{"id":"https://openalex.org/W4389880977","doi":"https://doi.org/10.1371/journal.pcbi.1011708","title":"Mechanistic insight into the functional role of human sinoatrial node conduction pathways and pacemaker compartments heterogeneity: A computer model analysis","display_name":"Mechanistic insight into the functional role of human sinoatrial node conduction pathways and pacemaker compartments heterogeneity: A computer model analysis","publication_year":2023,"publication_date":"2023-12-18","ids":{"openalex":"https://openalex.org/W4389880977","doi":"https://doi.org/10.1371/journal.pcbi.1011708","pmid":"https://pubmed.ncbi.nlm.nih.gov/38109436"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011708","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011708","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1011708","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023771081","display_name":"Jichao Zhao","orcid":"https://orcid.org/0000-0003-3303-0401"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Jichao Zhao","raw_affiliation_strings":["Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand"],"affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073996618","display_name":"Roshan Sharma","orcid":null},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Roshan Sharma","raw_affiliation_strings":["Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand"],"affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008970921","display_name":"Anuradha Kalyanasundaram","orcid":"https://orcid.org/0000-0003-2432-458X"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anuradha Kalyanasundaram","raw_affiliation_strings":["Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia; The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America","Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia","The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia; The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia","institution_ids":[]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006076618","display_name":"James J. Kennelly","orcid":"https://orcid.org/0000-0002-7631-5426"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"James Kennelly","raw_affiliation_strings":["Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand"],"affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009284742","display_name":"Jieyun Bai","orcid":"https://orcid.org/0000-0002-2847-350X"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Jieyun Bai","raw_affiliation_strings":["Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand"],"affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368963","display_name":"Ning Li","orcid":"https://orcid.org/0000-0001-6750-4308"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ning Li","raw_affiliation_strings":["Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia; The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America","Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia","The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia; The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia","institution_ids":[]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023533339","display_name":"Alexander V. Panfilov","orcid":"https://orcid.org/0000-0003-2643-642X"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Alexander Panfilov","raw_affiliation_strings":["Gent University, Gent, Belgium"],"affiliations":[{"raw_affiliation_string":"Gent University, Gent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008164687","display_name":"Vadim V. Fedorov","orcid":"https://orcid.org/0000-0003-1035-4569"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vadim V. Fedorov","raw_affiliation_strings":["Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia; The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America","Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia","The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia; The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Department of Physiology & Cell Biology, Bob and Corrine Frick Center for Heart Failure and Arrhythmia","institution_ids":[]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America","institution_ids":["https://openalex.org/I2802841970"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5006076618","https://openalex.org/A5008164687","https://openalex.org/A5008970921","https://openalex.org/A5009284742","https://openalex.org/A5023533339","https://openalex.org/A5023771081","https://openalex.org/A5073996618","https://openalex.org/A5100368963"],"corresponding_institution_ids":["https://openalex.org/I154130895","https://openalex.org/I2802841970","https://openalex.org/I32597200"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.7351,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.8697011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"19","issue":"12","first_page":"e1011708","last_page":"e1011708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sinoatrial-node","display_name":"Sinoatrial node","score":0.8486621379852295},{"id":"https://openalex.org/keywords/sinus-rhythm","display_name":"Sinus rhythm","score":0.6099398732185364},{"id":"https://openalex.org/keywords/adenosine","display_name":"Adenosine","score":0.5677177906036377},{"id":"https://openalex.org/keywords/ex-vivo","display_name":"Ex vivo","score":0.554884135723114},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.47629180550575256},{"id":"https://openalex.org/keywords/electrical-conduction-system-of-the-heart","display_name":"Electrical conduction system of the heart","score":0.4352865219116211},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4235914349555969},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3884564936161041},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.3863975405693054},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37199667096138},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.3374595642089844},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.2812648415565491},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2499595284461975},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"Electrocardiography","score":0.1868038773536682},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.1772022843360901}],"concepts":[{"id":"https://openalex.org/C2778542873","wikidata":"https://www.wikidata.org/wiki/Q286020","display_name":"Sinoatrial node","level":4,"score":0.8486621379852295},{"id":"https://openalex.org/C2775914520","wikidata":"https://www.wikidata.org/wiki/Q12335414","display_name":"Sinus rhythm","level":3,"score":0.6099398732185364},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5677177906036377},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.554884135723114},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47629180550575256},{"id":"https://openalex.org/C104397207","wikidata":"https://www.wikidata.org/wiki/Q72711","display_name":"Electrical conduction system of the heart","level":3,"score":0.4352865219116211},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4235914349555969},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3884564936161041},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.3863975405693054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37199667096138},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3374595642089844},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2812648415565491},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2499595284461975},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.1868038773536682},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.1772022843360901},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1011708","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011708","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38109436","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38109436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:archive.ugent.be:01HXYW2E0NPQ97TF9EB4QTYPTV","is_oa":true,"landing_page_url":"http://hdl.handle.net/1854/LU-01HXYW2E0NPQ97TF9EB4QTYPTV","pdf_url":"https://biblio.ugent.be/publication/01HXYW2E0NPQ97TF9EB4QTYPTV/file/01HXYW9WHPKWWW6324EXPZBHY0.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1553-7358","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:10760897","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10760897","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10760897/pdf/pcbi.1011708.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:52a3118755d14e33a7bc3850f2a3f789","is_oa":true,"landing_page_url":"https://doaj.org/article/52a3118755d14e33a7bc3850f2a3f789","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 12, p e1011708 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011708","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011708","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2230864117","display_name":null,"funder_award_id":"HL115580","funder_id":"https://openalex.org/F4320320780","funder_display_name":"National Heart Foundation of New Zealand"},{"id":"https://openalex.org/G3269138130","display_name":null,"funder_award_id":"HL115580","funder_id":"https://openalex.org/F4320334749","funder_display_name":"Health Research Council of New Zealand"},{"id":"https://openalex.org/G3489908837","display_name":null,"funder_award_id":"HL135109","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4176239400","display_name":null,"funder_award_id":"21/355","funder_id":"https://openalex.org/F4320334749","funder_display_name":"Health Research Council of New Zealand"},{"id":"https://openalex.org/G4761057161","display_name":null,"funder_award_id":"HL115580","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5076696557","display_name":null,"funder_award_id":"HL115580","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6296159921","display_name":null,"funder_award_id":"HL135109","funder_id":"https://openalex.org/F4320320780","funder_display_name":"National Heart Foundation of New Zealand"},{"id":"https://openalex.org/G7194334639","display_name":null,"funder_award_id":"HL135109","funder_id":"https://openalex.org/F4320334749","funder_display_name":"Health Research Council of New Zealand"},{"id":"https://openalex.org/G820331890","display_name":null,"funder_award_id":"HL135109","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320320774","display_name":"Royal Society Te Ap\u0101rangi","ror":"https://ror.org/04tajb587"},{"id":"https://openalex.org/F4320320780","display_name":"National Heart Foundation of New Zealand","ror":"https://ror.org/02xwkbq98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334749","display_name":"Health Research Council of New Zealand","ror":"https://ror.org/00zbf3d93"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1956843844","https://openalex.org/W1968529582","https://openalex.org/W1980991616","https://openalex.org/W1993785510","https://openalex.org/W1995072913","https://openalex.org/W1997580522","https://openalex.org/W2032636400","https://openalex.org/W2032665297","https://openalex.org/W2034798701","https://openalex.org/W2052273285","https://openalex.org/W2084874490","https://openalex.org/W2106281384","https://openalex.org/W2115402966","https://openalex.org/W2127777817","https://openalex.org/W2129656446","https://openalex.org/W2143911014","https://openalex.org/W2163797200","https://openalex.org/W2166297399","https://openalex.org/W2168186911","https://openalex.org/W2203772677","https://openalex.org/W2400826384","https://openalex.org/W2501661547","https://openalex.org/W2531345437","https://openalex.org/W2533507734","https://openalex.org/W2572483377","https://openalex.org/W2586672809","https://openalex.org/W2737204392","https://openalex.org/W2748189346","https://openalex.org/W2753761054","https://openalex.org/W2768956314","https://openalex.org/W2904216605","https://openalex.org/W3001004190","https://openalex.org/W3014244669","https://openalex.org/W3088847368","https://openalex.org/W3106219733","https://openalex.org/W3156919371","https://openalex.org/W3173198643","https://openalex.org/W3202608345","https://openalex.org/W4200100685","https://openalex.org/W4295648540","https://openalex.org/W4302362385","https://openalex.org/W4324130099"],"related_works":["https://openalex.org/W2037961547","https://openalex.org/W2351679095","https://openalex.org/W1987185984","https://openalex.org/W2914484697","https://openalex.org/W2069376195","https://openalex.org/W4205550511","https://openalex.org/W2360175685","https://openalex.org/W2589411422","https://openalex.org/W83780517","https://openalex.org/W92750742"],"abstract_inverted_index":{"The":[0,190],"sinoatrial":[1,62],"node":[2],"(SAN),":[3],"the":[4,8,13,25,31,69,78,85,98,117,121,125,157,168,172,193,198,203,212,232,250,267,273],"primary":[5],"pacemaker":[6,41,159,206],"of":[7,18,24,34,50,80,88,97,108,120,128,156,195,205,214,217,272,285],"heart,":[9],"is":[10,115,176],"responsible":[11],"for":[12,178,282],"initiation":[14],"and":[15,45,54,105,132,150,160,174,182,208,220,230,258,269,276,288],"robust":[16,32,179],"regulation":[17,33],"sinus":[19,35],"rhythm.":[20],"3D":[21,102],"mapping":[22,107],"studies":[23],"ex-vivo":[26,109],"human":[27,89,110,199,251,274],"heart":[28],"suggested":[29],"that":[30,116,167,240],"rhythm":[36],"relies":[37],"on":[38,101],"specialized":[39],"fibrotically-insulated":[40],"compartments":[42,140,201],"(head,":[43],"center":[44],"tail)":[46],"with":[47,71],"heterogeneous":[48,126],"expressions":[49],"key":[51,113],"ion":[52],"channels":[53],"receptors.":[55],"They":[56],"also":[57],"revealed":[58],"up":[59],"to":[60,143,254],"five":[61],"conduction":[63,229,289],"pathways":[64],"(SACPs),":[65],"which":[66],"electrically":[67],"connect":[68],"SAN":[70,99,122,138,147,173,180,185,200,228,252,275,286,293],"neighboring":[72],"right":[73],"atrium":[74],"(RA).":[75],"To":[76],"elucidate":[77],"role":[79],"these":[81],"structural-molecular":[82],"factors":[83],"in":[84,192,211,223],"functional":[86,104,270],"robustness":[87],"SAN,":[90],"we":[91,165,238],"developed":[92],"comprehensive":[93],"biophysical":[94],"computer":[95,264],"models":[96],"based":[100],"structural,":[103],"molecular":[106],"hearts.":[111],"Our":[112],"finding":[114],"electrical":[118],"insulation":[119],"except":[123],"SACPs,":[124],"expression":[127,194],"If,":[129],"INa":[130,218,244],"currents":[131],"adenosine":[133,188,248],"A1":[134],"receptors":[135],"(A1R)":[136],"across":[137],"pacemaker-conduction":[139],"are":[141],"required":[142,177],"experimentally":[144],"reproduce":[145],"observed":[146],"activation":[148],"patterns":[149],"important":[151],"phenomena":[152],"such":[153],"as":[154,290,292],"shifts":[155],"leading":[158],"preferential":[161,209,233],"SACP.":[162],"In":[163,261],"particular,":[164],"found":[166],"insulating":[169],"border":[170],"between":[171],"RA,":[175],"function":[181],"protection":[183],"from":[184,235],"arrest":[186],"during":[187],"challenge.":[189],"heterogeneity":[191],"A1R":[196],"within":[197],"underlies":[202],"direction":[204],"shift":[207,231],"SACPs":[210,224],"presence":[213],"adenosine.":[215],"Alterations":[216],"current":[219],"fibrotic":[221,242],"remodelling":[222],"can":[225,277],"significantly":[226],"modulate":[227],"SACP/exit":[234],"SAN.":[236],"Finally,":[237],"show":[239],"disease-induced":[241],"remodeling,":[243],"suppression":[245],"or":[246],"increased":[247],"make":[249],"vulnerable":[253],"pacing-induced":[255],"exit":[256],"blocks":[257],"reentrant":[259],"arrhythmia.":[260],"summary,":[262],"our":[263],"model":[265],"recapitulates":[266],"structural":[268],"features":[271],"be":[278],"a":[279],"valuable":[280],"tool":[281],"investigating":[283],"mechanisms":[284,295],"automaticity":[287],"well":[291],"arrhythmia":[294],"under":[296],"different":[297],"pathophysiological":[298],"conditions.":[299]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}