{"id":"https://openalex.org/W4391018493","doi":"https://doi.org/10.1371/journal.pcbi.1011487","title":"Postinhibitory excitation in motoneurons can be facilitated by hyperpolarization-activated inward currents: A simulation study","display_name":"Postinhibitory excitation in motoneurons can be facilitated by hyperpolarization-activated inward currents: A simulation study","publication_year":2024,"publication_date":"2024-01-19","ids":{"openalex":"https://openalex.org/W4391018493","doi":"https://doi.org/10.1371/journal.pcbi.1011487","pmid":"https://pubmed.ncbi.nlm.nih.gov/38241412"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011487","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011487","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011487&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011487&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025940735","display_name":"Laura Schmid","orcid":"https://orcid.org/0000-0002-1781-8429"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Laura Schmid","raw_affiliation_strings":["Institute for Modelling and Simulation of Biomechanical Systems, University of Stuttgart, Stuttgart, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1781-8429","affiliations":[{"raw_affiliation_string":"Institute for Modelling and Simulation of Biomechanical Systems, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021841828","display_name":"Thomas Klotz","orcid":"https://orcid.org/0000-0002-0503-9815"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Klotz","raw_affiliation_strings":["Institute for Modelling and Simulation of Biomechanical Systems, University of Stuttgart, Stuttgart, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0503-9815","affiliations":[{"raw_affiliation_string":"Institute for Modelling and Simulation of Biomechanical Systems, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008095093","display_name":"Oliver R\u00f6hrle","orcid":"https://orcid.org/0000-0002-1934-6525"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]},{"id":"https://openalex.org/I31582689","display_name":"Stuttgart Technical University of Applied Sciences","ror":"https://ror.org/039gdg280","country_code":"DE","type":"education","lineage":["https://openalex.org/I31582689"]},{"id":"https://openalex.org/I4210125693","display_name":"Simulation Technologies (United States)","ror":"https://ror.org/02ypd5h61","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125693"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Oliver R\u00f6hrle","raw_affiliation_strings":["Institute for Modelling and Simulation of Biomechanical Systems, University of Stuttgart, Stuttgart, Germany","Stuttgart Center for Simulation Sciences (SC SimTech), University of Stuttgart, Stuttgart, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1934-6525","affiliations":[{"raw_affiliation_string":"Institute for Modelling and Simulation of Biomechanical Systems, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Stuttgart Center for Simulation Sciences (SC SimTech), University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346","https://openalex.org/I31582689","https://openalex.org/I4210125693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102765207","display_name":"Randall K. Powers","orcid":"https://orcid.org/0000-0003-0957-5583"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randall K. Powers","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032001702","display_name":"Francesco Negro","orcid":"https://orcid.org/0000-0002-9094-8932"},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Negro","raw_affiliation_strings":["Department of Clinical and Experimental Sciences, Universit\u00e0 degli Studi di Brescia, Brescia, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9094-8932","affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Sciences, Universit\u00e0 degli Studi di Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081333112","display_name":"Utku \u015e. Yavuz","orcid":"https://orcid.org/0000-0002-6968-8064"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Utku \u015e. Yavuz","raw_affiliation_strings":["Department of Biomedical Signals and Systems, Faculty of Electrical Engineering, Mathematics and Computer Sciences, University of Twente, Enschede, Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-6968-8064","affiliations":[{"raw_affiliation_string":"Department of Biomedical Signals and Systems, Faculty of Electrical Engineering, Mathematics and Computer Sciences, University of Twente, Enschede, Netherlands","institution_ids":["https://openalex.org/I94624287"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5008095093","https://openalex.org/A5021841828","https://openalex.org/A5025940735","https://openalex.org/A5032001702","https://openalex.org/A5081333112","https://openalex.org/A5102765207"],"corresponding_institution_ids":["https://openalex.org/I100066346","https://openalex.org/I201448701","https://openalex.org/I31582689","https://openalex.org/I4210125693","https://openalex.org/I79940851","https://openalex.org/I94624287"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.634,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.58437941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"20","issue":"1","first_page":"e1011487","last_page":"e1011487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11449","display_name":"Mechanical and Optical Resonators","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.7907440662384033},{"id":"https://openalex.org/keywords/hyperpolarization","display_name":"Hyperpolarization (physics)","score":0.7218201756477356},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.6670032143592834},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6434474587440491},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.5559883117675781},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.4888874590396881},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"Membrane potential","score":0.48782041668891907},{"id":"https://openalex.org/keywords/motor-neuron","display_name":"Motor neuron","score":0.48310065269470215},{"id":"https://openalex.org/keywords/excitation","display_name":"Excitation","score":0.47613170742988586},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4659460783004761},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.41426950693130493},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3844577670097351},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2908830940723419},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.12696540355682373},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.10586810111999512},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"Spinal cord","score":0.08255189657211304}],"concepts":[{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.7907440662384033},{"id":"https://openalex.org/C131453863","wikidata":"https://www.wikidata.org/wiki/Q1641079","display_name":"Hyperpolarization (physics)","level":3,"score":0.7218201756477356},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.6670032143592834},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6434474587440491},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5559883117675781},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4888874590396881},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.48782041668891907},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.48310065269470215},{"id":"https://openalex.org/C83581075","wikidata":"https://www.wikidata.org/wiki/Q1361503","display_name":"Excitation","level":2,"score":0.47613170742988586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4659460783004761},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.41426950693130493},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3844577670097351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2908830940723419},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.12696540355682373},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10586810111999512},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.08255189657211304},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1011487","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011487","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011487&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38241412","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38241412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:ris.utwente.nl:publications/8e830bb5-bda4-49a3-91dc-ff7b7c67c5ad","is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/8e830bb5-bda4-49a3-91dc-ff7b7c67c5ad","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schmid, L, Klotz, T, R\u00f6hrle, O, Powers, R K, Negro, F & Yavuz, U 2024, 'Postinhibitory excitation in motoneurons can be facilitated by hyperpolarization-activated inward currents : A simulation study', PLoS Computational Biology, vol. 20, no. 1, e1011487. https://doi.org/10.1371/journal.pcbi.1011487","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10843122","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10843122","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10843122/pdf/pcbi.1011487.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:ris.utwente.nl:openaire/8e830bb5-bda4-49a3-91dc-ff7b7c67c5ad","is_oa":true,"landing_page_url":"https://research.utwente.nl/files/355501462/journal.pcbi.1011487.pdf","pdf_url":"https://ris.utwente.nl/ws/files/355501462/journal.pcbi.1011487.pdf","source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Schmid, L, Klotz, T, R\u00f6hrle, O, Powers, R K, Negro, F & Yavuz, U 2024, 'Postinhibitory excitation in motoneurons can be facilitated by hyperpolarization-activated inward currents : A simulation study', PLoS Computational Biology, vol. 20, no. 1, e1011487. https://doi.org/10.1371/journal.pcbi.1011487","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:59bec7af2f7d4104ad93e26fbef7b7a7","is_oa":true,"landing_page_url":"https://doaj.org/article/59bec7af2f7d4104ad93e26fbef7b7a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 1, p e1011487 (2024)","raw_type":"article"},{"id":"pmh:oai:iris.unibs.it:11379/617705","is_oa":true,"landing_page_url":"https://hdl.handle.net/11379/617705","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011487","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011487","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011487&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1128036556","display_name":null,"funder_award_id":"SPP 2311 (465243391)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2022546044","display_name":null,"funder_award_id":"SPP 2311","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2546427498","display_name":null,"funder_award_id":"101045605","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G7468498537","display_name":"Ein datengetriebenes Optimierungsframework zur Verbesserung des Verst\u00e4ndnisses\nvon Anpassungen des neuromuskul\u00e4ren Systems an Gehirnpathologien","funder_award_id":"465243391","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G891504687","display_name":null,"funder_award_id":"101055186","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4391018493.pdf","grobid_xml":"https://content.openalex.org/works/W4391018493.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W181689146","https://openalex.org/W1849270082","https://openalex.org/W1968244260","https://openalex.org/W1978226545","https://openalex.org/W1985940938","https://openalex.org/W1990517441","https://openalex.org/W1993752540","https://openalex.org/W2004879773","https://openalex.org/W2008222794","https://openalex.org/W2011352780","https://openalex.org/W2014654157","https://openalex.org/W2016730940","https://openalex.org/W2021102226","https://openalex.org/W2030807885","https://openalex.org/W2031856781","https://openalex.org/W2033447200","https://openalex.org/W2038651998","https://openalex.org/W2046080806","https://openalex.org/W2054225626","https://openalex.org/W2054404435","https://openalex.org/W2066784785","https://openalex.org/W2067142718","https://openalex.org/W2080515858","https://openalex.org/W2085306742","https://openalex.org/W2085374455","https://openalex.org/W2086236755","https://openalex.org/W2113867799","https://openalex.org/W2117453669","https://openalex.org/W2118352903","https://openalex.org/W2118621245","https://openalex.org/W2129968729","https://openalex.org/W2134273148","https://openalex.org/W2136024120","https://openalex.org/W2139448891","https://openalex.org/W2145460573","https://openalex.org/W2207052072","https://openalex.org/W2290981976","https://openalex.org/W2302128506","https://openalex.org/W2311855608","https://openalex.org/W2328795247","https://openalex.org/W2346981077","https://openalex.org/W2395514224","https://openalex.org/W2440168604","https://openalex.org/W2785847583","https://openalex.org/W2904817101","https://openalex.org/W2913715211","https://openalex.org/W2940480086","https://openalex.org/W2947850092","https://openalex.org/W2956085092","https://openalex.org/W3018660341","https://openalex.org/W3209914422"],"related_works":["https://openalex.org/W1998060356","https://openalex.org/W2060662231","https://openalex.org/W1973357121","https://openalex.org/W2049451847","https://openalex.org/W2411060286","https://openalex.org/W2030681710","https://openalex.org/W1984026462","https://openalex.org/W2131436118","https://openalex.org/W4402759330","https://openalex.org/W2049304326"],"abstract_inverted_index":{"Postinhibitory":[0],"excitation":[1,50,212],"is":[2,32,165],"a":[3,7,110,114,216,224],"transient":[4],"overshoot":[5],"of":[6,29,75,83,101,135,178,182,195],"neuron's":[8],"baseline":[9,170],"firing":[10,116,137,171],"rate":[11,172],"following":[12],"an":[13,62,104,128],"inhibitory":[14,105,129,146,161],"stimulus":[15,147],"and":[16,35,39,148,164,213],"can":[17,53,70,108,124,209],"be":[18,54,125],"observed":[19],"in":[20,22,51,113,193],"vivo":[21],"human":[23,84,197],"motoneurons.":[24,76],"However,":[25],"the":[26,72,80,88,99,122,133,136,141,145,149,154,160,169,176,188,196],"biophysical":[27],"origin":[28],"this":[30],"phenomenon":[31],"still":[33],"unknown":[34],"both":[36],"reflex":[37],"pathways":[38],"intrinsic":[40],"motoneuron":[41,221],"properties":[42],"have":[43],"been":[44],"proposed.":[45],"We":[46],"hypothesized":[47],"that":[48,98,121,200,207],"postinhibitory":[49,73,155,202,211],"motoneurons":[52],"facilitated":[55],"by":[56,103,127],"hyperpolarization-activated":[57],"inward":[58],"currents":[59],"(h-currents).":[60],"Using":[61],"electrical":[63],"circuit":[64],"model,":[65],"we":[66,78],"investigated":[67],"how":[68],"h-currents":[69,102,208],"modulate":[71],"response":[74],"Further,":[77,153],"analyzed":[79],"spike":[81],"trains":[82],"motor":[85,198],"units":[86,199],"from":[87,187],"tibialis":[89],"anterior":[90],"muscle":[91],"during":[92],"reciprocal":[93],"inhibition.":[94,226],"The":[95],"simulations":[96],"revealed":[97],"activation":[100],"postsynaptic":[106],"potential":[107],"cause":[109],"short-term":[111],"increase":[112,220],"motoneuron's":[115],"probability.":[117],"This":[118,204],"result":[119],"suggests":[120,206],"neuron":[123],"excited":[126],"stimulus.":[130],"In":[131],"detail,":[132],"modulation":[134],"probability":[138],"depends":[139],"on":[140],"time":[142],"delay":[143],"between":[144],"previous":[150],"action":[151],"potential.":[152],"excitation's":[156],"strength":[157],"correlates":[158],"with":[159,168],"stimulus's":[162],"amplitude":[163],"negatively":[166],"correlated":[167],"as":[173,175,185,215],"well":[174],"level":[177],"input":[179],"noise.":[180],"Hallmarks":[181],"h-current":[183],"activity,":[184],"identified":[186],"modeling":[189],"study,":[190],"were":[191],"found":[192],"50%":[194],"showed":[201],"excitation.":[203],"study":[205],"facilitate":[210],"act":[214],"modulatory":[217],"system":[218],"to":[219],"excitability":[222],"after":[223],"strong":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}