{"id":"https://openalex.org/W4393928710","doi":"https://doi.org/10.1371/journal.pcbi.1012012","title":"DBDNMF: A Dual Branch Deep Neural Matrix Factorization method for drug response prediction","display_name":"DBDNMF: A Dual Branch Deep Neural Matrix Factorization method for drug response prediction","publication_year":2024,"publication_date":"2024-04-04","ids":{"openalex":"https://openalex.org/W4393928710","doi":"https://doi.org/10.1371/journal.pcbi.1012012","pmid":"https://pubmed.ncbi.nlm.nih.gov/38574114"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012012","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012012","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012012&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012012&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100387512","display_name":"Hui Liu","orcid":"https://orcid.org/0000-0001-7158-913X"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Liu","raw_affiliation_strings":["School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422352","display_name":"Feng Wang","orcid":"https://orcid.org/0000-0002-6707-4958"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Wang","raw_affiliation_strings":["School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101312615","display_name":"Jian Yu","orcid":"https://orcid.org/0000-0002-2047-2043"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Yu","raw_affiliation_strings":["School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110707618","display_name":"Yong Pan","orcid":"https://orcid.org/0000-0002-9180-0729"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Pan","raw_affiliation_strings":["School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079822453","display_name":"Chaoju Gong","orcid":"https://orcid.org/0000-0002-8058-4194"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]},{"id":"https://openalex.org/I4210143072","display_name":"Xuzhou No.1 People's Hospital","ror":"https://ror.org/05ca6eb43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143072"]},{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chaoju Gong","raw_affiliation_strings":["Department of Ophthalmology, Xuzhou First People's Hospital, Xuzhou, Jiangsu, China","School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Xuzhou First People's Hospital, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210143072","https://openalex.org/I177388780"]},{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107194340","display_name":"Liang Zhang","orcid":"https://orcid.org/0000-0002-5055-1527"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]},{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liang Zhang","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu, China","School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210132906"]},{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100351875","display_name":"Lin Zhang","orcid":"https://orcid.org/0000-0002-7404-5231"},"institutions":[{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]},{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu, China","School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I4210132906"]},{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu, China","institution_ids":["https://openalex.org/I25757504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5079822453","https://openalex.org/A5100351875","https://openalex.org/A5100387512","https://openalex.org/A5100422352","https://openalex.org/A5101312615","https://openalex.org/A5107194340","https://openalex.org/A5110707618"],"corresponding_institution_ids":["https://openalex.org/I177388780","https://openalex.org/I25757504","https://openalex.org/I4210132906","https://openalex.org/I4210143072"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.4594,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.82561367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"20","issue":"4","first_page":"e1012012","last_page":"e1012012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"Non-negative matrix factorization","score":0.699900209903717},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6014180183410645},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.5927909016609192},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5731369256973267},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5710393190383911},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.46372291445732117},{"id":"https://openalex.org/keywords/matrix","display_name":"Matrix (chemical analysis)","score":0.4330102503299713},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.42914924025535583},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.42793476581573486},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.41231292486190796},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.34210261702537537},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.0949433445930481}],"concepts":[{"id":"https://openalex.org/C152671427","wikidata":"https://www.wikidata.org/wiki/Q10843505","display_name":"Non-negative matrix factorization","level":4,"score":0.699900209903717},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6014180183410645},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.5927909016609192},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5731369256973267},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5710393190383911},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.46372291445732117},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4330102503299713},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.42914924025535583},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.42793476581573486},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.41231292486190796},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.34210261702537537},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0949433445930481},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1012012","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012012","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012012&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38574114","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38574114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11020650","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11020650","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11020650/pdf/pcbi.1012012.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1012012","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012012","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c3af2278821a42da9538528f82cc66e4","is_oa":true,"landing_page_url":"https://doaj.org/article/c3af2278821a42da9538528f82cc66e4","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 4, p e1012012 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012012","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012012","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1012012&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.5699999928474426}],"awards":[{"id":"https://openalex.org/G1143551653","display_name":null,"funder_award_id":"61971422","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1231421488","display_name":null,"funder_award_id":"under","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3744313044","display_name":null,"funder_award_id":"Social","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4020255992","display_name":null,"funder_award_id":"Project","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5939423041","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393928710.pdf","grobid_xml":"https://content.openalex.org/works/W4393928710.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1660272883","https://openalex.org/W1981711832","https://openalex.org/W2004638738","https://openalex.org/W2007178835","https://openalex.org/W2026351725","https://openalex.org/W2037406737","https://openalex.org/W2041993682","https://openalex.org/W2047198790","https://openalex.org/W2054917860","https://openalex.org/W2060204507","https://openalex.org/W2076063813","https://openalex.org/W2081808304","https://openalex.org/W2144169031","https://openalex.org/W2145962650","https://openalex.org/W2153867442","https://openalex.org/W2154196978","https://openalex.org/W2161394680","https://openalex.org/W2165534057","https://openalex.org/W2388163742","https://openalex.org/W2601380465","https://openalex.org/W2742007096","https://openalex.org/W2948897453","https://openalex.org/W2950063908","https://openalex.org/W2955502047","https://openalex.org/W2963820674","https://openalex.org/W2976952765","https://openalex.org/W3137482466","https://openalex.org/W3192677404","https://openalex.org/W3198971962","https://openalex.org/W4214499256","https://openalex.org/W4214825092","https://openalex.org/W4220941902","https://openalex.org/W4221050837","https://openalex.org/W4226103310","https://openalex.org/W4255949318","https://openalex.org/W4282572164","https://openalex.org/W4292723103","https://openalex.org/W6662155302"],"related_works":["https://openalex.org/W2127243424","https://openalex.org/W4390394189","https://openalex.org/W2037504162","https://openalex.org/W2539013788","https://openalex.org/W2792706544","https://openalex.org/W1568451138","https://openalex.org/W2156699640","https://openalex.org/W2045265907","https://openalex.org/W2972997031","https://openalex.org/W2146544734"],"abstract_inverted_index":{"Anti-cancer":[0],"response":[1,66,108,183,200],"of":[2,19,37,41,65,92,98,132,149,159,167,177,223],"cell":[3,53,135,209],"lines":[4,54,136,210],"to":[5,122,203,218],"drugs":[6,51,133,197],"is":[7,25,31],"in":[8,16,170],"urgent":[9],"need":[10],"for":[11,34,60,88,106],"individualized":[12],"precision":[13,20],"medical":[14],"decision-making":[15],"the":[17,48,89,96,124,129,142,157,175,213,220],"era":[18],"medicine.":[21],"Measurements":[22],"with":[23,198,228],"wet-experiments":[24],"time-consuming":[26],"and":[27,29,52,86,134,140,165,189,208],"expensive":[28],"it":[30],"almost":[32],"impossible":[33],"wide":[35],"ranges":[36],"application.":[38],"The":[39,191],"design":[40],"computational":[42],"models":[43],"that":[44,77,174,196],"can":[45],"precisely":[46],"predict":[47],"responses":[49],"between":[50],"could":[55],"provide":[56],"a":[57,113,147],"credible":[58],"reference":[59],"further":[61],"research.":[62],"Existing":[63],"methods":[64],"prediction":[67,91,179,184],"based":[68],"on":[69,156],"matrix":[70,145],"factorization":[71],"or":[72,80,103],"neural":[73,151],"networks":[74],"have":[75],"revealed":[76],"both":[78],"linear":[79,102],"nonlinear":[81,104],"latent":[82,130],"characteristics":[83],"are":[84,226],"applicable":[85],"effective":[87],"precise":[90],"drug":[93,107,178,182],"responses.":[94],"However,":[95],"majority":[97],"them":[99],"consider":[100],"only":[101],"relationships":[105],"prediction.":[109],"Herein,":[110],"we":[111],"propose":[112],"Dual":[114],"Branch":[115],"Deep":[116],"Neural":[117],"Matrix":[118],"Factorization":[119],"(DBDNMF)":[120],"method":[121],"address":[123],"above-mentioned":[125],"issues.":[126],"DBDNMF":[127],"learns":[128],"representation":[131],"through":[137,146],"flexible":[138],"inputs":[139],"reconstructs":[141],"partially":[143],"observed":[144],"series":[148],"hidden":[150],"network":[152],"layers.":[153],"Experimental":[154],"results":[155,194],"datasets":[158],"Cancer":[160,171],"Cell":[161],"Line":[162],"Encyclopedia":[163],"(CCLE)":[164],"Genomics":[166],"Drug":[168],"Sensitivity":[169],"(GDSC)":[172],"show":[173,195],"accuracy":[176],"exceeds":[180],"state-of-the-art":[181],"algorithms,":[185],"demonstrating":[186],"its":[187],"reliability":[188],"stability.":[190],"hierarchical":[192],"clustering":[193],"similar":[199,205],"levels":[201],"tend":[202,217],"target":[204],"signaling":[206],"pathway,":[207],"coming":[211],"from":[212],"same":[214,221],"tissue":[215],"subtype":[216],"share":[219],"pattern":[222],"response,":[224],"which":[225],"consistent":[227],"previously":[229],"published":[230],"studies.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-03-25T14:56:36.534964","created_date":"2025-10-10T00:00:00"}
