{"id":"https://openalex.org/W4394841133","doi":"https://doi.org/10.1371/journal.pcbi.1011437","title":"How robust are estimates of key parameters in standard viral dynamic models?","display_name":"How robust are estimates of key parameters in standard viral dynamic models?","publication_year":2024,"publication_date":"2024-04-16","ids":{"openalex":"https://openalex.org/W4394841133","doi":"https://doi.org/10.1371/journal.pcbi.1011437","pmid":"https://pubmed.ncbi.nlm.nih.gov/38626190"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011437","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011437","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011437&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011437&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071676719","display_name":"Carolin Zitzmann","orcid":"https://orcid.org/0000-0001-5188-0042"},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carolin Zitzmann","raw_affiliation_strings":["Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035803088","display_name":"Ruian Ke","orcid":"https://orcid.org/0000-0001-5307-8934"},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ruian Ke","raw_affiliation_strings":["Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033826368","display_name":"Ruy M. Ribeiro","orcid":"https://orcid.org/0000-0002-3988-8241"},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ruy M. Ribeiro","raw_affiliation_strings":["Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058338534","display_name":"Alan S. Perelson","orcid":"https://orcid.org/0000-0002-2455-0002"},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan S. Perelson","raw_affiliation_strings":["Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico"],"raw_orcid":"https://orcid.org/0000-0002-2455-0002","affiliations":[{"raw_affiliation_string":"Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico","institution_ids":["https://openalex.org/I1343871089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033826368","https://openalex.org/A5035803088","https://openalex.org/A5058338534","https://openalex.org/A5071676719"],"corresponding_institution_ids":["https://openalex.org/I1343871089"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":9.4778,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.98953478,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"20","issue":"4","first_page":"e1011437","last_page":"e1011437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.8839862942695618},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5594630241394043},{"id":"https://openalex.org/keywords/infectivity","display_name":"Infectivity","score":0.4879169166088104},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.4663291275501251},{"id":"https://openalex.org/keywords/viral-pathogenesis","display_name":"Viral pathogenesis","score":0.4661259651184082},{"id":"https://openalex.org/keywords/viral-hepatitis","display_name":"Viral hepatitis","score":0.43641868233680725},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.4353024661540985},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.38102254271507263},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.3606764078140259},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3469778895378113},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33339452743530273},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.2929527163505554},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.28214597702026367},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1874586045742035}],"concepts":[{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.8839862942695618},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5594630241394043},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.4879169166088104},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.4663291275501251},{"id":"https://openalex.org/C140933497","wikidata":"https://www.wikidata.org/wiki/Q7933606","display_name":"Viral pathogenesis","level":4,"score":0.4661259651184082},{"id":"https://openalex.org/C2777072776","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Viral hepatitis","level":2,"score":0.43641868233680725},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4353024661540985},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38102254271507263},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3606764078140259},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3469778895378113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33339452743530273},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2929527163505554},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.28214597702026367},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1874586045742035},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1011437","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011437","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011437&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38626190","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38626190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11051641","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11051641","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11051641/pdf/pcbi.1011437.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:45cdf49905ea4fbfa561b5fd6d0f08c1","is_oa":false,"landing_page_url":"https://doaj.org/article/45cdf49905ea4fbfa561b5fd6d0f08c1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 4, p e1011437 (2024)","raw_type":"article"},{"id":"pmh:oai:osti.gov:2337720","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/2337720","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:2341340","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/2341340","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:2406571","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/2406571","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011437","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011437","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011437&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8299999833106995}],"awards":[{"id":"https://openalex.org/G1668019184","display_name":null,"funder_award_id":"R01-AI152703 and U54-HL143541","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G1710748723","display_name":null,"funder_award_id":"U54-HL143541","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2356915424","display_name":null,"funder_award_id":"89233218CNA000001","funder_id":"https://openalex.org/F4320337547","funder_display_name":"Laboratory Directed Research and Development"},{"id":"https://openalex.org/G2400472844","display_name":null,"funder_award_id":"AI078881","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5648902721","display_name":null,"funder_award_id":"R01-AI078881","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G6605557409","display_name":null,"funder_award_id":"AI152703","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6683013672","display_name":null,"funder_award_id":"R01-AI152703","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6915041508","display_name":null,"funder_award_id":"20200695ER","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G7500863821","display_name":null,"funder_award_id":"89233218CNA000001","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G8087689195","display_name":null,"funder_award_id":"20200743ER","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G8363525507","display_name":null,"funder_award_id":"R01-AI078881","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8659807574","display_name":null,"funder_award_id":"89233218CNA000001","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337547","display_name":"Laboratory Directed Research and Development","ror":"https://ror.org/01e41cf67"},{"id":"https://openalex.org/F4320338304","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394841133.pdf","grobid_xml":"https://content.openalex.org/works/W4394841133.grobid-xml"},"referenced_works_count":141,"referenced_works":["https://openalex.org/W760058531","https://openalex.org/W1879700306","https://openalex.org/W1980441640","https://openalex.org/W1983951850","https://openalex.org/W1991592276","https://openalex.org/W2007134915","https://openalex.org/W2014184548","https://openalex.org/W2014903591","https://openalex.org/W2014954855","https://openalex.org/W2019559865","https://openalex.org/W2026407589","https://openalex.org/W2031966433","https://openalex.org/W2033980528","https://openalex.org/W2041769542","https://openalex.org/W2042492606","https://openalex.org/W2043064608","https://openalex.org/W2048439088","https://openalex.org/W2051269276","https://openalex.org/W2061146727","https://openalex.org/W2061657962","https://openalex.org/W2072122090","https://openalex.org/W2088534886","https://openalex.org/W2089726099","https://openalex.org/W2091129202","https://openalex.org/W2096598657","https://openalex.org/W2106378149","https://openalex.org/W2109977701","https://openalex.org/W2112153513","https://openalex.org/W2112391961","https://openalex.org/W2112639149","https://openalex.org/W2112939785","https://openalex.org/W2113105229","https://openalex.org/W2119950877","https://openalex.org/W2133748753","https://openalex.org/W2139054265","https://openalex.org/W2143079142","https://openalex.org/W2146089461","https://openalex.org/W2159482231","https://openalex.org/W2160063406","https://openalex.org/W2165676801","https://openalex.org/W2168003330","https://openalex.org/W2168648059","https://openalex.org/W2341484909","https://openalex.org/W2397538922","https://openalex.org/W2409568733","https://openalex.org/W2411447930","https://openalex.org/W2412909330","https://openalex.org/W2460362894","https://openalex.org/W2515696031","https://openalex.org/W2529443144","https://openalex.org/W2549787299","https://openalex.org/W2569851255","https://openalex.org/W2609504358","https://openalex.org/W2741511733","https://openalex.org/W2769768203","https://openalex.org/W2808362850","https://openalex.org/W2852166527","https://openalex.org/W2887542578","https://openalex.org/W2899323717","https://openalex.org/W2908941646","https://openalex.org/W2910697814","https://openalex.org/W2953378801","https://openalex.org/W2959231597","https://openalex.org/W2989707811","https://openalex.org/W3003668884","https://openalex.org/W3003675638","https://openalex.org/W3004686667","https://openalex.org/W3004912618","https://openalex.org/W3005802419","https://openalex.org/W3006065484","https://openalex.org/W3006364226","https://openalex.org/W3008582897","https://openalex.org/W3008827533","https://openalex.org/W3010233963","https://openalex.org/W3012605404","https://openalex.org/W3012864042","https://openalex.org/W3013594674","https://openalex.org/W3013893137","https://openalex.org/W3014512461","https://openalex.org/W3014712943","https://openalex.org/W3015571324","https://openalex.org/W3016587465","https://openalex.org/W3020184843","https://openalex.org/W3021957499","https://openalex.org/W3024439384","https://openalex.org/W3029944349","https://openalex.org/W3030748957","https://openalex.org/W3033102011","https://openalex.org/W3035973582","https://openalex.org/W3036391214","https://openalex.org/W3048334038","https://openalex.org/W3091654554","https://openalex.org/W3093988179","https://openalex.org/W3095240514","https://openalex.org/W3095872801","https://openalex.org/W3110513543","https://openalex.org/W3119992512","https://openalex.org/W3126160188","https://openalex.org/W3126293391","https://openalex.org/W3126652124","https://openalex.org/W3126996402","https://openalex.org/W3132630010","https://openalex.org/W3137515854","https://openalex.org/W3139167208","https://openalex.org/W3139286950","https://openalex.org/W3139456908","https://openalex.org/W3167263937","https://openalex.org/W3173969676","https://openalex.org/W3174276657","https://openalex.org/W3181889816","https://openalex.org/W3196608863","https://openalex.org/W3201102531","https://openalex.org/W3204426344","https://openalex.org/W3216106237","https://openalex.org/W3217549965","https://openalex.org/W4205707138","https://openalex.org/W4207075428","https://openalex.org/W4212941773","https://openalex.org/W4213036333","https://openalex.org/W4221135099","https://openalex.org/W4221137326","https://openalex.org/W4225158892","https://openalex.org/W4225159506","https://openalex.org/W4225502791","https://openalex.org/W4226145347","https://openalex.org/W4226229984","https://openalex.org/W4235051927","https://openalex.org/W4235988835","https://openalex.org/W4289261585","https://openalex.org/W4293368015","https://openalex.org/W4295932440","https://openalex.org/W4298139532","https://openalex.org/W4313639197","https://openalex.org/W4323353295","https://openalex.org/W4364380346","https://openalex.org/W4378976426","https://openalex.org/W4384283521","https://openalex.org/W4385516341","https://openalex.org/W4386851993","https://openalex.org/W6673390461","https://openalex.org/W6778480730"],"related_works":["https://openalex.org/W2008875895","https://openalex.org/W1970932468","https://openalex.org/W1932710078","https://openalex.org/W1995328853","https://openalex.org/W1983916957","https://openalex.org/W2510793503","https://openalex.org/W1976788601","https://openalex.org/W2330877710","https://openalex.org/W2151894560","https://openalex.org/W3190981607"],"abstract_inverted_index":{"Mathematical":[0],"models":[1],"of":[2,43,75,91,126,134,136,157,171,174,183,200,219,246,277,290,297,311],"viral":[3,49,64,76,99,120,141,147,167,210,258,313],"infection":[4,106,164,175,278],"have":[5],"been":[6],"developed,":[7],"fitted":[8],"to":[9,118,145,165,178,225,256,264,304,327],"data,":[10,185,315,322],"and":[11,28,96,181,208,283],"provide":[12,302],"insight":[13],"into":[14],"disease":[15,193],"pathogenesis":[16],"for":[17,32],"multiple":[18],"agents":[19,33,44],"that":[20,34,45,320],"cause":[21,35,46],"chronic":[22,47],"infection,":[23,92],"including":[24],"HIV,":[25],"hepatitis":[26],"C,":[27],"B":[29],"virus.":[30],"However,":[31,109],"acute":[36,41],"infections":[37],"or":[38,60,240],"during":[39],"the":[40,62,72,89,93,104,115,124,127,132,146,155,161,172,179,197,209,217,231,249,254,271,275,295,309],"stage":[42],"infections,":[48],"load":[50,142,148,259,314],"data":[51,70,85,143,220,237,247],"are":[52,176,203,213,325],"often":[53],"collected":[54],"after":[55,61],"symptoms":[56],"develop,":[57],"usually":[58],"around":[59],"peak":[63,119,149,166,257],"load.":[65,168],"Consequently,":[66],"we":[67,130,153,301],"frequently":[68],"lack":[69,245],"in":[71,98,191,248,287,294,308],"initial":[73],"phase":[74,252],"growth,":[77],"i.e.,":[78],"when":[79,140,152,235,323],"pre-symptomatic":[80],"transmission":[81],"events":[82],"occur.":[83],"Missing":[84],"may":[86,122],"make":[87],"estimating":[88],"time":[90,117,162,173,255,276],"infectious":[94],"period,":[95],"parameters":[97,139,159,189,215,234,292,307,330],"dynamic":[100],"models,":[101],"such":[102,113,195],"as":[103,114,196],"cell":[105],"rate,":[107],"difficult.":[108],"having":[110],"extra":[111],"information,":[112],"average":[116],"load,":[121],"improve":[123],"robustness":[125,133,218],"estimation.":[128],"Here,":[129],"evaluated":[131],"estimates":[135,170,289],"key":[137,214],"model":[138,233,306,329],"prior":[144],"is":[150,238],"missing,":[151],"know":[154],"values":[156,224,227],"some":[158],"and/or":[160],"from":[163,280],"Although":[169],"sensitive":[177],"quality":[180],"amount":[182],"available":[184],"particularly":[186],"pre-peak,":[187],"other":[188,272],"important":[190],"understanding":[192],"pathogenesis,":[194],"loss":[198],"rate":[199,212],"infected":[201],"cells,":[202],"less":[204],"sensitive.":[205],"Viral":[206],"infectivity":[207],"production":[211],"affecting":[216],"fits.":[221],"Fixing":[222],"their":[223],"literature":[226],"can":[228],"help":[229],"estimate":[230,328],"remaining":[232],"pre-peak":[236,250],"missing":[239],"limited.":[241],"We":[242],"find":[243],"a":[244,265],"growth":[251,268],"underestimates":[253],"by":[260],"several":[261],"days,":[262],"leading":[263],"shorter":[266],"predicted":[267],"phase.":[269],"On":[270],"hand,":[273],"knowing":[274],"(e.g.,":[279],"epidemiological":[281],"data)":[282],"fixing":[284],"it":[285],"results":[286,317],"good":[288],"dynamical":[291],"even":[293],"absence":[296,310],"early":[298,312],"data.":[299],"While":[300],"ways":[303],"approximate":[305],"our":[316],"also":[318],"suggest":[319],"these":[321],"available,":[324],"needed":[326],"more":[331],"precisely.":[332]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-06T09:05:17.133730","created_date":"2025-10-10T00:00:00"}
