{"id":"https://openalex.org/W4386597884","doi":"https://doi.org/10.1371/journal.pcbi.1011438","title":"Pathfinder: Protein folding pathway prediction based on conformational sampling","display_name":"Pathfinder: Protein folding pathway prediction based on conformational sampling","publication_year":2023,"publication_date":"2023-09-11","ids":{"openalex":"https://openalex.org/W4386597884","doi":"https://doi.org/10.1371/journal.pcbi.1011438","pmid":"https://pubmed.ncbi.nlm.nih.gov/37695768"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011438","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011438","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011438&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011438&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101242958","display_name":"Zhaohong Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhaohong Huang","raw_affiliation_strings":["College of Information Engineering, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078605363","display_name":"Xinyue Cui","orcid":null},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinyue Cui","raw_affiliation_strings":["College of Information Engineering, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109541284","display_name":"Yuhao Xia","orcid":"https://orcid.org/0009-0003-3323-5949"},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuhao Xia","raw_affiliation_strings":["College of Information Engineering, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072066185","display_name":"Kailong Zhao","orcid":"https://orcid.org/0000-0003-0593-4809"},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kailong Zhao","raw_affiliation_strings":["College of Information Engineering, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049735973","display_name":"Guijun Zhang","orcid":"https://orcid.org/0000-0002-7815-5884"},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guijun Zhang","raw_affiliation_strings":["College of Information Engineering, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-7815-5884","affiliations":[{"raw_affiliation_string":"College of Information Engineering, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5049735973","https://openalex.org/A5072066185","https://openalex.org/A5078605363","https://openalex.org/A5101242958","https://openalex.org/A5109541284"],"corresponding_institution_ids":["https://openalex.org/I55712492"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.8898,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.85920312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"19","issue":"9","first_page":"e1011438","last_page":"e1011438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.7025127410888672},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.6996855735778809},{"id":"https://openalex.org/keywords/conformational-ensembles","display_name":"Conformational ensembles","score":0.5282047390937805},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5138816833496094},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"Protein structure prediction","score":0.4845966100692749},{"id":"https://openalex.org/keywords/pathfinder","display_name":"Pathfinder","score":0.465629518032074},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.4647971987724304},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.42816242575645447},{"id":"https://openalex.org/keywords/downhill-folding","display_name":"Downhill folding","score":0.41737863421440125},{"id":"https://openalex.org/keywords/protein-superfamily","display_name":"Protein superfamily","score":0.4171893894672394},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37566912174224854},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33021676540374756},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.30466723442077637},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2964065968990326},{"id":"https://openalex.org/keywords/phi-value-analysis","display_name":"Phi value analysis","score":0.25995826721191406},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.15800023078918457},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14776062965393066},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09310269355773926}],"concepts":[{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.7025127410888672},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.6996855735778809},{"id":"https://openalex.org/C2777936996","wikidata":"https://www.wikidata.org/wiki/Q17148461","display_name":"Conformational ensembles","level":3,"score":0.5282047390937805},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5138816833496094},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.4845966100692749},{"id":"https://openalex.org/C2778940482","wikidata":"https://www.wikidata.org/wiki/Q7144753","display_name":"Pathfinder","level":2,"score":0.465629518032074},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.4647971987724304},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.42816242575645447},{"id":"https://openalex.org/C46449900","wikidata":"https://www.wikidata.org/wiki/Q5303170","display_name":"Downhill folding","level":4,"score":0.41737863421440125},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.4171893894672394},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37566912174224854},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33021676540374756},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30466723442077637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2964065968990326},{"id":"https://openalex.org/C162203774","wikidata":"https://www.wikidata.org/wiki/Q7181581","display_name":"Phi value analysis","level":3,"score":0.25995826721191406},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.15800023078918457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14776062965393066},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09310269355773926},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1011438","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011438","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011438&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37695768","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37695768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10513300","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10513300","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10513300/pdf/pcbi.1011438.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:abe871372d93418faff42a4f03ca4526","is_oa":true,"landing_page_url":"https://doaj.org/article/abe871372d93418faff42a4f03ca4526","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 9, p e1011438 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011438","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011438","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011438&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1320274221","display_name":null,"funder_award_id":"2022ZD0115103","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G320835743","display_name":null,"funder_award_id":"LZ20F030002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3775454306","display_name":null,"funder_award_id":"62173304","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G460379816","display_name":null,"funder_award_id":"LZ20F030002","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386597884.pdf","grobid_xml":"https://content.openalex.org/works/W4386597884.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1548178570","https://openalex.org/W1561923743","https://openalex.org/W1570122994","https://openalex.org/W1626583747","https://openalex.org/W1964296596","https://openalex.org/W1966084755","https://openalex.org/W1967612331","https://openalex.org/W1978675310","https://openalex.org/W1982643972","https://openalex.org/W1988146888","https://openalex.org/W1997108831","https://openalex.org/W2000114467","https://openalex.org/W2005096951","https://openalex.org/W2012108346","https://openalex.org/W2020716464","https://openalex.org/W2034563863","https://openalex.org/W2042133316","https://openalex.org/W2052963427","https://openalex.org/W2056760934","https://openalex.org/W2061510091","https://openalex.org/W2066000489","https://openalex.org/W2067236515","https://openalex.org/W2071870204","https://openalex.org/W2072391950","https://openalex.org/W2085531037","https://openalex.org/W2088510066","https://openalex.org/W2089597488","https://openalex.org/W2091114929","https://openalex.org/W2097617033","https://openalex.org/W2115824900","https://openalex.org/W2123132657","https://openalex.org/W2126157913","https://openalex.org/W2130479394","https://openalex.org/W2139236870","https://openalex.org/W2139344563","https://openalex.org/W2146134187","https://openalex.org/W2156098042","https://openalex.org/W2164617854","https://openalex.org/W2174708591","https://openalex.org/W2329336071","https://openalex.org/W2519539312","https://openalex.org/W2608970480","https://openalex.org/W2614053601","https://openalex.org/W2660691091","https://openalex.org/W2793216035","https://openalex.org/W2907292200","https://openalex.org/W2911475376","https://openalex.org/W2912360054","https://openalex.org/W2951531210","https://openalex.org/W2955168413","https://openalex.org/W2978380288","https://openalex.org/W2980128132","https://openalex.org/W2989859371","https://openalex.org/W2998620327","https://openalex.org/W3106016894","https://openalex.org/W3162614523","https://openalex.org/W3175798418","https://openalex.org/W3177828909","https://openalex.org/W3178212622","https://openalex.org/W3186179742","https://openalex.org/W3210505348","https://openalex.org/W3211795435","https://openalex.org/W3211840902","https://openalex.org/W3214529535","https://openalex.org/W4205827692","https://openalex.org/W4210460281","https://openalex.org/W4210629402","https://openalex.org/W4214942061","https://openalex.org/W4221084264","https://openalex.org/W4225939435","https://openalex.org/W4229373389","https://openalex.org/W4249733541","https://openalex.org/W4288428465","https://openalex.org/W4289948291","https://openalex.org/W4313332815","https://openalex.org/W4323075934","https://openalex.org/W6750052739"],"related_works":["https://openalex.org/W2166486258","https://openalex.org/W646353556","https://openalex.org/W3023334178","https://openalex.org/W2164446846","https://openalex.org/W2015324867","https://openalex.org/W3199272077","https://openalex.org/W2141010032","https://openalex.org/W4225552973","https://openalex.org/W2123053169","https://openalex.org/W3211689971"],"abstract_inverted_index":{"The":[0,79,126,204],"study":[1],"of":[2,14,22,29,49,67,109,123,153],"protein":[3,34,55,113,201,235],"folding":[4,30,50,56,114,147,161,192,202,213,225,236],"mechanism":[5,28],"is":[6,13,94,102,129],"a":[7,54,90],"challenge":[8],"in":[9,76],"molecular":[10],"biology,":[11],"which":[12],"great":[15],"significance":[16],"for":[17,177],"revealing":[18],"the":[19,26,39,42,47,68,73,77,98,106,119,175,178,183],"movement":[20],"rules":[21],"biological":[23,168,188,218],"macromolecules,":[24],"understanding":[25],"pathogenic":[27],"diseases,":[31],"and":[32,71,149,227],"designing":[33],"engineering":[35],"materials.":[36],"Based":[37],"on":[38,131],"hypothesis":[40],"that":[41,93,207],"conformational":[43,69],"sampling":[44,66],"trajectory":[45],"contain":[46,223],"information":[48],"pathway,":[51],"we":[52,143,158,173],"propose":[53],"pathway":[57],"prediction":[58,180],"algorithm":[59,92],"named":[60,86],"Pathfinder.":[61],"Firstly,":[62],"Pathfinder":[63,128],"performs":[64],"large-scale":[65],"space":[70],"clusters":[72],"decoys":[74],"obtained":[75,82],"sampling.":[78],"heterogeneous":[80],"conformations":[81],"by":[83,97,167],"clustering":[84],"are":[85,116],"seed":[87,110,124],"states.":[88,111,125],"Then,":[89],"resampling":[91],"not":[95],"constrained":[96],"local":[99],"energy":[100],"basin":[101],"designed":[103],"to":[104,163,196,215,233],"obtain":[105],"transition":[107,121],"probabilities":[108,122],"Finally,":[112],"pathways":[115,148,162,193,214],"inferred":[117],"from":[118],"maximum":[120],"proposed":[127],"tested":[130],"our":[132],"developed":[133],"test":[134],"set":[135],"(34":[136],"proteins).":[137],"For":[138,155,170,182],"11":[139],"widely":[140],"studied":[141],"proteins,":[142,157,172],"correctly":[144],"predicted":[145,159,195],"their":[146,160],"specifically":[150],"analyzed":[151,174],"5":[152],"them.":[154],"13":[156],"be":[164,230],"further":[165],"verified":[166],"experiments.":[169],"6":[171],"reasons":[176],"low":[179],"accuracy.":[181],"other":[184],"4":[185],"proteins":[186,221],"without":[187],"experiment":[189],"results,":[190],"potential":[191],"were":[194],"provide":[197],"new":[198],"insights":[199],"into":[200],"mechanism.":[203],"results":[205],"reveal":[206],"structural":[208],"analogs":[209],"may":[210,222,229],"have":[211],"different":[212,217],"express":[216],"functions,":[219],"homologous":[220],"common":[224],"pathways,":[226],"\u03b1-helices":[228],"more":[231],"prone":[232],"early":[234],"than":[237],"\u03b2-strands.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}