{"id":"https://openalex.org/W4387665886","doi":"https://doi.org/10.1371/journal.pcbi.1011565","title":"Pervasive, conserved secondary structure in highly charged protein regions","display_name":"Pervasive, conserved secondary structure in highly charged protein regions","publication_year":2023,"publication_date":"2023-10-16","ids":{"openalex":"https://openalex.org/W4387665886","doi":"https://doi.org/10.1371/journal.pcbi.1011565","pmid":"https://pubmed.ncbi.nlm.nih.gov/37844070"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011565","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011565","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011565&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011565&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040351730","display_name":"Catherine G. Triandafillou","orcid":"https://orcid.org/0000-0002-6715-3795"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Catherine G. Triandafillou","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023517705","display_name":"Rosalind Wenshan Pan","orcid":"https://orcid.org/0009-0005-0778-3794"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rosalind Wenshan Pan","raw_affiliation_strings":["Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America","Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075498364","display_name":"Aaron R. Dinner","orcid":"https://orcid.org/0000-0001-8328-6427"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aaron R. Dinner","raw_affiliation_strings":["Department of Chemistry, University of Chicago, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057885534","display_name":"D. Allan Drummond","orcid":"https://orcid.org/0000-0001-7018-7059"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. Allan Drummond","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, United States of America","Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5023517705","https://openalex.org/A5040351730","https://openalex.org/A5057885534","https://openalex.org/A5075498364"],"corresponding_institution_ids":["https://openalex.org/I122411786","https://openalex.org/I40347166","https://openalex.org/I79576946"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.4669,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.67909529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"19","issue":"10","first_page":"e1011565","last_page":"e1011565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48994866013526917},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.4671446979045868},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"Protein structure prediction","score":0.4520424008369446},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4362007677555084},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3443017601966858},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33360180258750916},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18300968408584595},{"id":"https://openalex.org/keywords/base-sequence","display_name":"Base sequence","score":0.17400017380714417},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12188893556594849},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.07016950845718384}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48994866013526917},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.4671446979045868},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.4520424008369446},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4362007677555084},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3443017601966858},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33360180258750916},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18300968408584595},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.17400017380714417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12188893556594849},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.07016950845718384}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1011565","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011565","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011565&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37844070","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37844070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10602382","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10602382","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10602382/pdf/pcbi.1011565.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:uchicago.tind.io:9286","is_oa":true,"landing_page_url":"http://knowledge.uchicago.edu/record/9286","pdf_url":null,"source":{"id":"https://openalex.org/S4306402460","display_name":"Knowledge@UChicago (University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40347166","host_organization_name":"University of Chicago","host_organization_lineage":["https://openalex.org/I40347166"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://knowledge.uchicago.edu/record/9286","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:40cc7b87a8974ed7808832dd547080a9","is_oa":true,"landing_page_url":"https://doaj.org/article/40cc7b87a8974ed7808832dd547080a9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 10, p e1011565 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011565","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011565","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011565&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.7099999785423279}],"awards":[{"id":"https://openalex.org/G1994823736","display_name":null,"funder_award_id":"W911NF-14-1-0411","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G2343845489","display_name":null,"funder_award_id":"R35 GM136381","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3056106946","display_name":null,"funder_award_id":"W911NF-14-1-0411","funder_id":"https://openalex.org/F4320332447","funder_display_name":"U.S. Army"},{"id":"https://openalex.org/G3424441068","display_name":null,"funder_award_id":"W911NF-14-1","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G4562378851","display_name":null,"funder_award_id":"Fellowship","funder_id":"https://openalex.org/F4320306271","funder_display_name":"Damon Runyon Cancer Research Foundation"},{"id":"https://openalex.org/G4990785898","display_name":null,"funder_award_id":"GM136381","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5186096395","display_name":null,"funder_award_id":"R35 GM136381","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6597527788","display_name":null,"funder_award_id":"DRG-2465-22","funder_id":"https://openalex.org/F4320306271","funder_display_name":"Damon Runyon Cancer Research Foundation"},{"id":"https://openalex.org/G7452299184","display_name":null,"funder_award_id":"W911NF","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G7875298384","display_name":null,"funder_award_id":"UChicago Quantitative Biology Summer Fellowship","funder_id":"https://openalex.org/F4320338040","funder_display_name":"Biological and Physical Sciences Division"},{"id":"https://openalex.org/G8263010635","display_name":null,"funder_award_id":"GM144278","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8998121839","display_name":null,"funder_award_id":"911NF","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"}],"funders":[{"id":"https://openalex.org/F4320306271","display_name":"Damon Runyon Cancer Research Foundation","ror":"https://ror.org/01gd7b947"},{"id":"https://openalex.org/F4320309626","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320332447","display_name":"U.S. Army","ror":"https://ror.org/00afsp483"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338040","display_name":"Biological and Physical Sciences Division","ror":null},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387665886.pdf","grobid_xml":"https://content.openalex.org/works/W4387665886.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1519266993","https://openalex.org/W1817457239","https://openalex.org/W1895367194","https://openalex.org/W1980015132","https://openalex.org/W1994840640","https://openalex.org/W1995864101","https://openalex.org/W2023100445","https://openalex.org/W2035238742","https://openalex.org/W2043308634","https://openalex.org/W2043591644","https://openalex.org/W2049476357","https://openalex.org/W2051119339","https://openalex.org/W2051916497","https://openalex.org/W2076742999","https://openalex.org/W2085002173","https://openalex.org/W2093140735","https://openalex.org/W2094384279","https://openalex.org/W2100383597","https://openalex.org/W2111796925","https://openalex.org/W2113759638","https://openalex.org/W2114823344","https://openalex.org/W2119527946","https://openalex.org/W2120156669","https://openalex.org/W2138323709","https://openalex.org/W2141832377","https://openalex.org/W2147988069","https://openalex.org/W2150860983","https://openalex.org/W2168639701","https://openalex.org/W2171722004","https://openalex.org/W2345490732","https://openalex.org/W2467565876","https://openalex.org/W2590059905","https://openalex.org/W2590568317","https://openalex.org/W2611048578","https://openalex.org/W2790635752","https://openalex.org/W2794093079","https://openalex.org/W2808121690","https://openalex.org/W2810866092","https://openalex.org/W2896365450","https://openalex.org/W2897790977","https://openalex.org/W2912126500","https://openalex.org/W2912250830","https://openalex.org/W2922638464","https://openalex.org/W2951817054","https://openalex.org/W2955418283","https://openalex.org/W3112131467","https://openalex.org/W3156051371","https://openalex.org/W3177828909","https://openalex.org/W3184265853","https://openalex.org/W3194955130","https://openalex.org/W3195375135","https://openalex.org/W3199354990","https://openalex.org/W3203936353","https://openalex.org/W3215954549","https://openalex.org/W4206985672","https://openalex.org/W4213208821","https://openalex.org/W4225670827","https://openalex.org/W4281751249","https://openalex.org/W4281790889","https://openalex.org/W4286901109","https://openalex.org/W4295422291","https://openalex.org/W4309263978","https://openalex.org/W4313490807","https://openalex.org/W4387934645","https://openalex.org/W6840854595"],"related_works":["https://openalex.org/W2946599741","https://openalex.org/W2593264178","https://openalex.org/W3171039768","https://openalex.org/W2136856901","https://openalex.org/W2368468053","https://openalex.org/W2058542300","https://openalex.org/W2043066834","https://openalex.org/W1564749278","https://openalex.org/W2294851134","https://openalex.org/W3215498386"],"abstract_inverted_index":{"Understanding":[0],"how":[1],"protein":[2,53],"sequences":[3,33],"confer":[4],"function":[5,41],"remains":[6],"a":[7,111],"defining":[8],"challenge":[9],"in":[10,42,68,141],"molecular":[11],"biology.":[12],"Two":[13],"approaches":[14],"have":[15],"yielded":[16],"enormous":[17],"insight":[18],"yet":[19],"are":[20,59],"often":[21,86],"pursued":[22],"separately:":[23],"structure-based,":[24],"where":[25,32],"sequence-encoded":[26],"structures":[27],"mediate":[28],"function,":[29],"and":[30,36,71,98,128,148,168],"disorder-based,":[31],"dictate":[34],"physicochemical":[35],"dynamical":[37],"properties":[38],"which":[39,58],"determine":[40],"the":[43,116,150,159],"absence":[44],"of":[45,79,118,145,152,161],"stable":[46],"structure.":[47],"Here":[48],"we":[49,74],"study":[50],"highly":[51,142,153],"charged":[52,56,143,154],"regions":[54,81,144],"(>40%":[55],"residues),":[57],"routinely":[60],"presumed":[61],"to":[62,88],"be":[63],"disordered.":[64],"Using":[65],"recent":[66],"advances":[67],"structure":[69,119,134],"prediction":[70],"experimental":[72],"structures,":[73],"show":[75,109,131],"that":[76,110,132],"roughly":[77],"40%":[78],"these":[80],"form":[82],"well-structured":[83],"helices.":[84,107],"Features":[85],"used":[87],"predict":[89],"disorder-high":[90],"charge":[91,127],"density,":[92],"low":[93,95],"hydrophobicity,":[94],"sequence":[96],"complexity,":[97],"evolutionarily":[99],"varying":[100],"length-are":[101],"also":[102],"compatible":[103],"with":[104],"solvated,":[105],"variable-length":[106],"We":[108,130],"simple":[112],"composition":[113],"classifier":[114],"predicts":[115],"existence":[117],"far":[120],"better":[121],"than":[122,138,164],"well-established":[123],"heuristics":[124],"based":[125],"on":[126],"hydropathy.":[129],"helical":[133],"is":[135],"more":[136],"prevalent":[137],"previously":[139],"appreciated":[140],"diverse":[146],"proteomes":[147],"characterize":[149],"conservation":[151],"regions.":[155],"Our":[156],"results":[157],"underscore":[158],"importance":[160],"integrating,":[162],"rather":[163],"choosing":[165],"between,":[166],"structure-":[167],"disorder-based":[169],"approaches.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
