{"id":"https://openalex.org/W4409416475","doi":"https://doi.org/10.1371/journal.pcbi.1012149","title":"Revealing non-trivial information structures in aneural biological tissues via functional connectivity","display_name":"Revealing non-trivial information structures in aneural biological tissues via functional connectivity","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409416475","doi":"https://doi.org/10.1371/journal.pcbi.1012149","pmid":"https://pubmed.ncbi.nlm.nih.gov/40228211"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012149","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012149","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1012149","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011096047","display_name":"Douglas Blackiston","orcid":"https://orcid.org/0000-0001-7231-0196"},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Blackiston","raw_affiliation_strings":["Allen Discovery Center, Tufts University, Medford, Massachusetts, United States of America","Department of Biology, Tufts University, Medford, Massachusetts, United States of America","Institute for Computationally-Designed Organisms, UVM, Burlington, Vermont and Tufts, Medford, Massachusetts, United States of America","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7231-0196","affiliations":[{"raw_affiliation_string":"Allen Discovery Center, Tufts University, Medford, Massachusetts, United States of America","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Biology, Tufts University, Medford, Massachusetts, United States of America","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Institute for Computationally-Designed Organisms, UVM, Burlington, Vermont and Tufts, Medford, Massachusetts, United States of America","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360565","display_name":"Hannah Dromiack","orcid":"https://orcid.org/0000-0003-3097-9718"},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Dromiack","raw_affiliation_strings":["BEYOND Center for Fundamental Concepts in Science, Arizona State University, Tempe, Arizona, United States of America","Department of Physics, Arizona State University, Tempe, Arizona, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3097-9718","affiliations":[{"raw_affiliation_string":"BEYOND Center for Fundamental Concepts in Science, Arizona State University, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Department of Physics, Arizona State University, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015588760","display_name":"Caitlin Grasso","orcid":"https://orcid.org/0000-0002-8286-5520"},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin Grasso","raw_affiliation_strings":["Department of Computer Science, University of Vermont, Burlington, Vermont, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Vermont, Burlington, Vermont, United States of America","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025272478","display_name":"Thomas F. Varley","orcid":"https://orcid.org/0000-0002-3317-9882"},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas F Varley","raw_affiliation_strings":["Department of Complex Systems and Data Science, University of Vermont, Burlington, Vermont, United States of America","Department of Computer Science, University of Vermont, Burlington, Vermont, United States of America","School of Informatics, Computing, and Engineering, Indiana University, Bloomington, Indiana, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-3317-9882","affiliations":[{"raw_affiliation_string":"Department of Complex Systems and Data Science, University of Vermont, Burlington, Vermont, United States of America","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Computer Science, University of Vermont, Burlington, Vermont, United States of America","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"School of Informatics, Computing, and Engineering, Indiana University, Bloomington, Indiana, United States of America","institution_ids":["https://openalex.org/I4210119109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036864421","display_name":"Douglas Moore","orcid":"https://orcid.org/0000-0003-4003-4320"},"institutions":[{"id":"https://openalex.org/I4210136390","display_name":"Alphacore (United States)","ror":"https://ror.org/032sjsv10","country_code":"US","type":"company","lineage":["https://openalex.org/I4210136390"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas G Moore","raw_affiliation_strings":["Alpha 39 Research, Tempe, Arizona, United States of America","BEYOND Center for Fundamental Concepts in Science, Arizona State University, Tempe, Arizona, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alpha 39 Research, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I4210136390"]},{"raw_affiliation_string":"BEYOND Center for Fundamental Concepts in Science, Arizona State University, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010576781","display_name":"Krishna Srinivasan","orcid":null},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna Kannan Srinivasan","raw_affiliation_strings":["Department of Complex Systems and Data Science, University of Vermont, Burlington, Vermont, United States of America","Department of Computer Science, University of Vermont, Burlington, Vermont, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Complex Systems and Data Science, University of Vermont, Burlington, Vermont, United States of America","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Computer Science, University of Vermont, Burlington, Vermont, United States of America","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002202464","display_name":"Olaf Sporns","orcid":"https://orcid.org/0000-0001-7265-4036"},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olaf Sporns","raw_affiliation_strings":["Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States of America","institution_ids":["https://openalex.org/I4210119109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113316116","display_name":"Joshua Bongard","orcid":null},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Bongard","raw_affiliation_strings":["Department of Computer Science, University of Vermont, Burlington, Vermont, United States of America","Institute for Computationally-Designed Organisms, UVM, Burlington, Vermont and Tufts, Medford, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Vermont, Burlington, Vermont, United States of America","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Institute for Computationally-Designed Organisms, UVM, Burlington, Vermont and Tufts, Medford, Massachusetts, United States of America","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085228887","display_name":"Michael Levin","orcid":"https://orcid.org/0000-0001-7292-8084"},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Levin","raw_affiliation_strings":["Allen Discovery Center, Tufts University, Medford, Massachusetts, United States of America","Department of Biology, Tufts University, Medford, Massachusetts, United States of America","Institute for Computationally-Designed Organisms, UVM, Burlington, Vermont and Tufts, Medford, Massachusetts, United States of America","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allen Discovery Center, Tufts University, Medford, Massachusetts, United States of America","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Biology, Tufts University, Medford, Massachusetts, United States of America","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Institute for Computationally-Designed Organisms, UVM, Burlington, Vermont and Tufts, Medford, Massachusetts, United States of America","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088286793","display_name":"Sara Imari Walker","orcid":"https://orcid.org/0000-0001-5779-2772"},"institutions":[{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara I Walker","raw_affiliation_strings":["BEYOND Center for Fundamental Concepts in Science, Arizona State University, Tempe, Arizona, United States of America","Santa Fe Institute, Santa Fe, New Mexico, United States of America","School of Earth and Space Exploration, Arizona State University, Tempe, Arizona, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5779-2772","affiliations":[{"raw_affiliation_string":"BEYOND Center for Fundamental Concepts in Science, Arizona State University, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Santa Fe Institute, Santa Fe, New Mexico, United States of America","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"School of Earth and Space Exploration, Arizona State University, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":8.4421,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.97795,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"21","issue":"4","first_page":"e1012149","last_page":"e1012149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12813","display_name":"Plant and Biological Electrophysiology Studies","score":0.9902999997138977,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5533556342124939},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5416517853736877},{"id":"https://openalex.org/keywords/xenopus","display_name":"Xenopus","score":0.4742661714553833},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4654890298843384},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.45666390657424927},{"id":"https://openalex.org/keywords/organoid","display_name":"Organoid","score":0.45308011770248413},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.44204792380332947},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42751550674438477},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.4179689586162567},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.39930692315101624},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3377026915550232}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5533556342124939},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5416517853736877},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.4742661714553833},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4654890298843384},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45666390657424927},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.45308011770248413},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.44204792380332947},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42751550674438477},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.4179689586162567},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39930692315101624},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3377026915550232},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1371/journal.pcbi.1012149","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012149","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40228211","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40228211","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11996219","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11996219","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012149","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012149","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W899419236","https://openalex.org/W1508769776","https://openalex.org/W1965019773","https://openalex.org/W1983161750","https://openalex.org/W1987345946","https://openalex.org/W1989248251","https://openalex.org/W1995875735","https://openalex.org/W2017570951","https://openalex.org/W2018940918","https://openalex.org/W2033618759","https://openalex.org/W2041782669","https://openalex.org/W2044845657","https://openalex.org/W2051427284","https://openalex.org/W2061564920","https://openalex.org/W2063032535","https://openalex.org/W2071116308","https://openalex.org/W2076394578","https://openalex.org/W2082073167","https://openalex.org/W2084479203","https://openalex.org/W2118253874","https://openalex.org/W2120927917","https://openalex.org/W2122019197","https://openalex.org/W2123029908","https://openalex.org/W2139250080","https://openalex.org/W2140383195","https://openalex.org/W2156289700","https://openalex.org/W2156667312","https://openalex.org/W2160803964","https://openalex.org/W2166296674","https://openalex.org/W2166404638","https://openalex.org/W2167279371","https://openalex.org/W2167822639","https://openalex.org/W2186974783","https://openalex.org/W2410837675","https://openalex.org/W2510009535","https://openalex.org/W2565207773","https://openalex.org/W2586318486","https://openalex.org/W2588517580","https://openalex.org/W2596228834","https://openalex.org/W2599641104","https://openalex.org/W2606745140","https://openalex.org/W2617749727","https://openalex.org/W2626192157","https://openalex.org/W2746618017","https://openalex.org/W2796032663","https://openalex.org/W2810939025","https://openalex.org/W2889027629","https://openalex.org/W2923485613","https://openalex.org/W2952141781","https://openalex.org/W2963041679","https://openalex.org/W2981152501","https://openalex.org/W2999228461","https://openalex.org/W3033386295","https://openalex.org/W3033513666","https://openalex.org/W3035258118","https://openalex.org/W3045727900","https://openalex.org/W3047031122","https://openalex.org/W3092065379","https://openalex.org/W3092361193","https://openalex.org/W3094017755","https://openalex.org/W3101542317","https://openalex.org/W3110661317","https://openalex.org/W3111521801","https://openalex.org/W3119411185","https://openalex.org/W3123819033","https://openalex.org/W3132661792","https://openalex.org/W3151434123","https://openalex.org/W3161618575","https://openalex.org/W3169192468","https://openalex.org/W4220918847","https://openalex.org/W4221102240","https://openalex.org/W4284686477","https://openalex.org/W4292998926","https://openalex.org/W4310060722","https://openalex.org/W4321002171","https://openalex.org/W4362706205","https://openalex.org/W4366602649","https://openalex.org/W4366816023","https://openalex.org/W4384820866","https://openalex.org/W4385638366","https://openalex.org/W4389098778","https://openalex.org/W4394708891","https://openalex.org/W4407960430","https://openalex.org/W6624130565"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W78967844","https://openalex.org/W3213185671","https://openalex.org/W4210989272","https://openalex.org/W4206945140","https://openalex.org/W4386628104","https://openalex.org/W2509687359","https://openalex.org/W2362023034","https://openalex.org/W2947028852","https://openalex.org/W2063941210"],"abstract_inverted_index":{"A":[0],"central":[1],"challenge":[2],"in":[3,12,92,230,247,264],"the":[4,58,74,88,102,191,214,241,291],"progression":[5],"of":[6,9,66,79,96,216,237,240,281,286,293,306],"a":[7,39,115,298],"variety":[8],"open":[10],"questions":[11],"biology,":[13],"such":[14],"as":[15],"morphogenesis,":[16],"wound":[17],"healing,":[18],"and":[19,34,76,108,113,154,177,202,204,234,254,273,302],"development,":[20],"is":[21,28,208],"learning":[22],"from":[23,45,101,133],"empirical":[24],"data":[25],"how":[26,63,257],"information":[27,77,130,288,307],"integrated":[29],"to":[30,54,72,141,232,260,270,283,296],"support":[31],"tissue-level":[32],"function":[33],"behavior.":[35],"Information-theoretic":[36],"approaches":[37],"provide":[38,297],"quantitative":[40],"framework":[41,295],"for":[42,118,164],"extracting":[43],"patterns":[44],"data,":[46],"but":[47],"so":[48],"far":[49],"have":[50],"been":[51],"predominantly":[52],"applied":[53],"neuronal":[55,265],"systems":[56],"at":[57],"tissue-level.":[59],"Here,":[60],"we":[61,86,244],"demonstrate":[62],"time":[64,134],"series":[65,135],"Ca2+":[67,246],"dynamics":[68,78],"can":[69,267],"be":[70,268],"used":[71],"identify":[73],"structure":[75,180,239],"other":[80],"biological":[81],"tissues.":[82],"To":[83],"this":[84,217],"end,":[85],"expressed":[87],"calcium":[89,110],"reporter":[90],"GCaMP6s":[91],"an":[93],"organoid":[94,159],"system":[95],"explanted":[97],"amphibian":[98],"epidermis":[99],"derived":[100,136],"African":[103],"clawed":[104],"frog":[105],"Xenopus":[106,248],"laevis,":[107],"imaged":[109],"activity":[111],"pre-":[112],"post-":[114],"puncture":[116],"injury,":[117,197,226,233],"six":[119],"replicate":[120],"organoids.":[121],"We":[122,145,157,277],"constructed":[123],"functional":[124,185,262],"connectivity":[125,166,186,263],"networks":[126,160],"by":[127],"computing":[128],"mutual":[129],"between":[131,300],"cells":[132],"using":[137],"medical":[138],"imaging":[139],"techniques":[140],"track":[142],"intracellular":[143],"Ca2+.":[144],"analyzed":[146],"network":[147],"properties":[148],"including":[149],"degree":[150,175],"distribution,":[151],"spatial":[152,182],"embedding,":[153],"modular":[155],"structure.":[156],"find":[158],"exhibit":[161],"potential":[162,292],"evidence":[163],"more":[165,303],"than":[167],"null":[168],"models,":[169],"with":[170,181],"our":[171,188,220,251,294],"models":[172,285],"displaying":[173],"high":[174],"hubs":[176],"mesoscale":[178],"community":[179],"clustering.":[183],"Utilizing":[184],"networks,":[187],"model":[189],"suggests":[190],"tissue":[192,272],"retains":[193],"non-random":[194],"features":[195],"after":[196,225],"displays":[198],"long":[199],"range":[200],"correlations":[201],"structure,":[203],"non-trivial":[205],"clustering":[206],"that":[207],"not":[209],"necessarily":[210],"spatially":[211],"dependent.":[212],"In":[213],"context":[215],"reconstruction":[218],"method":[219],"results":[221],"suggest":[222],"increased":[223],"integration":[224],"possible":[227],"cellular":[228],"coordination":[229],"response":[231],"some":[235],"type":[236],"generative":[238],"anatomy.":[242],"While":[243],"study":[245],"epidermal":[249],"cells,":[250],"computational":[252],"approach":[253],"analyses":[255,282],"highlight":[256],"methods":[258,280],"developed":[259],"analyze":[261],"tissues":[266],"generalized":[269],"any":[271],"fluorescent":[274],"signal":[275],"type.":[276],"discuss":[278],"expanded":[279],"improve":[284],"non-neuronal":[287],"processing":[289],"highlighting":[290],"bridge":[299],"neuroscience":[301],"basal":[304],"modes":[305],"processing.":[308]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6}],"updated_date":"2026-06-13T07:54:00.901334","created_date":"2025-10-10T00:00:00"}