{"id":"https://openalex.org/W4396667405","doi":"https://doi.org/10.1371/journal.pcbi.1012085","title":"Differential disruptions in population coding along the dorsal-ventral axis of CA1 in the APP/PS1 mouse model of A\u03b2 pathology","display_name":"Differential disruptions in population coding along the dorsal-ventral axis of CA1 in the APP/PS1 mouse model of A\u03b2 pathology","publication_year":2024,"publication_date":"2024-05-06","ids":{"openalex":"https://openalex.org/W4396667405","doi":"https://doi.org/10.1371/journal.pcbi.1012085"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012085","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012085","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012085&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012085&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055258237","display_name":"Udaysankar Chockanathan","orcid":"https://orcid.org/0000-0002-4469-1371"},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Udaysankar Chockanathan","raw_affiliation_strings":["Ernest J. Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","Medical Scientist Training Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","Neuroscience Graduate Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4469-1371","affiliations":[{"raw_affiliation_string":"Ernest J. Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Medical Scientist Training Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Neuroscience Graduate Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072509657","display_name":"Krishnan Padmanabhan","orcid":"https://orcid.org/0000-0002-3255-8346"},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Krishnan Padmanabhan","raw_affiliation_strings":["Intellectual and Developmental Disabilities Research Center, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","Neuroscience Graduate Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","Medical Scientist Training Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","Center for Visual Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","Ernest J. Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-3255-8346","affiliations":[{"raw_affiliation_string":"Intellectual and Developmental Disabilities Research Center, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Neuroscience Graduate Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Medical Scientist Training Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Center for Visual Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"Ernest J. Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America","institution_ids":["https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055258237","https://openalex.org/A5072509657"],"corresponding_institution_ids":["https://openalex.org/I5388228"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.5922,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.67204559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"20","issue":"5","first_page":"e1012085","last_page":"e1012085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.779688835144043},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7365362644195557},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6010745763778687},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48536813259124756},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3840416669845581},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24603590369224548}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.779688835144043},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7365362644195557},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6010745763778687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48536813259124756},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3840416669845581},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24603590369224548},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1012085","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012085","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012085&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11098488","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11098488","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11098488/pdf/pcbi.1012085.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1012085","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012085","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:6e17bd1033634df4802f2f50785f023a","is_oa":true,"landing_page_url":"https://doaj.org/article/6e17bd1033634df4802f2f50785f023a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 5, p e1012085 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012085","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012085","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012085&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5299999713897705,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2210185307","display_name":null,"funder_award_id":"T32 GM007356","funder_id":"https://openalex.org/F4320332646","funder_display_name":"Center for Visual Science"},{"id":"https://openalex.org/G2377501598","display_name":null,"funder_award_id":"T32 GM007356","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G380135951","display_name":null,"funder_award_id":"R01MH11392","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7820465813","display_name":null,"funder_award_id":"GM007356","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G829837817","display_name":null,"funder_award_id":"1749772","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308654","display_name":"Cystinosis Research Foundation","ror":"https://ror.org/045ggm846"},{"id":"https://openalex.org/F4320310246","display_name":"University of Rochester","ror":"https://ror.org/022kthw22"},{"id":"https://openalex.org/F4320313677","display_name":"Arthur J. Schmitt Foundation","ror":null},{"id":"https://openalex.org/F4320332646","display_name":"Center for Visual Science","ror":"https://ror.org/022kthw22"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4396667405.pdf"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W1517826336","https://openalex.org/W1805431826","https://openalex.org/W1886575365","https://openalex.org/W1971853827","https://openalex.org/W1974098012","https://openalex.org/W1975141413","https://openalex.org/W1982785464","https://openalex.org/W1983083547","https://openalex.org/W1983784678","https://openalex.org/W1993023011","https://openalex.org/W1999653836","https://openalex.org/W1999825136","https://openalex.org/W2010924378","https://openalex.org/W2018947767","https://openalex.org/W2020436531","https://openalex.org/W2020951538","https://openalex.org/W2021199403","https://openalex.org/W2021510996","https://openalex.org/W2027579198","https://openalex.org/W2037129823","https://openalex.org/W2038365936","https://openalex.org/W2043297459","https://openalex.org/W2048685634","https://openalex.org/W2051005796","https://openalex.org/W2052515926","https://openalex.org/W2052742260","https://openalex.org/W2052918792","https://openalex.org/W2054802697","https://openalex.org/W2055883416","https://openalex.org/W2055932491","https://openalex.org/W2062605351","https://openalex.org/W2062698830","https://openalex.org/W2067810163","https://openalex.org/W2068084797","https://openalex.org/W2070913242","https://openalex.org/W2077785499","https://openalex.org/W2078917784","https://openalex.org/W2081826483","https://openalex.org/W2082151254","https://openalex.org/W2082429191","https://openalex.org/W2086671591","https://openalex.org/W2087790185","https://openalex.org/W2087965324","https://openalex.org/W2088189569","https://openalex.org/W2092257137","https://openalex.org/W2092764200","https://openalex.org/W2109221379","https://openalex.org/W2111050644","https://openalex.org/W2117509237","https://openalex.org/W2122065036","https://openalex.org/W2122813545","https://openalex.org/W2124214624","https://openalex.org/W2126079698","https://openalex.org/W2131180711","https://openalex.org/W2138223008","https://openalex.org/W2139092938","https://openalex.org/W2141532872","https://openalex.org/W2145735461","https://openalex.org/W2145805363","https://openalex.org/W2147101007","https://openalex.org/W2147238273","https://openalex.org/W2148606196","https://openalex.org/W2150240029","https://openalex.org/W2150746478","https://openalex.org/W2156220037","https://openalex.org/W2159838014","https://openalex.org/W2167822639","https://openalex.org/W2169308121","https://openalex.org/W2171148473","https://openalex.org/W2186584449","https://openalex.org/W2239186975","https://openalex.org/W2258879186","https://openalex.org/W2293146851","https://openalex.org/W2410446460","https://openalex.org/W2465504877","https://openalex.org/W2467288641","https://openalex.org/W2474977510","https://openalex.org/W2508029759","https://openalex.org/W2513112263","https://openalex.org/W2525578234","https://openalex.org/W2527442128","https://openalex.org/W2560195555","https://openalex.org/W2566689527","https://openalex.org/W2581980900","https://openalex.org/W2605115788","https://openalex.org/W2765951602","https://openalex.org/W2783200177","https://openalex.org/W2787419526","https://openalex.org/W2811470308","https://openalex.org/W2887886989","https://openalex.org/W2893120089","https://openalex.org/W2895687586","https://openalex.org/W2910357997","https://openalex.org/W2910716778","https://openalex.org/W2949152232","https://openalex.org/W2949763225","https://openalex.org/W2952481429","https://openalex.org/W2952878217","https://openalex.org/W2955564464","https://openalex.org/W2984898909","https://openalex.org/W2989721744","https://openalex.org/W2994839442","https://openalex.org/W2994944959","https://openalex.org/W2996854824","https://openalex.org/W2999183700","https://openalex.org/W3000751455","https://openalex.org/W3033644139","https://openalex.org/W3153582690","https://openalex.org/W3154338194","https://openalex.org/W3196220433","https://openalex.org/W3201662917","https://openalex.org/W3205034325","https://openalex.org/W4214832314","https://openalex.org/W4391528506","https://openalex.org/W6682100860","https://openalex.org/W6683308368"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"Disease":[1],"(AD)":[2],"is":[3,19,47],"characterized":[4],"by":[5],"a":[6,121,131],"range":[7],"of":[8,65,100,105,133,136,176,184,232],"behavioral":[9,43,230],"alterations,":[10],"including":[11],"memory":[12],"loss":[13],"and":[14,63,81,92,109,129,158,241],"psychiatric":[15],"symptoms.":[16],"While":[17],"there":[18],"evidence":[20],"that":[21,48,191,217,227,245],"molecular":[22],"pathologies,":[23],"such":[24,41],"as":[25,118,160],"amyloid":[26],"beta":[27],"(A\u03b2),":[28],"contribute":[29],"to":[30,40,89,145,162,180,210],"AD,":[31],"it":[32],"remains":[33],"unclear":[34],"how":[35],"this":[36],"histopathology":[37],"gives":[38],"rise":[39],"disparate":[42],"deficits.":[44],"One":[45],"hypothesis":[46],"A\u03b2":[49,106,218,246],"exerts":[50,219],"differential":[51],"effects":[52,221],"on":[53,60],"neuronal":[54,75,115,239],"circuits":[55,240],"across":[56,222],"brain":[57],"regions,":[58,225],"depending":[59],"the":[61,96,134,173,181,185,192,211,228,242],"neurophysiology":[62],"connectivity":[64],"different":[66,223,243],"areas.":[67],"To":[68],"test":[69],"this,":[70],"we":[71,171,215],"recorded":[72],"from":[73],"large":[74],"populations":[76],"in":[77,95,114,141,150,196,202,206,238,249],"dorsal":[78],"CA1":[79,83],"(dCA1)":[80],"ventral":[82],"(vCA1),":[84],"two":[85],"hippocampal":[86,224],"areas":[87],"known":[88],"be":[90],"structurally":[91],"functionally":[93],"diverse,":[94],"APP/PS1":[97,142,152,207],"mouse":[98],"model":[99],"amyloidosis.":[101],"Despite":[102],"similar":[103],"levels":[104],"pathology,":[107],"dCA1":[108,198],"vCA1":[110,204],"showed":[111],"distinct":[112,220],"disruptions":[113,244],"population":[116,177,186],"activity":[117,137,178],"animals":[119],"navigated":[120],"virtual":[122],"reality":[123],"environment.":[124],"In":[125],"dCA1,":[126],"pairwise":[127],"correlations":[128,157],"entropy,":[130],"measure":[132],"diversity":[135],"patterns,":[138],"were":[139],"decreased":[140,201],"mice":[143,153,208],"relative":[144,209],"age-matched":[146],"C57BL/6":[147],"controls.":[148,165,212],"However,":[149],"vCA1,":[151],"had":[154],"increased":[155,195],"pair-wise":[156],"entropy":[159,169],"compared":[161],"age":[163],"matched":[164],"Finally,":[166],"using":[167],"maximum":[168],"models,":[170],"connected":[172],"microscopic":[174],"features":[175,183],"(correlations)":[179],"macroscopic":[182],"code":[187],"(entropy).":[188],"We":[189],"found":[190,216],"models\u2019":[193],"performance":[194],"predicting":[197,203],"activity,":[199,205],"but":[200],"Taken":[213],"together,":[214],"suggesting":[226],"various":[229],"deficits":[231],"AD":[233],"may":[234],"reflect":[235],"underlying":[236],"heterogeneities":[237],"pathology":[247],"causes":[248],"those":[250],"circuits.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-30T09:04:40.226872","created_date":"2025-10-10T00:00:00"}