{"id":"https://openalex.org/W4396939104","doi":"https://doi.org/10.1371/journal.pcbi.1011372","title":"Identification of Low-Complexity Domains by Compositional Signatures Reveals Class-Specific Frequencies and Functions Across the Domains of Life","display_name":"Identification of Low-Complexity Domains by Compositional Signatures Reveals Class-Specific Frequencies and Functions Across the Domains of Life","publication_year":2024,"publication_date":"2024-05-15","ids":{"openalex":"https://openalex.org/W4396939104","doi":"https://doi.org/10.1371/journal.pcbi.1011372","pmid":"https://pubmed.ncbi.nlm.nih.gov/38748749"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011372","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011372","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1011372","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087578611","display_name":"Sean M. Cascarina","orcid":"https://orcid.org/0000-0002-3054-2332"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sean M. Cascarina","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-3054-2332","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, United States of America","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066681016","display_name":"Eric D. Ross","orcid":"https://orcid.org/0000-0002-6473-9977"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric D. Ross","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, United States of America","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066681016","https://openalex.org/A5087578611"],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6251,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.64243782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"20","issue":"5","first_page":"e1011372","last_page":"e1011372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.7519768476486206},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5969403386116028},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.5357038378715515},{"id":"https://openalex.org/keywords/model-organism","display_name":"Model organism","score":0.50710129737854},{"id":"https://openalex.org/keywords/three-domain-system","display_name":"Three-domain system","score":0.49991822242736816},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.44817885756492615},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.42340773344039917},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4185165762901306},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30684763193130493},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.23729157447814941},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14611485600471497},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.10715121030807495}],"concepts":[{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.7519768476486206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5969403386116028},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5357038378715515},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.50710129737854},{"id":"https://openalex.org/C188880781","wikidata":"https://www.wikidata.org/wiki/Q2430501","display_name":"Three-domain system","level":4,"score":0.49991822242736816},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.44817885756492615},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.42340773344039917},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4185165762901306},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30684763193130493},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.23729157447814941},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14611485600471497},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.10715121030807495}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1011372","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011372","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:38748749","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38748749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11132505","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11132505","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11132505/pdf/pcbi.1011372.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ff4ef4e7fac24312b15f70268f460c01","is_oa":true,"landing_page_url":"https://doaj.org/article/ff4ef4e7fac24312b15f70268f460c01","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 20, Iss 5, p e1011372 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011372","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011372","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/12","score":0.4300000071525574,"display_name":"Responsible consumption and production"}],"awards":[{"id":"https://openalex.org/G3559959239","display_name":null,"funder_award_id":"R35GM130352","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5424111711","display_name":null,"funder_award_id":"2201538","funder_id":"https://openalex.org/F4320332538","funder_display_name":"University of Colorado Boulder"},{"id":"https://openalex.org/G7040118477","display_name":"CC* Compute: HPC Services for the Colorado State University System","funder_award_id":"2201538","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309627","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17"},{"id":"https://openalex.org/F4320332538","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1497984091","https://openalex.org/W1518685117","https://openalex.org/W1766761376","https://openalex.org/W1843070187","https://openalex.org/W1908298847","https://openalex.org/W1972376083","https://openalex.org/W1974279135","https://openalex.org/W1996816368","https://openalex.org/W2024315349","https://openalex.org/W2035238742","https://openalex.org/W2036792148","https://openalex.org/W2041440237","https://openalex.org/W2041491989","https://openalex.org/W2046231927","https://openalex.org/W2049476357","https://openalex.org/W2051916497","https://openalex.org/W2053780937","https://openalex.org/W2062382507","https://openalex.org/W2080186079","https://openalex.org/W2080694029","https://openalex.org/W2080940431","https://openalex.org/W2089431713","https://openalex.org/W2096950454","https://openalex.org/W2104412724","https://openalex.org/W2107751663","https://openalex.org/W2114823344","https://openalex.org/W2120549166","https://openalex.org/W2123178347","https://openalex.org/W2126155530","https://openalex.org/W2129672765","https://openalex.org/W2134280519","https://openalex.org/W2139565054","https://openalex.org/W2146926661","https://openalex.org/W2154610073","https://openalex.org/W2157179113","https://openalex.org/W2183718311","https://openalex.org/W2264948396","https://openalex.org/W2770091706","https://openalex.org/W2785487547","https://openalex.org/W2794654572","https://openalex.org/W2803645344","https://openalex.org/W2808121690","https://openalex.org/W2845591014","https://openalex.org/W2896610620","https://openalex.org/W2936163503","https://openalex.org/W2936216122","https://openalex.org/W2950448148","https://openalex.org/W2954453835","https://openalex.org/W2969702847","https://openalex.org/W2971718802","https://openalex.org/W2981156386","https://openalex.org/W3002679225","https://openalex.org/W3010929769","https://openalex.org/W3011713314","https://openalex.org/W3013185667","https://openalex.org/W3017333675","https://openalex.org/W3033689906","https://openalex.org/W3081090897","https://openalex.org/W3091174223","https://openalex.org/W3093561871","https://openalex.org/W3105227545","https://openalex.org/W3158874019","https://openalex.org/W3164928220","https://openalex.org/W3193435674","https://openalex.org/W3199971302","https://openalex.org/W3206567733","https://openalex.org/W3210299387","https://openalex.org/W4220875218","https://openalex.org/W4221129295","https://openalex.org/W4225255203","https://openalex.org/W4226201541","https://openalex.org/W4255096940","https://openalex.org/W4283031733","https://openalex.org/W4283463448","https://openalex.org/W4286203348","https://openalex.org/W4296229385","https://openalex.org/W4306362495","https://openalex.org/W4306784391","https://openalex.org/W4307216088","https://openalex.org/W4386255197","https://openalex.org/W4388835185","https://openalex.org/W4393660537","https://openalex.org/W4394052116"],"related_works":["https://openalex.org/W4223896405","https://openalex.org/W2059629050","https://openalex.org/W2074740504","https://openalex.org/W3013644380","https://openalex.org/W1996935079","https://openalex.org/W3210243923","https://openalex.org/W2145833061","https://openalex.org/W2258998699","https://openalex.org/W1998405066","https://openalex.org/W2171737904"],"abstract_inverted_index":{"Low-complexity":[0],"domains":[1],"(LCDs)":[2],"in":[3,8,62,69,83,114,159,200,217,223],"proteins":[4],"are":[5,66,163],"typically":[6],"enriched":[7],"one":[9],"or":[10],"two":[11],"predominant":[12],"amino":[13,108,112],"acids.":[14],"As":[15],"a":[16,75,218],"result,":[17],"LCDs":[18,57,82,100,239],"often":[19],"exhibit":[20],"unusual":[21,96],"structural/biophysical":[22],"tendencies":[23],"and":[24,41,78,95,110,140,149,226,235],"can":[25,171],"occupy":[26,59],"functional":[27,79,236],"niches.":[28],"However,":[29],"for":[30,174],"each":[31,115,175],"organism,":[32,138],"protein":[33],"sequences":[34],"must":[35],"be":[36,172,185],"compatible":[37],"with":[38,90,179,193],"intracellular":[39],"biomolecules":[40],"physicochemical":[42],"environment,":[43],"both":[44,105],"of":[45,81,98,121,128,136,146,168,177,209,221,238],"which":[46],"vary":[47],"from":[48],"organism":[49],"to":[50,104,184],"organism.":[51],"This":[52],"raises":[53],"the":[54,106,232],"possibility":[55],"that":[56,65],"may":[58],"sequence":[60],"spaces":[61],"select":[63],"organisms":[64],"otherwise":[67],"prohibited":[68],"most":[70],"organisms.":[71,126],"Here,":[72],"we":[73],"report":[74],"comprehensive":[76],"survey":[77],"analysis":[80,203],"all":[84,154,210,241],"known":[85,242],"reference":[86],"proteomes":[87],"(>21k":[88],"organisms),":[89],"added":[91],"focus":[92],"on":[93],"rare":[94,169],"types":[97],"LCDs.":[99],"were":[101,190],"classified":[102],"according":[103],"primary":[107],"acid":[109,113],"secondary":[111],"LCD":[116,122,129,147,156,181,188,211,224],"sequence,":[117],"facilitating":[118],"detailed":[119],"comparisons":[120],"class":[123],"frequencies":[124,148,225],"across":[125,196,240],"Examination":[127],"classes":[130,157,170,182,189,212],"at":[131],"different":[132],"depths":[133],"(i.e.,":[134],"domain":[135,176],"life,":[137,178],"protein,":[139],"per-residue":[141],"levels)":[142],"reveals":[143],"unique":[144],"facets":[145],"functions.":[150,227],"To":[151],"our":[152],"surprise,":[153],"400":[155],"occur":[158],"nature,":[160],"although":[161],"some":[162],"exceptionally":[164],"rare.":[165],"A":[166],"number":[167],"defined":[173],"many":[180,197],"appearing":[183],"eukaryote-specific.":[186],"Certain":[187],"consistently":[191],"associated":[192],"identical":[194],"functions":[195],"organisms,":[198,215],"particularly":[199],"eukaryotes.":[201],"Our":[202],"methods":[204],"enable":[205],"simultaneous,":[206],"direct":[207],"comparison":[208],"between":[213],"individual":[214],"resulting":[216],"proteome-scale":[219],"view":[220],"differences":[222],"Together,":[228],"these":[229],"results":[230],"highlight":[231],"remarkable":[233],"diversity":[234],"specificity":[237],"life":[243],"forms.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3}],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2025-10-10T00:00:00"}
