107],"control":[109],"muscles.":[111],"introduce":[113],"specific":[114,285],"parameters":[115],"account":[117],"involuntary":[119],"VB":[121,173],"hyperventilation":[123],"induced":[124],"STE.":[126],"modeled":[128],"as":[131],"an":[132,256],"electrical":[133],"input":[134],"amygdala":[137,147],"based":[138],"on":[139],"prior":[140],"indicating":[142,255],"that":[143],"leads":[145],"hyperactivity.":[148],"predictions":[150,275],"tidal":[155],"volume,":[156],"minute":[157],"ventilation,":[158],"are":[162],"validated":[163],"against":[164],"literature":[165],"data":[166],"obtained":[167],"during":[168],"various":[169,277],"conditions,":[170],"including":[171],"different":[172],"patterns":[174],"(ranging":[175],"from":[176],"6":[177,237],"14":[179],"bpm),":[180],"active":[181],"passive":[183],"knee":[184],"flexion":[185],"load.":[189],"The":[190],"demonstrates":[192],"good":[193],"agreement":[194],"results":[197],"highlights":[199],"its":[200],"ability":[201],"explore":[203],"mechanism":[205],"differences.":[208],"predicts":[211],"variability":[214],"(HRV)":[215],"indices":[216],"total":[218],"power":[219],"spectral":[220],"density":[221],"ellipse":[224],"area":[225],"Poincar\u00e9":[227],"plot.":[228],"Notably,":[229],"slow":[230],"deep":[231],"at":[233],"BR":[235],"bpm":[238],"increases":[239],"HRV":[240,253],"indices,":[241,254],"promoting":[242],"relaxation":[243],"cognitive":[245],"performance.":[246],"Conversely,":[247],"elevates":[249],"but":[251],"reduces":[252],"unstable":[257],"risky":[259],"state":[260],"health.":[265],"Overall,":[266],"our":[267],"proposed":[268],"provides":[271],"reasonable":[274],"values,":[279],"accounting":[280],"variations":[283],"through":[284],"parameters.":[286]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}