{"id":"https://openalex.org/W4389429408","doi":"https://doi.org/10.1371/journal.pcbi.1011660","title":"Dissolution of spiral wave\u2019s core using cardiac optogenetics","display_name":"Dissolution of spiral wave\u2019s core using cardiac optogenetics","publication_year":2023,"publication_date":"2023-12-07","ids":{"openalex":"https://openalex.org/W4389429408","doi":"https://doi.org/10.1371/journal.pcbi.1011660","pmid":"https://pubmed.ncbi.nlm.nih.gov/38060618"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011660","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011660","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1011660","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052878460","display_name":"Sayedeh Hussaini","orcid":"https://orcid.org/0000-0002-6247-0177"},"institutions":[{"id":"https://openalex.org/I4210088711","display_name":"Max Planck Institute for Dynamics and Self-Organization","ror":"https://ror.org/0087djs12","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210088711"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sayedeh Hussaini","raw_affiliation_strings":["DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Germany","Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6247-0177","affiliations":[{"raw_affiliation_string":"DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192","https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210088711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093437590","display_name":"Sarah L. L\u00e4dke","orcid":"https://orcid.org/0009-0007-6187-6670"},"institutions":[{"id":"https://openalex.org/I4210088711","display_name":"Max Planck Institute for Dynamics and Self-Organization","ror":"https://ror.org/0087djs12","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210088711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sarah L. L\u00e4dke","raw_affiliation_strings":["Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210088711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067851081","display_name":"Johannes Schr\u00f6der-Schetelig","orcid":"https://orcid.org/0000-0003-3590-028X"},"institutions":[{"id":"https://openalex.org/I4210088711","display_name":"Max Planck Institute for Dynamics and Self-Organization","ror":"https://ror.org/0087djs12","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210088711"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Johannes Schr\u00f6der-Schetelig","raw_affiliation_strings":["DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Germany","Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3590-028X","affiliations":[{"raw_affiliation_string":"DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192","https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210088711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085560226","display_name":"Vishalini Venkatesan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210088711","display_name":"Max Planck Institute for Dynamics and Self-Organization","ror":"https://ror.org/0087djs12","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210088711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Vishalini Venkatesan","raw_affiliation_strings":["Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210088711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016011768","display_name":"Ra\u00fal A. Qui\u00f1onez Uribe","orcid":null},"institutions":[{"id":"https://openalex.org/I4210088711","display_name":"Max Planck Institute for Dynamics and Self-Organization","ror":"https://ror.org/0087djs12","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210088711"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ra\u00fal A. Qui\u00f1onez Uribe","raw_affiliation_strings":["DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210088711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070210340","display_name":"Claudia Richter","orcid":"https://orcid.org/0000-0003-3871-639X"},"institutions":[{"id":"https://openalex.org/I2801496451","display_name":"German Primate Center","ror":"https://ror.org/02f99v835","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2801496451","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I4210088711","display_name":"Max Planck Institute for Dynamics and Self-Organization","ror":"https://ror.org/0087djs12","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210088711"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Claudia Richter","raw_affiliation_strings":["DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany","WG Cardiovascular Optogenetics, Lab Animal Science Unit, Leibniz Institute for Primate research, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210088711"]},{"raw_affiliation_string":"WG Cardiovascular Optogenetics, Lab Animal Science Unit, Leibniz Institute for Primate research, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I2801496451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068388115","display_name":"Rupamanjari Majumder","orcid":"https://orcid.org/0000-0002-3851-9225"},"institutions":[{"id":"https://openalex.org/I4210088711","display_name":"Max Planck Institute for Dynamics and Self-Organization","ror":"https://ror.org/0087djs12","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210088711"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Rupamanjari Majumder","raw_affiliation_strings":["DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Germany","Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192","https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210088711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026079304","display_name":"Stefan Luther","orcid":"https://orcid.org/0000-0001-7214-8125"},"institutions":[{"id":"https://openalex.org/I4210088711","display_name":"Max Planck Institute for Dynamics and Self-Organization","ror":"https://ror.org/0087djs12","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210088711"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan Luther","raw_affiliation_strings":["DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","Institute for the Dynamics of Complex Systems, G\u00f6ttingen University, Germany","Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Germany","Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7214-8125","affiliations":[{"raw_affiliation_string":"DZHK (German Center for Cardiovascular Research), Partner Site G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for the Dynamics of Complex Systems, G\u00f6ttingen University, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, University Medical Center G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I74656192","https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210088711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5016011768","https://openalex.org/A5026079304","https://openalex.org/A5052878460","https://openalex.org/A5067851081","https://openalex.org/A5068388115","https://openalex.org/A5070210340","https://openalex.org/A5085560226","https://openalex.org/A5093437590"],"corresponding_institution_ids":["https://openalex.org/I2801496451","https://openalex.org/I4210088711","https://openalex.org/I4210116730","https://openalex.org/I4210127591","https://openalex.org/I74656192"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6783,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.83626815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"19","issue":"12","first_page":"e1011660","last_page":"e1011660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/defibrillation","display_name":"Defibrillation","score":0.8143067359924316},{"id":"https://openalex.org/keywords/optical-mapping","display_name":"Optical mapping","score":0.7486978769302368},{"id":"https://openalex.org/keywords/spiral-wave","display_name":"Spiral wave","score":0.6395366787910461},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"Ventricular fibrillation","score":0.6350014209747314},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"Cardiac arrhythmia","score":0.5561650991439819},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.5042170286178589},{"id":"https://openalex.org/keywords/spiral","display_name":"Spiral (railway)","score":0.5015382766723633},{"id":"https://openalex.org/keywords/ventricular-tachycardia","display_name":"Ventricular tachycardia","score":0.49262815713882446},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4480646848678589},{"id":"https://openalex.org/keywords/reentry","display_name":"Reentry","score":0.43678298592567444},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"Cardiac electrophysiology","score":0.42903172969818115},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4268919825553894},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3953723907470703},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3537713289260864},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.2271423637866974},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.14633938670158386},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.0739070475101471}],"concepts":[{"id":"https://openalex.org/C2777795826","wikidata":"https://www.wikidata.org/wiki/Q954202","display_name":"Defibrillation","level":2,"score":0.8143067359924316},{"id":"https://openalex.org/C28289500","wikidata":"https://www.wikidata.org/wiki/Q7098868","display_name":"Optical mapping","level":2,"score":0.7486978769302368},{"id":"https://openalex.org/C2777485032","wikidata":"https://www.wikidata.org/wiki/Q22908993","display_name":"Spiral wave","level":3,"score":0.6395366787910461},{"id":"https://openalex.org/C2781005686","wikidata":"https://www.wikidata.org/wiki/Q848662","display_name":"Ventricular fibrillation","level":2,"score":0.6350014209747314},{"id":"https://openalex.org/C2988455589","wikidata":"https://www.wikidata.org/wiki/Q189331","display_name":"Cardiac arrhythmia","level":3,"score":0.5561650991439819},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5042170286178589},{"id":"https://openalex.org/C174128100","wikidata":"https://www.wikidata.org/wiki/Q846907","display_name":"Spiral (railway)","level":2,"score":0.5015382766723633},{"id":"https://openalex.org/C2776331378","wikidata":"https://www.wikidata.org/wiki/Q56002","display_name":"Ventricular tachycardia","level":2,"score":0.49262815713882446},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4480646848678589},{"id":"https://openalex.org/C2777720157","wikidata":"https://www.wikidata.org/wiki/Q7306947","display_name":"Reentry","level":2,"score":0.43678298592567444},{"id":"https://openalex.org/C61381695","wikidata":"https://www.wikidata.org/wiki/Q3302130","display_name":"Cardiac electrophysiology","level":3,"score":0.42903172969818115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4268919825553894},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3953723907470703},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3537713289260864},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.2271423637866974},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.14633938670158386},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0739070475101471},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1011660","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011660","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38060618","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38060618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10729946","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10729946","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10729946/pdf/pcbi.1011660.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:94ce6904c9894a3dbb4d8ebe3ce250d3","is_oa":true,"landing_page_url":"https://doaj.org/article/94ce6904c9894a3dbb4d8ebe3ce250d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 12, p e1011660 (2023)","raw_type":"article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/139824","is_oa":true,"landing_page_url":"https://sfb1002.med.uni-goettingen.de/production/literature/publications/497","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011660","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011660","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2092439215","display_name":null,"funder_award_id":"SFB 1002","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320312069","display_name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","ror":"https://ror.org/031t5w623"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1594025385","https://openalex.org/W1819512171","https://openalex.org/W1834287853","https://openalex.org/W1965371036","https://openalex.org/W1974924914","https://openalex.org/W1978253480","https://openalex.org/W2004675361","https://openalex.org/W2012955553","https://openalex.org/W2025261511","https://openalex.org/W2030690554","https://openalex.org/W2030719871","https://openalex.org/W2034786923","https://openalex.org/W2042110107","https://openalex.org/W2048885193","https://openalex.org/W2057724362","https://openalex.org/W2061399986","https://openalex.org/W2065814524","https://openalex.org/W2083456832","https://openalex.org/W2099252075","https://openalex.org/W2153888863","https://openalex.org/W2156811718","https://openalex.org/W2158442181","https://openalex.org/W2161984704","https://openalex.org/W2171907703","https://openalex.org/W2199320796","https://openalex.org/W2281015413","https://openalex.org/W2320382602","https://openalex.org/W2325927156","https://openalex.org/W2403024317","https://openalex.org/W2411443981","https://openalex.org/W2507714698","https://openalex.org/W2536845690","https://openalex.org/W2613159373","https://openalex.org/W2741283297","https://openalex.org/W2788564573","https://openalex.org/W2789696592","https://openalex.org/W2889228819","https://openalex.org/W2891055541","https://openalex.org/W2900328615","https://openalex.org/W2950118098","https://openalex.org/W3124072936","https://openalex.org/W3208837797","https://openalex.org/W4225128256","https://openalex.org/W4295540525","https://openalex.org/W4320487482"],"related_works":["https://openalex.org/W1991136249","https://openalex.org/W1486910795","https://openalex.org/W3112687503","https://openalex.org/W1473478927","https://openalex.org/W2051797955","https://openalex.org/W2297280163","https://openalex.org/W2586419495","https://openalex.org/W1981404395","https://openalex.org/W2013788222","https://openalex.org/W2076786320"],"abstract_inverted_index":{"Rotating":[0],"spiral":[1,53,155,164,178],"waves":[2],"in":[3,94,101,198],"the":[4,32,44,60,74,87,128,139,143,151,163,167,171,177,203],"heart":[5,33,119],"are":[6,20],"associated":[7],"with":[8],"life-threatening":[9],"cardiac":[10,98,209],"arrhythmias":[11,19],"such":[12],"as":[13,66],"ventricular":[14,122],"tachycardia":[15],"and":[16,103,205],"fibrillation.":[17],"These":[18],"treated":[21],"by":[22,35],"a":[23,37,79,121,154,188],"process":[24],"called":[25],"defibrillation,":[26,65],"which":[27,130,197],"forces":[28],"electrical":[29],"resynchronization":[30],"of":[31,52,82,91,115,127,142,153,170,176,191,207],"tissue":[34,99],"delivering":[36],"single":[38],"global":[39,107],"high-voltage":[40],"shock":[41],"directly":[42],"to":[43,49,133,160,174,187],"heart.":[45],"This":[46],"method":[47],"leads":[48],"immediate":[50],"termination":[51,89,126,175],"waves.":[54],"However,":[55],"this":[56],"may":[57],"not":[58],"be":[59],"only":[61],"mechanism":[62],"underlying":[63],"successful":[64],"certain":[67],"scenarios":[68],"have":[69],"also":[70],"been":[71],"reported,":[72],"where":[73],"arrhythmia":[75,93,123,192],"terminated":[76],"slowly,":[77],"over":[78],"finite":[80],"period":[81],"time.":[83],"Here,":[84],"we":[85],"investigate":[86],"slow":[88,125,195],"dynamics":[90,193],"an":[92,116],"optogenetically":[95],"modified":[96],"murine":[97],"both":[100],"silico":[102],"ex":[104],"vivo":[105],"during":[106,120,138,194],"illumination":[108],"at":[109],"low":[110],"light":[111],"intensities.":[112],"Optical":[113],"imaging":[114],"intact":[117],"mouse":[118],"shows":[124],"arrhythmia,":[129],"is":[131,156],"due":[132],"action":[134],"potential":[135],"prolongation":[136],"observed":[137],"last":[140],"rotation":[141],"wave.":[144,179],"Our":[145],"numerical":[146],"studies":[147],"show":[148],"that":[149,182],"when":[150],"core":[152],"illuminated,":[157],"it":[158],"begins":[159],"expand,":[161],"pushing":[162],"arm":[165],"towards":[166],"inexcitable":[168],"boundary":[169],"domain,":[172],"leading":[173],"We":[180],"believe":[181],"these":[183],"fundamental":[184],"findings":[185],"lead":[186],"better":[189],"understanding":[190],"termination,":[196],"turn":[199],"has":[200],"implications":[201],"for":[202],"improvement":[204],"development":[206],"new":[208],"defibrillation":[210],"techniques.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
