{"id":"https://openalex.org/W38527066","doi":"https://doi.org/10.1371/journal.pcbi.1011968","title":"325.\u65b0\u898f\u7d4c\u53e3\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u5264AA673\u306e\u6297\u5598\u606f\u4f5c\u7528\u6a5f\u4f5c : II.SRS-A\u306b\u5bfe\u3059\u308b\u62ee\u6297\u4f5c\u7528( \u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u7642\u6cd5(III)\u65b0\u3057\u3044\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u85ac)","display_name":"325.\u65b0\u898f\u7d4c\u53e3\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u5264AA673\u306e\u6297\u5598\u606f\u4f5c\u7528\u6a5f\u4f5c : II.SRS-A\u306b\u5bfe\u3059\u308b\u62ee\u6297\u4f5c\u7528( \u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u7642\u6cd5(III)\u65b0\u3057\u3044\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u85ac)","publication_year":1983,"publication_date":"1983-08-30","ids":{"openalex":"https://openalex.org/W38527066","doi":"https://doi.org/10.1371/journal.pcbi.1011968","mag":"38527066"},"language":"en","primary_location":{"id":"mag:38527066","is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/110002413497","pdf_url":null,"source":{"id":"https://openalex.org/S2911331770","display_name":"Arerug\u012b/Arerugi","issn_l":"0021-4884","issn":["0021-4884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arerug\u012b/Arerugi","raw_type":null},"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027103621","display_name":"\u4e45 \u6817\u6728","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u4e45 \u6817\u6728","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030616511","display_name":"\u6b66\u4fca \u897f\u6761","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6b66\u4fca \u897f\u6761","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055289312","display_name":"\u6cbb\u5f66 \u7267\u91ce","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6cbb\u5f66 \u7267\u91ce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046688930","display_name":"\u5eb7\u5b50 \u82a6\u7530","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5eb7\u5b50 \u82a6\u7530","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073827587","display_name":"\u826f\u5b5d \u7267","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u826f\u5b5d \u7267","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0028961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"8","first_page":"856","last_page":"e1011968"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9605000019073486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9605000019073486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2712959945201874}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2712959945201874}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:38527066","is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/110002413497","pdf_url":null,"source":{"id":"https://openalex.org/S2911331770","display_name":"Arerug\u012b/Arerugi","issn_l":"0021-4884","issn":["0021-4884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arerug\u012b/Arerugi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5}],"awards":[{"id":"https://openalex.org/G3713641797","display_name":null,"funder_award_id":"U24 HG012212","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G832945463","display_name":null,"funder_award_id":"U24HG012212","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Enrichment":[0],"analysis":[1,28],"is":[2],"frequently":[3],"used":[4],"in":[5,38,58,102,125,159],"combination":[6],"with":[7,68,144],"differential":[8],"expression":[9],"data":[10],"to":[11,88,118],"investigate":[12],"potential":[13],"commonalities":[14],"amongst":[15],"lists":[16],"of":[17,49,74,77,91,107,123,139,155],"genes":[18,37,109,124],"and":[19,113,147],"generate":[20],"hypotheses":[21],"for":[22,120],"further":[23],"experiments.":[24],"However,":[25],"current":[26],"enrichment":[27,162],"approaches":[29,65],"on":[30,99],"pathways":[31,67,140,156],"ignore":[32],"the":[33,55,83,89,121,128,150],"functional":[34],"relationships":[35],"between":[36],"a":[39,47,59,62],"pathway,":[40],"particularly":[41],"OR":[42],"logic":[43],"that":[44,141,149],"occurs":[45],"when":[46],"set":[48],"proteins":[50],"can":[51],"each":[52],"individually":[53],"perform":[54],"same":[56],"step":[57],"pathway.":[60],"As":[61],"result,":[63],"these":[64],"miss":[66],"large":[69],"or":[70],"multiple":[71],"sets":[72,106,117],"because":[73],"an":[75],"inflation":[76],"pathway":[78],"size":[79],"(when":[80],"measured":[81],"as":[82,110],"total":[84],"gene":[85,160],"count)":[86],"relative":[87],"number":[90,122],"steps.":[92],"We":[93,104,134],"address":[94],"this":[95,145],"problem":[96],"by":[97],"enriching":[98],"step-enabling":[100],"entities":[101],"pathways.":[103],"treat":[105],"protein-coding":[108],"single":[111],"entities,":[112],"we":[114],"also":[115],"weight":[116],"account":[119],"them":[126],"using":[127],"multivariate":[129],"Fisher's":[130],"noncentral":[131],"hypergeometric":[132],"distribution.":[133],"then":[135],"show":[136],"three":[137],"examples":[138],"are":[142],"recovered":[143],"method":[146],"find":[148],"results":[151],"have":[152],"significant":[153],"proportions":[154],"not":[157],"found":[158],"list":[161],"analysis.":[163]},"counts_by_year":[],"updated_date":"2025-07-23T07:32:55.869846","created_date":"2016-06-24T00:00:00"}