{"id":"https://openalex.org/W4402977972","doi":"https://doi.org/10.1371/journal.pcbi.1012491","title":"Study of impacts of two types of cellular aging on the yeast bud morphogenesis","display_name":"Study of impacts of two types of cellular aging on the yeast bud morphogenesis","publication_year":2024,"publication_date":"2024-09-30","ids":{"openalex":"https://openalex.org/W4402977972","doi":"https://doi.org/10.1371/journal.pcbi.1012491","pmid":"https://pubmed.ncbi.nlm.nih.gov/39348424"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012491","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012491","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1012491","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101729908","display_name":"Kevin Tsai","orcid":"https://orcid.org/0000-0003-0312-9144"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Tsai","raw_affiliation_strings":["Department of Mathematics, University of California, Riverside, California, United States of America","Interdisciplinary Center for Quantitative Modeling in Biology, University of California, Riverside, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Interdisciplinary Center for Quantitative Modeling in Biology, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101081366","display_name":"Zhen Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Zhou","raw_affiliation_strings":["Department of Molecular Biology, School of Biological Sciences, University of California, San Diego, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, School of Biological Sciences, University of California, San Diego, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113745343","display_name":"Jiadong Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiadong Yang","raw_affiliation_strings":["Department of Molecular, Cell and Systems Biology, University of California, Riverside, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cell and Systems Biology, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100600731","display_name":"Zhiliang Xu","orcid":"https://orcid.org/0000-0003-0527-605X"},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiliang Xu","raw_affiliation_strings":["Applied and Computational Mathematics and Statistics Department, University of Notre Dame, Notre Dame, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied and Computational Mathematics and Statistics Department, University of Notre Dame, Notre Dame, Indiana, United States of America","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080267047","display_name":"Shixin Xu","orcid":"https://orcid.org/0000-0002-8207-7313"},"institutions":[{"id":"https://openalex.org/I4210159968","display_name":"Duke Kunshan University","ror":"https://ror.org/04sr5ys16","country_code":"CN","type":"education","lineage":["https://openalex.org/I170897317","https://openalex.org/I37461747","https://openalex.org/I4210159968"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shixin Xu","raw_affiliation_strings":["Zu Chongzhi Center for Mathematics and Computational Sciences, Duke Kunshan University, Kunshan, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zu Chongzhi Center for Mathematics and Computational Sciences, Duke Kunshan University, Kunshan, Jiangsu, China","institution_ids":["https://openalex.org/I4210159968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087549934","display_name":"Roya Zandi","orcid":"https://orcid.org/0000-0001-8769-0419"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roya Zandi","raw_affiliation_strings":["Biophysics Graduate Program, University of California, Riverside, California, United States of America","Department of Physics and Astronomy, University of California, Riverside, California, United States of America","Interdisciplinary Center for Quantitative Modeling in Biology, University of California, Riverside, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Graduate Program, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Department of Physics and Astronomy, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Interdisciplinary Center for Quantitative Modeling in Biology, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047936092","display_name":"Nan Hao","orcid":"https://orcid.org/0000-0003-2857-4789"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Hao","raw_affiliation_strings":["Department of Molecular Biology, School of Biological Sciences, University of California, San Diego, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, School of Biological Sciences, University of California, San Diego, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650403","display_name":"Weitao Chen","orcid":"https://orcid.org/0000-0003-3362-5982"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weitao Chen","raw_affiliation_strings":["Biophysics Graduate Program, University of California, Riverside, California, United States of America","Department of Mathematics, University of California, Riverside, California, United States of America","Department of Molecular, Cell and Systems Biology, University of California, Riverside, California, United States of America","Interdisciplinary Center for Quantitative Modeling in Biology, University of California, Riverside, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Graduate Program, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Department of Mathematics, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Department of Molecular, Cell and Systems Biology, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Interdisciplinary Center for Quantitative Modeling in Biology, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000234159","display_name":"Mark Alber","orcid":"https://orcid.org/0000-0002-7153-1138"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Mark Alber","raw_affiliation_strings":["Biophysics Graduate Program, University of California, Riverside, California, United States of America","Department of Mathematics, University of California, Riverside, California, United States of America","Interdisciplinary Center for Quantitative Modeling in Biology, University of California, Riverside, California, United States of America","Mathematical Institute, Leiden University, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-7153-1138","affiliations":[{"raw_affiliation_string":"Biophysics Graduate Program, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Department of Mathematics, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Interdisciplinary Center for Quantitative Modeling in Biology, University of California, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Mathematical Institute, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.4965,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62335134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"20","issue":"9","first_page":"e1012491","last_page":"e1012491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.9739999771118164,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphogenesis","display_name":"Morphogenesis","score":0.7188490629196167},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7069001197814941},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.6611592769622803},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5970463752746582},{"id":"https://openalex.org/keywords/budding","display_name":"Budding","score":0.5678113698959351},{"id":"https://openalex.org/keywords/budding-yeast","display_name":"Budding yeast","score":0.4588805139064789},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.43289926648139954},{"id":"https://openalex.org/keywords/model-organism","display_name":"Model organism","score":0.429823637008667},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.3723534345626831},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.26684731245040894}],"concepts":[{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.7188490629196167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7069001197814941},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6611592769622803},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5970463752746582},{"id":"https://openalex.org/C198410946","wikidata":"https://www.wikidata.org/wiki/Q845312","display_name":"Budding","level":2,"score":0.5678113698959351},{"id":"https://openalex.org/C2992884146","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Budding yeast","level":4,"score":0.4588805139064789},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43289926648139954},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.429823637008667},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.3723534345626831},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26684731245040894},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1012491","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012491","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:39348424","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39348424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt109081xw","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/109081xw","pdf_url":"https://escholarship.org/content/qt109081xw/qt109081xw.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 20, iss 9","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11476777","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11476777","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11476777/pdf/pcbi.1012491.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:osti.gov:2449657","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/2449657","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012491","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012491","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Responsible consumption and production","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/12"}],"awards":[{"id":"https://openalex.org/G1774047169","display_name":null,"funder_award_id":"R01AG068112","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G1929891357","display_name":null,"funder_award_id":"MRI-2215705","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2029375272","display_name":null,"funder_award_id":"R01AG086348","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G2276110842","display_name":null,"funder_award_id":"74860","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G2573548193","display_name":null,"funder_award_id":"R01 AG086348","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2767063327","display_name":"MODULUS: Integrative multiscale modeling and multimodal experiments to decode systems-level molecular mecanisms of epithelial systems","funder_award_id":"2029814","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G336349173","display_name":null,"funder_award_id":"2029814, 2424826","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3894772981","display_name":null,"funder_award_id":"M21PR3267","funder_id":"https://openalex.org/F4320308590","funder_display_name":"University of California"},{"id":"https://openalex.org/G5503571670","display_name":null,"funder_award_id":"DMS-2029814","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5720237739","display_name":"CAREER: Multiscale Model for Cell Morphogenesis and Tissue Development in Plant Leaves","funder_award_id":"2338630","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5908253534","display_name":null,"funder_award_id":"DMR-2131963","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6072674921","display_name":null,"funder_award_id":"R01 GM144595","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6658815364","display_name":"Collaborative Research: eMB: Data-driven mechano-chemical  models of morphogenesis on deforming domains","funder_award_id":"2424826","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7196764177","display_name":null,"funder_award_id":"74860","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G8074115912","display_name":null,"funder_award_id":"R01 AG068112","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8238154194","display_name":null,"funder_award_id":"R01GM144595","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G8399528858","display_name":null,"funder_award_id":"R01AG056440","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G8835811235","display_name":null,"funder_award_id":"R01 AG056440","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320308590","display_name":"University of California","ror":"https://ror.org/00pjdza24"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1900964625","https://openalex.org/W1963578989","https://openalex.org/W1970247880","https://openalex.org/W1972223629","https://openalex.org/W1986589629","https://openalex.org/W1992663222","https://openalex.org/W1995973116","https://openalex.org/W2008513207","https://openalex.org/W2010109767","https://openalex.org/W2012418095","https://openalex.org/W2017529721","https://openalex.org/W2020017362","https://openalex.org/W2031361571","https://openalex.org/W2037747220","https://openalex.org/W2039219870","https://openalex.org/W2040430592","https://openalex.org/W2043204154","https://openalex.org/W2051408713","https://openalex.org/W2058462185","https://openalex.org/W2071551238","https://openalex.org/W2082483577","https://openalex.org/W2082649271","https://openalex.org/W2092587339","https://openalex.org/W2105375182","https://openalex.org/W2107625694","https://openalex.org/W2121633995","https://openalex.org/W2121874812","https://openalex.org/W2124405153","https://openalex.org/W2125914562","https://openalex.org/W2129055445","https://openalex.org/W2129614684","https://openalex.org/W2130444344","https://openalex.org/W2134949824","https://openalex.org/W2135020156","https://openalex.org/W2151395941","https://openalex.org/W2154164675","https://openalex.org/W2171202879","https://openalex.org/W2270410177","https://openalex.org/W2508179613","https://openalex.org/W2610808930","https://openalex.org/W2783010612","https://openalex.org/W2792299140","https://openalex.org/W2793567263","https://openalex.org/W2808556041","https://openalex.org/W2809114534","https://openalex.org/W2811276198","https://openalex.org/W2891983546","https://openalex.org/W2901652858","https://openalex.org/W2921688087","https://openalex.org/W2951969649","https://openalex.org/W2969001447","https://openalex.org/W2972781959","https://openalex.org/W2977158954","https://openalex.org/W3011082858","https://openalex.org/W3022605091","https://openalex.org/W3028341957","https://openalex.org/W3039957690","https://openalex.org/W3043302462","https://openalex.org/W3080726285","https://openalex.org/W3120557553","https://openalex.org/W3124060618","https://openalex.org/W3158340414","https://openalex.org/W4205239230","https://openalex.org/W4296757366","https://openalex.org/W4300979612","https://openalex.org/W4367173695"],"related_works":["https://openalex.org/W2188534709","https://openalex.org/W2207860391","https://openalex.org/W2528336156","https://openalex.org/W4250522875","https://openalex.org/W2010133910","https://openalex.org/W2464479560","https://openalex.org/W4393827685","https://openalex.org/W769743217","https://openalex.org/W2979355489","https://openalex.org/W2169256639"],"abstract_inverted_index":{"Understanding":[0],"the":[1,4,58,64,156,177,184,189,193,200,216,244,249],"mechanisms":[2],"of":[3,66,144,159,192,218,248],"cellular":[5,34,234],"aging":[6,59,68,92,145,166,235],"processes":[7],"is":[8],"crucial":[9],"for":[10,17,32],"attempting":[11],"to":[12,138,233,243],"extend":[13],"organismal":[14],"lifespan":[15,115],"and":[16,44,75,123,136,140,238,246],"studying":[18,33],"age-related":[19],"degenerative":[20],"diseases.":[21],"Yeast":[22],"cells":[23,53,87,107],"divide":[24],"through":[25],"budding,":[26,160],"providing":[27],"a":[28,180],"classical":[29],"biological":[30],"model":[31,133,151,211],"aging.":[35],"With":[36],"their":[37,114],"powerful":[38],"genetics,":[39],"relatively":[40],"short":[41],"cell":[42,220,240],"cycle,":[43],"well-established":[45],"signaling":[46],"pathways":[47],"also":[48],"found":[49],"in":[50,70,104,119,164,205,207,236],"animals,":[51],"yeast":[52,71,237],"offer":[54],"valuable":[55],"insights":[56],"into":[57,89],"process.":[60],"Recent":[61],"experiments":[62,206],"suggested":[63],"existence":[65],"two":[67,91],"modes":[69,93],"characterized":[72],"by":[73,171,183,225],"nucleolar":[74],"mitochondrial":[76],"declines,":[77],"respectively.":[78],"By":[79],"analyzing":[80],"experimental":[81],"data,":[82],"this":[83,208],"study":[84],"shows":[85],"that":[86,108,154,215],"evolving":[88],"those":[90],"behave":[94],"differently":[95],"when":[96],"they":[97],"are":[98],"young.":[99],"While":[100],"buds":[101,112],"grow":[102],"linearly":[103],"both":[105],"modes,":[106],"consistently":[109],"generate":[110],"spherical":[111],"throughout":[113],"demonstrate":[116],"greater":[117],"efficacy":[118],"controlling":[120],"bud":[121,147,162,178,195,250],"size":[122],"growth":[124],"rate":[125],"at":[126,176],"young":[127],"ages.":[128],"A":[129],"three-dimensional":[130],"multiscale":[131],"chemical-mechanical":[132],"was":[134],"developed":[135],"used":[137],"suggest":[139,214],"test":[141],"hypothesized":[142],"impacts":[143],"on":[146],"morphogenesis.":[148],"Experimentally":[149],"calibrated":[150],"simulations":[152],"showed":[153],"during":[155,199],"early":[157],"stage":[158,202],"tubular":[161,194],"shape":[163],"one":[165],"mode":[167],"could":[168,196,229],"be":[169,197,230],"generated":[170],"locally":[172],"inserting":[173],"new":[174,219],"materials":[175],"tip,":[179],"process":[181],"guided":[182],"polarized":[185],"Cdc42":[186],"signal.":[187],"Furthermore,":[188],"aspect":[190,251],"ratio":[191],"stabilized":[198],"late":[201],"as":[203],"observed":[204],"work.":[209],"The":[210],"simulation":[212],"results":[213],"localization":[217],"surface":[221],"material":[222],"insertion,":[223],"regulated":[224],"chemical":[226],"signal":[227],"polarization,":[228],"weakened":[231],"due":[232],"other":[239],"types,":[241],"leading":[242],"change":[245],"stabilization":[247],"ratio.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-07-18T07:39:51.176621","created_date":"2025-10-10T00:00:00"}
