{"id":"https://openalex.org/W4396214815","doi":"https://doi.org/10.1371/journal.pcbi.1012068","title":"A novel hypergraph model for identifying and prioritizing personalized drivers in cancer","display_name":"A novel hypergraph model for identifying and prioritizing personalized drivers in cancer","publication_year":2024,"publication_date":"2024-04-29","ids":{"openalex":"https://openalex.org/W4396214815","doi":"https://doi.org/10.1371/journal.pcbi.1012068","pmid":"https://pubmed.ncbi.nlm.nih.gov/38683860"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012068","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012068","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012068&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012068&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081128142","display_name":"Naiqian Zhang","orcid":"https://orcid.org/0000-0003-0800-0016"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Naiqian Zhang","raw_affiliation_strings":["School of Mathematics and Statistics, Shandong University, Weihai, China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Shandong University, Weihai, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018101012","display_name":"Fubin Ma","orcid":"https://orcid.org/0000-0001-7372-1800"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fubin Ma","raw_affiliation_strings":["School of Mathematics and Statistics, Shandong University, Weihai, China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Shandong University, Weihai, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101924086","display_name":"Dong Guo","orcid":"https://orcid.org/0000-0002-6228-0349"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210123583","display_name":"Weihai Municipal Hospital","ror":"https://ror.org/03vpa9q11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210123583"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dong Guo","raw_affiliation_strings":["Department of Central Lab, Weihai Municipal Hospital, Shandong University, Weihai, China","School of Mathematics and Statistics, Shandong University, Weihai, China"],"affiliations":[{"raw_affiliation_string":"Department of Central Lab, Weihai Municipal Hospital, Shandong University, Weihai, China","institution_ids":["https://openalex.org/I4210123583","https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Mathematics and Statistics, Shandong University, Weihai, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070743854","display_name":"Yuxuan Pang","orcid":"https://orcid.org/0000-0002-6778-7034"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuxuan Pang","raw_affiliation_strings":["SDU-ANU Joint Science College, Shandong University, Weihai, China"],"affiliations":[{"raw_affiliation_string":"SDU-ANU Joint Science College, Shandong University, Weihai, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022305660","display_name":"Chenye Wang","orcid":"https://orcid.org/0000-0001-5033-5376"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenye Wang","raw_affiliation_strings":["School of Mathematics and Statistics, Shandong University, Weihai, China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Shandong University, Weihai, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038357504","display_name":"Yusen Zhang","orcid":"https://orcid.org/0000-0003-3842-1153"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yusen Zhang","raw_affiliation_strings":["School of Mathematics and Statistics, Shandong University, Weihai, China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Shandong University, Weihai, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021047181","display_name":"Xiaoqi Zheng","orcid":"https://orcid.org/0000-0002-1832-4404"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoqi Zheng","raw_affiliation_strings":["Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100769001","display_name":"Ming\u2010Yi Wang","orcid":"https://orcid.org/0000-0002-7710-4743"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210123583","display_name":"Weihai Municipal Hospital","ror":"https://ror.org/03vpa9q11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210123583"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingyi Wang","raw_affiliation_strings":["Department of Central Lab, Weihai Municipal Hospital, Shandong University, Weihai, China","School of Mathematics and Statistics, Shandong University, Weihai, China"],"affiliations":[{"raw_affiliation_string":"Department of Central Lab, Weihai Municipal Hospital, Shandong University, Weihai, China","institution_ids":["https://openalex.org/I4210123583","https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Mathematics and Statistics, Shandong University, Weihai, China","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5018101012","https://openalex.org/A5021047181","https://openalex.org/A5022305660","https://openalex.org/A5038357504","https://openalex.org/A5070743854","https://openalex.org/A5081128142","https://openalex.org/A5100769001","https://openalex.org/A5101924086"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I183067930","https://openalex.org/I4210123583"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.1449,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.76654015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"20","issue":"4","first_page":"e1012068","last_page":"e1012068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.5510698556900024},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5231124758720398},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5085183382034302},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.5078840851783752},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4981715679168701},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4274942874908447},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3841734230518341},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.27954548597335815}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5510698556900024},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5231124758720398},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5085183382034302},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.5078840851783752},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4981715679168701},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4274942874908447},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3841734230518341},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27954548597335815}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1012068","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012068","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012068&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38683860","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38683860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11081510","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11081510","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11081510/pdf/pcbi.1012068.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:238e51f6d0b6435a86ca88e241c47540","is_oa":true,"landing_page_url":"https://doaj.org/article/238e51f6d0b6435a86ca88e241c47540","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 4, p e1012068 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012068","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012068","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012068&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1231421488","display_name":null,"funder_award_id":"under","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3907532300","display_name":null,"funder_award_id":"62072277","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3956605221","display_name":null,"funder_award_id":"61877064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G864299621","display_name":null,"funder_award_id":"61972257","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4396214815.pdf"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W46998317","https://openalex.org/W1546709038","https://openalex.org/W1982564236","https://openalex.org/W2009720434","https://openalex.org/W2088891952","https://openalex.org/W2094122486","https://openalex.org/W2096173332","https://openalex.org/W2134508297","https://openalex.org/W2152176732","https://openalex.org/W2157123927","https://openalex.org/W2158485828","https://openalex.org/W2159482845","https://openalex.org/W2168303063","https://openalex.org/W2206969062","https://openalex.org/W2215244420","https://openalex.org/W2329659234","https://openalex.org/W2403741880","https://openalex.org/W2419140434","https://openalex.org/W2558715006","https://openalex.org/W2626355241","https://openalex.org/W2784142616","https://openalex.org/W2915168078","https://openalex.org/W2921650138","https://openalex.org/W2929679098","https://openalex.org/W2959566316","https://openalex.org/W2963414755","https://openalex.org/W2983296017","https://openalex.org/W3028304854","https://openalex.org/W3035748924","https://openalex.org/W3039502227","https://openalex.org/W3047825284","https://openalex.org/W3083538704","https://openalex.org/W3104679143","https://openalex.org/W3105663757","https://openalex.org/W3107626709","https://openalex.org/W3128646645","https://openalex.org/W3130182721","https://openalex.org/W3134537321","https://openalex.org/W3145162608","https://openalex.org/W3155789909","https://openalex.org/W3159959119","https://openalex.org/W3165484362","https://openalex.org/W3165855328","https://openalex.org/W3194388440","https://openalex.org/W3195703735","https://openalex.org/W3207393606","https://openalex.org/W4205566319","https://openalex.org/W4207072382","https://openalex.org/W4220831425","https://openalex.org/W4225906571","https://openalex.org/W4230962320","https://openalex.org/W4280590223","https://openalex.org/W4294216483","https://openalex.org/W4300075680","https://openalex.org/W6684379593","https://openalex.org/W6688221520","https://openalex.org/W6791350495","https://openalex.org/W6812500106"],"related_works":["https://openalex.org/W1967821671","https://openalex.org/W3030842346","https://openalex.org/W2531653299","https://openalex.org/W1969795570","https://openalex.org/W2125789691","https://openalex.org/W2063781606","https://openalex.org/W4290263427","https://openalex.org/W2060097039","https://openalex.org/W2055789824","https://openalex.org/W3186634338"],"abstract_inverted_index":{"Cancer":[0],"development":[1],"is":[2,43],"driven":[3],"by":[4,234],"an":[5],"accumulation":[6],"of":[7,11,36,64,78,84,112,124,130,223,241,245],"a":[8,44,69,101,113,128,213],"small":[9],"number":[10],"driver":[12,38,71,85,96,160,198,228],"genetic":[13],"mutations":[14,27],"that":[15,153,187],"confer":[16],"the":[17,22,62,75,81,94,109,121,134,166,238,242],"selective":[18],"growth":[19],"advantage":[20],"to":[21,31,92,107],"cell,":[23],"while":[24],"most":[25],"passenger":[26],"do":[28],"not":[29],"contribute":[30],"tumor":[32,202,209,231,253],"progression.":[33],"The":[34,142,196],"identification":[35],"these":[37],"genes":[39,111,126,136,161,229],"responsible":[40],"for":[41,74],"tumorigenesis":[42],"crucial":[45],"step":[46,215],"in":[47,156],"designing":[48],"effective":[49],"cancer":[50,148,171],"treatments.":[51],"Although":[52],"many":[53],"computational":[54],"methods":[55,66,177],"have":[56],"been":[57],"developed":[58],"with":[59],"this":[60],"purpose,":[61],"majority":[63],"existing":[65,175],"solely":[67],"provided":[68],"single":[70,114],"gene":[72,139],"list":[73],"entire":[76],"cohort":[77],"patients,":[79],"ignoring":[80],"high":[82,243],"heterogeneity":[83,210],"events":[86],"across":[87,127,169],"patients.":[88],"It":[89],"remains":[90],"challenging":[91],"identify":[93,190],"personalized":[95,197,217,227],"genes.":[97],"Here,":[98],"we":[99],"propose":[100],"novel":[102,226],"method":[103],"(PDRWH),":[104],"which":[105],"aims":[106],"prioritize":[108],"mutated":[110],"patient":[115],"based":[116],"on":[117,120,146,230,252],"their":[118],"impact":[119],"abnormal":[122],"expression":[123,140,244],"downstream":[125],"group":[129],"patients":[131],"who":[132],"share":[133],"co-mutation":[135],"and":[137,162,193,211],"similar":[138],"profiles.":[141],"wide":[143],"experimental":[144],"results":[145,184],"16":[147],"datasets":[149],"from":[150],"TCGA":[151],"showed":[152],"PDRWH":[154,173,188],"excels":[155],"identifying":[157],"known":[158],"general":[159],"tumor-specific":[163],"drivers.":[164,195],"In":[165],"comparative":[167],"testing":[168],"five":[170],"types,":[172],"outperformed":[174],"individual-level":[176],"as":[178,180],"well":[179],"cohort-level":[181],"methods.":[182],"Our":[183],"also":[185,220],"demonstrated":[186],"could":[189,200],"both":[191],"common":[192],"rare":[194],"profiles":[199],"improve":[201],"stratification,":[203],"providing":[204],"new":[205],"insights":[206],"into":[207],"understanding":[208],"taking":[212],"further":[214],"toward":[216],"treatment.":[218],"We":[219],"validated":[221],"one":[222],"our":[224],"predicted":[225],"cell":[232,254],"proliferation":[233],"vitro":[235],"cell-based":[236],"assays,":[237],"promoting":[239],"effect":[240],"Low-density":[246],"lipoprotein":[247],"receptor-related":[248],"protein":[249],"1":[250],"(LRP1)":[251],"proliferation.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
