{"id":"https://openalex.org/W4387823402","doi":"https://doi.org/10.1371/journal.pcbi.1011568","title":"Analyzing histone ChIP-seq data with a bin-based probability of being signal","display_name":"Analyzing histone ChIP-seq data with a bin-based probability of being signal","publication_year":2023,"publication_date":"2023-10-20","ids":{"openalex":"https://openalex.org/W4387823402","doi":"https://doi.org/10.1371/journal.pcbi.1011568","pmid":"https://pubmed.ncbi.nlm.nih.gov/37862349"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011568","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011568","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011568&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011568&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039596172","display_name":"Vivian Hecht","orcid":"https://orcid.org/0000-0003-4110-1388"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vivian Hecht","raw_affiliation_strings":["Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061667537","display_name":"Kevin Dong","orcid":"https://orcid.org/0000-0001-7205-9165"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin Dong","raw_affiliation_strings":["Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009967852","display_name":"Sreshtaa Rajesh","orcid":null},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sreshtaa Rajesh","raw_affiliation_strings":["Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023462847","display_name":"Polina Shpilker","orcid":"https://orcid.org/0000-0002-6761-7326"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Polina Shpilker","raw_affiliation_strings":["Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090056334","display_name":"Siddarth Wekhande","orcid":"https://orcid.org/0009-0008-7539-8718"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Siddarth Wekhande","raw_affiliation_strings":["Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002408678","display_name":"Noam Shoresh","orcid":"https://orcid.org/0000-0002-5482-5046"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Noam Shoresh","raw_affiliation_strings":["Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002408678","https://openalex.org/A5009967852","https://openalex.org/A5023462847","https://openalex.org/A5039596172","https://openalex.org/A5061667537","https://openalex.org/A5090056334"],"corresponding_institution_ids":["https://openalex.org/I107606265"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.3049,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.6433614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"19","issue":"10","first_page":"e1011568","last_page":"e1011568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bin","display_name":"Bin","score":0.7392845749855042},{"id":"https://openalex.org/keywords/epigenomics","display_name":"Epigenomics","score":0.6646308898925781},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6086435914039612},{"id":"https://openalex.org/keywords/histone","display_name":"Histone","score":0.5977000594139099},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.5918973684310913},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5035545229911804},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.419209748506546},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37424516677856445},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.355500191450119},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3156943619251251},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25630176067352295},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22264516353607178},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.22070765495300293},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.19493770599365234},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17470914125442505},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.1445123255252838},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.07849419116973877}],"concepts":[{"id":"https://openalex.org/C156273044","wikidata":"https://www.wikidata.org/wiki/Q4913766","display_name":"Bin","level":2,"score":0.7392845749855042},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.6646308898925781},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6086435914039612},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5977000594139099},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.5918973684310913},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5035545229911804},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.419209748506546},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37424516677856445},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.355500191450119},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3156943619251251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25630176067352295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22264516353607178},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.22070765495300293},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19493770599365234},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17470914125442505},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.1445123255252838},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.07849419116973877},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000081204","descriptor_name":"Chromatin Immunoprecipitation Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081204","descriptor_name":"Chromatin Immunoprecipitation Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081204","descriptor_name":"Chromatin Immunoprecipitation Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081204","descriptor_name":"Chromatin Immunoprecipitation Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081204","descriptor_name":"Chromatin Immunoprecipitation Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1011568","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011568","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011568&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37862349","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37862349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10619820","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10619820","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10619820/pdf/pcbi.1011568.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9fea0f493fd54680be07e30ca209f7ab","is_oa":true,"landing_page_url":"https://doaj.org/article/9fea0f493fd54680be07e30ca209f7ab","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 10, p e1011568 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011568","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011568","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011568&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.4399999976158142}],"awards":[{"id":"https://openalex.org/G2843951847","display_name":null,"funder_award_id":"UM1HG011986","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G4228729980","display_name":null,"funder_award_id":"UM1HG009390","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320314070","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387823402.pdf","grobid_xml":"https://content.openalex.org/works/W4387823402.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1844405070","https://openalex.org/W1865845132","https://openalex.org/W1968931043","https://openalex.org/W1997817740","https://openalex.org/W2018742603","https://openalex.org/W2042458542","https://openalex.org/W2071762518","https://openalex.org/W2109714489","https://openalex.org/W2112706474","https://openalex.org/W2131116802","https://openalex.org/W2131610374","https://openalex.org/W2155826575","https://openalex.org/W2158734721","https://openalex.org/W2166244392","https://openalex.org/W2171111703","https://openalex.org/W2171808845","https://openalex.org/W2179438025","https://openalex.org/W2277285385","https://openalex.org/W2385696187","https://openalex.org/W2403874820","https://openalex.org/W2514448720","https://openalex.org/W2582660596","https://openalex.org/W2791759760","https://openalex.org/W2801470635","https://openalex.org/W2950493549","https://openalex.org/W2953357410","https://openalex.org/W3014261926","https://openalex.org/W3018266729","https://openalex.org/W3023953516","https://openalex.org/W3080563305","https://openalex.org/W3104481701","https://openalex.org/W3198502742","https://openalex.org/W3203232566","https://openalex.org/W4221068576","https://openalex.org/W4231356616","https://openalex.org/W4285043220"],"related_works":["https://openalex.org/W2107701374","https://openalex.org/W1616588898","https://openalex.org/W4249504934","https://openalex.org/W2183416055","https://openalex.org/W2568867011","https://openalex.org/W1994114538","https://openalex.org/W2413205705","https://openalex.org/W2735644334","https://openalex.org/W138879321","https://openalex.org/W4318473910"],"abstract_inverted_index":{"Histone":[0],"ChIP-seq":[1,91],"is":[2],"one":[3,126],"of":[4,16,29,63,119,180,193],"the":[5,10,14,27,158],"primary":[6],"methods":[7],"for":[8,50,86,182],"charting":[9],"cellular":[11],"epigenomic":[12],"landscape,":[13],"components":[15],"which":[17,196],"play":[18],"a":[19,81,97,108,117,143],"critical":[20],"regulatory":[21,30],"role":[22],"in":[23,66,90,136],"gene":[24],"expression.":[25],"Analyzing":[26],"activity":[28],"elements":[31],"across":[32],"datasets":[33],"and":[34,45,57,83,125,150,166,171,185,189],"cell":[35],"types":[36],"can":[37,167,197],"be":[38,168,198],"challenging":[39],"due":[40],"to":[41,101,106,115,127,146,160],"shifting":[42],"peak":[43,76],"positions":[44],"normalization":[46],"artifacts":[47],"resulting":[48],"from,":[49],"example,":[51],"differing":[52],"read":[53],"depths,":[54],"ChIP":[55],"efficiencies,":[56],"target":[58],"sizes.":[59],"Moreover,":[60],"broad":[61,184],"regions":[62,89,149],"enrichment":[64],"seen":[65],"repressive":[67],"histone":[68,187],"marks":[69],"often":[70],"evade":[71],"detection":[72],"by":[73,156,200],"commonly":[74],"used":[75],"callers.":[77],"Here,":[78],"we":[79],"present":[80],"simple":[82],"versatile":[84],"method":[85],"identifying":[87],"enriched":[88,148],"data":[92,159,206],"that":[93,162],"relies":[94],"on":[95],"estimating":[96],"gamma":[98],"distribution":[99,114],"fit":[100],"non-overlapping":[102],"5kB":[103],"genomic":[104],"bins":[105],"establish":[107],"global":[109],"background.":[110],"We":[111,177],"use":[112],"this":[113],"assign":[116],"probability":[118],"being":[120],"signal":[121],"(PBS)":[122],"between":[123],"zero":[124],"each":[128],"5":[129],"kB":[130],"bin.":[131],"This":[132],"approach,":[133],"while":[134],"lower":[135],"resolution":[137],"than":[138],"typical":[139],"peak-calling":[140],"methods,":[141],"provides":[142],"straightforward":[144],"way":[145],"identify":[147],"compare":[151],"enrichments":[152],"among":[153],"multiple":[154],"datasets,":[155],"transforming":[157],"values":[161],"are":[163],"universally":[164],"normalized":[165],"readily":[169],"visualized":[170],"integrated":[172],"with":[173,204],"downstream":[174,205],"analysis":[175],"methods.":[176],"demonstrate":[178],"applications":[179],"PBS":[181,202],"both":[183],"narrow":[186],"marks,":[188],"provide":[190],"several":[191],"illustrations":[192],"biological":[194],"insights":[195],"gleaned":[199],"integrating":[201],"scores":[203],"types.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}
