{"id":"https://openalex.org/W4405492896","doi":"https://doi.org/10.1371/journal.pcbi.1012216","title":"Model supports asymmetric regulation across the intercellular junction for collective cell polarization","display_name":"Model supports asymmetric regulation across the intercellular junction for collective cell polarization","publication_year":2024,"publication_date":"2024-12-17","ids":{"openalex":"https://openalex.org/W4405492896","doi":"https://doi.org/10.1371/journal.pcbi.1012216","pmid":"https://pubmed.ncbi.nlm.nih.gov/39689113"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012216","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012216","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012216&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012216&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098993835","display_name":"Katherine Levandosky","orcid":null},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katherine Levandosky","raw_affiliation_strings":["Department of Mathematics, Northeastern University, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Northeastern University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052281149","display_name":"Calina Copos","orcid":"https://orcid.org/0000-0002-8006-4834"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Calina Copos","raw_affiliation_strings":["Department of Biology, Northeastern University, Boston, Massachusetts, United States of America","Department of Mathematics, Northeastern University, Boston, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8006-4834","affiliations":[{"raw_affiliation_string":"Department of Biology, Northeastern University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Department of Mathematics, Northeastern University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I12912129"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052281149","https://openalex.org/A5098993835"],"corresponding_institution_ids":["https://openalex.org/I12912129"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.5212,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.65308661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"20","issue":"12","first_page":"e1012216","last_page":"e1012216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-polarity","display_name":"Cell polarity","score":0.862297773361206},{"id":"https://openalex.org/keywords/polarity","display_name":"Polarity (international relations)","score":0.6144624352455139},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.5450421571731567},{"id":"https://openalex.org/keywords/asymmetric-cell-division","display_name":"Asymmetric cell division","score":0.47677093744277954},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4596831798553467},{"id":"https://openalex.org/keywords/limiting","display_name":"Limiting","score":0.4589894711971283},{"id":"https://openalex.org/keywords/polarization","display_name":"Polarization (electrochemistry)","score":0.4425739347934723},{"id":"https://openalex.org/keywords/cell-junction","display_name":"Cell junction","score":0.4346213638782501},{"id":"https://openalex.org/keywords/cytoplasm","display_name":"Cytoplasm","score":0.4256318211555481},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.41433316469192505},{"id":"https://openalex.org/keywords/actin","display_name":"Actin","score":0.41305816173553467},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.38176706433296204},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.34884876012802124},{"id":"https://openalex.org/keywords/cell-division","display_name":"Cell division","score":0.3005681335926056},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2205994427204132},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09113115072250366}],"concepts":[{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.862297773361206},{"id":"https://openalex.org/C2777361361","wikidata":"https://www.wikidata.org/wiki/Q1112585","display_name":"Polarity (international relations)","level":3,"score":0.6144624352455139},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5450421571731567},{"id":"https://openalex.org/C2778977658","wikidata":"https://www.wikidata.org/wiki/Q4812070","display_name":"Asymmetric cell division","level":4,"score":0.47677093744277954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4596831798553467},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4589894711971283},{"id":"https://openalex.org/C205049153","wikidata":"https://www.wikidata.org/wiki/Q2698605","display_name":"Polarization (electrochemistry)","level":2,"score":0.4425739347934723},{"id":"https://openalex.org/C29350253","wikidata":"https://www.wikidata.org/wiki/Q189073","display_name":"Cell junction","level":3,"score":0.4346213638782501},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4256318211555481},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41433316469192505},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.41305816173553467},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38176706433296204},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34884876012802124},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.3005681335926056},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2205994427204132},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09113115072250366},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1012216","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012216","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012216&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:39689113","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39689113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11687927","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11687927","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11687927/pdf/pcbi.1012216.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:97f3c419198a4314b302753e01c6a4ba","is_oa":false,"landing_page_url":"https://doaj.org/article/97f3c419198a4314b302753e01c6a4ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 12, p e1012216 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012216","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012216","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012216&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6123741929","display_name":null,"funder_award_id":"DMS2209494","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405492896.pdf","grobid_xml":"https://content.openalex.org/works/W4405492896.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1536116871","https://openalex.org/W1583843945","https://openalex.org/W1930235823","https://openalex.org/W1963773881","https://openalex.org/W1965837217","https://openalex.org/W1971527051","https://openalex.org/W1974033128","https://openalex.org/W1974047237","https://openalex.org/W1974655589","https://openalex.org/W1979346765","https://openalex.org/W1979701688","https://openalex.org/W1979984413","https://openalex.org/W1981656331","https://openalex.org/W1988642695","https://openalex.org/W2002189052","https://openalex.org/W2011146811","https://openalex.org/W2012778906","https://openalex.org/W2016591815","https://openalex.org/W2019731805","https://openalex.org/W2021500235","https://openalex.org/W2027052704","https://openalex.org/W2032619326","https://openalex.org/W2036071626","https://openalex.org/W2039701501","https://openalex.org/W2040210675","https://openalex.org/W2057733044","https://openalex.org/W2067917704","https://openalex.org/W2069202441","https://openalex.org/W2077080652","https://openalex.org/W2083192142","https://openalex.org/W2090536111","https://openalex.org/W2096791952","https://openalex.org/W2098410928","https://openalex.org/W2099731590","https://openalex.org/W2124774068","https://openalex.org/W2130430747","https://openalex.org/W2133426307","https://openalex.org/W2141932305","https://openalex.org/W2151815494","https://openalex.org/W2162807561","https://openalex.org/W2163740123","https://openalex.org/W2164318727","https://openalex.org/W2168263902","https://openalex.org/W2168391253","https://openalex.org/W2169335155","https://openalex.org/W2239975768","https://openalex.org/W2260235413","https://openalex.org/W2262060930","https://openalex.org/W2329525671","https://openalex.org/W2486610915","https://openalex.org/W2550568864","https://openalex.org/W2561300890","https://openalex.org/W2562280663","https://openalex.org/W2607420905","https://openalex.org/W2610808930","https://openalex.org/W2745444063","https://openalex.org/W2771096237","https://openalex.org/W2782095023","https://openalex.org/W2896243061","https://openalex.org/W2896359189","https://openalex.org/W2951771980","https://openalex.org/W2980203451","https://openalex.org/W2997007510","https://openalex.org/W3029236276","https://openalex.org/W3034141515","https://openalex.org/W3106615546","https://openalex.org/W3215484490","https://openalex.org/W4205614716","https://openalex.org/W4283801460","https://openalex.org/W4285803258","https://openalex.org/W4297225312","https://openalex.org/W4385619992","https://openalex.org/W4388441842","https://openalex.org/W4398794090","https://openalex.org/W4399809875"],"related_works":["https://openalex.org/W2141200120","https://openalex.org/W3009711854","https://openalex.org/W2337869705","https://openalex.org/W2599684899","https://openalex.org/W2986598445","https://openalex.org/W2049035842","https://openalex.org/W2078272401","https://openalex.org/W1966072954","https://openalex.org/W1975338046","https://openalex.org/W2108905954"],"abstract_inverted_index":{"Symmetry":[0],"breaking,":[1],"which":[2],"is":[3,213,236],"ubiquitous":[4],"in":[5,30,141,221],"biological":[6,205],"cells,":[7],"functionally":[8],"enables":[9],"directed":[10],"cell":[11,26,41,103],"movement":[12,42],"and":[13,28,37,132,145,218],"organized":[14],"embryogenesis.":[15],"Prior":[16],"to":[17,22,86,90,104,107,197],"movement,":[18],"cells":[19,147],"break":[20],"symmetry":[21,111],"form":[23],"a":[24,31,121,127],"well-defined":[25],"front":[27],"rear":[29],"process":[32],"called":[33],"polarization.":[34],"In":[35,120],"developing":[36],"regenerating":[38],"tissues,":[39],"collective":[40,80],"requires":[43],"the":[44,47,50,62,72,75,114,118,138,167,176,191,199,222,231],"coordination":[45],"of":[46,49,53,65,129,137,143,156,162,178,193,224,227,233],"polarity":[48,97,139],"migration":[51],"machineries":[52],"neighboring":[54],"cells.":[55],"Though":[56],"several":[57],"works":[58],"shed":[59],"light":[60],"on":[61,71],"molecular":[63,200],"basis":[64],"polarity,":[66],"fewer":[67],"studies":[68],"have":[69],"focused":[70],"regulation":[73,155,212],"across":[74,117,166],"cell-cell":[76],"junction":[77,216],"required":[78,202],"for":[79,203],"polarization,":[81],"thus":[82],"limiting":[83],"our":[84],"ability":[85],"connect":[87],"tissue-level":[88],"dynamics":[89],"subcellular":[91],"interactions.":[92],"Here,":[93],"we":[94,124,173,208],"investigated":[95],"how":[96],"signals":[98],"are":[99],"communicated":[100],"from":[101],"one":[102],"its":[105],"neighbor":[106],"ensure":[108],"coordinated":[109],"front-to-rear":[110],"breaking":[112],"with":[113,152],"same":[115],"orientation":[116],"group.":[119],"theoretical":[122],"setting,":[123],"systematically":[125],"searched":[126],"variety":[128],"intercellular":[130],"interactions":[131,201],"identified":[133],"that":[134,210,220],"co-alignment":[135],"arrangement":[136],"axes":[140],"groups":[142],"two":[144],"four":[146],"can":[148],"only":[149],"be":[150],"achieved":[151,214],"strong":[153],"asymmetric":[154,211],"Rho":[157],"GTPases":[158],"or":[159,185],"enhanced":[160],"assembly":[161],"complementary":[163],"F-actin":[164],"structures":[165],"junction.":[168],"Our":[169],"results":[170,189],"held":[171],"if":[172],"further":[174],"assumed":[175],"presence":[177],"an":[179],"external":[180],"stimulus,":[181],"intrinsic":[182],"cell-to-cell":[183],"variability,":[184],"larger":[186],"groups.":[187],"The":[188],"underline":[190],"potential":[192],"using":[194],"quantitative":[195],"models":[196],"probe":[198],"macroscopic":[204],"phenomena.":[206],"Lastly,":[207],"posit":[209],"through":[215],"proteins":[217],"predict":[219],"absence":[223],"cytoplasmic":[225],"tails":[226],"such":[228],"linker":[229],"proteins,":[230],"likeliness":[232],"doublet":[234],"co-polarity":[235],"greatly":[237],"diminished.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}