{"id":"https://openalex.org/W4390692246","doi":"https://doi.org/10.1371/journal.pcbi.1011754","title":"Systems approach for congruence and selection of cancer models towards precision medicine","display_name":"Systems approach for congruence and selection of cancer models towards precision medicine","publication_year":2024,"publication_date":"2024-01-10","ids":{"openalex":"https://openalex.org/W4390692246","doi":"https://doi.org/10.1371/journal.pcbi.1011754","pmid":"https://pubmed.ncbi.nlm.nih.gov/38198519"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011754","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011754","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011754&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011754&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023539012","display_name":"Jian Zou","orcid":"https://orcid.org/0009-0006-9624-6487"},"institutions":[{"id":"https://openalex.org/I4210153612","display_name":"Chongqing Public Health Medical Center","ror":"https://ror.org/04dcmpg83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153612"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Zou","raw_affiliation_strings":["Department of Statistics, School of Public Health, Chongqing Medical University, Chongqing, China"],"raw_orcid":"https://orcid.org/0009-0006-9624-6487","affiliations":[{"raw_affiliation_string":"Department of Statistics, School of Public Health, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I4210153612","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088020914","display_name":"Osama Shiraz Shah","orcid":"https://orcid.org/0000-0003-4756-4535"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210097282","display_name":"Magee-Womens Research Institute","ror":"https://ror.org/00rnw4e09","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097282"]},{"id":"https://openalex.org/I4210127473","display_name":"Cancer Research Center","ror":"https://ror.org/03fbwjm33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210127473"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Osama Shah","raw_affiliation_strings":["Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Magee-Womens Research Institute, Pittsburgh, Pennsylvania, United States of America","Women's Cancer Research Center, UPMC Hillman Cancer Center (HCC), Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210097282"]},{"raw_affiliation_string":"Women's Cancer Research Center, UPMC Hillman Cancer Center (HCC), Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210127473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028190064","display_name":"Yu\u2010Chiao Chiu","orcid":"https://orcid.org/0000-0003-1647-8634"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yu-Chiao Chiu","raw_affiliation_strings":["Cancer Therapeutics Program, UPMC Hillman Cancer Center (HCC), Pittsburgh, Pennsylvania, United States of America","Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapeutics Program, UPMC Hillman Cancer Center (HCC), Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210128526"]},{"raw_affiliation_string":"Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059242731","display_name":"Tianzhou Ma","orcid":"https://orcid.org/0000-0003-3605-0811"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tianzhou Ma","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, University of Maryland, College Park, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, University of Maryland, College Park, Maryland, United States of America","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112842596","display_name":"Jennifer M. Atkinson","orcid":"https://orcid.org/0000-0001-5164-5114"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210097282","display_name":"Magee-Womens Research Institute","ror":"https://ror.org/00rnw4e09","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097282"]},{"id":"https://openalex.org/I4210127473","display_name":"Cancer Research Center","ror":"https://ror.org/03fbwjm33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210127473"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer M. Atkinson","raw_affiliation_strings":["Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Magee-Womens Research Institute, Pittsburgh, Pennsylvania, United States of America","Women's Cancer Research Center, UPMC Hillman Cancer Center (HCC), Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210097282"]},{"raw_affiliation_string":"Women's Cancer Research Center, UPMC Hillman Cancer Center (HCC), Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210127473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100889027","display_name":"Steffi Oesterreich","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210097282","display_name":"Magee-Womens Research Institute","ror":"https://ror.org/00rnw4e09","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097282"]},{"id":"https://openalex.org/I4210127473","display_name":"Cancer Research Center","ror":"https://ror.org/03fbwjm33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210127473"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steffi Oesterreich","raw_affiliation_strings":["Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Magee-Womens Research Institute, Pittsburgh, Pennsylvania, United States of America","Women's Cancer Research Center, UPMC Hillman Cancer Center (HCC), Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210097282"]},{"raw_affiliation_string":"Women's Cancer Research Center, UPMC Hillman Cancer Center (HCC), Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210127473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041977512","display_name":"Adrian V. Lee","orcid":"https://orcid.org/0000-0001-9917-514X"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210097282","display_name":"Magee-Womens Research Institute","ror":"https://ror.org/00rnw4e09","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097282"]},{"id":"https://openalex.org/I4210127473","display_name":"Cancer Research Center","ror":"https://ror.org/03fbwjm33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210127473"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adrian V. Lee","raw_affiliation_strings":["Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Magee-Womens Research Institute, Pittsburgh, Pennsylvania, United States of America","Women's Cancer Research Center, UPMC Hillman Cancer Center (HCC), Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9917-514X","affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210097282"]},{"raw_affiliation_string":"Women's Cancer Research Center, UPMC Hillman Cancer Center (HCC), Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210127473"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023821329","display_name":"George C. Tseng","orcid":"https://orcid.org/0000-0002-5447-1014"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George C. Tseng","raw_affiliation_strings":["Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5023539012","https://openalex.org/A5023821329","https://openalex.org/A5028190064","https://openalex.org/A5041977512","https://openalex.org/A5059242731","https://openalex.org/A5088020914","https://openalex.org/A5100889027","https://openalex.org/A5112842596"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210097282","https://openalex.org/I4210127473","https://openalex.org/I4210128526","https://openalex.org/I4210153612","https://openalex.org/I66946132","https://openalex.org/I87780372"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.682,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.82711817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"e1011754","last_page":"e1011754"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.6346779465675354},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5897018313407898},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.5870972275733948},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5422604084014893},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.5306645035743713},{"id":"https://openalex.org/keywords/congruence","display_name":"Congruence (geometry)","score":0.5054912567138672},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"Cancer cell lines","score":0.4703771471977234},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4332343339920044},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.41576775908470154},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"Triple-negative breast cancer","score":0.41357338428497314},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39459067583084106},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.37528717517852783},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3221879005432129},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31616657972335815},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3120189905166626},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.25501322746276855},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.21166592836380005},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.13619408011436462},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1267053186893463}],"concepts":[{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.6346779465675354},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5897018313407898},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.5870972275733948},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5422604084014893},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5306645035743713},{"id":"https://openalex.org/C132074034","wikidata":"https://www.wikidata.org/wiki/Q154210","display_name":"Congruence (geometry)","level":2,"score":0.5054912567138672},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.4703771471977234},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4332343339920044},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.41576775908470154},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.41357338428497314},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39459067583084106},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.37528717517852783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3221879005432129},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31616657972335815},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3120189905166626},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.25501322746276855},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21166592836380005},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13619408011436462},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1267053186893463},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1011754","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011754","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011754&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38198519","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38198519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10805322","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10805322","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10805322/pdf/pcbi.1011754.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d6056c710d1441368e8499b836e820b4","is_oa":true,"landing_page_url":"https://doaj.org/article/d6056c710d1441368e8499b836e820b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 1, p e1011754 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011754","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011754","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011754&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6399999856948853,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1603006142","display_name":null,"funder_award_id":"SAC110021","funder_id":"https://openalex.org/F4320311413","funder_display_name":"Susan G. Komen"},{"id":"https://openalex.org/G218842218","display_name":null,"funder_award_id":"R01LM014142","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2195582371","display_name":null,"funder_award_id":"P30CA047904","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2364596853","display_name":null,"funder_award_id":"RRID:SCR_022735","funder_id":"https://openalex.org/F4320333934","funder_display_name":"Center for Research Computing, University of Pittsburgh"},{"id":"https://openalex.org/G2592393619","display_name":null,"funder_award_id":"SCR_022735","funder_id":"https://openalex.org/F4320333934","funder_display_name":"Center for Research Computing, University of Pittsburgh"},{"id":"https://openalex.org/G338621059","display_name":null,"funder_award_id":"CA252378","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G545913016","display_name":null,"funder_award_id":"SAC160073","funder_id":"https://openalex.org/F4320311413","funder_display_name":"Susan G. Komen"},{"id":"https://openalex.org/G5480413479","display_name":null,"funder_award_id":"R01LM014142","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G5844536782","display_name":null,"funder_award_id":"P30CA047904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6084658512","display_name":null,"funder_award_id":"SCR_022735","funder_id":"https://openalex.org/F4320310174","funder_display_name":"University of Pittsburgh"},{"id":"https://openalex.org/G642779400","display_name":null,"funder_award_id":"S10OD028483","funder_id":"https://openalex.org/F4320310174","funder_display_name":"University of Pittsburgh"},{"id":"https://openalex.org/G7429738042","display_name":null,"funder_award_id":"P30CA047904","funder_id":"https://openalex.org/F4320310174","funder_display_name":"University of Pittsburgh"},{"id":"https://openalex.org/G8439618131","display_name":null,"funder_award_id":"R21LM012752","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G865749150","display_name":null,"funder_award_id":"S10OD028483","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320311413","display_name":"Susan G. Komen","ror":"https://ror.org/02nadbe75"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333934","display_name":"Center for Research Computing, University of Pittsburgh","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390692246.pdf","grobid_xml":"https://content.openalex.org/works/W4390692246.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1591396078","https://openalex.org/W1831050183","https://openalex.org/W1908864745","https://openalex.org/W1997338647","https://openalex.org/W2005829575","https://openalex.org/W2027717478","https://openalex.org/W2041455809","https://openalex.org/W2046640029","https://openalex.org/W2066122607","https://openalex.org/W2106332137","https://openalex.org/W2107665951","https://openalex.org/W2109016302","https://openalex.org/W2110065044","https://openalex.org/W2119387367","https://openalex.org/W2120865735","https://openalex.org/W2122955072","https://openalex.org/W2126728600","https://openalex.org/W2127342819","https://openalex.org/W2130410032","https://openalex.org/W2130879249","https://openalex.org/W2132619562","https://openalex.org/W2133540952","https://openalex.org/W2141224543","https://openalex.org/W2142739240","https://openalex.org/W2146907783","https://openalex.org/W2156734818","https://openalex.org/W2159482845","https://openalex.org/W2169353806","https://openalex.org/W2179438025","https://openalex.org/W2214074259","https://openalex.org/W2231812902","https://openalex.org/W2513942179","https://openalex.org/W2566148122","https://openalex.org/W2604586440","https://openalex.org/W2614443510","https://openalex.org/W2737053924","https://openalex.org/W2766498732","https://openalex.org/W2774001339","https://openalex.org/W2789183911","https://openalex.org/W2794521141","https://openalex.org/W2804974301","https://openalex.org/W2886855629","https://openalex.org/W2889326414","https://openalex.org/W2891050841","https://openalex.org/W2892236348","https://openalex.org/W2902030866","https://openalex.org/W2944727022","https://openalex.org/W2946202501","https://openalex.org/W2964233382","https://openalex.org/W2965821518","https://openalex.org/W2971567983","https://openalex.org/W2985009327","https://openalex.org/W2997733260","https://openalex.org/W3009792884","https://openalex.org/W3014321973","https://openalex.org/W3028182697","https://openalex.org/W3033746536","https://openalex.org/W3033869790","https://openalex.org/W3036962145","https://openalex.org/W3039012272","https://openalex.org/W3040646360","https://openalex.org/W3044893532","https://openalex.org/W3047194675","https://openalex.org/W3099862724","https://openalex.org/W3118931304","https://openalex.org/W3119242039","https://openalex.org/W3152491896","https://openalex.org/W3158981225","https://openalex.org/W3159143144","https://openalex.org/W3192991259","https://openalex.org/W4220854791","https://openalex.org/W4224256325","https://openalex.org/W4294216483","https://openalex.org/W4317934708","https://openalex.org/W4360871171","https://openalex.org/W4361279848","https://openalex.org/W4362549579","https://openalex.org/W6785161123"],"related_works":["https://openalex.org/W3082935376","https://openalex.org/W4386960999","https://openalex.org/W2899657781","https://openalex.org/W4322484660","https://openalex.org/W3193951088","https://openalex.org/W4388011470","https://openalex.org/W4230423494","https://openalex.org/W4298001029","https://openalex.org/W4393252403","https://openalex.org/W4383105306"],"abstract_inverted_index":{"Cancer":[0],"models":[1,93,182],"are":[2,41,168],"instrumental":[3],"as":[4,30,145],"a":[5,20,24,64,79,95],"substitute":[6],"for":[7,85,151,158,183],"human":[8,53,105],"studies":[9,157],"and":[10,15,36,55,73,81,87,107,115,139,164,178],"to":[11,44,48,52,56,119,174],"expedite":[12],"basic,":[13],"translational,":[14],"clinical":[16],"cancer":[17,22,61,92,108,124,162,176,181],"research.":[18,153],"For":[19],"given":[21],"type,":[23],"wide":[25],"selection":[26],"of":[27,75],"models,":[28,40],"such":[29],"cell":[31,149],"lines,":[32],"patient-derived":[33,165],"xenografts,":[34],"organoids":[35],"genetically":[37],"modified":[38],"murine":[39],"often":[42],"available":[43],"researchers.":[45],"However,":[46],"how":[47],"quantify":[49],"their":[50],"congruence":[51,113],"tumors":[54],"select":[57],"the":[58,89,121,146],"most":[59,90,122,147],"appropriate":[60,123],"model":[62,109,125],"is":[63,130,172],"largely":[65],"unsolved":[66],"issue.":[67],"Here,":[68],"we":[69],"present":[70],"Congruence":[71],"Analysis":[72],"Selection":[74],"CAncer":[76],"Models":[77],"(CASCAM),":[78],"statistical":[80],"machine":[82],"learning":[83],"framework":[84],"authenticating":[86],"selecting":[88],"representative":[91,148],"in":[94],"pathway-specific":[96],"manner":[97],"using":[98,132],"transcriptomic":[99],"data.":[100],"CASCAM":[101,171],"provides":[102],"harmonization":[103],"between":[104],"tumor":[106],"omics":[110],"data,":[111],"systematic":[112],"quantification,":[114],"pathway-based":[116],"topological":[117],"visualization":[118],"determine":[120],"selection.":[126],"The":[127],"systems":[128],"approach":[129],"presented":[131],"invasive":[133],"lobular":[134],"breast":[135,161],"carcinoma":[136],"(ILC)":[137],"subtype":[138,177],"suggesting":[140],"CAMA1":[141],"followed":[142],"by":[143],"UACC3133":[144],"lines":[150],"ILC":[152],"Two":[154],"additional":[155],"case":[156],"triple":[159],"negative":[160],"(TNBC)":[163],"xenograft/organoid":[166],"(PDX/PDO)":[167],"further":[169],"investigated.":[170],"generalizable":[173],"any":[175],"will":[179],"authenticate":[180],"faithful":[184],"non-human":[185],"preclinical":[186],"research":[187],"towards":[188],"precision":[189],"medicine.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-05-26T13:28:51.108037","created_date":"2025-10-10T00:00:00"}
