{"id":"https://openalex.org/W4404469702","doi":"https://doi.org/10.1371/journal.pcbi.1012596","title":"A dynamical systems model for the total fission rate in Drp1-dependent mitochondrial fission","display_name":"A dynamical systems model for the total fission rate in Drp1-dependent mitochondrial fission","publication_year":2024,"publication_date":"2024-11-18","ids":{"openalex":"https://openalex.org/W4404469702","doi":"https://doi.org/10.1371/journal.pcbi.1012596","pmid":"https://pubmed.ncbi.nlm.nih.gov/39556606"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012596","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012596","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1012596","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114684138","display_name":"Anna K. Leinheiser","orcid":null},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I2801811543","display_name":"Fraternal Order of Eagles","ror":"https://ror.org/01er75989","country_code":"US","type":"education","lineage":["https://openalex.org/I2801811543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna K. Leinheiser","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine, Francois M. Abboud Cardiovascular Research Center, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, United States of America","Department of Mathematics, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":"https://orcid.org/0009-0001-3377-1843","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine, Francois M. Abboud Cardiovascular Research Center, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I2801811543"]},{"raw_affiliation_string":"Department of Mathematics, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070129458","display_name":"Colleen Mitchell","orcid":"https://orcid.org/0000-0001-9443-7542"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Colleen C. Mitchell","raw_affiliation_strings":["Department of Mathematics, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9443-7542","affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027122026","display_name":"Ethan Rooke","orcid":null},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Rooke","raw_affiliation_strings":["Department of Mathematics, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":"https://orcid.org/0009-0003-8755-5884","affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070992833","display_name":"Stefan Strack","orcid":"https://orcid.org/0000-0002-6175-7280"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Strack","raw_affiliation_strings":["Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6175-7280","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025425176","display_name":"Chad E. Grueter","orcid":"https://orcid.org/0000-0001-8950-742X"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I2801811543","display_name":"Fraternal Order of Eagles","ror":"https://ror.org/01er75989","country_code":"US","type":"education","lineage":["https://openalex.org/I2801811543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad E. Grueter","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine, Francois M. Abboud Cardiovascular Research Center, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine, Francois M. Abboud Cardiovascular Research Center, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, United States of America","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I2801811543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070129458"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.16,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50659499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"20","issue":"11","first_page":"e1012596","last_page":"e1012596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"Mitochondrial fission","score":0.6458908915519714},{"id":"https://openalex.org/keywords/fission","display_name":"Fission","score":0.5051622986793518},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.35350099205970764},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3016290068626404},{"id":"https://openalex.org/keywords/mitochondrion","display_name":"Mitochondrion","score":0.24286594986915588},{"id":"https://openalex.org/keywords/nuclear-physics","display_name":"Nuclear physics","score":0.12737444043159485},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.07123526930809021}],"concepts":[{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.6458908915519714},{"id":"https://openalex.org/C12294094","wikidata":"https://www.wikidata.org/wiki/Q929080","display_name":"Fission","level":3,"score":0.5051622986793518},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.35350099205970764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3016290068626404},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.24286594986915588},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.12737444043159485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07123526930809021},{"id":"https://openalex.org/C152568617","wikidata":"https://www.wikidata.org/wiki/Q2348","display_name":"Neutron","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1012596","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012596","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:39556606","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39556606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11611272","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11611272","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11611272/pdf/pcbi.1012596.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:07f5749b915d43469dde082614603cd6","is_oa":false,"landing_page_url":"https://doaj.org/article/07f5749b915d43469dde082614603cd6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 11, p e1012596 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012596","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012596","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.8899999856948853}],"awards":[{"id":"https://openalex.org/G7468621801","display_name":"Mediator kinase regulation of cardiac hypertrophy","funder_award_id":"969976","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1914770541","https://openalex.org/W1981049765","https://openalex.org/W1989026904","https://openalex.org/W2004939344","https://openalex.org/W2029204107","https://openalex.org/W2029767409","https://openalex.org/W2044929466","https://openalex.org/W2046967306","https://openalex.org/W2048730719","https://openalex.org/W2058028795","https://openalex.org/W2058359969","https://openalex.org/W2067989161","https://openalex.org/W2069545979","https://openalex.org/W2074341964","https://openalex.org/W2088765131","https://openalex.org/W2099837354","https://openalex.org/W2126337135","https://openalex.org/W2137844183","https://openalex.org/W2173233184","https://openalex.org/W2200229144","https://openalex.org/W2267961811","https://openalex.org/W2301918656","https://openalex.org/W2569457803","https://openalex.org/W2756051998","https://openalex.org/W2782426736","https://openalex.org/W2803890843","https://openalex.org/W2887345219","https://openalex.org/W2953108515","https://openalex.org/W3014403841","https://openalex.org/W3164775823","https://openalex.org/W4280542947","https://openalex.org/W4312362262","https://openalex.org/W4327967379","https://openalex.org/W6751717471"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W4391375266","https://openalex.org/W4205962052","https://openalex.org/W1232242392","https://openalex.org/W4205218873","https://openalex.org/W4231925940","https://openalex.org/W4251578316","https://openalex.org/W4206318357","https://openalex.org/W4207041248"],"abstract_inverted_index":{"Mitochondrial":[0],"hyperfission":[1],"in":[2,146],"response":[3],"to":[4,23,55,182,189,194],"cellular":[5],"insult":[6],"is":[7,19,94],"associated":[8],"with":[9,84,180],"reduced":[10],"energy":[11],"production":[12],"and":[13,29,52,103,105,110,154,186],"programmed":[14],"cell":[15],"death.":[16],"Thus,":[17],"there":[18],"a":[20,39,67,75,81,183,212],"critical":[21],"need":[22],"understand":[24],"the":[25,31,61,78,95,108,117,129,134,140,143,152,155,167,216,221],"molecular":[26],"mechanisms":[27],"coordinating":[28],"regulating":[30],"complex":[32],"process":[33],"of":[34,44,69,77,98,127,137,142,223],"mitochondrial":[35,50,99,119],"fission.":[36],"We":[37],"develop":[38],"nonlinear":[40],"dynamical":[41],"systems":[42],"model":[43,79],"dynamin":[45],"related":[46],"protein":[47],"one":[48],"(Drp1)-dependent":[49],"fission":[51,63,100,158,217],"use":[53],"it":[54,178],"identify":[56],"parameters":[57],"which":[58],"can":[59,124],"regulate":[60],"total":[62,96,157],"rate":[64,112,132,136],"(TFR)":[65],"as":[66,128,174,191,227],"function":[68],"time.":[70],"The":[71,121],"TFR":[72,153],"defined":[73],"from":[74],"nondimensionalization":[76,141],"undergoes":[80],"Hopf":[82],"bifurcation":[83,85],"parameter":[86],"[Formula:":[87,91,207],"see":[88,92,208],"text]":[89,93,209],"where":[90],"concentration":[97],"factor":[101],"(Mff)":[102],"k+":[104],"k-":[106],"are":[107],"association":[109],"dissociation":[111],"constants":[113],"between":[114],"oligomers":[115],"on":[116,162,199,215],"outer":[118],"membrane.":[120],"variable":[122],"\u03bc":[123,175,181,192,200],"be":[125],"thought":[126],"maximum":[130],"build":[131],"over":[133],"disassembling":[135],"oligomers.":[138],"Though":[139],"system":[144],"results":[145],"four":[147],"dimensionless":[148],"parameters,":[149,225],"we":[150],"found":[151],"cumulative":[156,168],"(TF)":[159],"depend":[160],"strongly":[161],"only":[163],"one,":[164],"\u03bc.":[165],"Interestingly,":[166],"TF":[169],"does":[170],"not":[171],"monotonically":[172],"increase":[173],"increases.":[176],"Instead":[177],"increases":[179],"certain":[184],"point":[185],"then":[187],"begins":[188],"decrease":[190],"continues":[193],"increase.":[195],"This":[196],"non-monotone":[197],"dependence":[198],"suggests":[201],"interventions":[202],"targeting":[203],"k+,":[204],"k-,":[205],"or":[206],"may":[210,229],"have":[211],"non-intuitive":[213],"impact":[214,222],"mechanism.":[218],"Thus":[219],"understanding":[220],"regulatory":[224],"such":[226],"\u03bc,":[228],"assist":[230],"future":[231],"therapeutic":[232],"target":[233],"selection.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}