{"id":"https://openalex.org/W4385335422","doi":"https://doi.org/10.1371/journal.pcbi.1011336","title":"Implications of differential size-scaling of cell-cycle regulators on cell size homeostasis","display_name":"Implications of differential size-scaling of cell-cycle regulators on cell size homeostasis","publication_year":2023,"publication_date":"2023-07-28","ids":{"openalex":"https://openalex.org/W4385335422","doi":"https://doi.org/10.1371/journal.pcbi.1011336","pmid":"https://pubmed.ncbi.nlm.nih.gov/37506170"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011336","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011336","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011336&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011336&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084354049","display_name":"Xiangrui Ji","orcid":"https://orcid.org/0000-0003-3434-6520"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiangrui Ji","raw_affiliation_strings":["Yuanpei College, Peking University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-3434-6520","affiliations":[{"raw_affiliation_string":"Yuanpei College, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100674233","display_name":"Jie Lin","orcid":"https://orcid.org/0000-0002-2027-4661"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Lin","raw_affiliation_strings":["Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-2027-4661","affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084354049","https://openalex.org/A5100674233"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210160507"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.2691,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.61640801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"19","issue":"7","first_page":"e1011336","last_page":"e1011336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.7302471995353699},{"id":"https://openalex.org/keywords/cell-division","display_name":"Cell division","score":0.6667309999465942},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.5560942888259888},{"id":"https://openalex.org/keywords/cell-size","display_name":"Cell size","score":0.5527037978172302},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5338531732559204},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5121464729309082},{"id":"https://openalex.org/keywords/scaling","display_name":"Scaling","score":0.49548423290252686},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.41667449474334717},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2422783076763153},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2232455611228943}],"concepts":[{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.7302471995353699},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.6667309999465942},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5560942888259888},{"id":"https://openalex.org/C3017597547","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell size","level":2,"score":0.5527037978172302},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5338531732559204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5121464729309082},{"id":"https://openalex.org/C99844830","wikidata":"https://www.wikidata.org/wiki/Q102441924","display_name":"Scaling","level":2,"score":0.49548423290252686},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41667449474334717},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2422783076763153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2232455611228943},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1011336","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011336","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011336&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37506170","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37506170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10411824","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10411824","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10411824/pdf/pcbi.1011336.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3abda651ba5f49cc820cd55f52e36b15","is_oa":true,"landing_page_url":"https://doaj.org/article/3abda651ba5f49cc820cd55f52e36b15","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 7, p e1011336 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011336","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011336","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011336&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8272864169","display_name":null,"funder_award_id":"2021YFF1200500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385335422.pdf","grobid_xml":"https://content.openalex.org/works/W4385335422.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1829149466","https://openalex.org/W1925665659","https://openalex.org/W1949134079","https://openalex.org/W1968146089","https://openalex.org/W1972312016","https://openalex.org/W1985217551","https://openalex.org/W1986616568","https://openalex.org/W1997200609","https://openalex.org/W2005665415","https://openalex.org/W2015038174","https://openalex.org/W2024391964","https://openalex.org/W2028457150","https://openalex.org/W2034744178","https://openalex.org/W2035091349","https://openalex.org/W2044463066","https://openalex.org/W2051723837","https://openalex.org/W2052948442","https://openalex.org/W2064460491","https://openalex.org/W2078477504","https://openalex.org/W2085020901","https://openalex.org/W2088059732","https://openalex.org/W2088127501","https://openalex.org/W2097005988","https://openalex.org/W2108185984","https://openalex.org/W2111452172","https://openalex.org/W2122121413","https://openalex.org/W2123416375","https://openalex.org/W2133401281","https://openalex.org/W2144504620","https://openalex.org/W2149641002","https://openalex.org/W2150750144","https://openalex.org/W2153501719","https://openalex.org/W2171280873","https://openalex.org/W2171416668","https://openalex.org/W2172213445","https://openalex.org/W2177398160","https://openalex.org/W2188142152","https://openalex.org/W2194184864","https://openalex.org/W2283051572","https://openalex.org/W2283557773","https://openalex.org/W2319985900","https://openalex.org/W2610986680","https://openalex.org/W2674402523","https://openalex.org/W2750653488","https://openalex.org/W2751416180","https://openalex.org/W2797048935","https://openalex.org/W2804741713","https://openalex.org/W2911928150","https://openalex.org/W2931448452","https://openalex.org/W2949329647","https://openalex.org/W2949523314","https://openalex.org/W2950130215","https://openalex.org/W2951563547","https://openalex.org/W2952594353","https://openalex.org/W2985267612","https://openalex.org/W3005737795","https://openalex.org/W3006926844","https://openalex.org/W3015169825","https://openalex.org/W3044410178","https://openalex.org/W3048587850","https://openalex.org/W3089117620","https://openalex.org/W3096214562","https://openalex.org/W3130403261","https://openalex.org/W3172646184","https://openalex.org/W3200920417","https://openalex.org/W3203875270","https://openalex.org/W3212365398","https://openalex.org/W3216552758","https://openalex.org/W4239833133","https://openalex.org/W4245389020","https://openalex.org/W4280529518","https://openalex.org/W4292379725","https://openalex.org/W4388500963"],"related_works":["https://openalex.org/W3032526538","https://openalex.org/W2387704253","https://openalex.org/W3022642502","https://openalex.org/W2379910594","https://openalex.org/W1972509069","https://openalex.org/W2561416304","https://openalex.org/W2521560206","https://openalex.org/W4382786356","https://openalex.org/W3009790915","https://openalex.org/W4297311555"],"abstract_inverted_index":{"Accurate":[0],"timing":[1,19],"of":[2,20,26,54,95,116,132,153,177,183,185,206,213],"division":[3,21,139],"and":[4,47,49,71,110],"size":[5,60,83,123,137,187,196,215],"homeostasis":[6],"is":[7,22,140],"crucial":[8],"for":[9,14],"cells.":[10],"A":[11],"potential":[12],"mechanism":[13,41,212],"cells":[15],"to":[16,44,125],"decide":[17],"the":[18,23,51,58,76,85,93,105,117,121,126,133,135,147,150,154,158,160,171,175,181,190,193,203],"differential":[24,149,204],"scaling":[25,52,152,205],"regulatory":[27,55],"protein":[28],"copy":[29],"numbers":[30],"with":[31,81,120,142,167],"cell":[32,59,72,82,90,106,122,136,186,195,214],"size.":[33],"However,":[34],"it":[35],"remains":[36,188],"unclear":[37],"whether":[38],"such":[39],"a":[40,65,99,113,129,178,210],"can":[42,107],"lead":[43],"robust":[45,211],"growth":[46],"division,":[48],"how":[50],"behaviors":[53],"proteins":[56],"influence":[57],"distribution.":[61],"Here":[62],"we":[63],"study":[64],"mathematical":[66],"model":[67,166],"combining":[68],"gene":[69],"expression":[70],"growth,":[73],"in":[74],"which":[75],"cell-cycle":[77,155,207],"activators":[78],"scale":[79,87],"superlinearly":[80],"while":[84],"inhibitors":[86],"sublinearly.":[88],"The":[89],"divides":[91],"once":[92],"ratio":[94],"their":[96],"concentrations":[97],"reaches":[98],"threshold":[100,118],"value.":[101],"We":[102],"find":[103],"that":[104,143,173,202],"robustly":[108],"grow":[109],"divide":[111],"within":[112],"finite":[114],"range":[115],"value":[119],"proportional":[124],"ploidy.":[127],"In":[128],"stochastic":[130],"version":[131],"model,":[134],"at":[138,144],"uncorrelated":[141],"birth.":[145],"Also,":[146],"more":[148],"cell-size":[151,161],"regulators":[156,169,208],"is,":[157],"narrower":[159],"distribution":[162],"is.":[163],"Intriguingly,":[164],"our":[165],"multiple":[168],"rationalizes":[170],"observation":[172],"after":[174],"deletion":[176],"single":[179],"regulator,":[180],"coefficient":[182],"variation":[184],"roughly":[189],"same":[191],"though":[192],"average":[194],"changes":[197],"significantly.":[198],"Our":[199],"work":[200],"reveals":[201],"provides":[209],"control.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}