{"id":"https://openalex.org/W4388487446","doi":"https://doi.org/10.1371/journal.pcbi.1011607","title":"Modeling cell populations metabolism and competition under maximum power constraints","display_name":"Modeling cell populations metabolism and competition under maximum power constraints","publication_year":2023,"publication_date":"2023-11-08","ids":{"openalex":"https://openalex.org/W4388487446","doi":"https://doi.org/10.1371/journal.pcbi.1011607","pmid":"https://pubmed.ncbi.nlm.nih.gov/37939139"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011607","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011607","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011607&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011607&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052428074","display_name":"Luigi Conte","orcid":null},"institutions":[{"id":"https://openalex.org/I149461666","display_name":"Ca' Foscari University of Venice","ror":"https://ror.org/04yzxz566","country_code":"IT","type":"education","lineage":["https://openalex.org/I149461666"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luigi Conte","raw_affiliation_strings":["Centre for the Study of the Systemic Dynamics of Complex Diseases, Venezia Mestre, Italy","Department of Environmental Sciences, Informatics and Statistics, Ca' Foscari University of Venice, Venezia Mestre, Italy","Department of Physics, Sapienza University of Rome, Roma, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7284-7524","affiliations":[{"raw_affiliation_string":"Centre for the Study of the Systemic Dynamics of Complex Diseases, Venezia Mestre, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Environmental Sciences, Informatics and Statistics, Ca' Foscari University of Venice, Venezia Mestre, Italy","institution_ids":["https://openalex.org/I149461666"]},{"raw_affiliation_string":"Department of Physics, Sapienza University of Rome, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009338340","display_name":"F. Gonella","orcid":"https://orcid.org/0000-0001-8504-5301"},"institutions":[{"id":"https://openalex.org/I149461666","display_name":"Ca' Foscari University of Venice","ror":"https://ror.org/04yzxz566","country_code":"IT","type":"education","lineage":["https://openalex.org/I149461666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Gonella","raw_affiliation_strings":["Centre for the Study of the Systemic Dynamics of Complex Diseases, Venezia Mestre, Italy","Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Venezia Mestre, Italy","THE NEW INSTITUTE Centre for Environmental Humanities (NICHE), Venezia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the Study of the Systemic Dynamics of Complex Diseases, Venezia Mestre, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, Venezia Mestre, Italy","institution_ids":["https://openalex.org/I149461666"]},{"raw_affiliation_string":"THE NEW INSTITUTE Centre for Environmental Humanities (NICHE), Venezia, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090645044","display_name":"Andrea Giansanti","orcid":"https://orcid.org/0000-0002-8113-8188"},"institutions":[{"id":"https://openalex.org/I160013858","display_name":"Istituto Nazionale di Fisica Nucleare","ror":"https://ror.org/005ta0471","country_code":"IT","type":"funder","lineage":["https://openalex.org/I160013858"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Andrea Giansanti","raw_affiliation_strings":["Department of Physics, Sapienza University of Rome, Roma, Italy","Istituto Nazionale di Fisica Nucleare, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Sapienza University of Rome, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Istituto Nazionale di Fisica Nucleare, Roma, Italy","institution_ids":["https://openalex.org/I160013858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022224624","display_name":"Axel Kleidon","orcid":"https://orcid.org/0000-0002-3798-0730"},"institutions":[{"id":"https://openalex.org/I4210154168","display_name":"Max Planck Institute for Biogeochemistry","ror":"https://ror.org/051yxp643","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210154168"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Axel Kleidon","raw_affiliation_strings":["Biospheric Theory and Modeling Group, Max Planck Institute for Biogeochemistry, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biospheric Theory and Modeling Group, Max Planck Institute for Biogeochemistry, Jena, Germany","institution_ids":["https://openalex.org/I4210154168"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018769545","display_name":"Alessandra Romano","orcid":"https://orcid.org/0000-0002-6333-4433"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alessandra Romano","raw_affiliation_strings":["Centre for the Study of the Systemic Dynamics of Complex Diseases, Venezia Mestre, Italy","Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for the Study of the Systemic Dynamics of Complex Diseases, Venezia Mestre, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5009338340","https://openalex.org/A5018769545","https://openalex.org/A5022224624","https://openalex.org/A5052428074","https://openalex.org/A5090645044"],"corresponding_institution_ids":["https://openalex.org/I149461666","https://openalex.org/I160013858","https://openalex.org/I39063666","https://openalex.org/I4210154168","https://openalex.org/I861853513"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.4308,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.59426723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"19","issue":"11","first_page":"e1011607","last_page":"e1011607"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.503386914730072},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.49583515524864197},{"id":"https://openalex.org/keywords/competition","display_name":"Competition (biology)","score":0.489229679107666},{"id":"https://openalex.org/keywords/dissipative-system","display_name":"Dissipative system","score":0.4737211763858795},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4634115397930145},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.4600084125995636},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.42069441080093384},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.37554386258125305},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.36341941356658936},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3550693988800049},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3240644931793213},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.22748708724975586}],"concepts":[{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.503386914730072},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.49583515524864197},{"id":"https://openalex.org/C91306197","wikidata":"https://www.wikidata.org/wiki/Q45767","display_name":"Competition (biology)","level":2,"score":0.489229679107666},{"id":"https://openalex.org/C99692599","wikidata":"https://www.wikidata.org/wiki/Q596577","display_name":"Dissipative system","level":2,"score":0.4737211763858795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4634115397930145},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.4600084125995636},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.42069441080093384},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.37554386258125305},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36341941356658936},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3550693988800049},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3240644931793213},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22748708724975586},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1011607","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011607","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011607&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37939139","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37939139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:iris.unive.it:10278/5044261","is_oa":true,"landing_page_url":"https://hdl.handle.net/10278/5044261","pdf_url":"https://iris.unive.it/bitstream/10278/5044261/1/journal.pcbi.1011607.pdf","source":{"id":"https://openalex.org/S4306402336","display_name":"ARCA (Universit\u00e0 Ca' Foscari Venezia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149461666","host_organization_name":"Ca' Foscari University of Venice","host_organization_lineage":["https://openalex.org/I149461666"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10659174","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10659174","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10659174/pdf/pcbi.1011607.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:87292d5b2f404c3aadde987537faa71b","is_oa":true,"landing_page_url":"https://doaj.org/article/87292d5b2f404c3aadde987537faa71b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 11, p e1011607 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011607","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011607","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011607&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6299999952316284,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388487446.pdf","grobid_xml":"https://content.openalex.org/works/W4388487446.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1482646691","https://openalex.org/W1505897668","https://openalex.org/W1564643673","https://openalex.org/W1802606188","https://openalex.org/W1983017040","https://openalex.org/W1988265934","https://openalex.org/W1994813850","https://openalex.org/W1999765733","https://openalex.org/W2005284010","https://openalex.org/W2011892782","https://openalex.org/W2033591223","https://openalex.org/W2033760933","https://openalex.org/W2046280953","https://openalex.org/W2048329976","https://openalex.org/W2051342143","https://openalex.org/W2052944775","https://openalex.org/W2053660802","https://openalex.org/W2054683888","https://openalex.org/W2062533676","https://openalex.org/W2067145595","https://openalex.org/W2087154532","https://openalex.org/W2097259163","https://openalex.org/W2103948957","https://openalex.org/W2106353254","https://openalex.org/W2127222213","https://openalex.org/W2137205298","https://openalex.org/W2142289369","https://openalex.org/W2155581408","https://openalex.org/W2161271430","https://openalex.org/W2163575276","https://openalex.org/W2164549228","https://openalex.org/W2170515647","https://openalex.org/W2223535266","https://openalex.org/W2295129153","https://openalex.org/W2502949459","https://openalex.org/W2536256403","https://openalex.org/W2537551256","https://openalex.org/W2549396793","https://openalex.org/W2562505905","https://openalex.org/W2564110939","https://openalex.org/W2617949040","https://openalex.org/W2625253716","https://openalex.org/W2753965489","https://openalex.org/W2774997108","https://openalex.org/W2884258243","https://openalex.org/W2899786482","https://openalex.org/W2902733144","https://openalex.org/W2960323991","https://openalex.org/W2974619755","https://openalex.org/W3003257820","https://openalex.org/W3015296663","https://openalex.org/W3045230440","https://openalex.org/W3083134941","https://openalex.org/W3103145119","https://openalex.org/W3113932382","https://openalex.org/W3114692785","https://openalex.org/W3118815801","https://openalex.org/W3138298183","https://openalex.org/W3169541150","https://openalex.org/W4229535299","https://openalex.org/W4234455222","https://openalex.org/W4246404602","https://openalex.org/W4254358219","https://openalex.org/W4254465655","https://openalex.org/W4294544773","https://openalex.org/W4300059230","https://openalex.org/W4322617185","https://openalex.org/W6662597919","https://openalex.org/W6747644443"],"related_works":["https://openalex.org/W2371200319","https://openalex.org/W2367609594","https://openalex.org/W2350320737","https://openalex.org/W2391455523","https://openalex.org/W2739518152","https://openalex.org/W2091416718","https://openalex.org/W9469511","https://openalex.org/W2015853617","https://openalex.org/W1568871354","https://openalex.org/W2360035557"],"abstract_inverted_index":{"Ecological":[0],"interactions":[1,183],"are":[2],"fundamental":[3],"at":[4],"the":[5,9,61,64,104,112,141,149,174,181,188,218,231],"cellular":[6,15,94],"scale,":[7],"addressing":[8],"possibility":[10],"of":[11,14,22,39,63,66,98,107,122,138,160,163,173,177,198,220,226,233],"a":[12,29,52,67,76,120,136,170,192,209,227,239],"description":[13,172],"systems":[16],"that":[17,33,75],"uses":[18],"language":[19],"and":[20,37,46,92,187,206],"principles":[21],"ecology.":[23],"In":[24],"this":[25,56],"work,":[26],"we":[27,54],"use":[28,197],"minimal":[30,77],"ecological":[31,182,214],"approach":[32],"encompasses":[34],"growth,":[35],"adaptation":[36],"survival":[38,161],"cell":[40,44,81],"populations":[41,82],"to":[42,59,103,125,154,211,241],"model":[43,78,116,215,253],"metabolisms":[45],"competition":[47],"under":[48],"energetic":[49],"constraints.":[50],"As":[51],"proof-of-concept,":[53],"apply":[55],"general":[57],"formulation":[58],"study":[60],"dynamics":[62],"onset":[65,219],"specific":[68],"blood":[69],"cancer-called":[70],"Multiple":[71,99],"Myeloma.":[72],"We":[73],"show":[74],"describing":[79],"antagonist":[80],"competing":[83],"for":[84,129],"limited":[85],"resources,":[86],"as":[87,222],"regulated":[88],"by":[89,119],"microenvironmental":[90],"factors":[91],"internal":[93],"structures,":[95],"reproduces":[96,217],"patterns":[97],"Myeloma":[100],"evolution,":[101],"due":[102],"uncontrolled":[105],"proliferation":[106],"cancerous":[108],"plasma":[109,133,185,234],"cells":[110,186],"within":[111],"bone":[113,142],"marrow.":[114,143],"The":[115,144,196],"is":[117,208],"characterized":[118],"class":[121],"regime":[123],"shifts":[124],"more":[126,243],"dissipative":[127],"states":[128,225],"selectively":[130],"advantaged":[131],"malignant":[132],"cells,":[134],"reflecting":[135],"breakdown":[137],"self-regulation":[139],"in":[140,191,203],"transition":[145],"times":[146,162],"obtained":[147],"from":[148,152],"simulations":[150],"range":[151],"years":[153],"decades":[155],"consistently":[156],"with":[157,252],"clinical":[158],"observations":[159],"patients.":[164],"This":[165,236],"irreversible":[166],"dynamical":[167],"behavior":[168],"represents":[169],"possible":[171],"incurable":[175],"nature":[176],"myelomas":[178,221],"based":[179],"on":[180],"between":[184,224],"microenvironment,":[189],"embedded":[190],"larger":[193],"complex":[194,244],"system.":[195],"ATP":[199],"equivalent":[200],"energy":[201],"units":[202],"defining":[204],"stocks":[205],"flows":[207],"key":[210],"constructing":[212],"an":[213],"which":[216,229,248],"transitions":[223],"system":[228],"reflects":[230],"energetics":[232],"cells.":[235],"work":[237],"provides":[238],"basis":[240],"construct":[242],"models":[245],"representing":[246],"myelomas,":[247],"can":[249],"be":[250],"compared":[251],"ecosystems.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}