{"id":"https://openalex.org/W4406857848","doi":"https://doi.org/10.1371/journal.pcbi.1012318","title":"Biophysical modeling and experimental analysis of the dynamics of C. elegans body-wall muscle cells","display_name":"Biophysical modeling and experimental analysis of the dynamics of C. elegans body-wall muscle cells","publication_year":2025,"publication_date":"2025-01-27","ids":{"openalex":"https://openalex.org/W4406857848","doi":"https://doi.org/10.1371/journal.pcbi.1012318","pmid":"https://pubmed.ncbi.nlm.nih.gov/39869659"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012318","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012318","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1012318","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114192055","display_name":"Xuexing Du","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuexing Du","raw_affiliation_strings":["Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China","Ministry of Education Key Laboratory of Scientific and Engineering Computing, Shanghai Jiao Tong University, Shanghai, China","School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":"https://orcid.org/0009-0002-8687-3218","affiliations":[{"raw_affiliation_string":"Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Ministry of Education Key Laboratory of Scientific and Engineering Computing, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052582483","display_name":"Jennifer Crodelle","orcid":"https://orcid.org/0000-0002-3402-4372"},"institutions":[{"id":"https://openalex.org/I195575238","display_name":"Middlebury College","ror":"https://ror.org/0217hb928","country_code":"US","type":"education","lineage":["https://openalex.org/I195575238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer Crodelle","raw_affiliation_strings":["Department of Mathematics and Statistics, Middlebury College, Middlebury, Vermont, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, Middlebury College, Middlebury, Vermont, United States of America","institution_ids":["https://openalex.org/I195575238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066544484","display_name":"Victor J. Barranca","orcid":"https://orcid.org/0000-0002-8853-7608"},"institutions":[{"id":"https://openalex.org/I118020396","display_name":"Swarthmore College","ror":"https://ror.org/012dg8a96","country_code":"US","type":"education","lineage":["https://openalex.org/I118020396"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Victor James Barranca","raw_affiliation_strings":["Department of Mathematics and Statistics, Swarthmore College, Swarthmore, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, Swarthmore College, Swarthmore, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I118020396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101467046","display_name":"Songting Li","orcid":"https://orcid.org/0000-0002-0977-6943"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Songting Li","raw_affiliation_strings":["Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China","Ministry of Education Key Laboratory of Scientific and Engineering Computing, Shanghai Jiao Tong University, Shanghai, China","School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Ministry of Education Key Laboratory of Scientific and Engineering Computing, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yunzhu Shi","orcid":null},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunzhu Shi","raw_affiliation_strings":["Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035431023","display_name":"Shangbang Gao","orcid":"https://orcid.org/0000-0001-5431-4628"},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shangbang Gao","raw_affiliation_strings":["Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067151233","display_name":"Douglas Zhou","orcid":"https://orcid.org/0000-0001-6631-2961"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Douglas Zhou","raw_affiliation_strings":["Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China","Ministry of Education Key Laboratory of Scientific and Engineering Computing, Shanghai Jiao Tong University, Shanghai, China","School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China","Shanghai Frontier Science Center of Modern Analysis, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0001-6631-2961","affiliations":[{"raw_affiliation_string":"Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Ministry of Education Key Laboratory of Scientific and Engineering Computing, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shanghai Frontier Science Center of Modern Analysis, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5035431023","https://openalex.org/A5052582483","https://openalex.org/A5066544484","https://openalex.org/A5067151233","https://openalex.org/A5101467046","https://openalex.org/A5114192055"],"corresponding_institution_ids":["https://openalex.org/I118020396","https://openalex.org/I183067930","https://openalex.org/I195575238","https://openalex.org/I47720641"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2823,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.75225965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"21","issue":"1","first_page":"e1012318","last_page":"e1012318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9569000005722046,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.7985038757324219},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6018115878105164},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.5797654390335083},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.5050724148750305},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.47538530826568604},{"id":"https://openalex.org/keywords/depolarization","display_name":"Depolarization","score":0.4716457724571228},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.44538652896881104},{"id":"https://openalex.org/keywords/parametric-model","display_name":"Parametric model","score":0.4299437701702118},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"Membrane potential","score":0.4192480444908142},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.41068035364151},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.38216105103492737},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2702571153640747},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2688433527946472},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22773608565330505},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15328794717788696}],"concepts":[{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.7985038757324219},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6018115878105164},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.5797654390335083},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5050724148750305},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.47538530826568604},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.4716457724571228},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.44538652896881104},{"id":"https://openalex.org/C24574437","wikidata":"https://www.wikidata.org/wiki/Q7135228","display_name":"Parametric model","level":3,"score":0.4299437701702118},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.4192480444908142},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.41068035364151},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38216105103492737},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2702571153640747},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2688433527946472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22773608565330505},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15328794717788696},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032342","descriptor_name":"Muscle Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1012318","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012318","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:39869659","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39869659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11781704","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11781704","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11781704/pdf/pcbi.1012318.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2dfc85d70e384463a840917476bc6aba","is_oa":true,"landing_page_url":"https://doaj.org/article/2dfc85d70e384463a840917476bc6aba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 1, p e1012318 (2025)","raw_type":"article"},{"id":"pmh:oai:works.swarthmore.edu:fac-math-stat-1321","is_oa":true,"landing_page_url":"https://works.swarthmore.edu/fac-math-stat/336","pdf_url":null,"source":{"id":"https://openalex.org/S4377196506","display_name":"Works - Scholarship, Research, & Creative Expression (Swarthmore College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I118020396","host_organization_name":"Swarthmore College","host_organization_lineage":["https://openalex.org/I118020396"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mathematics & Statistics Faculty Works","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012318","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012318","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.5699999928474426}],"awards":[{"id":"https://openalex.org/G3735139270","display_name":null,"funder_award_id":"12250710674","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4322342470","display_name":null,"funder_award_id":"No. 32371189","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4420291536","display_name":null,"funder_award_id":"2023YFF1204200","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5115323417","display_name":null,"funder_award_id":"12225109","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5983346858","display_name":null,"funder_award_id":"12271361","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6320664385","display_name":"\u795e\u7ecf\u5143\u7f51\u7edc\u5747\u8861\u6001\u52a8\u529b\u5b66\u7279\u5f81\u7684\u7814\u7a76\u4e0e\u5e94\u7528","funder_award_id":"12071287","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7432154200","display_name":null,"funder_award_id":"24JS2810400","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G7509335664","display_name":null,"funder_award_id":"32371189","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8188867759","display_name":null,"funder_award_id":"32020103007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W815205242","https://openalex.org/W1576161124","https://openalex.org/W1578017152","https://openalex.org/W1587671188","https://openalex.org/W1904905451","https://openalex.org/W1965555277","https://openalex.org/W1975214103","https://openalex.org/W1985562221","https://openalex.org/W1985690171","https://openalex.org/W1985940938","https://openalex.org/W1990323937","https://openalex.org/W1993704798","https://openalex.org/W1998612644","https://openalex.org/W2000129051","https://openalex.org/W2005532410","https://openalex.org/W2006615800","https://openalex.org/W2008002200","https://openalex.org/W2009558990","https://openalex.org/W2017888677","https://openalex.org/W2026753216","https://openalex.org/W2029063333","https://openalex.org/W2047750300","https://openalex.org/W2055435981","https://openalex.org/W2067680101","https://openalex.org/W2073612535","https://openalex.org/W2079441999","https://openalex.org/W2084636147","https://openalex.org/W2085781026","https://openalex.org/W2085967372","https://openalex.org/W2091724603","https://openalex.org/W2092236011","https://openalex.org/W2093997861","https://openalex.org/W2094409491","https://openalex.org/W2097290895","https://openalex.org/W2101899622","https://openalex.org/W2112666468","https://openalex.org/W2116079555","https://openalex.org/W2118320651","https://openalex.org/W2123976402","https://openalex.org/W2130163282","https://openalex.org/W2133351202","https://openalex.org/W2140685510","https://openalex.org/W2146252121","https://openalex.org/W2152502422","https://openalex.org/W2153110368","https://openalex.org/W2160938187","https://openalex.org/W2165618729","https://openalex.org/W2165892338","https://openalex.org/W2171794902","https://openalex.org/W2172513721","https://openalex.org/W2551595439","https://openalex.org/W2573137292","https://openalex.org/W2579882351","https://openalex.org/W2619016545","https://openalex.org/W2753890080","https://openalex.org/W2756213110","https://openalex.org/W2770531235","https://openalex.org/W2786029688","https://openalex.org/W2788759834","https://openalex.org/W2807113328","https://openalex.org/W2810616246","https://openalex.org/W2827473365","https://openalex.org/W2892156472","https://openalex.org/W2945598669","https://openalex.org/W2955244609","https://openalex.org/W3031514878","https://openalex.org/W3081344392","https://openalex.org/W3092320867","https://openalex.org/W4200585604","https://openalex.org/W4205206402","https://openalex.org/W4221167295","https://openalex.org/W4280627437","https://openalex.org/W4288050765","https://openalex.org/W4293819959","https://openalex.org/W4304731997","https://openalex.org/W4384282644","https://openalex.org/W4390113411","https://openalex.org/W4391528539","https://openalex.org/W6665983684","https://openalex.org/W6754582864","https://openalex.org/W6781024405"],"related_works":["https://openalex.org/W2026124448","https://openalex.org/W2060662231","https://openalex.org/W1991683799","https://openalex.org/W1984026462","https://openalex.org/W2039760353","https://openalex.org/W153215394","https://openalex.org/W2055246478","https://openalex.org/W1571290156","https://openalex.org/W4255426901","https://openalex.org/W2111857563"],"abstract_inverted_index":{"This":[0,90],"study":[1],"combines":[2],"experimental":[3],"techniques":[4],"and":[5,23,38,57,112,134,181,190,197],"mathematical":[6],"modeling":[7,145],"to":[8,60,103,109,128,164,205],"investigate":[9],"the":[10,32,62,68,86,101,104,146,177],"dynamics":[11,147],"of":[12,106,187],"C.":[13,188],"elegans":[14],"body-wall":[15,159],"muscle":[16,107,160,184],"cells.":[17],"Specifically,":[18],"by":[19,121],"conducting":[20],"voltage":[21],"clamp":[22],"mutant":[24,149],"experiments,":[25],"we":[26,77,152],"identify":[27],"key":[28],"ion":[29],"channels,":[30],"particularly":[31],"L-type":[33],"voltage-gated":[34],"calcium":[35],"channel":[36],"(EGL-19)":[37],"potassium":[39],"channels":[40,56],"(SHK-1,":[41],"SLO-2),":[42],"which":[43,162],"are":[44],"crucial":[45],"for":[46,54,84,143],"generating":[47],"action":[48],"potentials.":[49],"We":[50,117],"develop":[51,78],"Hodgkin-Huxley-based":[52],"models":[53],"these":[55],"integrate":[58],"them":[59],"capture":[61],"cells'":[63],"electrical":[64],"activity.":[65],"To":[66],"ensure":[67],"model":[69,102,120,186,206],"accurately":[70,144],"reflects":[71],"cellular":[72,126],"responses":[73,105,127],"under":[74],"depolarizing":[75],"currents,":[76],"a":[79,165],"parallel":[80,94],"simulation-based":[81],"inference":[82],"method":[83,91,201],"determining":[85],"model's":[87],"free":[88],"parameters.":[89],"performs":[92],"rapid":[93],"sampling":[95],"across":[96],"high-dimensional":[97],"parameter":[98,115],"spaces,":[99],"fitting":[100],"cells":[108],"specific":[110],"stimuli":[111,131],"yielding":[113],"accurate":[114],"estimates.":[116],"validate":[118],"our":[119,137,191],"comparing":[122],"its":[123],"predictions":[124],"against":[125],"various":[129],"current":[130],"in":[132,148,158,208],"experiments":[133],"show":[135],"that":[136],"approach":[138],"effectively":[139],"determines":[140],"suitable":[141],"parameters":[142],"cases.":[150],"Additionally,":[151],"discover":[153],"an":[154],"optimal":[155],"response":[156],"frequency":[157],"cells,":[161],"corresponds":[163],"burst":[166],"firing":[167,172],"mode":[168],"rather":[169],"than":[170],"regular":[171],"mode.":[173],"Our":[174],"work":[175],"provides":[176],"first":[178],"experimentally":[179],"constrained":[180],"biophysically":[182],"detailed":[183],"cell":[185],"elegans,":[189],"analytical":[192],"framework":[193],"combined":[194],"with":[195],"robust":[196],"efficient":[198],"parametric":[199],"estimation":[200],"can":[202],"be":[203],"extended":[204],"construction":[207],"other":[209],"species.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-22T08:00:12.763002","created_date":"2025-10-10T00:00:00"}