{"id":"https://openalex.org/W4392282880","doi":"https://doi.org/10.1371/journal.pcbi.1011928","title":"HormoneBayes: A novel Bayesian framework for the analysis of pulsatile hormone dynamics","display_name":"HormoneBayes: A novel Bayesian framework for the analysis of pulsatile hormone dynamics","publication_year":2024,"publication_date":"2024-02-29","ids":{"openalex":"https://openalex.org/W4392282880","doi":"https://doi.org/10.1371/journal.pcbi.1011928","pmid":"https://pubmed.ncbi.nlm.nih.gov/38422116"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011928","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011928","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011928&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011928&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070122398","display_name":"Margaritis Voliotis","orcid":"https://orcid.org/0000-0001-6488-7198"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Margaritis Voliotis","raw_affiliation_strings":["Department of Mathematics and Living Systems Institute, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6488-7198","affiliations":[{"raw_affiliation_string":"Department of Mathematics and Living Systems Institute, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059291634","display_name":"Ali Abbara","orcid":"https://orcid.org/0000-0003-2795-5256"},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ali Abbara","raw_affiliation_strings":["Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032311525","display_name":"Julia Prague","orcid":"https://orcid.org/0000-0001-6502-4757"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I2801242002","display_name":"Royal Devon and Exeter Hospital","ror":"https://ror.org/03jrh3t05","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801242002"]},{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Julia K. Prague","raw_affiliation_strings":["College of Medicine and Health, University of Exeter, Exeter, United Kingdom","Department of Diabetes and Endocrinology, MacLeod Diabetes and Endocrine Centre, Royal Devon and Exeter Hospital, Exeter, United Kingdom","Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine and Health, University of Exeter, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]},{"raw_affiliation_string":"Department of Diabetes and Endocrinology, MacLeod Diabetes and Endocrine Centre, Royal Devon and Exeter Hospital, Exeter, United Kingdom","institution_ids":["https://openalex.org/I2801242002"]},{"raw_affiliation_string":"Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003698342","display_name":"Johannes D. Veldhuis","orcid":"https://orcid.org/0000-0002-6477-7092"},"institutions":[{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Johannes D. Veldhuis","raw_affiliation_strings":["Emeritus Mayo Clinic, Rochester, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emeritus Mayo Clinic, Rochester, Michigan, United States of America","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4210111179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049466158","display_name":"Waljit S. Dhillo","orcid":"https://orcid.org/0000-0001-5950-4316"},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Waljit S. Dhillo","raw_affiliation_strings":["Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033339412","display_name":"Krasimira Tsaneva\u2010Atanasova","orcid":"https://orcid.org/0000-0002-6294-7051"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Krasimira Tsaneva-Atanasova","raw_affiliation_strings":["Department of Mathematics and Living Systems Institute, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-6294-7051","affiliations":[{"raw_affiliation_string":"Department of Mathematics and Living Systems Institute, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003698342","https://openalex.org/A5032311525","https://openalex.org/A5033339412","https://openalex.org/A5049466158","https://openalex.org/A5059291634","https://openalex.org/A5070122398"],"corresponding_institution_ids":["https://openalex.org/I23923803","https://openalex.org/I2801242002","https://openalex.org/I2801748203","https://openalex.org/I4210111179","https://openalex.org/I4210146710","https://openalex.org/I47508984"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.03259201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"20","issue":"2","first_page":"e1011928","last_page":"e1011928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11927","display_name":"Plant Reproductive Biology","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"Luteinizing hormone","score":0.661296010017395},{"id":"https://openalex.org/keywords/pulsatile-flow","display_name":"Pulsatile flow","score":0.6409846544265747},{"id":"https://openalex.org/keywords/ultradian-rhythm","display_name":"Ultradian rhythm","score":0.6117739081382751},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5240461826324463},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.5231127142906189},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"Follicle-stimulating hormone","score":0.4821428954601288},{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"Gonadotropin-releasing hormone","score":0.48127907514572144},{"id":"https://openalex.org/keywords/polycystic-ovary","display_name":"Polycystic ovary","score":0.47024005651474},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"Hypothalamus","score":0.42417576909065247},{"id":"https://openalex.org/keywords/hormone","display_name":"Hormone","score":0.40536874532699585},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36714285612106323},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3056250810623169},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"Circadian rhythm","score":0.18011131882667542},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"Insulin resistance","score":0.08163157105445862}],"concepts":[{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.661296010017395},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.6409846544265747},{"id":"https://openalex.org/C136792703","wikidata":"https://www.wikidata.org/wiki/Q377893","display_name":"Ultradian rhythm","level":3,"score":0.6117739081382751},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5240461826324463},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5231127142906189},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.4821428954601288},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.48127907514572144},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.47024005651474},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.42417576909065247},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.40536874532699585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36714285612106323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3056250810623169},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.18011131882667542},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.08163157105445862},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1011928","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011928","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011928&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38422116","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38422116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10931492","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10931492","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10931492/pdf/pcbi.1011928.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1011928","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011928","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b93b68696b0143058d9c0329bf89c500","is_oa":true,"landing_page_url":"https://doaj.org/article/b93b68696b0143058d9c0329bf89c500","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 2, p e1011928 (2024)","raw_type":"article"},{"id":"pmh:oai:https://rde.dspace-express.com:11287/623211","is_oa":true,"landing_page_url":"https://hdl.handle.net/11287/623211","pdf_url":null,"source":{"id":"https://openalex.org/S4306401891","display_name":"Royal Devon and Exeter Research Repository (Royal Devon and Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801242002","host_organization_name":"Royal Devon and Exeter Hospital","host_organization_lineage":["https://openalex.org/I2801242002"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:ore.exeter.ac.uk:10871/135461","is_oa":true,"landing_page_url":"http://hdl.handle.net/10871/135461","pdf_url":null,"source":{"id":"https://openalex.org/S4306401998","display_name":"Open Research Exeter (University of Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I23923803","host_organization_name":"University of Exeter","host_organization_lineage":["https://openalex.org/I23923803"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011928","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011928","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011928&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1436783943","display_name":null,"funder_award_id":"EP/N014391/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G175695938","display_name":null,"funder_award_id":"CS-2018","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G2356961186","display_name":"A novel mechanism underlying GnRH pulse generation by KNDy neurones","funder_award_id":"BB/S000550/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3357434843","display_name":null,"funder_award_id":"BB/W005883/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3598489648","display_name":null,"funder_award_id":"BB/S000550/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3871642164","display_name":"A novel mechanism underlying GnRH pulse generation by KNDy neurones","funder_award_id":"BB/S001255/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4269863038","display_name":null,"funder_award_id":"MR/M024954/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6634156223","display_name":null,"funder_award_id":"CS-2018-18-ST2-002","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6793727554","display_name":null,"funder_award_id":"EP/N014391/2","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G688401098","display_name":"EPSRC Centre for Predictive Modelling in Healthcare","funder_award_id":"EP/N014391/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7156302826","display_name":"EPSRC Hub for Quantitative Modelling in Healthcare","funder_award_id":"EP/T017856/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8356995930","display_name":null,"funder_award_id":"EP/T017856/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8538258685","display_name":null,"funder_award_id":"BB/S001255/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4392282880.pdf"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1511747216","https://openalex.org/W1513279135","https://openalex.org/W1545319692","https://openalex.org/W1880023255","https://openalex.org/W1983780873","https://openalex.org/W1999321551","https://openalex.org/W2037938652","https://openalex.org/W2056485240","https://openalex.org/W2077563872","https://openalex.org/W2078220496","https://openalex.org/W2106706098","https://openalex.org/W2110243057","https://openalex.org/W2178428451","https://openalex.org/W2256630402","https://openalex.org/W2289729162","https://openalex.org/W2474876498","https://openalex.org/W2482566988","https://openalex.org/W2604269555","https://openalex.org/W2767899680","https://openalex.org/W2778713681","https://openalex.org/W2883735573","https://openalex.org/W2916697480","https://openalex.org/W2917251084","https://openalex.org/W2951416778","https://openalex.org/W2981370465","https://openalex.org/W3116839761","https://openalex.org/W3166812348","https://openalex.org/W4381488301","https://openalex.org/W6680456232"],"related_works":["https://openalex.org/W80206153","https://openalex.org/W2555438545","https://openalex.org/W4387523829","https://openalex.org/W2024796694","https://openalex.org/W2410967782","https://openalex.org/W2113835591","https://openalex.org/W2583443600","https://openalex.org/W2292416077","https://openalex.org/W2607989943","https://openalex.org/W2134449442"],"abstract_inverted_index":{"The":[0,146],"hypothalamus":[1],"is":[2,17,39,56,69,93,101,106,245],"the":[3,23,70,116,198,269],"central":[4],"regulator":[5],"of":[6,12,22,75,115,243,254,274,279,284],"reproductive":[7,43,218,285],"hormone":[8,15,29,34,264,286],"secretion.":[9],"Pulsatile":[10],"secretion":[11,187],"gonadotropin":[13],"releasing":[14],"(GnRH)":[16],"fundamental":[18],"to":[19,26,87,120,136,142,151,165,271],"physiological":[20],"stimulation":[21],"pituitary":[24],"gland":[25],"release":[27],"luteinizing":[28],"(LH)":[30],"and":[31,51,68,104,169,188,191,220,224,232,266],"follicle":[32],"stimulating":[33],"(FSH).":[35],"Furthermore,":[36],"GnRH":[37],"pulsatility":[38,211],"altered":[40],"in":[41,59,96,195,212,217,222],"common":[42],"disorders":[44],"such":[45],"as":[46],"polycystic":[47],"ovary":[48],"syndrome":[49],"(PCOS)":[50],"hypothalamic":[52,153,171],"amenorrhea":[53],"(HA).":[54],"LH":[55,77,117,140,144,157,193,210],"measured":[57,80],"routinely":[58],"clinical":[60,97,214,277],"practice":[61,98],"using":[62],"an":[63],"automated":[64],"chemiluminescent":[65],"immunoassay":[66],"method":[67,177],"gold":[71],"standard":[72],"surrogate":[73],"marker":[74],"GnRH.":[76],"can":[78,132,208],"be":[79,133],"at":[81],"frequent":[82],"intervals":[83],"(e.g.,":[84,226],"10":[85],"minutely)":[86],"assess":[88,143],"GnRH/LH":[89],"pulsatility.":[90,145],"However,":[91],"this":[92,176],"rarely":[94],"done":[95],"because":[99],"it":[100],"resource":[102],"intensive,":[103],"there":[105],"no":[107],"open-access,":[108],"graphical":[109],"interface":[110],"software":[111],"for":[112,180],"computational":[113],"analysis":[114],"data":[118],"available":[119],"clinicians.":[121],"Here":[122],"we":[123],"present":[124],"hormoneBayes,":[125],"a":[126,251],"novel":[127],"open-access":[128],"Bayesian":[129],"framework":[130,147,257],"that":[131,155,175,205,246],"easily":[134],"applied":[135],"reliably":[137],"analyze":[138],"serial":[139],"measurements":[141],"utilizes":[148],"parsimonious":[149],"models":[150],"simulate":[152],"signals":[154],"drive":[156],"dynamics,":[158],"together":[159],"with":[160,197,236,282],"state-of-the-art":[161],"(sequential)":[162],"Monte-Carlo":[163],"methods":[164,260],"infer":[166],"key":[167,181],"parameters":[168,183,207],"latent":[170],"dynamics.":[172],"We":[173,203],"show":[174,204],"provides":[178,250],"estimates":[179],"pulse":[182],"including":[184,216],"inter-pulse":[185],"interval,":[186],"clearance":[189],"rates":[190],"identifies":[192],"pulses":[194],"line":[196],"widely":[199],"used":[200],"deconvolution":[201],"method.":[202],"these":[206],"distinguish":[209],"different":[213],"contexts":[215],"health":[219],"disease":[221],"men":[223],"women":[225,230,235],"healthy":[227,229],"men,":[228],"before":[231],"after":[233],"menopause,":[234],"HA":[237],"or":[238],"PCOS).":[239],"A":[240],"further":[241],"advantage":[242],"hormoneBayes":[244],"our":[247],"mathematical":[248],"approach":[249],"quantified":[252],"estimation":[253],"uncertainty.":[255],"Our":[256],"will":[258],"complement":[259],"enabling":[261],"real-time":[262],"in-vivo":[263],"monitoring":[265],"therefore":[267],"has":[268],"potential":[270],"assist":[272],"translation":[273],"personalized,":[275],"data-driven,":[276],"care":[278],"patients":[280],"presenting":[281],"conditions":[283],"dysfunction.":[287]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}