{"id":"https://openalex.org/W4390604169","doi":"https://doi.org/10.1371/journal.pcbi.1011785","title":"sc2MeNetDrug: A computational tool to uncover inter-cell signaling targets and identify relevant drugs based on single cell RNA-seq data","display_name":"sc2MeNetDrug: A computational tool to uncover inter-cell signaling targets and identify relevant drugs based on single cell RNA-seq data","publication_year":2024,"publication_date":"2024-01-05","ids":{"openalex":"https://openalex.org/W4390604169","doi":"https://doi.org/10.1371/journal.pcbi.1011785","pmid":"https://pubmed.ncbi.nlm.nih.gov/38181047"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011785","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011785","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011785&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011785&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069049743","display_name":"Jiarui Feng","orcid":"https://orcid.org/0000-0002-3409-6819"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jiarui Feng","raw_affiliation_strings":["Department of Computer Science and Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America","Institute for Informatics (I2), Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Institute for Informatics (I2), Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014356331","display_name":"S. Peter Goedegebuure","orcid":"https://orcid.org/0000-0001-7084-3378"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. Peter Goedegebuure","raw_affiliation_strings":["Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, United States of America","Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063777597","display_name":"Amanda Zeng","orcid":null},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amanda Zeng","raw_affiliation_strings":["Department of Computer Science and Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100691000","display_name":"Ye Bi","orcid":"https://orcid.org/0000-0002-3939-791X"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ye Bi","raw_affiliation_strings":["Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100427963","display_name":"Ting Wang","orcid":"https://orcid.org/0000-0002-6800-242X"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ting Wang","raw_affiliation_strings":["Department of Genetics, Washington University in St. Louis, St. Louis, Missouri, United States of America","McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I114277686","https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071367198","display_name":"Philip Payne","orcid":"https://orcid.org/0000-0002-9532-2998"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip Payne","raw_affiliation_strings":["Institute for Informatics (I2), Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Institute for Informatics (I2), Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449520","display_name":"Li Ding","orcid":"https://orcid.org/0000-0003-1517-2975"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Li Ding","raw_affiliation_strings":["Department of Genetics, Washington University in St. Louis, St. Louis, Missouri, United States of America","Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America","Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"McDonnell Genome Institute, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I114277686","https://openalex.org/I204465549"]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066901504","display_name":"David G. DeNardo","orcid":"https://orcid.org/0000-0002-3655-5783"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David DeNardo","raw_affiliation_strings":["Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, United States of America","Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060050760","display_name":"William G. Hawkins","orcid":"https://orcid.org/0000-0001-7087-3585"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William Hawkins","raw_affiliation_strings":["Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, United States of America","Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081302342","display_name":"Ryan C. Fields","orcid":"https://orcid.org/0000-0001-6176-8943"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryan C. Fields","raw_affiliation_strings":["Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, United States of America","Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100780432","display_name":"Fuhai Li","orcid":"https://orcid.org/0000-0002-3773-146X"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fuhai Li","raw_affiliation_strings":["Department of Pediatrics, Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","Institute for Informatics (I2), Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Institute for Informatics (I2), Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5014356331","https://openalex.org/A5060050760","https://openalex.org/A5063777597","https://openalex.org/A5066901504","https://openalex.org/A5069049743","https://openalex.org/A5071367198","https://openalex.org/A5081302342","https://openalex.org/A5100427963","https://openalex.org/A5100449520","https://openalex.org/A5100691000","https://openalex.org/A5100780432"],"corresponding_institution_ids":["https://openalex.org/I114277686","https://openalex.org/I204465549"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.4036,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.79325955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"e1011785","last_page":"e1011785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.5246831774711609},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5237707495689392},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5199341177940369},{"id":"https://openalex.org/keywords/cell-signaling","display_name":"Cell signaling","score":0.48947346210479736},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.43900784850120544},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35463735461235046},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.3529260456562042},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3299613893032074},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.10196614265441895},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10100725293159485}],"concepts":[{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.5246831774711609},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5237707495689392},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5199341177940369},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.48947346210479736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43900784850120544},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35463735461235046},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3529260456562042},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3299613893032074},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10196614265441895},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10100725293159485}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1011785","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011785","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011785&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38181047","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38181047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10796047","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10796047","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10796047/pdf/pcbi.1011785.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-4009","is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/3025","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:8803c78ee8174e8c9d10b0eabfe098d4","is_oa":true,"landing_page_url":"https://doaj.org/article/8803c78ee8174e8c9d10b0eabfe098d4","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 1, p e1011785 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011785","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011785","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011785&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6981070056","display_name":null,"funder_award_id":"M-II-2019-802","funder_id":"https://openalex.org/F4320311176","funder_display_name":"Children's Discovery Institute"},{"id":"https://openalex.org/G8369323886","display_name":null,"funder_award_id":"1R21AG078799-01A1","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8853103523","display_name":null,"funder_award_id":"1R01LM013902-01A1","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320311176","display_name":"Children's Discovery Institute","ror":"https://ror.org/02swjdp46"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390604169.pdf","grobid_xml":"https://content.openalex.org/works/W4390604169.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1498681739","https://openalex.org/W1560424863","https://openalex.org/W1980940682","https://openalex.org/W1996223952","https://openalex.org/W1997944395","https://openalex.org/W2000552348","https://openalex.org/W2005483591","https://openalex.org/W2042017613","https://openalex.org/W2048253455","https://openalex.org/W2066469619","https://openalex.org/W2070602352","https://openalex.org/W2086834665","https://openalex.org/W2095064853","https://openalex.org/W2103017472","https://openalex.org/W2116784956","https://openalex.org/W2130410032","https://openalex.org/W2137460766","https://openalex.org/W2146046417","https://openalex.org/W2159482845","https://openalex.org/W2165232124","https://openalex.org/W2167115031","https://openalex.org/W2170446609","https://openalex.org/W2266948109","https://openalex.org/W2612467560","https://openalex.org/W2767891136","https://openalex.org/W2772548919","https://openalex.org/W2800392236","https://openalex.org/W2805040392","https://openalex.org/W2811465553","https://openalex.org/W2886347923","https://openalex.org/W2888615663","https://openalex.org/W2898821675","https://openalex.org/W2900411771","https://openalex.org/W2900569176","https://openalex.org/W2906881526","https://openalex.org/W2942678593","https://openalex.org/W2947548345","https://openalex.org/W2949177718","https://openalex.org/W2949237386","https://openalex.org/W2949471597","https://openalex.org/W2952602120","https://openalex.org/W2954610188","https://openalex.org/W2973805821","https://openalex.org/W2991182267","https://openalex.org/W2992151131","https://openalex.org/W2997280954","https://openalex.org/W3000520074","https://openalex.org/W3007935255","https://openalex.org/W3037059823","https://openalex.org/W3131128826","https://openalex.org/W3135901822","https://openalex.org/W3146687755","https://openalex.org/W3157602736","https://openalex.org/W3164692211","https://openalex.org/W3165616893","https://openalex.org/W4220699304","https://openalex.org/W4291021602","https://openalex.org/W4313454730","https://openalex.org/W6683372584","https://openalex.org/W6755861362","https://openalex.org/W6987539266"],"related_works":["https://openalex.org/W4307993920","https://openalex.org/W1898241694","https://openalex.org/W2036616013","https://openalex.org/W4390695629","https://openalex.org/W2068787210","https://openalex.org/W3157307916","https://openalex.org/W2141091415","https://openalex.org/W2786822253","https://openalex.org/W2895456557","https://openalex.org/W4401169882"],"abstract_inverted_index":{"Single-cell":[0],"RNA":[1],"sequencing":[2],"(scRNA-seq)":[3],"is":[4],"a":[5,112,149,198],"powerful":[6],"technology":[7],"to":[8,65,88,163,203],"investigate":[9,66],"the":[10,25,67,84,90,93,171,205,212],"transcriptional":[11],"programs":[12],"in":[13,43,136,144],"stromal,":[14],"immune,":[15],"and":[16,46,49,52,69,82,102,110,118,134,179,185,221],"disease":[17,44,168],"cells,":[18,72],"like":[19],"tumor":[20,31],"cells":[21],"or":[22,30,34],"neurons":[23],"within":[24,38,167,175],"Alzheimer's":[26],"Disease":[27],"(AD)":[28],"brain":[29],"microenvironment":[32],"(ME)":[33],"niche.":[35],"Cell-cell":[36],"communications":[37,79,220],"ME":[39,81],"play":[40],"important":[41],"roles":[42],"progression":[45],"immunotherapy":[47],"response":[48],"are":[50,108,124],"novel":[51,150,217,222],"critical":[53,115],"therapeutic":[54,223],"targets.":[55],"Though":[56],"many":[57],"tools":[58],"of":[59,71,80,97,114,216],"scRNA-seq":[60,106,137,161,213],"analysis":[61,95,116,207],"have":[62,129],"been":[63],"developed":[64,148],"heterogeneity":[68],"sub-populations":[70],"few":[73],"were":[74],"designed":[75,159],"for":[76,126],"uncovering":[77],"cell-cell":[78,193],"predicting":[83],"potentially":[85,191],"effective":[86,103,187],"drugs":[87,104,188],"inhibit":[89],"communications.":[91,195],"Moreover,":[92],"data":[94,107,121,138,162,206],"processes":[96,117],"discovering":[98],"signaling":[99,173,194,219],"communication":[100],"networks":[101],"using":[105,160],"complex":[109],"involve":[111],"set":[113],"external":[119],"supportive":[120],"resources,":[122],"which":[123,209],"difficult":[125],"researchers":[127],"who":[128],"no":[130],"strong":[131],"computational":[132,152],"background":[133],"training":[135],"analysis.":[139],"To":[140],"address":[141],"these":[142],"challenges,":[143],"this":[145],"study,":[146],"we":[147],"open-source":[151],"tool,":[153],"sc2MeNetDrug":[154,196],"(https://fuhaililab.github.io/sc2MeNetDrug/).":[155],"It":[156],"was":[157],"specifically":[158],"identify":[164],"cell":[165,177,183],"types":[166,178],"MEs,":[169],"uncover":[170],"dysfunctional":[172],"pathways":[174],"individual":[176],"interactions":[180],"among":[181],"different":[182],"types,":[184],"predict":[186],"that":[189],"can":[190,210],"disrupt":[192],"provided":[197],"user-friendly":[199],"graphical":[200],"user":[201],"interface":[202],"encapsulate":[204],"modules,":[208],"facilitate":[211],"data-based":[214],"discovery":[215],"inter-cell":[218],"regimens.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}