{"id":"https://openalex.org/W4395069719","doi":"https://doi.org/10.1371/journal.pcbi.1012066","title":"Validity conditions of approximations for a target-mediated drug disposition model: A novel first-order approximation and its comparison to other approximations","display_name":"Validity conditions of approximations for a target-mediated drug disposition model: A novel first-order approximation and its comparison to other approximations","publication_year":2024,"publication_date":"2024-04-24","ids":{"openalex":"https://openalex.org/W4395069719","doi":"https://doi.org/10.1371/journal.pcbi.1012066","pmid":"https://pubmed.ncbi.nlm.nih.gov/38656966"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012066","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012066","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1012066","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070959072","display_name":"Jong Hyuk Byun","orcid":"https://orcid.org/0000-0001-6334-8176"},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Hyuk Byun","raw_affiliation_strings":["Department of Mathematics and Institute of Mathematical Science, Pusan National University, Busan, Republic of Korea","Institute for Future Earth, Pusan National University, Busan, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-6334-8176","affiliations":[{"raw_affiliation_string":"Department of Mathematics and Institute of Mathematical Science, Pusan National University, Busan, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Institute for Future Earth, Pusan National University, Busan, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101341372","display_name":"Hye Seon Jeon","orcid":null},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hye Seon Jeon","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026070944","display_name":"Hwi\u2010yeol Yun","orcid":"https://orcid.org/0000-0001-8793-2449"},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hwi-yeol Yun","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea","Department of Bio-AI Convergence, Chungnam National University, Daejeon, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-8793-2449","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Department of Bio-AI Convergence, Chungnam National University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067034493","display_name":"Jae Kyoung Kim","orcid":"https://orcid.org/0000-0001-7842-2172"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]},{"id":"https://openalex.org/I4210158432","display_name":"National Institute for Mathematical Sciences","ror":"https://ror.org/04n7py080","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210158432"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jae Kyoung Kim","raw_affiliation_strings":["Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea","Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7842-2172","affiliations":[{"raw_affiliation_string":"Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424","https://openalex.org/I4210158432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5026070944","https://openalex.org/A5067034493","https://openalex.org/A5101341372"],"corresponding_institution_ids":["https://openalex.org/I157485424","https://openalex.org/I196345858","https://openalex.org/I4210104335","https://openalex.org/I4210158432"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.358,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.88480373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"20","issue":"4","first_page":"e1012066","last_page":"e1012066"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5623999238014221},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.513398289680481},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4769117534160614},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.43779510259628296},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.43730342388153076},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.28213590383529663},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18020975589752197}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5623999238014221},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.513398289680481},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4769117534160614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43779510259628296},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.43730342388153076},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28213590383529663},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18020975589752197}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1012066","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012066","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38656966","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38656966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11090311","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11090311","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11090311/pdf/pcbi.1012066.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1012066","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012066","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:1de7f4eb70b643da97351ebde5c34844","is_oa":true,"landing_page_url":"https://doaj.org/article/1de7f4eb70b643da97351ebde5c34844","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 4, p e1012066 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012066","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012066","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1082368316","display_name":null,"funder_award_id":"NRF\u20102022R1A2C1010929","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4338546216","display_name":null,"funder_award_id":"RS\u20102023\u201000301938","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G482713564","display_name":null,"funder_award_id":"IBS-R029-C3","funder_id":"https://openalex.org/F4320326441","funder_display_name":"Institute for Basic Science"},{"id":"https://openalex.org/G5296843710","display_name":null,"funder_award_id":"RS-2023-00210403","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8850967928","display_name":null,"funder_award_id":"R029-C3","funder_id":"https://openalex.org/F4320326441","funder_display_name":"Institute for Basic Science"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320326441","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W28215347","https://openalex.org/W76525280","https://openalex.org/W1566149917","https://openalex.org/W1572373855","https://openalex.org/W1969371715","https://openalex.org/W1980085157","https://openalex.org/W1994500037","https://openalex.org/W1998532042","https://openalex.org/W1998842497","https://openalex.org/W2000447888","https://openalex.org/W2002162541","https://openalex.org/W2002164453","https://openalex.org/W2012929832","https://openalex.org/W2016521145","https://openalex.org/W2025475039","https://openalex.org/W2034176270","https://openalex.org/W2034775283","https://openalex.org/W2038536277","https://openalex.org/W2042091666","https://openalex.org/W2054739927","https://openalex.org/W2063386545","https://openalex.org/W2075835338","https://openalex.org/W2113182862","https://openalex.org/W2164977460","https://openalex.org/W2809161909","https://openalex.org/W2950586838","https://openalex.org/W3018346404","https://openalex.org/W3019669427","https://openalex.org/W3087397444","https://openalex.org/W3094345105","https://openalex.org/W3098388038","https://openalex.org/W3165754949","https://openalex.org/W3205173002","https://openalex.org/W4311583108","https://openalex.org/W6634297730"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"Target-mediated":[0],"drug":[1,128,142,184],"disposition":[2],"(TMDD)":[3],"is":[4,123],"a":[5,9,14,110,147,171],"phenomenon":[6],"characterized":[7],"by":[8],"drug's":[10],"high-affinity":[11],"binding":[12],"to":[13,152],"target":[15,51,133],"molecule,":[16],"which":[17,72],"significantly":[18],"influences":[19],"its":[20,53],"pharmacokinetic":[21],"profile":[22],"within":[23],"an":[24],"organism.":[25],"The":[26],"comprehensive":[27],"TMDD":[28,57,89,177],"model":[29,93,102],"delineates":[30],"this":[31],"interaction,":[32],"yet":[33],"it":[34],"may":[35],"become":[36],"overly":[37],"complex":[38],"and":[39,109,149,186],"computationally":[40],"demanding":[41],"in":[42],"the":[43,50,68,84,91,96,100,105,114],"absence":[44],"of":[45,86,113],"specific":[46],"concentration":[47],"data":[48],"for":[49,140,173],"or":[52],"complexes.":[54],"Consequently,":[55],"simplified":[56,88,176],"models":[58,74,178],"employing":[59],"quasi-steady":[60],"state":[61],"approximations":[62],"(QSSAs)":[63],"have":[64],"been":[65],"introduced;":[66],"however,":[67],"precise":[69],"conditions":[70],"under":[71],"these":[73],"yield":[75],"accurate":[76],"results":[77],"require":[78],"further":[79],"elucidation.":[80],"Here,":[81],"we":[82,119],"establish":[83],"validity":[85],"three":[87],"models:":[90],"Michaelis-Menten":[92],"reduced":[94,103],"with":[95,104,154,163],"standard":[97],"QSSA":[98,107,116],"(mTMDD),":[99],"QSS":[101],"total":[106,115,132],"(qTMDD),":[108],"first-order":[111],"approximation":[112],"(pTMDD).":[117],"Specifically,":[118],"find":[120],"that":[121],"mTMDD":[122],"applicable":[124],"only":[125],"when":[126],"initial":[127],"concentrations":[129],"substantially":[130],"exceed":[131],"concentrations,":[134],"while":[135,179],"qTMDD":[136],"can":[137],"be":[138],"used":[139],"all":[141],"concentrations.":[143],"Notably,":[144],"pTMDD":[145],"offers":[146],"simpler":[148],"faster":[150],"alternative":[151],"qTMDD,":[153],"broader":[155],"applicability":[156],"than":[157],"mTMDD.":[158],"These":[159],"findings":[160,169],"are":[161],"confirmed":[162],"antibody-drug":[164],"conjugate":[165],"real-world":[166],"data.":[167],"Our":[168],"provide":[170],"framework":[172],"selecting":[174],"appropriate":[175],"ensuring":[180],"accuracy,":[181],"potentially":[182],"enhancing":[183],"development":[185],"facilitating":[187],"safer,":[188],"more":[189],"personalized":[190],"treatments.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}