{"id":"https://openalex.org/W4394769402","doi":"https://doi.org/10.1371/journal.pcbi.1012022","title":"StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling","display_name":"StellarPath: Hierarchical-vertical multi-omics classifier synergizes stable markers and interpretable similarity networks for patient profiling","publication_year":2024,"publication_date":"2024-04-12","ids":{"openalex":"https://openalex.org/W4394769402","doi":"https://doi.org/10.1371/journal.pcbi.1012022","pmid":"https://pubmed.ncbi.nlm.nih.gov/38607982"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012022","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012022","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012022&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012022&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022215099","display_name":"Luca Giudice","orcid":"https://orcid.org/0000-0003-0593-4067"},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Luca Giudice","raw_affiliation_strings":["A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0003-0593-4067","affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101615099","display_name":"Ahmed Mohamed","orcid":"https://orcid.org/0000-0003-1121-1527"},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Ahmed Mohamed","raw_affiliation_strings":["A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0003-1121-1527","affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000776705","display_name":"Tarja Malm","orcid":"https://orcid.org/0000-0002-9530-7472"},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Tarja Malm","raw_affiliation_strings":["A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland"],"raw_orcid":"https://orcid.org/0000-0002-9530-7472","affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000776705","https://openalex.org/A5022215099","https://openalex.org/A5101615099"],"corresponding_institution_ids":["https://openalex.org/I175532246"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2705,"currency":"EUR","value_usd":2917},"fwci":0.9975,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.73093857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"20","issue":"4","first_page":"e1012022","last_page":"e1012022"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.6793895959854126},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6452142000198364},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6147143244743347},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5500062704086304},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.5253902077674866},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.47566765546798706},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.44789889454841614},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.428888738155365},{"id":"https://openalex.org/keywords/similarity-measure","display_name":"Similarity measure","score":0.4181656837463379},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.41599684953689575},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.18996712565422058}],"concepts":[{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.6793895959854126},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6452142000198364},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6147143244743347},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5500062704086304},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5253902077674866},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.47566765546798706},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.44789889454841614},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.428888738155365},{"id":"https://openalex.org/C2776517306","wikidata":"https://www.wikidata.org/wiki/Q29017317","display_name":"Similarity measure","level":2,"score":0.4181656837463379},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.41599684953689575},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.18996712565422058},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1012022","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012022","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012022&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38607982","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38607982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11042724","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11042724","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11042724/pdf/pcbi.1012022.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1012022","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012022","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:21386579c61b40a0a8ea737100b45f98","is_oa":true,"landing_page_url":"https://doaj.org/article/21386579c61b40a0a8ea737100b45f98","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 4, p e1012022 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012022","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012022","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012022&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2127216948","display_name":"Research and innovation for brain health throughout life","funder_award_id":"101034307","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2713099850","display_name":"Clinical and experimental study on human neuronal circuitry and cellular heterogeneity impacted by early Alzheimer's disease -related pathology in iNPH patients (CLEAR)","funder_award_id":"339763","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G4290964515","display_name":"Yksil\u00f6llistetty Terveys \u2014 It\u00e4-Suomen yliopisto (6478/31/2019)","funder_award_id":"6478/31/2019","funder_id":"https://openalex.org/F4320328501","funder_display_name":"Business Finland"},{"id":"https://openalex.org/G4684310092","display_name":null,"funder_award_id":"339763","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320328501","display_name":"Business Finland","ror":"https://ror.org/05bgf9v38"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4394769402.pdf"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1497915798","https://openalex.org/W1511754883","https://openalex.org/W1950779829","https://openalex.org/W1983395516","https://openalex.org/W1991415686","https://openalex.org/W1992045522","https://openalex.org/W1999668761","https://openalex.org/W1999777663","https://openalex.org/W2000509813","https://openalex.org/W2011417152","https://openalex.org/W2031822229","https://openalex.org/W2043548405","https://openalex.org/W2044692345","https://openalex.org/W2061958715","https://openalex.org/W2081098333","https://openalex.org/W2101472630","https://openalex.org/W2103017472","https://openalex.org/W2103385435","https://openalex.org/W2115260641","https://openalex.org/W2116762360","https://openalex.org/W2125543544","https://openalex.org/W2126398084","https://openalex.org/W2130410032","https://openalex.org/W2133428001","https://openalex.org/W2133465414","https://openalex.org/W2135230352","https://openalex.org/W2154790710","https://openalex.org/W2156782835","https://openalex.org/W2159482845","https://openalex.org/W2162143298","https://openalex.org/W2167482691","https://openalex.org/W2172019913","https://openalex.org/W2179438025","https://openalex.org/W2219705851","https://openalex.org/W2229782077","https://openalex.org/W2236822143","https://openalex.org/W2253528542","https://openalex.org/W2285093314","https://openalex.org/W2470355111","https://openalex.org/W2557833574","https://openalex.org/W2624021832","https://openalex.org/W2796366395","https://openalex.org/W2804161943","https://openalex.org/W2807280338","https://openalex.org/W2807754974","https://openalex.org/W2897825874","https://openalex.org/W2917109272","https://openalex.org/W2922706703","https://openalex.org/W2950942463","https://openalex.org/W2963867646","https://openalex.org/W2984424339","https://openalex.org/W2993255638","https://openalex.org/W2999309192","https://openalex.org/W3005151153","https://openalex.org/W3010971361","https://openalex.org/W3010999813","https://openalex.org/W3082866537","https://openalex.org/W3095200063","https://openalex.org/W3096326190","https://openalex.org/W3096602912","https://openalex.org/W3099862724","https://openalex.org/W3107452708","https://openalex.org/W3119157777","https://openalex.org/W3126232929","https://openalex.org/W3128053495","https://openalex.org/W3128292279","https://openalex.org/W3139484903","https://openalex.org/W3139872481","https://openalex.org/W3152339141","https://openalex.org/W3210024567","https://openalex.org/W4205347394","https://openalex.org/W4207083495","https://openalex.org/W4230962320","https://openalex.org/W4254086237","https://openalex.org/W4280492560","https://openalex.org/W4282913188","https://openalex.org/W4294216483","https://openalex.org/W4294558607","https://openalex.org/W4297151314","https://openalex.org/W4310045055","https://openalex.org/W4362657526","https://openalex.org/W4392453298","https://openalex.org/W6685221449","https://openalex.org/W6689017042"],"related_works":["https://openalex.org/W4293226380","https://openalex.org/W2161444195","https://openalex.org/W2985540061","https://openalex.org/W2319693127","https://openalex.org/W308539617","https://openalex.org/W2072263576","https://openalex.org/W2474567666","https://openalex.org/W1940044583","https://openalex.org/W2806903871","https://openalex.org/W4320802053"],"abstract_inverted_index":{"The":[0,15,28],"Patient":[1],"Similarity":[2],"Network":[3],"paradigm":[4,215],"implies":[5],"modeling":[6],"the":[7,61,64,67,70,73,76,80,92,190,213],"similarity":[8,16,71,115,139],"between":[9],"patients":[10,169,194],"based":[11,170],"on":[12,60,171,207],"specific":[13],"data.":[14],"can":[17,31],"summarize":[18],"patients'":[19,143],"relationships":[20],"from":[21],"high-dimensional":[22],"data,":[23,66,129],"such":[24],"as":[25],"biological":[26],"omics.":[27],"end":[29],"PSN":[30,214],"undergo":[32],"un/supervised":[33],"learning":[34],"tasks":[35],"while":[36],"being":[37],"strongly":[38],"interpretable,":[39],"tailored":[40],"for":[41,83,121,223],"precision":[42],"medicine,":[43],"and":[44,58,79,100,113,124,135,154,159,179,204,216,221],"ready":[45],"to":[46,117,140],"be":[47],"analyzed":[48],"with":[49],"graph-theory":[50],"methods.":[51],"However,":[52],"these":[53],"benefits":[54],"are":[55],"not":[56],"guaranteed":[57],"depend":[59],"granularity":[62],"of":[63,69,75,192],"summarized":[65],"clarity":[68],"measure,":[72],"complexity":[74],"network's":[77],"topology,":[78],"implemented":[81],"methods":[82],"analysis.":[84],"To":[85],"date,":[86],"no":[87],"patient":[88,107,114,225],"classifier":[89,108],"fully":[90],"leverages":[91,110],"paradigm's":[93],"inherent":[94],"benefits.":[95],"PSNs":[96],"remain":[97],"complex,":[98],"unexploited,":[99],"meaningless.":[101],"We":[102],"present":[103],"StellarPath,":[104],"a":[105,137,208],"hierarchical-vertical":[106],"that":[109],"pathway":[111,144],"analysis":[112],"concepts":[116],"find":[118],"meaningful":[119],"features":[120],"both":[122],"classes":[123],"individuals.":[125],"StellarPath":[126,174],"processes":[127],"omics":[128],"hierarchically":[130],"integrates":[131],"them":[132],"into":[133],"pathways,":[134,153],"uses":[136],"novel":[138],"measure":[141],"how":[142],"activity":[145],"is":[146],"alike.":[147],"It":[148,185,211],"selects":[149],"biologically":[150],"relevant":[151],"molecules,":[152],"networks,":[155],"considering":[156],"molecule":[157],"stability":[158],"topology.":[160],"A":[161],"graph":[162],"convolutional":[163],"neural":[164],"network":[165],"then":[166],"predicts":[167],"unknown":[168],"known":[172],"cases.":[173],"excels":[175],"in":[176,188,196],"classification":[177],"performances":[178],"computational":[180],"resources":[181],"across":[182],"sixteen":[183],"datasets.":[184],"demonstrates":[186],"proficiency":[187],"inferring":[189],"class":[191],"new":[193,218],"described":[195],"external":[197],"independent":[198],"studies,":[199],"following":[200],"its":[201],"initial":[202],"training":[203],"testing":[205],"phases":[206],"local":[209],"dataset.":[210],"advances":[212],"provides":[217],"markers,":[219],"insights,":[220],"tools":[222],"in-depth":[224],"profiling.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-16T13:24:37.021932","created_date":"2025-10-10T00:00:00"}
