{"id":"https://openalex.org/W4386356872","doi":"https://doi.org/10.1371/journal.pcbi.1011434","title":"A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics","display_name":"A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4386356872","doi":"https://doi.org/10.1371/journal.pcbi.1011434","pmid":"https://pubmed.ncbi.nlm.nih.gov/37656758"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011434","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011434","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1011434","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088131273","display_name":"Roberta Lorenzi","orcid":"https://orcid.org/0000-0003-2034-118X"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Roberta Maria Lorenzi","raw_affiliation_strings":["Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy"],"raw_orcid":"https://orcid.org/0000-0003-2034-118X","affiliations":[{"raw_affiliation_string":"Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041703283","display_name":"Alice Geminiani","orcid":"https://orcid.org/0000-0002-9407-8719"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alice Geminiani","raw_affiliation_strings":["Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9407-8719","affiliations":[{"raw_affiliation_string":"Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000167304","display_name":"Yann Zerlaut","orcid":"https://orcid.org/0000-0003-0322-749X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Yann Zerlaut","raw_affiliation_strings":["Institut du Cerveau-Paris Brain Institute-ICM, Inserm, CNRS, APHP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France","Institut du Cerveau\u2014Paris Brain Institute\u2014ICM, Inserm, CNRS, APHP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut du Cerveau-Paris Brain Institute-ICM, Inserm, CNRS, APHP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210152724","https://openalex.org/I1294671590","https://openalex.org/I4210097159"]},{"raw_affiliation_string":"Institut du Cerveau\u2014Paris Brain Institute\u2014ICM, Inserm, CNRS, APHP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210097159","https://openalex.org/I4210121705","https://openalex.org/I39804081","https://openalex.org/I4210152724","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104163683","display_name":"Marialaura De Grazia","orcid":null},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marialaura De Grazia","raw_affiliation_strings":["Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022027790","display_name":"Alain Destexhe","orcid":"https://orcid.org/0000-0001-7405-0455"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Alain Destexhe","raw_affiliation_strings":["Paris-Saclay University, CNRS, Saclay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paris-Saclay University, CNRS, Saclay, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037442059","display_name":"Claudia A. M. Gandini Wheeler\u2010Kingshott","orcid":"https://orcid.org/0000-0002-4832-1300"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","IT"],"is_corresponding":true,"raw_author_name":"Claudia A. M. Gandini Wheeler-Kingshott","raw_affiliation_strings":["Brain Connectivity Center, IRCCS Mondino Foundation, Pavia, Italy","Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Connectivity Center, IRCCS Mondino Foundation, Pavia, Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014552492","display_name":"Fulvia Palesi","orcid":"https://orcid.org/0000-0001-5027-8770"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Fulvia Palesi","raw_affiliation_strings":["Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5027-8770","affiliations":[{"raw_affiliation_string":"Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006185953","display_name":"Claudia Casellato","orcid":"https://orcid.org/0000-0002-8729-0391"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Claudia Casellato","raw_affiliation_strings":["Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060051804","display_name":"Egidio D\u2019Angelo","orcid":"https://orcid.org/0000-0002-6007-7187"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Egidio D\u2019Angelo","raw_affiliation_strings":["Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","Brain Connectivity Center, IRCCS Mondino Foundation, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Brain Connectivity Center, IRCCS Mondino Foundation, Pavia, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5000167304","https://openalex.org/A5006185953","https://openalex.org/A5014552492","https://openalex.org/A5022027790","https://openalex.org/A5037442059","https://openalex.org/A5041703283","https://openalex.org/A5060051804","https://openalex.org/A5088131273","https://openalex.org/A5104163683"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I25217355","https://openalex.org/I277688954","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210121705","https://openalex.org/I4210151618","https://openalex.org/I4210152724","https://openalex.org/I45129253"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.2775,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.92547045,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"19","issue":"9","first_page":"e1011434","last_page":"e1011434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9865999817848206,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5720150470733643},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5436493754386902},{"id":"https://openalex.org/keywords/cerebellum","display_name":"Cerebellum","score":0.5199040770530701},{"id":"https://openalex.org/keywords/feed-forward","display_name":"Feed forward","score":0.5086208581924438},{"id":"https://openalex.org/keywords/cerebellar-cortex","display_name":"Cerebellar cortex","score":0.4908455014228821},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4801851511001587},{"id":"https://openalex.org/keywords/network-model","display_name":"Network model","score":0.47245195508003235},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.47072330117225647},{"id":"https://openalex.org/keywords/hebbian-theory","display_name":"Hebbian theory","score":0.4690442681312561},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.4251987040042877},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.41088324785232544},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.33103102445602417},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3014747202396393},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28790682554244995}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5720150470733643},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5436493754386902},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.5199040770530701},{"id":"https://openalex.org/C38858127","wikidata":"https://www.wikidata.org/wiki/Q5441228","display_name":"Feed forward","level":2,"score":0.5086208581924438},{"id":"https://openalex.org/C2992333117","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellar cortex","level":3,"score":0.4908455014228821},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4801851511001587},{"id":"https://openalex.org/C104122410","wikidata":"https://www.wikidata.org/wiki/Q1416406","display_name":"Network model","level":2,"score":0.47245195508003235},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.47072330117225647},{"id":"https://openalex.org/C111437709","wikidata":"https://www.wikidata.org/wiki/Q1277874","display_name":"Hebbian theory","level":3,"score":0.4690442681312561},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.4251987040042877},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41088324785232544},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.33103102445602417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3014747202396393},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28790682554244995},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1011434","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011434","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37656758","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37656758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-04281496v1","is_oa":true,"landing_page_url":"https://cnrs.hal.science/hal-04281496","pdf_url":"https://cnrs.hal.science/hal-04281496/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2023, 19 (9), pp.e1011434. ⟨10.1371/journal.pcbi.1011434⟩","raw_type":"Journal articles"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10177306","is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10177306/","pdf_url":"https://discovery.ucl.ac.uk/10177306/6/Wheeler-Kingshott_journal.pcbi.1011434.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   PLoS Computational Biology , 19  (9)    , Article e1011434. (2023)      ","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10501640","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10501640","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10501640/pdf/pcbi.1011434.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c2af305e8887474cb10e20e163538b54","is_oa":true,"landing_page_url":"https://doaj.org/article/c2af305e8887474cb10e20e163538b54","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 9, p e1011434 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011434","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011434","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1694509630","display_name":"Cholinergic and NMDAR-dependent recruitment of Layer 1 Interneuron shapes cortical motor Processing through network States Modulation","funder_award_id":"892175","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2266930904","display_name":"A 5 year prospective follow-up clinical and imaging investigation of demyelinating clinically isolated syndrome (CIS)","funder_award_id":"MR/S026088/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2487747176","display_name":null,"funder_award_id":"MR/S026088/1","funder_id":"https://openalex.org/F4320313882","funder_display_name":"Medical Research Charities Group"},{"id":"https://openalex.org/G3111988204","display_name":null,"funder_award_id":"11.10.2022","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3323308467","display_name":null,"funder_award_id":"PE0000006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3899020896","display_name":null,"funder_award_id":"B51E22000150006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4527360133","display_name":null,"funder_award_id":"892175","funder_id":"https://openalex.org/F4320338438","funder_display_name":"HORIZON EUROPE Marie Sklodowska-Curie Actions"},{"id":"https://openalex.org/G4530127105","display_name":null,"funder_award_id":"945539","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G4558954134","display_name":null,"funder_award_id":"BRC704/CAP/CGW","funder_id":"https://openalex.org/F4320315071","funder_display_name":"NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research"},{"id":"https://openalex.org/G5055238918","display_name":null,"funder_award_id":"CUP B51E22000150006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6900113999","display_name":null,"funder_award_id":"945539","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8423478724","display_name":null,"funder_award_id":"169111","funder_id":"https://openalex.org/F4320313243","funder_display_name":"Wings for Life"},{"id":"https://openalex.org/G8767435255","display_name":null,"funder_award_id":"945539","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320313243","display_name":"Wings for Life","ror":"https://ror.org/043zam433"},{"id":"https://openalex.org/F4320313882","display_name":"Medical Research Charities Group","ror":null},{"id":"https://openalex.org/F4320315071","display_name":"NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320050","display_name":"Ataxia UK","ror":"https://ror.org/03192vt15"},{"id":"https://openalex.org/F4320320084","display_name":"Multiple Sclerosis Society","ror":"https://ror.org/043fwdk81"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320328328","display_name":"Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi","ror":"https://ror.org/01qb1sw63"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320338438","display_name":"HORIZON EUROPE Marie Sklodowska-Curie Actions","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":136,"referenced_works":["https://openalex.org/W1184115476","https://openalex.org/W1746647265","https://openalex.org/W1907139638","https://openalex.org/W1952219964","https://openalex.org/W1963789865","https://openalex.org/W1967751939","https://openalex.org/W1969266707","https://openalex.org/W1977453932","https://openalex.org/W1978172053","https://openalex.org/W1984909609","https://openalex.org/W1984915453","https://openalex.org/W1985983039","https://openalex.org/W1989332852","https://openalex.org/W1990738189","https://openalex.org/W1996719125","https://openalex.org/W1997307080","https://openalex.org/W2016064870","https://openalex.org/W2016354087","https://openalex.org/W2019779022","https://openalex.org/W2023655930","https://openalex.org/W2026193431","https://openalex.org/W2028590620","https://openalex.org/W2036682006","https://openalex.org/W2037192432","https://openalex.org/W2042786405","https://openalex.org/W2046756894","https://openalex.org/W2051057512","https://openalex.org/W2051966316","https://openalex.org/W2052332898","https://openalex.org/W2057166223","https://openalex.org/W2063614034","https://openalex.org/W2063731880","https://openalex.org/W2063975027","https://openalex.org/W2069333865","https://openalex.org/W2070765152","https://openalex.org/W2078088488","https://openalex.org/W2078566502","https://openalex.org/W2087231528","https://openalex.org/W2087645794","https://openalex.org/W2091727926","https://openalex.org/W2092874151","https://openalex.org/W2105584468","https://openalex.org/W2112666468","https://openalex.org/W2113345172","https://openalex.org/W2117663940","https://openalex.org/W2120079537","https://openalex.org/W2123235605","https://openalex.org/W2127247755","https://openalex.org/W2128949090","https://openalex.org/W2129212414","https://openalex.org/W2142039948","https://openalex.org/W2145749918","https://openalex.org/W2146052710","https://openalex.org/W2149900811","https://openalex.org/W2155986795","https://openalex.org/W2160239507","https://openalex.org/W2204225291","https://openalex.org/W2229595996","https://openalex.org/W2341809225","https://openalex.org/W2345458134","https://openalex.org/W2512047319","https://openalex.org/W2519093832","https://openalex.org/W2547783202","https://openalex.org/W2567132653","https://openalex.org/W2588388246","https://openalex.org/W2754504948","https://openalex.org/W2807768758","https://openalex.org/W2885176719","https://openalex.org/W2886387331","https://openalex.org/W2887088391","https://openalex.org/W2895556906","https://openalex.org/W2905504093","https://openalex.org/W2909164028","https://openalex.org/W2911227059","https://openalex.org/W2911950020","https://openalex.org/W2911965397","https://openalex.org/W2922876238","https://openalex.org/W2928442685","https://openalex.org/W2948031228","https://openalex.org/W2948227879","https://openalex.org/W2952155612","https://openalex.org/W2952194729","https://openalex.org/W2953247723","https://openalex.org/W2978564343","https://openalex.org/W2986849718","https://openalex.org/W2993561046","https://openalex.org/W2996067309","https://openalex.org/W3002728796","https://openalex.org/W3005543067","https://openalex.org/W3015908580","https://openalex.org/W3019449754","https://openalex.org/W3021450790","https://openalex.org/W3024223917","https://openalex.org/W3041250095","https://openalex.org/W3046525949","https://openalex.org/W3092835645","https://openalex.org/W3096673542","https://openalex.org/W3101571838","https://openalex.org/W3103282891","https://openalex.org/W3109762433","https://openalex.org/W3113692425","https://openalex.org/W3129830605","https://openalex.org/W3154128550","https://openalex.org/W3160046761","https://openalex.org/W3160823891","https://openalex.org/W3171468289","https://openalex.org/W3190967461","https://openalex.org/W3191296514","https://openalex.org/W3198714172","https://openalex.org/W3207997624","https://openalex.org/W3210509854","https://openalex.org/W3211577326","https://openalex.org/W3214213572","https://openalex.org/W4200528459","https://openalex.org/W4205620088","https://openalex.org/W4205659303","https://openalex.org/W4214606307","https://openalex.org/W4214708366","https://openalex.org/W4220696751","https://openalex.org/W4220705355","https://openalex.org/W4220718010","https://openalex.org/W4220960544","https://openalex.org/W4225271248","https://openalex.org/W4225761550","https://openalex.org/W4226056364","https://openalex.org/W4226160583","https://openalex.org/W4280541218","https://openalex.org/W4282963949","https://openalex.org/W4288046563","https://openalex.org/W4289884060","https://openalex.org/W4301181055","https://openalex.org/W4304695198","https://openalex.org/W4308941896","https://openalex.org/W4377139030","https://openalex.org/W6814887898","https://openalex.org/W6846462161"],"related_works":["https://openalex.org/W3104020672","https://openalex.org/W3040845310","https://openalex.org/W2137674257","https://openalex.org/W3039382151","https://openalex.org/W2159992686","https://openalex.org/W1978872345","https://openalex.org/W2143361130","https://openalex.org/W2286391053","https://openalex.org/W2796453918","https://openalex.org/W2051329568"],"abstract_inverted_index":{"Mean-field":[0],"(MF)":[1],"models":[2,49,228],"are":[3,39,69,135],"computational":[4,45],"formalism":[5,24],"used":[6],"to":[7,41,173],"summarize":[8],"in":[9,137,171,193,225],"a":[10,84,123,159,206],"few":[11],"statistical":[12],"parameters":[13,134],"the":[14,44,54,66,76,88,109,164,179,182,197,214],"salient":[15],"biophysical":[16],"properties":[17,128,220],"of":[18,29,47,50,56,75,87,125,129,167,181,199,213],"an":[19],"inter-wired":[20],"neuronal":[21,130,169,219],"network.":[22],"Their":[23],"normally":[25],"incorporates":[26],"different":[27,168],"types":[28],"neurons":[30],"and":[31,82,99,102,108,132,177,196,221,232],"synapses":[32],"along":[33],"with":[34],"their":[35],"topological":[36,133],"organization.":[37],"MFs":[38,61],"crucial":[40],"efficiently":[42],"implement":[43],"modules":[46],"large-scale":[48],"brain":[51,223,227],"function,":[52],"maintaining":[53],"specificity":[55],"local":[57,148],"cortical":[58,188],"microcircuits.":[59],"While":[60],"have":[62,80],"been":[63],"generated":[64],"for":[65,72,210],"isocortex,":[67],"they":[68],"still":[70],"missing":[71],"other":[73],"parts":[74],"brain.":[77],"Here":[78],"we":[79],"designed":[81],"simulated":[83],"multi-layer":[85],"MF":[86,119,162,204],"cerebellar":[89,118,156,203],"microcircuit":[90,115],"(including":[91],"Granule":[92],"Cells,":[93,95],"Golgi":[94],"Molecular":[96],"Layer":[97],"Interneurons,":[98],"Purkinje":[100,183],"Cells)":[101],"validated":[103],"it":[104],"against":[105],"experimental":[106],"data":[107],"corresponding":[110],"spiking":[111],"neural":[112],"network":[113],"(SNN)":[114],"model.":[116],"The":[117,141,161,202],"was":[120,145],"built":[121],"using":[122,147],"system":[124],"equations,":[126],"where":[127],"populations":[131,170],"embedded":[136],"inter-dependent":[138],"transfer":[139],"functions.":[140],"model":[142],"time":[143],"constant":[144],"optimised":[146],"field":[149],"potentials":[150],"recorded":[151],"experimentally":[152],"from":[153],"acute":[154],"mouse":[155],"slices":[157],"as":[158],"template.":[160],"reproduced":[163],"average":[165],"dynamics":[166],"response":[172],"various":[174],"input":[175],"patterns":[176],"predicted":[178],"modulation":[180],"Cells":[184],"firing":[185],"depending":[186],"on":[187],"plasticity,":[189],"which":[190],"drives":[191],"learning":[192],"associative":[194],"tasks,":[195],"level":[198],"feedforward":[200],"inhibition.":[201],"provides":[205],"computationally":[207],"efficient":[208],"tool":[209],"future":[211],"investigations":[212],"causal":[215],"relationship":[216],"between":[217],"microscopic":[218],"ensemble":[222],"activity":[224],"virtual":[226],"addressing":[229],"both":[230],"physiological":[231],"pathological":[233],"conditions.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-14T07:44:22.658603","created_date":"2025-10-10T00:00:00"}