{"id":"https://openalex.org/W4401633762","doi":"https://doi.org/10.1371/journal.pcbi.1011940","title":"Spatial kinetics and immune control of murine cytomegalovirus infection in the salivary glands","display_name":"Spatial kinetics and immune control of murine cytomegalovirus infection in the salivary glands","publication_year":2024,"publication_date":"2024-08-16","ids":{"openalex":"https://openalex.org/W4401633762","doi":"https://doi.org/10.1371/journal.pcbi.1011940","pmid":"https://pubmed.ncbi.nlm.nih.gov/39150988"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011940","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011940","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011940&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011940&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058898669","display_name":"Catherine Byrne","orcid":"https://orcid.org/0000-0001-9183-3814"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Catherine M Byrne","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032455788","display_name":"Ana M\u00e1rquez","orcid":"https://orcid.org/0000-0001-9913-7688"},"institutions":[{"id":"https://openalex.org/I2802940977","display_name":"BC Centre for Disease Control","ror":"https://ror.org/05jyzx602","country_code":"CA","type":"funder","lineage":["https://openalex.org/I1308729876","https://openalex.org/I156965999","https://openalex.org/I2802940977"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Ana Citlali M\u00e1rquez","raw_affiliation_strings":["British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I2802940977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103077932","display_name":"Bing Cai","orcid":"https://orcid.org/0000-0002-3632-9866"},"institutions":[{"id":"https://openalex.org/I4210153200","display_name":"BC Children's Hospital","ror":"https://ror.org/04n901w50","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210153200"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Bing Cai","raw_affiliation_strings":["British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I4210153200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047644129","display_name":"Daniel Coombs","orcid":"https://orcid.org/0000-0002-8038-6278"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Daniel Coombs","raw_affiliation_strings":["Department of Mathematics, The University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0000-0002-8038-6278","affiliations":[{"raw_affiliation_string":"Department of Mathematics, The University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039597079","display_name":"Soren Gantt","orcid":"https://orcid.org/0000-0001-5743-3606"},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Soren Gantt","raw_affiliation_strings":["D\u00e9partement de Microbiologie, Infectiologie et Immunologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"],"raw_orcid":"https://orcid.org/0000-0001-5743-3606","affiliations":[{"raw_affiliation_string":"D\u00e9partement de Microbiologie, Infectiologie et Immunologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5032455788","https://openalex.org/A5039597079","https://openalex.org/A5047644129","https://openalex.org/A5058898669","https://openalex.org/A5103077932"],"corresponding_institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2802940977","https://openalex.org/I4210089486","https://openalex.org/I4210153200","https://openalex.org/I70931966"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7339,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.7322375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"20","issue":"8","first_page":"e1011940","last_page":"e1011940"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.8232749700546265},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.713675856590271},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.686540424823761},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.6843035817146301},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"Cytomegalovirus","score":0.6058120131492615},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5826480388641357},{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"Human cytomegalovirus","score":0.5767850279808044},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.44461682438850403},{"id":"https://openalex.org/keywords/spleen","display_name":"Spleen","score":0.42820537090301514},{"id":"https://openalex.org/keywords/immunity","display_name":"Immunity","score":0.41666683554649353},{"id":"https://openalex.org/keywords/virus-latency","display_name":"Virus latency","score":0.4140357971191406},{"id":"https://openalex.org/keywords/herpesviridae","display_name":"Herpesviridae","score":0.36014020442962646},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.32929545640945435},{"id":"https://openalex.org/keywords/viral-disease","display_name":"Viral disease","score":0.31314975023269653}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8232749700546265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.713675856590271},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.686540424823761},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6843035817146301},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.6058120131492615},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5826480388641357},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.5767850279808044},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.44461682438850403},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.42820537090301514},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.41666683554649353},{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.4140357971191406},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.36014020442962646},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.32929545640945435},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.31314975023269653}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018146","descriptor_name":"Muromegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018146","descriptor_name":"Muromegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018146","descriptor_name":"Muromegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018146","descriptor_name":"Muromegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018146","descriptor_name":"Muromegalovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018146","descriptor_name":"Muromegalovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018146","descriptor_name":"Muromegalovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018146","descriptor_name":"Muromegalovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1011940","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011940","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011940&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:39150988","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39150988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11357091","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11357091","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11357091/pdf/pcbi.1011940.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1011940","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011940","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011940","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011940","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011940&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G7838923595","display_name":null,"funder_award_id":"RGPIN-2018-05666","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401633762.pdf"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1515281699","https://openalex.org/W1544333260","https://openalex.org/W1572255594","https://openalex.org/W1910392772","https://openalex.org/W1944461161","https://openalex.org/W1968028452","https://openalex.org/W1969209186","https://openalex.org/W1971742580","https://openalex.org/W1973620681","https://openalex.org/W1977194426","https://openalex.org/W1979924927","https://openalex.org/W1987177740","https://openalex.org/W2009414050","https://openalex.org/W2013583809","https://openalex.org/W2018903405","https://openalex.org/W2020059558","https://openalex.org/W2025711278","https://openalex.org/W2049318736","https://openalex.org/W2072105499","https://openalex.org/W2072831620","https://openalex.org/W2081175226","https://openalex.org/W2092382267","https://openalex.org/W2095200251","https://openalex.org/W2103050338","https://openalex.org/W2107455909","https://openalex.org/W2108367007","https://openalex.org/W2113797309","https://openalex.org/W2115813759","https://openalex.org/W2127173326","https://openalex.org/W2141101353","https://openalex.org/W2150737854","https://openalex.org/W2151510006","https://openalex.org/W2158603770","https://openalex.org/W2165831623","https://openalex.org/W2202628408","https://openalex.org/W2277437543","https://openalex.org/W2282286414","https://openalex.org/W2302806166","https://openalex.org/W2344902925","https://openalex.org/W2521480424","https://openalex.org/W2550917340","https://openalex.org/W2569214264","https://openalex.org/W2604553471","https://openalex.org/W2763669316","https://openalex.org/W2799457316","https://openalex.org/W2903547395","https://openalex.org/W2903553017","https://openalex.org/W2921117533","https://openalex.org/W2950879364","https://openalex.org/W3009942959","https://openalex.org/W3010448212","https://openalex.org/W3010556790","https://openalex.org/W3122193668","https://openalex.org/W3194512587","https://openalex.org/W4213424120","https://openalex.org/W4288060960","https://openalex.org/W4386319480","https://openalex.org/W6910616057"],"related_works":["https://openalex.org/W3115487314","https://openalex.org/W2289321543","https://openalex.org/W2411851185","https://openalex.org/W2039484700","https://openalex.org/W2080281598","https://openalex.org/W2161016570","https://openalex.org/W2108646699","https://openalex.org/W2774889729","https://openalex.org/W2183452816","https://openalex.org/W3012542441"],"abstract_inverted_index":{"Human":[0],"cytomegalovirus":[1],"(HCMV)":[2],"is":[3],"the":[4,24,33,65,68,72,84,87,94,100,120,126,156,173,177],"most":[5],"common":[6],"congenital":[7],"infection.":[8,41,148,182],"Several":[9],"HCMV":[10],"vaccines":[11,37],"are":[12,46],"in":[13,71,93,125,162],"development,":[14],"but":[15],"none":[16],"have":[17],"yet":[18],"been":[19],"approved.":[20],"An":[21],"understanding":[22],"of":[23,26,36,50,67,111,136,146,158,170,181],"kinetics":[25],"CMV":[27,52,113],"replication":[28,53,92],"and":[29,57,79,90,96,122,129,131,153,165,179],"transmission":[30],"may":[31],"inform":[32],"rational":[34],"design":[35],"to":[38,102,151,167],"prevent":[39],"this":[40],"The":[42],"salivary":[43],"glands":[44],"(SG)":[45],"an":[47],"important":[48],"site":[49],"sustained":[51],"following":[54],"primary":[55],"infection":[56,171],"during":[58],"viral":[59,76,91,97,121],"reactivation":[60],"from":[61,99],"latency.":[62],"As":[63],"such,":[64],"strength":[66],"immune":[69,88,134,160],"response":[70,89],"SG":[73,101,174],"likely":[74],"influences":[75],"dissemination":[77,98],"within":[78,172],"between":[80,86],"hosts.":[81],"To":[82],"study":[83],"relationship":[85],"SG,":[95,127],"other":[103],"tissues,":[104],"mice":[105],"were":[106],"infected":[107],"with":[108],"low":[109],"doses":[110],"murine":[112],"(MCMV).":[114],"Following":[115],"intra-SG":[116],"inoculation,":[117],"we":[118,141],"characterized":[119],"immunological":[123],"dynamics":[124],"blood,":[128],"spleen,":[130],"identified":[132],"organ-specific":[133],"correlates":[135],"protection.":[137],"Using":[138],"these":[139],"data,":[140],"constructed":[142],"compartmental":[143],"mathematical":[144],"models":[145],"MCMV":[147],"Model":[149],"fitting":[150],"data":[152],"analysis":[154],"indicate":[155],"importance":[157],"cellular":[159],"responses":[161],"different":[163],"organs":[164],"point":[166],"a":[168],"threshold":[169],"necessary":[175],"for":[176],"establishment":[178],"spread":[180]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}