{"id":"https://openalex.org/W4405061254","doi":"https://doi.org/10.1371/journal.pcbi.1012573","title":"Modelling the effectiveness of antiviral treatment strategies to prevent household transmission of acute respiratory viruses","display_name":"Modelling the effectiveness of antiviral treatment strategies to prevent household transmission of acute respiratory viruses","publication_year":2024,"publication_date":"2024-12-05","ids":{"openalex":"https://openalex.org/W4405061254","doi":"https://doi.org/10.1371/journal.pcbi.1012573","pmid":"https://pubmed.ncbi.nlm.nih.gov/39636821"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012573","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012573","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012573&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012573&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115013640","display_name":"Hind Zaaraoui","orcid":"https://orcid.org/0000-0001-5200-1898"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4387156044","display_name":"Infection, Anti-microbiens, Mod\u00e9lisation, Evolution","ror":"https://ror.org/05hqep952","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387156044"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Hind Zaaraoui","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, IAME, INSERM, F-75018 Paris, France"],"raw_orcid":"https://orcid.org/0000-0001-5200-1898","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, IAME, INSERM, F-75018 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387156044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115013641","display_name":"Clarisse Schumer","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4387156044","display_name":"Infection, Anti-microbiens, Mod\u00e9lisation, Evolution","ror":"https://ror.org/05hqep952","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387156044"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Clarisse Schumer","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, IAME, INSERM, F-75018 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, IAME, INSERM, F-75018 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387156044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102990244","display_name":"Xavier Duval","orcid":"https://orcid.org/0000-0003-1079-4230"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4387156044","display_name":"Infection, Anti-microbiens, Mod\u00e9lisation, Evolution","ror":"https://ror.org/05hqep952","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387156044"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Xavier Duval","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, IAME, INSERM, F-75018 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, IAME, INSERM, F-75018 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387156044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002721139","display_name":"Bruno Hoen","orcid":"https://orcid.org/0000-0003-3070-3017"},"institutions":[{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Bruno Hoen","raw_affiliation_strings":["Campus Brabois Sant\u00e9, Universit\u00e9 de Lorraine, Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campus Brabois Sant\u00e9, Universit\u00e9 de Lorraine, Nancy, France","institution_ids":["https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061270982","display_name":"Lulla Opatowski","orcid":"https://orcid.org/0000-0001-8348-700X"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210103698","display_name":"Centre de recherche en Epid\u00e9miologie et Sant\u00e9 des Populations","ror":"https://ror.org/01ed4t417","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I277688954","https://openalex.org/I4210097159","https://openalex.org/I4210097159","https://openalex.org/I4210103698","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Lulla Opatowski","raw_affiliation_strings":["Epidemiology and Modelling of Antimicrobials Evasion research unit, Institut Pasteur, Paris, France","Universit\u00e9 Paris-Saclay, UVSQ, INSERM, CESP, Anti-infective evasion and pharmacoepidemiology research team, Montigny-Le-Bretonneux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology and Modelling of Antimicrobials Evasion research unit, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, UVSQ, INSERM, CESP, Anti-infective evasion and pharmacoepidemiology research team, Montigny-Le-Bretonneux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210103698","https://openalex.org/I195731000","https://openalex.org/I277688954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080451499","display_name":"J\u00e9r\u00e9mie Guedj","orcid":"https://orcid.org/0000-0002-5534-5482"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4387156044","display_name":"Infection, Anti-microbiens, Mod\u00e9lisation, Evolution","ror":"https://ror.org/05hqep952","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387156044"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J\u00e9r\u00e9mie Guedj","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, IAME, INSERM, F-75018 Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-5534-5482","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, IAME, INSERM, F-75018 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387156044"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002721139","https://openalex.org/A5061270982","https://openalex.org/A5080451499","https://openalex.org/A5102990244","https://openalex.org/A5115013640","https://openalex.org/A5115013641"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I157536573","https://openalex.org/I195731000","https://openalex.org/I204730241","https://openalex.org/I277688954","https://openalex.org/I4210103698","https://openalex.org/I4387156044","https://openalex.org/I90183372"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.0715,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.87125406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"20","issue":"12","first_page":"e1012573","last_page":"e1012573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.982200026512146,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9764000177383423,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.7893868684768677},{"id":"https://openalex.org/keywords/transmission","display_name":"Transmission (telecommunications)","score":0.758747935295105},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5968230962753296},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5113689303398132},{"id":"https://openalex.org/keywords/outbreak","display_name":"Outbreak","score":0.5051797032356262},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4829061031341553},{"id":"https://openalex.org/keywords/index-case","display_name":"Index case","score":0.4660879969596863},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.39016491174697876},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.36111634969711304},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.328898549079895},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.3064088821411133},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2886617183685303}],"concepts":[{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.7893868684768677},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.758747935295105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5968230962753296},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5113689303398132},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.5051797032356262},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4829061031341553},{"id":"https://openalex.org/C447327","wikidata":"https://www.wikidata.org/wiki/Q1639798","display_name":"Index case","level":3,"score":0.4660879969596863},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39016491174697876},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.36111634969711304},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.328898549079895},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3064088821411133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2886617183685303},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005191","descriptor_name":"Family Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005191","descriptor_name":"Family Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005191","descriptor_name":"Family Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005191","descriptor_name":"Family Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056990","descriptor_name":"Post-Exposure Prophylaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056990","descriptor_name":"Post-Exposure Prophylaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056990","descriptor_name":"Post-Exposure Prophylaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056990","descriptor_name":"Post-Exposure Prophylaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1012573","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012573","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012573&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:39636821","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39636821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11620401","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11620401","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11620401/pdf/pcbi.1012573.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:29ab73054bc94b0c974b210d3991734b","is_oa":true,"landing_page_url":"https://doaj.org/article/29ab73054bc94b0c974b210d3991734b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 12, p e1012573 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012573","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012573","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012573&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2589078675","display_name":null,"funder_award_id":"101016167","funder_id":"https://openalex.org/F4320338395","funder_display_name":"EIT Health"},{"id":"https://openalex.org/G7842005466","display_name":null,"funder_award_id":"Horizon 2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G838507393","display_name":null,"funder_award_id":"101016167","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338395","display_name":"EIT Health","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4405061254.pdf"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W2026407589","https://openalex.org/W2040261898","https://openalex.org/W2109977701","https://openalex.org/W2119950877","https://openalex.org/W2167620733","https://openalex.org/W2256712157","https://openalex.org/W2334783812","https://openalex.org/W2755849266","https://openalex.org/W3015848059","https://openalex.org/W3016137795","https://openalex.org/W3032216800","https://openalex.org/W3032373213","https://openalex.org/W3035973582","https://openalex.org/W3036626989","https://openalex.org/W3045248985","https://openalex.org/W3080312355","https://openalex.org/W3104457017","https://openalex.org/W3111985903","https://openalex.org/W3124695025","https://openalex.org/W3126652124","https://openalex.org/W3131800306","https://openalex.org/W3149518894","https://openalex.org/W3168069583","https://openalex.org/W3169557383","https://openalex.org/W3180528293","https://openalex.org/W3187723563","https://openalex.org/W3195003192","https://openalex.org/W3204153794","https://openalex.org/W3204426344","https://openalex.org/W3215790293","https://openalex.org/W3217549965","https://openalex.org/W4206797237","https://openalex.org/W4210823650","https://openalex.org/W4210933002","https://openalex.org/W4212904481","https://openalex.org/W4213152627","https://openalex.org/W4214673911","https://openalex.org/W4220824273","https://openalex.org/W4221050050","https://openalex.org/W4221135099","https://openalex.org/W4223921331","https://openalex.org/W4224289402","https://openalex.org/W4225613093","https://openalex.org/W4225834134","https://openalex.org/W4226148899","https://openalex.org/W4226236384","https://openalex.org/W4226525051","https://openalex.org/W4226532189","https://openalex.org/W4229041013","https://openalex.org/W4283763349","https://openalex.org/W4292622968","https://openalex.org/W4293780006","https://openalex.org/W4309126350","https://openalex.org/W4309657074","https://openalex.org/W4310643051","https://openalex.org/W4311676393","https://openalex.org/W4312113671","https://openalex.org/W4378976426","https://openalex.org/W4393931360","https://openalex.org/W6846841974"],"related_works":["https://openalex.org/W2127290136","https://openalex.org/W2098918420","https://openalex.org/W2113982733","https://openalex.org/W2152109263","https://openalex.org/W2043493326","https://openalex.org/W3029968069","https://openalex.org/W3190161344","https://openalex.org/W3042327795","https://openalex.org/W2760003764","https://openalex.org/W2510618923"],"abstract_inverted_index":{"Households":[0],"are":[1,161],"a":[2,25,81,102,126,208],"major":[3],"driver":[4],"of":[5,7,53,69,128,196,227,275],"transmission":[6,59,117,157,215,287],"acute":[8],"respiratory":[9],"viruses,":[10],"such":[11,70],"as":[12,24,234],"SARS-CoV-2":[13],"or":[14,39,43,135],"Influenza.":[15],"Until":[16],"now":[17],"antiviral":[18,108,256,276],"treatments":[19],"have":[20],"mostly":[21],"been":[22],"used":[23],"curative":[26],"treatment":[27,109,185,226,257],"in":[28,99,123,205,279],"symptomatic":[29],"individuals.":[30],"During":[31],"an":[32,282],"outbreak,":[33],"more":[34],"aggressive":[35],"strategies":[36,71,224,258],"involving":[37],"pre-":[38],"post-exposure":[40],"prophylaxis":[41],"(PrEP":[42],"PEP)":[44],"could":[45],"be":[46,149],"employed":[47],"to":[48,60,65,137,172,179,284],"further":[49],"reduce":[50,193,201],"the":[51,67,73,86,90,95,116,120,145,194,202,206,218,253,273],"risk":[52,118,195,216],"severe":[54,211],"disease":[55,212,289],"but":[56],"also":[57],"prevent":[58],"household":[61,182,232,268],"contacts.":[62,183],"In":[63,220,251],"order":[64],"understand":[66],"effectiveness":[68,113],"and":[72,94,119,151,158,170,213,231,248,265,288],"factors":[74],"that":[75,84,143,221],"may":[76],"modulate":[77],"them,":[78],"we":[79,105],"developed":[80],"multi-scale":[82],"model":[83],"follows":[85],"infection":[87],"at":[88],"both":[89,156,228],"individual-level":[91],"(viral":[92],"dynamics)":[93,98],"population-level":[96],"(transmission":[97],"households.":[100],"Using":[101],"simulation":[103],"study":[104,271],"explored":[106],"different":[107],"strategies,":[110],"evaluating":[111],"their":[112],"on":[114],"reducing":[115],"virological":[121,159,203],"burden":[122,160,204],"households":[124,280],"for":[125,166,210,261,266],"range":[127],"virus":[129],"characteristics":[130],"(e.g.,":[131],"secondary":[132],"attack":[133],"rate-SAR,":[134],"time":[136,171],"peak":[138,173,241],"viral":[139,174,242,286],"load).":[140],"We":[141],"found":[142],"when":[144,240],"index":[146,188,229],"case":[147,222,230],"can":[148,199],"identified":[150],"treated":[152],"before":[153],"symptom":[154,189,246],"onset,":[155,247],"reduced":[162],"by":[163],">":[164,238],"75%":[165],"most":[167],"SAR":[168,262],"values":[169],"load,":[175],"with":[176,236],"minimal":[177],"benefit":[178],"treat":[180],"additionally":[181],"While":[184],"initiated":[186],"after":[187,245],"onset":[190],"does":[191],"not":[192],"transmission,":[197],"it":[198],"still":[200],"household,":[207],"proxy":[209],"subsequent":[214],"outside":[217],"household.":[219],"optimal":[223,260],"involve":[225],"contacts":[233],"PEP,":[235],"efficacy":[237],"50%":[239],"load":[243],"occurs":[244],"30-50%":[249],"otherwise.":[250],"all":[252],"considered":[254],"cases,":[255],"were":[259],"ranging":[263],"20-60%,":[264],"larger":[267],"sizes.":[269],"This":[270],"highlights":[272],"opportunity":[274],"drug-based":[277],"interventions":[278],"during":[281],"outbreak":[283],"minimize":[285],"burden.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-06-20T22:02:38.213706","created_date":"2025-10-10T00:00:00"}
