{"id":"https://openalex.org/W4387344760","doi":"https://doi.org/10.1371/journal.pcbi.1011507","title":"Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment","display_name":"Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment","publication_year":2023,"publication_date":"2023-10-04","ids":{"openalex":"https://openalex.org/W4387344760","doi":"https://doi.org/10.1371/journal.pcbi.1011507","pmid":"https://pubmed.ncbi.nlm.nih.gov/37792732"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011507","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011507","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011507&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011507&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058023267","display_name":"Aymara Sancho\u2010Araiz","orcid":"https://orcid.org/0000-0001-7139-165X"},"institutions":[{"id":"https://openalex.org/I4210112085","display_name":"Navarre Institute of Health Research","ror":"https://ror.org/023d5h353","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210112085"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Aymara Sancho-Araiz","raw_affiliation_strings":["IdiSNA, Navarra Institute for Health Research, Pamplona, Spain","Pharmacometrics & Systems Pharmacology Group, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7139-165X","affiliations":[{"raw_affiliation_string":"IdiSNA, Navarra Institute for Health Research, Pamplona, Spain","institution_ids":["https://openalex.org/I4210112085"]},{"raw_affiliation_string":"Pharmacometrics & Systems Pharmacology Group, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082956749","display_name":"Zinnia P. Parra\u2010Guill\u00e9n","orcid":"https://orcid.org/0000-0003-1503-2710"},"institutions":[{"id":"https://openalex.org/I4210112085","display_name":"Navarre Institute of Health Research","ror":"https://ror.org/023d5h353","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210112085"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Zinnia P. Parra-Guillen","raw_affiliation_strings":["IdiSNA, Navarra Institute for Health Research, Pamplona, Spain","Pharmacometrics & Systems Pharmacology Group, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IdiSNA, Navarra Institute for Health Research, Pamplona, Spain","institution_ids":["https://openalex.org/I4210112085"]},{"raw_affiliation_string":"Pharmacometrics & Systems Pharmacology Group, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085280034","display_name":"J. Bragard","orcid":"https://orcid.org/0000-0003-3450-9609"},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jean Bragard","raw_affiliation_strings":["Department of Physics and Applied Math. University of Navarra, Pamplona, Spain","Institute of Data Science and Artificial Intelligence, DATAI, University of Navarra, Pamplona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3450-9609","affiliations":[{"raw_affiliation_string":"Department of Physics and Applied Math. University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Institute of Data Science and Artificial Intelligence, DATAI, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091718678","display_name":"Sergio Ardanza-Trevijano","orcid":"https://orcid.org/0000-0003-2827-5383"},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Sergio Ardanza","raw_affiliation_strings":["Department of Physics and Applied Math. University of Navarra, Pamplona, Spain","Institute of Data Science and Artificial Intelligence, DATAI, University of Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Applied Math. University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Institute of Data Science and Artificial Intelligence, DATAI, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069976655","display_name":"V\u00edctor Mangas\u2010Sanju\u00e1n","orcid":"https://orcid.org/0000-0002-3388-5023"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Victor Mangas-Sanjuan","raw_affiliation_strings":["Department of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, Valencia, Spain","Interuniversity Research Institute for Molecular Recognition and Technological Development, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]},{"raw_affiliation_string":"Interuniversity Research Institute for Molecular Recognition and Technological Development, Valencia, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087528420","display_name":"I\u00f1aki F. Troc\u00f3niz","orcid":"https://orcid.org/0000-0003-3700-8658"},"institutions":[{"id":"https://openalex.org/I4210112085","display_name":"Navarre Institute of Health Research","ror":"https://ror.org/023d5h353","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210112085"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"I\u00f1aki F. Troc\u00f3niz","raw_affiliation_strings":["IdiSNA, Navarra Institute for Health Research, Pamplona, Spain","Institute of Data Science and Artificial Intelligence, DATAI, University of Navarra, Pamplona, Spain","Pharmacometrics & Systems Pharmacology Group, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3700-8658","affiliations":[{"raw_affiliation_string":"IdiSNA, Navarra Institute for Health Research, Pamplona, Spain","institution_ids":["https://openalex.org/I4210112085"]},{"raw_affiliation_string":"Institute of Data Science and Artificial Intelligence, DATAI, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Pharmacometrics & Systems Pharmacology Group, Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058023267","https://openalex.org/A5069976655","https://openalex.org/A5082956749","https://openalex.org/A5085280034","https://openalex.org/A5087528420","https://openalex.org/A5091718678"],"corresponding_institution_ids":["https://openalex.org/I16097986","https://openalex.org/I4210112085","https://openalex.org/I88155538"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.4255,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.58581528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"19","issue":"10","first_page":"e1011507","last_page":"e1011507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.6117722988128662},{"id":"https://openalex.org/keywords/monotonic-function","display_name":"Monotonic function","score":0.5743733048439026},{"id":"https://openalex.org/keywords/gompertz-function","display_name":"Gompertz function","score":0.5734946131706238},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5008032321929932},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.4594295024871826},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"Tumor progression","score":0.45407944917678833},{"id":"https://openalex.org/keywords/tumor-cells","display_name":"Tumor cells","score":0.42609232664108276},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.41893160343170166},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40168461203575134},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3957682251930237},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.34001871943473816},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3204110562801361},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3050103783607483},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.2453089952468872},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22132408618927002},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20608773827552795},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.17377638816833496},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1388637125492096}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6117722988128662},{"id":"https://openalex.org/C72169020","wikidata":"https://www.wikidata.org/wiki/Q194404","display_name":"Monotonic function","level":2,"score":0.5743733048439026},{"id":"https://openalex.org/C134463574","wikidata":"https://www.wikidata.org/wiki/Q1011785","display_name":"Gompertz function","level":2,"score":0.5734946131706238},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5008032321929932},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.4594295024871826},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.45407944917678833},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.42609232664108276},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41893160343170166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40168461203575134},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3957682251930237},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34001871943473816},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3204110562801361},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3050103783607483},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2453089952468872},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22132408618927002},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20608773827552795},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.17377638816833496},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1388637125492096},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1011507","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011507","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011507&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37792732","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37792732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:dadun.unav.edu:10171/68596","is_oa":true,"landing_page_url":"https://hdl.handle.net/10171/68596","pdf_url":"https://dadun.unav.edu/bitstream/10171/68596/1/journal.pcbi.1011507.pdf","source":{"id":"https://openalex.org/S4306401514","display_name":"Deposito Adademico Digital Universidad De Navarra (University of Navarra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I88155538","host_organization_name":"Universidad de Navarra","host_organization_lineage":["https://openalex.org/I88155538"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10550146","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10550146","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10550146/pdf/pcbi.1011507.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:roderic.uv.es:10550/91911","is_oa":true,"landing_page_url":"https://hdl.handle.net/10550/91911","pdf_url":"https://roderic.uv.es/bitstreams/54b02916-8132-4bed-8a42-3d2d0a7e5811/download","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sancho Araiz, Aymara Parra Guill\u00e9n, Zinnia Patricia Bragard, Jean Rene Ardanza, Sergio Mangas Sanjuan, Victor Troc\u00f3niz, I\u00f1aki F. 2023 Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment Plos Computational Biology 19 10 1 18","raw_type":"journal article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1011507","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011507","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:83e6686c29df4c62b1781b73a62be77b","is_oa":true,"landing_page_url":"https://doaj.org/article/83e6686c29df4c62b1781b73a62be77b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 10, p e1011507 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011507","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011507","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011507&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.49000000953674316}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387344760.pdf","grobid_xml":"https://content.openalex.org/works/W4387344760.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W229946895","https://openalex.org/W812169397","https://openalex.org/W1535712589","https://openalex.org/W1553883171","https://openalex.org/W1941807065","https://openalex.org/W1980631767","https://openalex.org/W1993147091","https://openalex.org/W2012976204","https://openalex.org/W2013304036","https://openalex.org/W2040837794","https://openalex.org/W2052208722","https://openalex.org/W2074642772","https://openalex.org/W2093697174","https://openalex.org/W2101589741","https://openalex.org/W2101961850","https://openalex.org/W2113651311","https://openalex.org/W2118724241","https://openalex.org/W2126882378","https://openalex.org/W2135883845","https://openalex.org/W2138434918","https://openalex.org/W2144418840","https://openalex.org/W2150878211","https://openalex.org/W2162131389","https://openalex.org/W2346311492","https://openalex.org/W2436525403","https://openalex.org/W2461498055","https://openalex.org/W2552006856","https://openalex.org/W2554268745","https://openalex.org/W2561817867","https://openalex.org/W2577441975","https://openalex.org/W2604338864","https://openalex.org/W2771488961","https://openalex.org/W2802871758","https://openalex.org/W2900960361","https://openalex.org/W2966710588","https://openalex.org/W3008937982","https://openalex.org/W3037304192","https://openalex.org/W3121420611","https://openalex.org/W3198763557","https://openalex.org/W4223473674","https://openalex.org/W4229029322","https://openalex.org/W4237142329","https://openalex.org/W4299043053","https://openalex.org/W6633014411","https://openalex.org/W6681251169"],"related_works":["https://openalex.org/W2063062622","https://openalex.org/W122423376","https://openalex.org/W2294221646","https://openalex.org/W4312201105","https://openalex.org/W2985479685","https://openalex.org/W4361826906","https://openalex.org/W4387745385","https://openalex.org/W2286673285","https://openalex.org/W4213197580","https://openalex.org/W2318608430"],"abstract_inverted_index":{"Mathematical":[0],"modeling":[1],"of":[2,45,76,180,184,193,234],"unperturbed":[3,24],"and":[4,32,38,104,110,126,156,182,228],"perturbed":[5],"tumor":[6,25,66,88,97,102,141,174,214,226,236],"growth":[7,26,67,89,142,175,227],"dynamics":[8,68],"(TGD)":[9],"in":[10,90,162,186,198,208,221,246],"preclinical":[11,136,251],"experiments":[12,137],"provides":[13],"an":[14,58],"opportunity":[15,59],"to":[16,60,80,164,170,223,241],"establish":[17],"translational":[18],"frameworks.":[19],"The":[20,73,159],"most":[21],"commonly":[22],"used":[23,173,240],"models":[27,176],"(i.e.":[28,151,177],"linear,":[29],"exponential,":[30],"Gompertz":[31],"Simeoni)":[33],"describe":[34],"a":[35,70,82,140,199],"monotonic":[36],"increase":[37],"although":[39],"they":[40,129],"capture":[41],"the":[42,46,113,118,134,147,166,171,187,191,194,218,229,235],"mean":[43],"trend":[44],"data":[47],"reasonably":[48],"well,":[49],"systematic":[50],"model":[51,85,143,167],"misspecifications":[52],"can":[53,204,238],"be":[54,206,239],"identified.":[55],"This":[56],"represents":[57],"investigate":[61],"possible":[62],"underlying":[63],"mechanisms":[64],"controlling":[65],"through":[69],"mathematical":[71],"framework.":[72],"overall":[74],"goal":[75],"this":[77,94],"work":[78],"is":[79],"develop":[81],"data-driven":[83],"semi-mechanistic":[84],"describing":[86,224],"non-monotonic":[87,225],"untreated":[91],"mice.":[92],"For":[93],"purpose,":[95],"longitudinal":[96],"volume":[98],"profiles":[99],"from":[100],"different":[101,135,195,243],"types":[103],"cell":[105],"lines":[106],"were":[107,130],"pooled":[108],"together":[109],"analyzed":[111],"using":[112],"population":[114],"approach.":[115],"After":[116],"characterizing":[117],"oscillatory":[119],"patterns":[120],"(oscillator":[121],"half-periods":[122],"between":[123,149,231],"8-11":[124],"days)":[125],"confirming":[127],"that":[128],"systematically":[131],"observed":[132],"across":[133],"available":[138],"(p<10-9),":[139],"was":[144],"built":[145],"including":[146],"interplay":[148],"resources":[150],"oxygen":[152],"or":[153,248],"nutrients),":[154],"angiogenesis":[155],"cancer":[157],"cells.":[158],"new":[160,219],"structure,":[161],"addition":[163,222],"improving":[165],"diagnostic":[168],"compared":[169],"previously":[172],"AIC":[178],"reduction":[179],"71.48":[181],"absence":[183],"autocorrelation":[185],"residuals":[188],"(p>0.05)),":[189],"allows":[190],"evaluation":[192],"oncologic":[196],"treatments":[197],"mechanistic":[200],"way.":[201],"Drug":[202],"effects":[203],"potentially,":[205],"included":[207],"relevant":[209],"processes":[210],"taking":[211],"place":[212],"during":[213,250],"growth.":[215],"In":[216],"brief,":[217],"model,":[220],"interaction":[230],"biological":[232],"factors":[233],"microenvironment,":[237],"explore":[242],"drug":[244,252],"scenarios":[245],"monotherapy":[247],"combination":[249],"development.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
