{"id":"https://openalex.org/W4385256870","doi":"https://doi.org/10.1371/journal.pcbi.1011323","title":"Evaluating the utility of brightfield image data for mechanism of action prediction","display_name":"Evaluating the utility of brightfield image data for mechanism of action prediction","publication_year":2023,"publication_date":"2023-07-25","ids":{"openalex":"https://openalex.org/W4385256870","doi":"https://doi.org/10.1371/journal.pcbi.1011323","pmid":"https://pubmed.ncbi.nlm.nih.gov/37490493"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1011323","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011323","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011323&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011323&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037062871","display_name":"Philip J. Harrison","orcid":"https://orcid.org/0000-0003-4046-9017"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Philip John Harrison","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","Science for Life Laboratory, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Science for Life Laboratory, Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060642509","display_name":"Ankit Gupta","orcid":"https://orcid.org/0000-0002-9961-1041"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Ankit Gupta","raw_affiliation_strings":["Department of Information Technology, Uppsala University, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Information Technology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063974642","display_name":"Jonne Rietdijk","orcid":"https://orcid.org/0000-0003-3799-6684"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Jonne Rietdijk","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","Science for Life Laboratory, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Science for Life Laboratory, Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010333712","display_name":"H\u00e5kan Wieslander","orcid":"https://orcid.org/0000-0002-6289-7285"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"H\u00e5kan Wieslander","raw_affiliation_strings":["Department of Information Technology, Uppsala University, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Information Technology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070109614","display_name":"Jordi Carreras\u2010Puigvert","orcid":"https://orcid.org/0000-0002-7671-3707"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Jordi Carreras-Puigvert","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","Science for Life Laboratory, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Science for Life Laboratory, Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112675702","display_name":"Polina Georgiev","orcid":null},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Polina Georgiev","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","Science for Life Laboratory, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Science for Life Laboratory, Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028372092","display_name":"Carolina W\u00e4hlby","orcid":"https://orcid.org/0000-0002-4139-7003"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Carolina W\u00e4hlby","raw_affiliation_strings":["Department of Information Technology, Uppsala University, Uppsala, Sweden","Science for Life Laboratory, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Information Technology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Science for Life Laboratory, Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046663348","display_name":"Ola Spjuth","orcid":"https://orcid.org/0000-0002-8083-2864"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Ola Spjuth","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","Science for Life Laboratory, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Science for Life Laboratory, Uppsala, Sweden","institution_ids":["https://openalex.org/I2800139495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075025484","display_name":"Ida\u2010Maria Sintorn","orcid":"https://orcid.org/0000-0002-8307-7411"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Ida-Maria Sintorn","raw_affiliation_strings":["Department of Information Technology, Uppsala University, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Information Technology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5010333712","https://openalex.org/A5028372092","https://openalex.org/A5037062871","https://openalex.org/A5046663348","https://openalex.org/A5060642509","https://openalex.org/A5063974642","https://openalex.org/A5070109614","https://openalex.org/A5075025484","https://openalex.org/A5112675702"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":11.7593,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.98426108,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"19","issue":"7","first_page":"e1011323","last_page":"e1011323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.6306846737861633},{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"Fluorescence-lifetime imaging microscopy","score":0.5773310661315918},{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.5717157125473022},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5592181086540222},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.46885427832603455},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38998863101005554},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.3838519752025604},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3823290467262268},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.2261911928653717},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.120269775390625},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.10531473159790039},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0710916519165039}],"concepts":[{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.6306846737861633},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.5773310661315918},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.5717157125473022},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5592181086540222},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.46885427832603455},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38998863101005554},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.3838519752025604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3823290467262268},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2261911928653717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.120269775390625},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10531473159790039},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0710916519165039}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1011323","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011323","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011323&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:37490493","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37490493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10403126","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10403126","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10403126/pdf/pcbi.1011323.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:DiVA.org:uu-508612","is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-508612","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:85990f7293cc46fcb94d5072e05d47ac","is_oa":true,"landing_page_url":"https://doaj.org/article/85990f7293cc46fcb94d5072e05d47ac","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 19, Iss 7, p e1011323 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1011323","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1011323","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011323&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/8","display_name":"Decent work and economic growth","score":0.6700000166893005}],"awards":[{"id":"https://openalex.org/G1129664918","display_name":null,"funder_award_id":"22 2412 Pj","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G2507116792","display_name":null,"funder_award_id":"BD15-0008SB16-0046","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G3629116768","display_name":null,"funder_award_id":"22 2412 Pj","funder_id":"https://openalex.org/F4320313607","funder_display_name":"Swedish Cancer Foundation"},{"id":"https://openalex.org/G383028037","display_name":null,"funder_award_id":"2020-03731","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G561944777","display_name":null,"funder_award_id":"101057442","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"},{"id":"https://openalex.org/G5725902739","display_name":null,"funder_award_id":"FORMAS","funder_id":"https://openalex.org/F4320321033","funder_display_name":"Svenska Forskningsr\u00e5det Formas"},{"id":"https://openalex.org/G6073166506","display_name":null,"funder_award_id":"101057442 (REMEDI4ALL)","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"},{"id":"https://openalex.org/G6160978325","display_name":null,"funder_award_id":"2020-01865","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G6192776107","display_name":null,"funder_award_id":"SB16-0046","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G643302094","display_name":null,"funder_award_id":"101057014","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"},{"id":"https://openalex.org/G6946902168","display_name":null,"funder_award_id":"grants 2020-03731 and 2020-01865","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G7359653403","display_name":null,"funder_award_id":"BD15-0008","funder_id":"https://openalex.org/F4320320940","funder_display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning"},{"id":"https://openalex.org/G8001301338","display_name":null,"funder_award_id":"REMEDI4ALL","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"},{"id":"https://openalex.org/G8080935424","display_name":null,"funder_award_id":"unknown","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G855192738","display_name":null,"funder_award_id":"2022-00940","funder_id":"https://openalex.org/F4320321033","funder_display_name":"Svenska Forskningsr\u00e5det Formas"},{"id":"https://openalex.org/G8552238362","display_name":null,"funder_award_id":"ERC-2015-CoG 683810","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G8683756101","display_name":null,"funder_award_id":"support","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"}],"funders":[{"id":"https://openalex.org/F4320313607","display_name":"Swedish Cancer Foundation","ror":null},{"id":"https://openalex.org/F4320320940","display_name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","ror":"https://ror.org/044wr7g58"},{"id":"https://openalex.org/F4320321033","display_name":"Svenska Forskningsr\u00e5det Formas","ror":"https://ror.org/03pjs1y45"},{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F4320336380","display_name":"National Supercomputer Centre, Link\u00f6pings Universitet","ror":null},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385256870.pdf","grobid_xml":"https://content.openalex.org/works/W4385256870.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1583837637","https://openalex.org/W1998614190","https://openalex.org/W2060833045","https://openalex.org/W2088666810","https://openalex.org/W2107554012","https://openalex.org/W2134481788","https://openalex.org/W2187790974","https://openalex.org/W2194775991","https://openalex.org/W2236142945","https://openalex.org/W2341721391","https://openalex.org/W2480007569","https://openalex.org/W2509141893","https://openalex.org/W2596519089","https://openalex.org/W2728842897","https://openalex.org/W2751625431","https://openalex.org/W2758460571","https://openalex.org/W2792200327","https://openalex.org/W2797749376","https://openalex.org/W2899181753","https://openalex.org/W2905502540","https://openalex.org/W2919115771","https://openalex.org/W2922305141","https://openalex.org/W2952854804","https://openalex.org/W2963446712","https://openalex.org/W2980185817","https://openalex.org/W3136205387","https://openalex.org/W3185313283","https://openalex.org/W3207566749","https://openalex.org/W4200370303","https://openalex.org/W4282967624","https://openalex.org/W4284671611","https://openalex.org/W4291666467","https://openalex.org/W4303446359","https://openalex.org/W4306711282","https://openalex.org/W4365518049","https://openalex.org/W4391993840"],"related_works":["https://openalex.org/W4211107619","https://openalex.org/W2161433272","https://openalex.org/W2894139091","https://openalex.org/W1637909","https://openalex.org/W1983780159","https://openalex.org/W659245948","https://openalex.org/W2100235831","https://openalex.org/W2027597586","https://openalex.org/W2037608610","https://openalex.org/W2269675061"],"abstract_inverted_index":{"Fluorescence":[0],"staining":[1],"techniques,":[2],"such":[3],"as":[4],"Cell":[5],"Painting,":[6],"together":[7],"with":[8,44],"fluorescence":[9,30,102,127,164],"microscopy":[10,31],"have":[11,25,63],"proven":[12],"invaluable":[13],"for":[14,86,110,145,153,161],"visualizing":[15],"and":[16,22,36,66,129,140],"quantifying":[17],"the":[18,37,45,60,67,95,112,126,134,146,188],"effects":[19],"that":[20,180],"drugs":[21],"other":[23],"perturbations":[24],"on":[26,101,107,170],"cultured":[27],"cells.":[28],"However,":[29],"is":[32,151,166],"expensive,":[33],"time-consuming,":[34],"labor-intensive,":[35],"stains":[38],"applied":[39],"can":[40],"be":[41,84],"cytotoxic,":[42],"interfering":[43],"activity":[46],"under":[47],"study.":[48],"The":[49],"simplest":[50],"form":[51],"of":[52,98,114,117,156],"microscopy,":[53,55],"brightfield":[54,80,108],"lacks":[56],"these":[57,79],"downsides,":[58],"but":[59],"images":[61,81,103,109,128,165],"produced":[62],"low":[64],"contrast":[65],"cellular":[68],"compartments":[69],"are":[70],"difficult":[71],"to":[72,104,132],"discern.":[73],"Nevertheless,":[74],"by":[75,184],"harnessing":[76],"deep":[77],"learning,":[78],"may":[82],"still":[83],"sufficient":[85],"various":[87],"predictive":[88,96,143],"purposes.":[89],"In":[90],"this":[91],"study,":[92],"we":[93,137],"compared":[94],"performance":[97,144],"models":[99],"trained":[100,106],"those":[105],"predicting":[111],"mechanism":[113],"action":[115],"(MoA)":[116],"different":[118],"drugs.":[119],"We":[120],"also":[121,174],"extracted":[122],"CellProfiler":[123],"features":[124],"from":[125],"used":[130],"them":[131],"benchmark":[133],"performance.":[135],"Overall,":[136],"found":[138],"comparable":[139],"largely":[141],"correlated":[142],"two":[147],"imaging":[148],"modalities.":[149],"This":[150],"promising":[152],"future":[154],"studies":[155],"MoAs":[157],"in":[158],"time-lapse":[159],"experiments":[160],"which":[162],"using":[163],"problematic.":[167],"Explorations":[168],"based":[169],"explainable":[171],"AI":[172],"techniques":[173],"provided":[175],"valuable":[176],"insights":[177],"regarding":[178],"compounds":[179],"were":[181],"better":[182],"predicted":[183],"one":[185],"modality":[186],"over":[187],"other.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":11}],"updated_date":"2026-04-02T15:55:50.835912","created_date":"2025-10-10T00:00:00"}
