{"id":"https://openalex.org/W4400229236","doi":"https://doi.org/10.1371/journal.pcbi.1011570","title":"Detection of disease-specific signatures in B cell repertoires of lymphomas using machine learning","display_name":"Detection of disease-specific signatures in B cell repertoires of lymphomas using machine learning","publication_year":2024,"publication_date":"2024-07-02","ids":{"openalex":"https://openalex.org/W4400229236","doi":"https://doi.org/10.1371/journal.pcbi.1011570","pmid":"https://pubmed.ncbi.nlm.nih.gov/38954728"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011570","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011570","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011570&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011570&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009603075","display_name":"Paul Schmidt-Barbo","orcid":"https://orcid.org/0009-0008-0871-7555"},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Paul Schmidt-Barbo","raw_affiliation_strings":["Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany","Department of Biomedicine, Translational Immuno-Oncology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0009-0008-0871-7555","affiliations":[{"raw_affiliation_string":"Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedicine, Translational Immuno-Oncology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033350585","display_name":"Gabriel Kalweit","orcid":"https://orcid.org/0000-0003-4581-8810"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gabriel Kalweit","raw_affiliation_strings":["Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany","Neurorobotics Lab, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Neurorobotics Lab, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090578154","display_name":"Mehdi Naouar","orcid":"https://orcid.org/0009-0002-1557-2223"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mehdi Naouar","raw_affiliation_strings":["Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany","Neurorobotics Lab, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Neurorobotics Lab, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014071836","display_name":"Lisa Paschold","orcid":"https://orcid.org/0000-0003-0020-1315"},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Lisa Paschold","raw_affiliation_strings":["Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076005625","display_name":"Edith Willscher","orcid":"https://orcid.org/0000-0002-8786-4578"},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Edith Willscher","raw_affiliation_strings":["Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053146707","display_name":"Christoph Schulthei\u00df","orcid":"https://orcid.org/0000-0001-9789-5776"},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Christoph Schulthei\u00df","raw_affiliation_strings":["Department of Biomedicine, Translational Immuno-Oncology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-9789-5776","affiliations":[{"raw_affiliation_string":"Department of Biomedicine, Translational Immuno-Oncology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019299921","display_name":"Bruno M\u00e4rkl","orcid":"https://orcid.org/0000-0002-7704-850X"},"institutions":[{"id":"https://openalex.org/I2802007660","display_name":"University Hospital Augsburg","ror":"https://ror.org/03b0k9c14","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802007660"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bruno M\u00e4rkl","raw_affiliation_strings":["Pathology, University Hospital Augsburg, Augsburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, University Hospital Augsburg, Augsburg, Germany","institution_ids":["https://openalex.org/I2802007660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091441095","display_name":"Stefan Dirnhofer","orcid":null},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Stefan Dirnhofer","raw_affiliation_strings":["Pathology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041171016","display_name":"Alexandar Tzankov","orcid":"https://orcid.org/0000-0002-1100-3819"},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Alexandar Tzankov","raw_affiliation_strings":["Pathology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077205301","display_name":"Mascha Binder","orcid":"https://orcid.org/0000-0003-0663-3004"},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Mascha Binder","raw_affiliation_strings":["Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany","Department of Biomedicine, Translational Immuno-Oncology, University Hospital Basel, Basel, Switzerland","Medical Oncology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-0663-3004","affiliations":[{"raw_affiliation_string":"Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedicine, Translational Immuno-Oncology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Medical Oncology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033350585","display_name":"Gabriel Kalweit","orcid":"https://orcid.org/0000-0003-4581-8810"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Maria Kalweit","raw_affiliation_strings":["Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany","Neurorobotics Lab, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Neurorobotics Lab, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009603075","https://openalex.org/A5014071836","https://openalex.org/A5019299921","https://openalex.org/A5033350585","https://openalex.org/A5041171016","https://openalex.org/A5053146707","https://openalex.org/A5076005625","https://openalex.org/A5077205301","https://openalex.org/A5090578154","https://openalex.org/A5091441095"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2802007660","https://openalex.org/I2802542264","https://openalex.org/I68956291"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.7927,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.93653751,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"20","issue":"7","first_page":"e1011570","last_page":"e1011570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphoma","display_name":"Lymphoma","score":0.7980449199676514},{"id":"https://openalex.org/keywords/breakpoint-cluster-region","display_name":"breakpoint cluster region","score":0.7668132781982422},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"Chronic lymphocytic leukemia","score":0.6259955763816833},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"Logistic regression","score":0.5778571367263794},{"id":"https://openalex.org/keywords/b-cell-receptor","display_name":"B-cell receptor","score":0.5387161374092102},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4798274040222168},{"id":"https://openalex.org/keywords/b-cell","display_name":"B cell","score":0.4626413881778717},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.44900259375572205},{"id":"https://openalex.org/keywords/immunophenotyping","display_name":"Immunophenotyping","score":0.4326782822608948},{"id":"https://openalex.org/keywords/aggressive-lymphoma","display_name":"Aggressive lymphoma","score":0.42486053705215454},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3539237380027771},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3201940655708313},{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.2809011936187744},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.252099871635437},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2360653281211853},{"id":"https://openalex.org/keywords/rituximab","display_name":"Rituximab","score":0.17883223295211792},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1732056736946106},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1711711287498474},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.1647539734840393},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1458938717842102},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.09185737371444702},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08234778046607971}],"concepts":[{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.7980449199676514},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.7668132781982422},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.6259955763816833},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5778571367263794},{"id":"https://openalex.org/C157695867","wikidata":"https://www.wikidata.org/wiki/Q1100474","display_name":"B-cell receptor","level":4,"score":0.5387161374092102},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4798274040222168},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4626413881778717},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.44900259375572205},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.4326782822608948},{"id":"https://openalex.org/C2781214270","wikidata":"https://www.wikidata.org/wiki/Q4692282","display_name":"Aggressive lymphoma","level":4,"score":0.42486053705215454},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3539237380027771},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3201940655708313},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2809011936187744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.252099871635437},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2360653281211853},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.17883223295211792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1732056736946106},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1711711287498474},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1647539734840393},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1458938717842102},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.09185737371444702},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08234778046607971}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1011570","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011570","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011570&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38954728","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38954728","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11249212","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11249212","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11249212/pdf/pcbi.1011570.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:uni-augsburg.opus-bayern.de:114441","is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1144416","pdf_url":"https://opus.bibliothek.uni-augsburg.de/opus4/files/114441/journal.pcbi.1011570.pdf","source":{"id":"https://openalex.org/S4306400930","display_name":"OPUS (Augsburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I119916105","host_organization_name":"Augsburg University","host_organization_lineage":["https://openalex.org/I119916105"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1011570","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011570","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:5862e59d6f3944fab6b0a585b48f6768","is_oa":false,"landing_page_url":"https://doaj.org/article/5862e59d6f3944fab6b0a585b48f6768","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 7, p e1011570 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011570","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011570","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011570&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400229236.pdf","grobid_xml":"https://content.openalex.org/works/W4400229236.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W128133613","https://openalex.org/W1488069418","https://openalex.org/W1883768105","https://openalex.org/W1984284869","https://openalex.org/W1995875735","https://openalex.org/W2021945571","https://openalex.org/W2026496528","https://openalex.org/W2050600340","https://openalex.org/W2051540789","https://openalex.org/W2089041106","https://openalex.org/W2112081648","https://openalex.org/W2129509656","https://openalex.org/W2158819525","https://openalex.org/W2400090719","https://openalex.org/W2773009681","https://openalex.org/W2778020060","https://openalex.org/W2803735519","https://openalex.org/W2913283761","https://openalex.org/W2915999573","https://openalex.org/W2938678047","https://openalex.org/W2948816402","https://openalex.org/W2964046761","https://openalex.org/W2966282780","https://openalex.org/W2977512532","https://openalex.org/W2984351101","https://openalex.org/W2987990236","https://openalex.org/W3004586992","https://openalex.org/W3018609885","https://openalex.org/W3018796293","https://openalex.org/W3020657373","https://openalex.org/W3021413349","https://openalex.org/W3025106781","https://openalex.org/W3026078932","https://openalex.org/W3032044812","https://openalex.org/W3038110350","https://openalex.org/W3043902401","https://openalex.org/W3044470192","https://openalex.org/W3045611814","https://openalex.org/W3045714119","https://openalex.org/W3080575430","https://openalex.org/W3092983525","https://openalex.org/W3103855458","https://openalex.org/W3109772564","https://openalex.org/W3152578950","https://openalex.org/W3162236650","https://openalex.org/W3165067450","https://openalex.org/W3187735702","https://openalex.org/W3208716322","https://openalex.org/W4210984018","https://openalex.org/W4220847978","https://openalex.org/W4229363592","https://openalex.org/W4245248161","https://openalex.org/W4282917532","https://openalex.org/W4292849294","https://openalex.org/W4296709263","https://openalex.org/W4307178597","https://openalex.org/W4380323986","https://openalex.org/W6770304634"],"related_works":["https://openalex.org/W2141490130","https://openalex.org/W2364949035","https://openalex.org/W2034371596","https://openalex.org/W2339088386","https://openalex.org/W1762205131","https://openalex.org/W3142122206","https://openalex.org/W2089217336","https://openalex.org/W3005650764","https://openalex.org/W2000049641","https://openalex.org/W1918912342"],"abstract_inverted_index":{"The":[0],"classification":[1,178],"of":[2,16,24,48,64,82,91,102,155,161,192],"B":[3,20,109,115],"cell":[4,21,110,116],"lymphomas-mainly":[5],"based":[6,79],"on":[7,80,194,234],"light":[8],"microscopy":[9],"evaluation":[10],"by":[11,237],"a":[12,69,73,152,189,195,238],"pathologist-requires":[13],"many":[14],"years":[15],"training.":[17],"Since":[18],"the":[19,25,29,62,92,99,134,142,167,219],"receptor":[22],"(BCR)":[23],"lymphoma":[26,38,105,111,117,204,222],"clonotype":[27,145],"and":[28,72,88,119,132,206],"microenvironmental":[30],"immune":[31],"architecture":[32],"are":[33],"important":[34],"features":[35],"discriminating":[36],"different":[37],"subsets,":[39],"we":[40,213],"asked":[41],"whether":[42],"BCR":[43,100,231],"repertoire":[44,232],"next-generation":[45],"sequencing":[46],"(NGS)":[47],"lymphoma-infiltrated":[49,235],"tissues":[50,236],"in":[51,61,98,149,174,183],"conjunction":[52],"with":[53,124],"machine":[54,240],"learning":[55,241],"algorithms":[56],"could":[57],"have":[58],"diagnostic":[59],"utility":[60],"subclassification":[63],"these":[65],"cancers.":[66],"We":[67],"trained":[68,239],"random":[70],"forest":[71],"linear":[74,181],"classifier":[75],"via":[76],"logistic":[77,169],"regression":[78,170],"patterns":[81],"clonal":[83],"distribution,":[84],"VDJ":[85],"gene":[86],"usage":[87],"physico-chemical":[89],"properties":[90],"top-n":[93],"most":[94,143],"frequently":[95],"represented":[96],"clonotypes":[97,162],"repertoires":[101],"620":[103],"paradigmatic":[104],"samples-nodular":[106],"lymphocyte":[107],"predominant":[108],"(NLPBL),":[112],"diffuse":[113],"large":[114],"(DLBCL)":[118],"chronic":[120],"lymphocytic":[121],"leukemia":[122],"(CLL)-alongside":[123],"291":[125],"control":[126],"samples.":[127],"With":[128],"regard":[129],"to":[130],"DLBCL":[131],"CLL,":[133],"models":[135],"demonstrated":[136],"optimal":[137],"performance":[138],"when":[139],"utilizing":[140],"only":[141],"prevalent":[144],"for":[146],"classification,":[147],"while":[148],"NLPBL-that":[150],"has":[151],"dominant":[153],"background":[154],"non-malignant":[156],"bystander":[157],"cells-a":[158],"broader":[159],"array":[160],"enhanced":[163],"model":[164,171],"accuracy.":[165],"Surprisingly,":[166],"straightforward":[168],"performed":[172],"best":[173],"this":[175],"seemingly":[176],"complex":[177],"problem,":[179],"suggesting":[180],"separability":[182],"our":[184],"chosen":[185],"dimensions.":[186],"It":[187],"achieved":[188],"weighted":[190],"F1-score":[191],"0.84":[193],"test":[196],"cohort":[197],"including":[198],"125":[199],"samples":[200,208],"from":[201,209,227],"all":[202],"three":[203],"entities":[205,223],"58":[207],"healthy":[210],"individuals.":[211],"Together,":[212],"provide":[214],"proof-of-concept":[215],"that":[216],"at":[217],"least":[218],"3":[220],"studied":[221],"can":[224],"be":[225],"differentiated":[226],"each":[228],"other":[229],"using":[230],"NGS":[233],"model.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}